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The map label for this gene is adhE [H]

Identifier: 18311513

GI number: 18311513

Start: 2899180

End: 2901777

Strand: Reverse

Name: adhE [H]

Synonym: CPE2531

Alternate gene names: 18311513

Gene position: 2901777-2899180 (Counterclockwise)

Preceding gene: 18311514

Following gene: 18311512

Centisome position: 95.72

GC content: 35.45

Gene sequence:

>2598_bases
ATGAAAGTAACAAACGTAGATGAATTAATGCTTAGATTAGAGAAAGTTAGAGCAGCTCAAAAAGAGTTCTCAAAATTCTC
TCAAGAGCAAGTAGATGAAATATTTAGACAAGCAGCAGTAGCAGCTAATAATGAGAGAATCAGATTAGCAAAAATGGCTG
TTGAAGAATCAGGAATGGGTATAGTTGAAGATAAAGTTATAAAAAACCATTTTGCTGCAGAATATATATACAATAAATAT
AAAGATGAAAAAACTTGTGGAGTTATAGAAAAAGATGAATCATTTGGTATCACTAAAATAGCTGAACCAATAGGAGTTGT
AGCAGCAATCGTTCCTACTACAAACCCAACATCAACAGCTATATTCAAAGCTTTAATATCATTAAAGACTAGAAACGCTG
TATTCTTTTCACCACATCCAAGAGCTAAAAACTCAACAATAGAAGCAGCTAGAGTTGTTTTAGAAGCAGCTGTTAAAGCT
GGAGCTCCAAAAGATATAATCGGATGGATAGATGAGCCATCAGTTGAAATGTCACAAGTATTAATGGCAGAAGCTGATAT
CATACTAGCTACTGGTGGTCCAGGAATGGTTAAAGCAGCTTACTCATCAGGAAAACCAGCTATCGGGGTTGGAGCAGGTA
ATACACCAGCAATCATAGATGAAACAGCTCACTTAAAAATGGCAGTAAACTCAATATTATTATCAAAAACTTTCGATAAC
GGTGTTATCTGTGCATCAGAGCAAACAGTATTAGTTGTTGATAAAGTTTATGATGAGGTAAGAAAAGAGTTCGCTGATAG
AGGAGCTTACTTCTTAAAAGATAAAGAAATAGATAAAGTAAGAAAAACAATTTTAATAAATGGTAACTTAAATGCTAACA
TAGTTGGTCAATCAGCATGGAAAATAGCTGACATGGCAGGTGTTAAGGTTCCAAAAGATACTAAAGTTTTAATTGGTGAA
GTTGAGTCAGTTGAATTAGAAGAACCATTCTCACATGAAAAATTATCACCAGTATTAGGAATGTACAGAGTAGCTAACTT
TGAAGAAGCTTTAGTTAAAGCTGAAAGATTAGTTGAACTTGGTGGATTCGGACATACTTCAGTTTTATACACTGATACAA
TGAAATCACAAGACAGAGTTCAAAAATTCGGTGCAACTATGAAAACTGGTAGAACAATAATAAATATGCCATCAACTCAA
GGAGCTATCGGAGATATATACAACTTCAAGCTAGCACCATCATTAACATTAGGTTGTGGATCATGGGGTGGAAACTCAGT
TTCAGAAAACGTTGGTCCTAAACACTTAATGAATGTTAAGAGTGTAGCTGAGAGGAGAGAAAATATGCTTTGGTTCAGAG
TTCCAGAAAAAGTTTACTTCAAATATGGTGCTTTAGGAGTTGCTCTTAGAGAATTAAAAGATTTAAACAAGAAAAAAGTA
TTTATAGTAACAGACAACGTACTAGCTAGTCTAGGATATGTTGATAAAATAACAAGTGTTTTAGAAGAAATAGGTGTAGA
TTTCAGAGTATTCTCAGAAGTTACTCCAGACCCAACTTTAGCATGTGCTAAAAAAGGTGCTGAAGCAATGAGAAGCTATC
AACCAGATGCAATCATAGCTCTTGGTGGAGGTTCACCAATGGACGCTGCTAAGATTATGTGGGTAATGTATGAGCATCCA
GAAGTTGCTTTCGAAGATTTAGCAATGAGATTCATGGATATAAGAAAGAGAGTTTACCCATTCCCAACTATGGGTCAAAA
AGCTATGATGATTTCAGTTCCAACATCAGCTGGTACTGGTTCAGAAGTAACACCATTCGCAGTTATAACTGATGAAGAAT
CAGGAGTAAAATATCCATTAGCAGATTACGAGTTAACTCCAGATATGGCTATCATAGATGCTGAGCTTATGATGAACATG
CCAAAAGGATTAACAGCTGCATCAGGTATAGACGCATTAACTCATGCTTTAGAAGCTTACGTTTCAGTTTTAGCATCAGA
GTACACTAATGGATTAGCTTTAGAAGCTATAAGATTAATATTTAAATACTTACCACAAGCTTACGCTGAAGGTACTACAA
ACATAAAAGCAAGAGAAAAAATGGCTCATGCTTCAACAATGGCTGGTATGGCATTCGCTAACGCATTCTTAGGAGTATGT
CACTCAATGGCACACAAATTAGGATCAGAACACCATATAGCACACGGAGTTGCTAACGGAATCTTAATAGACCATGTAAT
AAGATTCAACGCTGTTGACAACCCAAGAAAACAAGCTGCATTCCCACAATACAAATATCCAAATGCTAAATGGAGATATG
CAGTAATCGCTGACTACTTAGGATTAGGTGGAAAGAACGAAGAAGAAAAAGTTAATAACTTAATCAAGGCTATAGATAAC
CTTAAGAAAACAGTTGGAATTCCTGCAACAATAGCTGACTGTGGAGTTTCAAAAGAATCATTCTACGCTACATTAGAAAA
AATGAGTGAAGATGCATTCGATGACCAATGTACAGGTGCTAACCCAAGATACCCATTAATAAGTGAAATCAAGCAAATGT
ACATCAATGCTTTCGAAGGTAAAAAAGACAGAGTTTAA

Upstream 100 bases:

>100_bases
AATGGAATTTTATTAAAGTTAAAAACTTAACTAAATGCTTTTAATTAATTTTTACATATATTATGAAAATAAGAAACTAA
TCTATAATGAGGTGGGTATC

Downstream 100 bases:

>100_bases
TAGCTTTGAAATAAGATAATAATAAATACTCACTAGATTATCTAGTGAGTATTTTTTTCTATAAAAATATGTAAAGATGT
ACTATTTGTTAAGATTTTAA

Product: bifunctional acetaldehyde-CoA/alcohol dehydrogenase

Products: NA

Alternate protein names: Alcohol dehydrogenase; ADH; Acetaldehyde dehydrogenase [acetylating]; ACDH [H]

Number of amino acids: Translated: 865; Mature: 865

Protein sequence:

>865_residues
MKVTNVDELMLRLEKVRAAQKEFSKFSQEQVDEIFRQAAVAANNERIRLAKMAVEESGMGIVEDKVIKNHFAAEYIYNKY
KDEKTCGVIEKDESFGITKIAEPIGVVAAIVPTTNPTSTAIFKALISLKTRNAVFFSPHPRAKNSTIEAARVVLEAAVKA
GAPKDIIGWIDEPSVEMSQVLMAEADIILATGGPGMVKAAYSSGKPAIGVGAGNTPAIIDETAHLKMAVNSILLSKTFDN
GVICASEQTVLVVDKVYDEVRKEFADRGAYFLKDKEIDKVRKTILINGNLNANIVGQSAWKIADMAGVKVPKDTKVLIGE
VESVELEEPFSHEKLSPVLGMYRVANFEEALVKAERLVELGGFGHTSVLYTDTMKSQDRVQKFGATMKTGRTIINMPSTQ
GAIGDIYNFKLAPSLTLGCGSWGGNSVSENVGPKHLMNVKSVAERRENMLWFRVPEKVYFKYGALGVALRELKDLNKKKV
FIVTDNVLASLGYVDKITSVLEEIGVDFRVFSEVTPDPTLACAKKGAEAMRSYQPDAIIALGGGSPMDAAKIMWVMYEHP
EVAFEDLAMRFMDIRKRVYPFPTMGQKAMMISVPTSAGTGSEVTPFAVITDEESGVKYPLADYELTPDMAIIDAELMMNM
PKGLTAASGIDALTHALEAYVSVLASEYTNGLALEAIRLIFKYLPQAYAEGTTNIKAREKMAHASTMAGMAFANAFLGVC
HSMAHKLGSEHHIAHGVANGILIDHVIRFNAVDNPRKQAAFPQYKYPNAKWRYAVIADYLGLGGKNEEEKVNNLIKAIDN
LKKTVGIPATIADCGVSKESFYATLEKMSEDAFDDQCTGANPRYPLISEIKQMYINAFEGKKDRV

Sequences:

>Translated_865_residues
MKVTNVDELMLRLEKVRAAQKEFSKFSQEQVDEIFRQAAVAANNERIRLAKMAVEESGMGIVEDKVIKNHFAAEYIYNKY
KDEKTCGVIEKDESFGITKIAEPIGVVAAIVPTTNPTSTAIFKALISLKTRNAVFFSPHPRAKNSTIEAARVVLEAAVKA
GAPKDIIGWIDEPSVEMSQVLMAEADIILATGGPGMVKAAYSSGKPAIGVGAGNTPAIIDETAHLKMAVNSILLSKTFDN
GVICASEQTVLVVDKVYDEVRKEFADRGAYFLKDKEIDKVRKTILINGNLNANIVGQSAWKIADMAGVKVPKDTKVLIGE
VESVELEEPFSHEKLSPVLGMYRVANFEEALVKAERLVELGGFGHTSVLYTDTMKSQDRVQKFGATMKTGRTIINMPSTQ
GAIGDIYNFKLAPSLTLGCGSWGGNSVSENVGPKHLMNVKSVAERRENMLWFRVPEKVYFKYGALGVALRELKDLNKKKV
FIVTDNVLASLGYVDKITSVLEEIGVDFRVFSEVTPDPTLACAKKGAEAMRSYQPDAIIALGGGSPMDAAKIMWVMYEHP
EVAFEDLAMRFMDIRKRVYPFPTMGQKAMMISVPTSAGTGSEVTPFAVITDEESGVKYPLADYELTPDMAIIDAELMMNM
PKGLTAASGIDALTHALEAYVSVLASEYTNGLALEAIRLIFKYLPQAYAEGTTNIKAREKMAHASTMAGMAFANAFLGVC
HSMAHKLGSEHHIAHGVANGILIDHVIRFNAVDNPRKQAAFPQYKYPNAKWRYAVIADYLGLGGKNEEEKVNNLIKAIDN
LKKTVGIPATIADCGVSKESFYATLEKMSEDAFDDQCTGANPRYPLISEIKQMYINAFEGKKDRV
>Mature_865_residues
MKVTNVDELMLRLEKVRAAQKEFSKFSQEQVDEIFRQAAVAANNERIRLAKMAVEESGMGIVEDKVIKNHFAAEYIYNKY
KDEKTCGVIEKDESFGITKIAEPIGVVAAIVPTTNPTSTAIFKALISLKTRNAVFFSPHPRAKNSTIEAARVVLEAAVKA
GAPKDIIGWIDEPSVEMSQVLMAEADIILATGGPGMVKAAYSSGKPAIGVGAGNTPAIIDETAHLKMAVNSILLSKTFDN
GVICASEQTVLVVDKVYDEVRKEFADRGAYFLKDKEIDKVRKTILINGNLNANIVGQSAWKIADMAGVKVPKDTKVLIGE
VESVELEEPFSHEKLSPVLGMYRVANFEEALVKAERLVELGGFGHTSVLYTDTMKSQDRVQKFGATMKTGRTIINMPSTQ
GAIGDIYNFKLAPSLTLGCGSWGGNSVSENVGPKHLMNVKSVAERRENMLWFRVPEKVYFKYGALGVALRELKDLNKKKV
FIVTDNVLASLGYVDKITSVLEEIGVDFRVFSEVTPDPTLACAKKGAEAMRSYQPDAIIALGGGSPMDAAKIMWVMYEHP
EVAFEDLAMRFMDIRKRVYPFPTMGQKAMMISVPTSAGTGSEVTPFAVITDEESGVKYPLADYELTPDMAIIDAELMMNM
PKGLTAASGIDALTHALEAYVSVLASEYTNGLALEAIRLIFKYLPQAYAEGTTNIKAREKMAHASTMAGMAFANAFLGVC
HSMAHKLGSEHHIAHGVANGILIDHVIRFNAVDNPRKQAAFPQYKYPNAKWRYAVIADYLGLGGKNEEEKVNNLIKAIDN
LKKTVGIPATIADCGVSKESFYATLEKMSEDAFDDQCTGANPRYPLISEIKQMYINAFEGKKDRV

Specific function: This enzyme has probably two activities:ADH, and ACDH [H]

COG id: COG1012

COG function: function code C; NAD-dependent aldehyde dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the iron- containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI133922590, Length=276, Percent_Identity=30.0724637681159, Blast_Score=93, Evalue=9e-19,
Organism=Escherichia coli, GI1787493, Length=865, Percent_Identity=64.971098265896, Blast_Score=1148, Evalue=0.0,
Organism=Escherichia coli, GI1789163, Length=405, Percent_Identity=36.5432098765432, Blast_Score=238, Evalue=1e-63,
Organism=Escherichia coli, GI48994951, Length=403, Percent_Identity=36.2282878411911, Blast_Score=233, Evalue=4e-62,
Organism=Escherichia coli, GI87082107, Length=406, Percent_Identity=32.512315270936, Blast_Score=202, Evalue=1e-52,
Organism=Escherichia coli, GI1788797, Length=361, Percent_Identity=34.6260387811634, Blast_Score=178, Evalue=1e-45,
Organism=Escherichia coli, GI1789386, Length=393, Percent_Identity=23.1552162849873, Blast_Score=77, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17537053, Length=292, Percent_Identity=28.0821917808219, Blast_Score=114, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6321181, Length=420, Percent_Identity=32.3809523809524, Blast_Score=211, Evalue=4e-55,
Organism=Drosophila melanogaster, GI24657991, Length=330, Percent_Identity=28.4848484848485, Blast_Score=91, Evalue=4e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001670
- InterPro:   IPR018211
- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016162
- InterPro:   IPR015590
- InterPro:   IPR012079 [H]

Pfam domain/function: PF00171 Aldedh; PF00465 Fe-ADH [H]

EC number: =1.1.1.1; =1.2.1.10 [H]

Molecular weight: Translated: 94641; Mature: 94641

Theoretical pI: Translated: 6.58; Mature: 6.58

Prosite motif: PS00913 ADH_IRON_1 ; PS00060 ADH_IRON_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVTNVDELMLRLEKVRAAQKEFSKFSQEQVDEIFRQAAVAANNERIRLAKMAVEESGMG
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHCCCC
IVEDKVIKNHFAAEYIYNKYKDEKTCGVIEKDESFGITKIAEPIGVVAAIVPTTNPTSTA
CHHHHHHHHHHHHHHHHHHHCCCCCCCCEECCCCCCHHHHHHHHHEEEEEECCCCCHHHH
IFKALISLKTRNAVFFSPHPRAKNSTIEAARVVLEAAVKAGAPKDIIGWIDEPSVEMSQV
HHHHHHHHHCCCEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHCCCCCCCHHHHHH
LMAEADIILATGGPGMVKAAYSSGKPAIGVGAGNTPAIIDETAHLKMAVNSILLSKTFDN
HHHCCCEEEEECCCCCEEEECCCCCCEEEECCCCCCCEECCHHHHHHHHHHHHHHCCCCC
GVICASEQTVLVVDKVYDEVRKEFADRGAYFLKDKEIDKVRKTILINGNLNANIVGQSAW
CEEEECCCEEEEHHHHHHHHHHHHHHCCCEEECCCHHHHHHHEEEEECCCCCEEECCCHH
KIADMAGVKVPKDTKVLIGEVESVELEEPFSHEKLSPVLGMYRVANFEEALVKAERLVEL
HHHHHCCCCCCCCCEEEEECCCCEECCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHH
GGFGHTSVLYTDTMKSQDRVQKFGATMKTGRTIINMPSTQGAIGDIYNFKLAPSLTLGCG
CCCCCCEEEEECCCCHHHHHHHHCCHHHCCCEEEECCCCCCCCCCCEEEEECCCEEEECC
SWGGNSVSENVGPKHLMNVKSVAERRENMLWFRVPEKVYFKYGALGVALRELKDLNKKKV
CCCCCCCCCCCCHHHHHHHHHHHHHHHCEEEEECCHHHHHHHHHHHHHHHHHHCCCCCEE
FIVTDNVLASLGYVDKITSVLEEIGVDFRVFSEVTPDPTLACAKKGAEAMRSYQPDAIIA
EEEECHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCHHHHHHHHHHHHHCCCCCEEEE
LGGGSPMDAAKIMWVMYEHPEVAFEDLAMRFMDIRKRVYPFPTMGQKAMMISVPTSAGTG
ECCCCCCCHHHEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCC
SEVTPFAVITDEESGVKYPLADYELTPDMAIIDAELMMNMPKGLTAASGIDALTHALEAY
CCCCCEEEEECCCCCCCCCCCCCCCCCCHHEEEHHHHHCCCCCCCHHHHHHHHHHHHHHH
VSVLASEYTNGLALEAIRLIFKYLPQAYAEGTTNIKAREKMAHASTMAGMAFANAFLGVC
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
HSMAHKLGSEHHIAHGVANGILIDHVIRFNAVDNPRKQAAFPQYKYPNAKWRYAVIADYL
HHHHHHCCCCCHHHHHHHCCHHHHHHHHCCCCCCCHHHCCCCCCCCCCCCEEHHHHHHHH
GLGGKNEEEKVNNLIKAIDNLKKTVGIPATIADCGVSKESFYATLEKMSEDAFDDQCTGA
CCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCC
NPRYPLISEIKQMYINAFEGKKDRV
CCCCHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MKVTNVDELMLRLEKVRAAQKEFSKFSQEQVDEIFRQAAVAANNERIRLAKMAVEESGMG
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHCCCC
IVEDKVIKNHFAAEYIYNKYKDEKTCGVIEKDESFGITKIAEPIGVVAAIVPTTNPTSTA
CHHHHHHHHHHHHHHHHHHHCCCCCCCCEECCCCCCHHHHHHHHHEEEEEECCCCCHHHH
IFKALISLKTRNAVFFSPHPRAKNSTIEAARVVLEAAVKAGAPKDIIGWIDEPSVEMSQV
HHHHHHHHHCCCEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHCCCCCCCHHHHHH
LMAEADIILATGGPGMVKAAYSSGKPAIGVGAGNTPAIIDETAHLKMAVNSILLSKTFDN
HHHCCCEEEEECCCCCEEEECCCCCCEEEECCCCCCCEECCHHHHHHHHHHHHHHCCCCC
GVICASEQTVLVVDKVYDEVRKEFADRGAYFLKDKEIDKVRKTILINGNLNANIVGQSAW
CEEEECCCEEEEHHHHHHHHHHHHHHCCCEEECCCHHHHHHHEEEEECCCCCEEECCCHH
KIADMAGVKVPKDTKVLIGEVESVELEEPFSHEKLSPVLGMYRVANFEEALVKAERLVEL
HHHHHCCCCCCCCCEEEEECCCCEECCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHH
GGFGHTSVLYTDTMKSQDRVQKFGATMKTGRTIINMPSTQGAIGDIYNFKLAPSLTLGCG
CCCCCCEEEEECCCCHHHHHHHHCCHHHCCCEEEECCCCCCCCCCCEEEEECCCEEEECC
SWGGNSVSENVGPKHLMNVKSVAERRENMLWFRVPEKVYFKYGALGVALRELKDLNKKKV
CCCCCCCCCCCCHHHHHHHHHHHHHHHCEEEEECCHHHHHHHHHHHHHHHHHHCCCCCEE
FIVTDNVLASLGYVDKITSVLEEIGVDFRVFSEVTPDPTLACAKKGAEAMRSYQPDAIIA
EEEECHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCHHHHHHHHHHHHHCCCCCEEEE
LGGGSPMDAAKIMWVMYEHPEVAFEDLAMRFMDIRKRVYPFPTMGQKAMMISVPTSAGTG
ECCCCCCCHHHEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCC
SEVTPFAVITDEESGVKYPLADYELTPDMAIIDAELMMNMPKGLTAASGIDALTHALEAY
CCCCCEEEEECCCCCCCCCCCCCCCCCCHHEEEHHHHHCCCCCCCHHHHHHHHHHHHHHH
VSVLASEYTNGLALEAIRLIFKYLPQAYAEGTTNIKAREKMAHASTMAGMAFANAFLGVC
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
HSMAHKLGSEHHIAHGVANGILIDHVIRFNAVDNPRKQAAFPQYKYPNAKWRYAVIADYL
HHHHHHCCCCCHHHHHHHCCHHHHHHHHCCCCCCCHHHCCCCCCCCCCCCEEHHHHHHHH
GLGGKNEEEKVNNLIKAIDNLKKTVGIPATIADCGVSKESFYATLEKMSEDAFDDQCTGA
CCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCC
NPRYPLISEIKQMYINAFEGKKDRV
CCCCHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8226639; 8300540; 11466286 [H]