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The map label for this gene is mepA [H]

Identifier: 18311517

GI number: 18311517

Start: 2903647

End: 2905014

Strand: Reverse

Name: mepA [H]

Synonym: CPE2535

Alternate gene names: 18311517

Gene position: 2905014-2903647 (Counterclockwise)

Preceding gene: 18311518

Following gene: 18311515

Centisome position: 95.83

GC content: 30.41

Gene sequence:

>1368_bases
ATGAAGGATCAAAAATTATTAGGGGAAGAATCAGAATTAAAGCTTTTGATCAAGTATTCGGTGCCAGCTATTATAGGTAT
GCTTGTAAATGCACTTTATAATATTGTTGATAGAATATTTATTGGACACATTCCAGGAGTTGGGCCAATGGCCATTACTG
GAGTTGGTATAACTATGCCAATTATGTCTATATTACTTGGTTTTGGAATGCTTATAGGGATTGGTGCTACTGCAAACATC
TCTATAAAATTTGGGCAAAATAAAAGAAAAGATGCAGAGAAAATATTAGGAAACTCTGTGGTCTTAATAACTATAATATC
TTTAGTTTTAACTATTGTTGGAATTGTATTTGCAAACAGTATTCTACACTTATTTGGAGCAAGTGAGGCTACAATTTTTT
ATGCAAAGGAATATATAAATGTAATACTTTTAGGAACTATATTTAATTTAATGTCATTCTCTTTATATAGTACAATTAGA
GCAGATGGAAATCCAAAGATGTCAGCTGCAGTAATGGTACTTGGATGTATTATAAATGTAATATTAGATGCAGTATTTAT
ATTTGTATTTAACTTAGGGATAAAAGGTGCGGCTTTAGCTACAGTAATTTCTCAAATAGTTACTACATTAATAATGCTTT
ATTATTATACATTAGGAGGATCAAACTTAAAATTAAAATTTGAAACTCTTAAATTAGATTGGAGATTAGTTAAGATAGTT
TTAGCTATAGGTGTAGCTCCGTTTTCAATGCAGATGGCTGCAAGTGTAGTTCAAGTAATAGCTAACAATGCACTAAGAAT
GTATGGAGGAGACTTAGCTATAGGAGCTATGGCGGCAATTTCTTCAATAGCAATGATATTTTTAATGCCTATATTTGGTA
TAAACCAAGGTTCACAGCCTATAATTGGATATAACTATGGAGCTAAGAAGTATGAAAGAGCTCAAAAAACAGTTAAGTTA
GCTATGATAGCAGCGACAACAATACTTGTTTTAGGAGGAATATTAATTCAAGCATTCCCAGCCTTAGTAATAAGTATGTT
TAATTCAGACCCTAAGCTTTTAGAAATAGGAGTTCCAGGATTAAGAATATATTTATTTATGATGCCTATAATAGGTATAT
CAATAATAGGATCTAACTATTTCCAATCAATAGGTAAAGCTAAGTTAGCAACTTTTTTAAGTTTATTAAGACAGGTTATA
CTTTTAATTCCTTTAACATTGGTCTTACCTAAGATTGCAGGATTAGGTTTAACAGGAGTTTGGTTAGCAGGTACAGTTTC
AGACTTCTTGTCTACAATAATAACTGGATTATTTATAATTAAAGAGTTTAAAAAAGAAGATAGTATAGAAGATGAAAAAG
CGATTTAA

Upstream 100 bases:

>100_bases
TTTTATTTTTAAAATTTCACTGACTAAAAAATTAAAATTAATGTATAATAGAAAAGTTAGTATATATTTAAGAAATATAG
ATTTAAAGGAGGAGAGGCTT

Downstream 100 bases:

>100_bases
AAAAAGCTGAGTTTAGAAATTTCTAAACTCAGCTTTCTTTTATATAATACCTTCGTCTTTTAATAAATCTTCAAGTTTTC
TTACTTTCTCTGTTAGAGTA

Product: MATE efflux family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 455; Mature: 455

Protein sequence:

>455_residues
MKDQKLLGEESELKLLIKYSVPAIIGMLVNALYNIVDRIFIGHIPGVGPMAITGVGITMPIMSILLGFGMLIGIGATANI
SIKFGQNKRKDAEKILGNSVVLITIISLVLTIVGIVFANSILHLFGASEATIFYAKEYINVILLGTIFNLMSFSLYSTIR
ADGNPKMSAAVMVLGCIINVILDAVFIFVFNLGIKGAALATVISQIVTTLIMLYYYTLGGSNLKLKFETLKLDWRLVKIV
LAIGVAPFSMQMAASVVQVIANNALRMYGGDLAIGAMAAISSIAMIFLMPIFGINQGSQPIIGYNYGAKKYERAQKTVKL
AMIAATTILVLGGILIQAFPALVISMFNSDPKLLEIGVPGLRIYLFMMPIIGISIIGSNYFQSIGKAKLATFLSLLRQVI
LLIPLTLVLPKIAGLGLTGVWLAGTVSDFLSTIITGLFIIKEFKKEDSIEDEKAI

Sequences:

>Translated_455_residues
MKDQKLLGEESELKLLIKYSVPAIIGMLVNALYNIVDRIFIGHIPGVGPMAITGVGITMPIMSILLGFGMLIGIGATANI
SIKFGQNKRKDAEKILGNSVVLITIISLVLTIVGIVFANSILHLFGASEATIFYAKEYINVILLGTIFNLMSFSLYSTIR
ADGNPKMSAAVMVLGCIINVILDAVFIFVFNLGIKGAALATVISQIVTTLIMLYYYTLGGSNLKLKFETLKLDWRLVKIV
LAIGVAPFSMQMAASVVQVIANNALRMYGGDLAIGAMAAISSIAMIFLMPIFGINQGSQPIIGYNYGAKKYERAQKTVKL
AMIAATTILVLGGILIQAFPALVISMFNSDPKLLEIGVPGLRIYLFMMPIIGISIIGSNYFQSIGKAKLATFLSLLRQVI
LLIPLTLVLPKIAGLGLTGVWLAGTVSDFLSTIITGLFIIKEFKKEDSIEDEKAI
>Mature_455_residues
MKDQKLLGEESELKLLIKYSVPAIIGMLVNALYNIVDRIFIGHIPGVGPMAITGVGITMPIMSILLGFGMLIGIGATANI
SIKFGQNKRKDAEKILGNSVVLITIISLVLTIVGIVFANSILHLFGASEATIFYAKEYINVILLGTIFNLMSFSLYSTIR
ADGNPKMSAAVMVLGCIINVILDAVFIFVFNLGIKGAALATVISQIVTTLIMLYYYTLGGSNLKLKFETLKLDWRLVKIV
LAIGVAPFSMQMAASVVQVIANNALRMYGGDLAIGAMAAISSIAMIFLMPIFGINQGSQPIIGYNYGAKKYERAQKTVKL
AMIAATTILVLGGILIQAFPALVISMFNSDPKLLEIGVPGLRIYLFMMPIIGISIIGSNYFQSIGKAKLATFLSLLRQVI
LLIPLTLVLPKIAGLGLTGVWLAGTVSDFLSTIITGLFIIKEFKKEDSIEDEKAI

Specific function: Multidrug resistance efflux protein [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily [H]

Homologues:

Organism=Escherichia coli, GI226510954, Length=434, Percent_Identity=22.3502304147465, Blast_Score=66, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528
- InterPro:   IPR015522 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 48985; Mature: 48985

Theoretical pI: Translated: 9.94; Mature: 9.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKDQKLLGEESELKLLIKYSVPAIIGMLVNALYNIVDRIFIGHIPGVGPMAITGVGITMP
CCCCCCCCCCCHHEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCCHHHH
IMSILLGFGMLIGIGATANISIKFGQNKRKDAEKILGNSVVLITIISLVLTIVGIVFANS
HHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
ILHLFGASEATIFYAKEYINVILLGTIFNLMSFSLYSTIRADGNPKMSAAVMVLGCIINV
HHHHHCCCCHHEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
ILDAVFIFVFNLGIKGAALATVISQIVTTLIMLYYYTLGGSNLKLKFETLKLDWRLVKIV
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEHHHHHHHHHH
LAIGVAPFSMQMAASVVQVIANNALRMYGGDLAIGAMAAISSIAMIFLMPIFGINQGSQP
HHHCCCCHHHHHHHHHHHHHHCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
IIGYNYGAKKYERAQKTVKLAMIAATTILVLGGILIQAFPALVISMFNSDPKLLEIGVPG
EEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCH
LRIYLFMMPIIGISIIGSNYFQSIGKAKLATFLSLLRQVILLIPLTLVLPKIAGLGLTGV
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
WLAGTVSDFLSTIITGLFIIKEFKKEDSIEDEKAI
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MKDQKLLGEESELKLLIKYSVPAIIGMLVNALYNIVDRIFIGHIPGVGPMAITGVGITMP
CCCCCCCCCCCHHEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCCHHHH
IMSILLGFGMLIGIGATANISIKFGQNKRKDAEKILGNSVVLITIISLVLTIVGIVFANS
HHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
ILHLFGASEATIFYAKEYINVILLGTIFNLMSFSLYSTIRADGNPKMSAAVMVLGCIINV
HHHHHCCCCHHEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
ILDAVFIFVFNLGIKGAALATVISQIVTTLIMLYYYTLGGSNLKLKFETLKLDWRLVKIV
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEHHHHHHHHHH
LAIGVAPFSMQMAASVVQVIANNALRMYGGDLAIGAMAAISSIAMIFLMPIFGINQGSQP
HHHCCCCHHHHHHHHHHHHHHCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
IIGYNYGAKKYERAQKTVKLAMIAATTILVLGGILIQAFPALVISMFNSDPKLLEIGVPG
EEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCH
LRIYLFMMPIIGISIIGSNYFQSIGKAKLATFLSLLRQVILLIPLTLVLPKIAGLGLTGV
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
WLAGTVSDFLSTIITGLFIIKEFKKEDSIEDEKAI
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA