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The map label for this gene is pepP [H]

Identifier: 18311512

GI number: 18311512

Start: 2897788

End: 2899032

Strand: Reverse

Name: pepP [H]

Synonym: CPE2530

Alternate gene names: 18311512

Gene position: 2899032-2897788 (Counterclockwise)

Preceding gene: 18311513

Following gene: 18311511

Centisome position: 95.63

GC content: 28.19

Gene sequence:

>1245_bases
ATGAAAAGTTTAGTTTTTACTAAAAACAGAGAGAATTTATTAAAGAAACTAGAAGACAATTCATTATTAGTTTTATTTGC
AGGAGAGGCTAAAAGAAAAACAGCAGATGAATATTTTCCATTTACTCCAAACAGAAACTTTTATTATTTAACAGGAGTAG
ATGAAGAAAAGCATATACTAATGATAAAGAAAATAAATGGTGTAGTTGATGAAGTACTTTATATACTAAAACCAAATTTA
GAGCAAGAAAGATGGACTGGAAAAACTATAAGAGATTATGAGGCTAAAGAAGTATCTGGCATAGAAAATATAAAATATTT
AGAAGAATTTAAAAGTGATTTAAATATGATTTTTACTAATGGAATTGCAGAAAATCTTTATTTAGATTTAGAAAGAGTTT
CATTTGATGAAGAAATGAGCAAAAGTCAAAGCTTTGCAAAGGAAGTTAAGGATAGATATCCTCAAGTAGTTATAAAAGAT
GTTTATTCTGATATAGCTTCTTTAAGACAAATTAAATGCAAAGAAGAAGTAGAGAAAATAAAAAAGGCTGCTCATATAAC
AGCTAAGGGTGTAGAACTTTTAATGAAAGAGTGTAAGCCTGGAATGAAAGAATATGAGTTAGAAGCATATTTTGATTTTT
ACTTAAAACAAAATGGAGTTAAAGATTATGCTTTTAAAACTATAGCAGCTGCTGGCGTAAATGCTGCTACTTTACACTAT
GTTGATAATAATAGTGAAATAAAAGATGGGGATTTAATTCTTTTTGATTTAGGTGCTCAAGTAAATTATTATAATGGAGA
TATTTCAAGAACATTCCCTGCTAATGGTAAGTTTACTAAGAGACAAAAAGAGGTTTATGAAGAAGTTTTAAAAGTAAATG
AAGAGATAATAAACTCTATTAGACCAGGAGTTGGATTCTATGAAATAAATGACAAAGCAAATAATCTTTTAGCTGAAGCT
TGTGTAAGATTAGGTCTTATAGAAGATAAAAAGGATTATAGAAAGTATTATTTCCACTCAATAGGACATAGTTTAGGACT
TGACACTCATGATGTTGGTAAGAGAGATATCATTCTTGAAGAAGGTATGGTTTATACTGTAGAGCCAGGATTATATATTG
AAGAAGAAGCTATAGGAATAAGAATAGAGGATGATGTTTTAGTTACTAAAGATGGCTGTGAAGTTCTAACAAAAGAATGT
ATTAAGTCTGTAGAAGATATAGAAAAGTTTATGAGTAATAGATAA

Upstream 100 bases:

>100_bases
AGTATTTTTTTCTATAAAAATATGTAAAGATGTACTATTTGTTAAGATTTTAAATCTTATATATGGTAAAATTTAATAAA
TAGGAATTGGAGGGATTAAG

Downstream 100 bases:

>100_bases
TTTTATAATTAACATTATTTTAAGAATAATAAGCTTTAAATTTGAAGAAATTAAGAGTAAAATGTAATAAAAATTAAAGA
GCAAACTATGGTTTAGGAGA

Product: xaa-pro aminopeptidase

Products: NA

Alternate protein names: Aminoacylproline aminopeptidase; Aminopeptidase P II; APP-II; X-Pro aminopeptidase [H]

Number of amino acids: Translated: 414; Mature: 414

Protein sequence:

>414_residues
MKSLVFTKNRENLLKKLEDNSLLVLFAGEAKRKTADEYFPFTPNRNFYYLTGVDEEKHILMIKKINGVVDEVLYILKPNL
EQERWTGKTIRDYEAKEVSGIENIKYLEEFKSDLNMIFTNGIAENLYLDLERVSFDEEMSKSQSFAKEVKDRYPQVVIKD
VYSDIASLRQIKCKEEVEKIKKAAHITAKGVELLMKECKPGMKEYELEAYFDFYLKQNGVKDYAFKTIAAAGVNAATLHY
VDNNSEIKDGDLILFDLGAQVNYYNGDISRTFPANGKFTKRQKEVYEEVLKVNEEIINSIRPGVGFYEINDKANNLLAEA
CVRLGLIEDKKDYRKYYFHSIGHSLGLDTHDVGKRDIILEEGMVYTVEPGLYIEEEAIGIRIEDDVLVTKDGCEVLTKEC
IKSVEDIEKFMSNR

Sequences:

>Translated_414_residues
MKSLVFTKNRENLLKKLEDNSLLVLFAGEAKRKTADEYFPFTPNRNFYYLTGVDEEKHILMIKKINGVVDEVLYILKPNL
EQERWTGKTIRDYEAKEVSGIENIKYLEEFKSDLNMIFTNGIAENLYLDLERVSFDEEMSKSQSFAKEVKDRYPQVVIKD
VYSDIASLRQIKCKEEVEKIKKAAHITAKGVELLMKECKPGMKEYELEAYFDFYLKQNGVKDYAFKTIAAAGVNAATLHY
VDNNSEIKDGDLILFDLGAQVNYYNGDISRTFPANGKFTKRQKEVYEEVLKVNEEIINSIRPGVGFYEINDKANNLLAEA
CVRLGLIEDKKDYRKYYFHSIGHSLGLDTHDVGKRDIILEEGMVYTVEPGLYIEEEAIGIRIEDDVLVTKDGCEVLTKEC
IKSVEDIEKFMSNR
>Mature_414_residues
MKSLVFTKNRENLLKKLEDNSLLVLFAGEAKRKTADEYFPFTPNRNFYYLTGVDEEKHILMIKKINGVVDEVLYILKPNL
EQERWTGKTIRDYEAKEVSGIENIKYLEEFKSDLNMIFTNGIAENLYLDLERVSFDEEMSKSQSFAKEVKDRYPQVVIKD
VYSDIASLRQIKCKEEVEKIKKAAHITAKGVELLMKECKPGMKEYELEAYFDFYLKQNGVKDYAFKTIAAAGVNAATLHY
VDNNSEIKDGDLILFDLGAQVNYYNGDISRTFPANGKFTKRQKEVYEEVLKVNEEIINSIRPGVGFYEINDKANNLLAEA
CVRLGLIEDKKDYRKYYFHSIGHSLGLDTHDVGKRDIILEEGMVYTVEPGLYIEEEAIGIRIEDDVLVTKDGCEVLTKEC
IKSVEDIEKFMSNR

Specific function: Unknown

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family [H]

Homologues:

Organism=Homo sapiens, GI11559925, Length=419, Percent_Identity=30.7875894988067, Blast_Score=200, Evalue=2e-51,
Organism=Homo sapiens, GI149589008, Length=477, Percent_Identity=28.7211740041929, Blast_Score=178, Evalue=7e-45,
Organism=Homo sapiens, GI260593665, Length=308, Percent_Identity=32.1428571428571, Blast_Score=158, Evalue=1e-38,
Organism=Homo sapiens, GI260593663, Length=471, Percent_Identity=26.963906581741, Blast_Score=141, Evalue=1e-33,
Organism=Homo sapiens, GI93141226, Length=266, Percent_Identity=28.9473684210526, Blast_Score=73, Evalue=5e-13,
Organism=Escherichia coli, GI1789275, Length=433, Percent_Identity=33.256351039261, Blast_Score=244, Evalue=9e-66,
Organism=Escherichia coli, GI1788728, Length=237, Percent_Identity=35.4430379746835, Blast_Score=147, Evalue=2e-36,
Organism=Escherichia coli, GI1790282, Length=288, Percent_Identity=23.9583333333333, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1786364, Length=259, Percent_Identity=22.007722007722, Blast_Score=65, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI17508215, Length=486, Percent_Identity=28.3950617283951, Blast_Score=159, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI71989583, Length=272, Percent_Identity=29.0441176470588, Blast_Score=120, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6320922, Length=443, Percent_Identity=27.765237020316, Blast_Score=164, Evalue=2e-41,
Organism=Saccharomyces cerevisiae, GI6321118, Length=453, Percent_Identity=29.3598233995585, Blast_Score=157, Evalue=2e-39,
Organism=Drosophila melanogaster, GI19920384, Length=421, Percent_Identity=28.0285035629454, Blast_Score=171, Evalue=9e-43,
Organism=Drosophila melanogaster, GI21357079, Length=464, Percent_Identity=29.3103448275862, Blast_Score=159, Evalue=5e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR007865
- InterPro:   IPR001131 [H]

Pfam domain/function: PF05195 AMP_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.11.9 [H]

Molecular weight: Translated: 47721; Mature: 47721

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSLVFTKNRENLLKKLEDNSLLVLFAGEAKRKTADEYFPFTPNRNFYYLTGVDEEKHIL
CCCCEEECCHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCCCEEEEECCCCCCEEE
MIKKINGVVDEVLYILKPNLEQERWTGKTIRDYEAKEVSGIENIKYLEEFKSDLNMIFTN
EEEHHHHHHHHHHHHHCCCCCHHHCCCCCHHCCCHHHHCCHHHHHHHHHHHHHHHEEHHC
GIAENLYLDLERVSFDEEMSKSQSFAKEVKDRYPQVVIKDVYSDIASLRQIKCKEEVEKI
CCHHHHEEEHHHHCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHH
KKAAHITAKGVELLMKECKPGMKEYELEAYFDFYLKQNGVKDYAFKTIAAAGVNAATLHY
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEEEEE
VDNNSEIKDGDLILFDLGAQVNYYNGDISRTFPANGKFTKRQKEVYEEVLKVNEEIINSI
ECCCCCCCCCCEEEEECCCEEEEECCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHHHH
RPGVGFYEINDKANNLLAEACVRLGLIEDKKDYRKYYFHSIGHSLGLDTHDVGKRDIILE
CCCCCEEEECCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEE
EGMVYTVEPGLYIEEEAIGIRIEDDVLVTKDGCEVLTKECIKSVEDIEKFMSNR
CCEEEEECCCCEEECCCEEEEEECCEEEECCCHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKSLVFTKNRENLLKKLEDNSLLVLFAGEAKRKTADEYFPFTPNRNFYYLTGVDEEKHIL
CCCCEEECCHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCCCEEEEECCCCCCEEE
MIKKINGVVDEVLYILKPNLEQERWTGKTIRDYEAKEVSGIENIKYLEEFKSDLNMIFTN
EEEHHHHHHHHHHHHHCCCCCHHHCCCCCHHCCCHHHHCCHHHHHHHHHHHHHHHEEHHC
GIAENLYLDLERVSFDEEMSKSQSFAKEVKDRYPQVVIKDVYSDIASLRQIKCKEEVEKI
CCHHHHEEEHHHHCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHH
KKAAHITAKGVELLMKECKPGMKEYELEAYFDFYLKQNGVKDYAFKTIAAAGVNAATLHY
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEEEEE
VDNNSEIKDGDLILFDLGAQVNYYNGDISRTFPANGKFTKRQKEVYEEVLKVNEEIINSI
ECCCCCCCCCCEEEEECCCEEEEECCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHHHH
RPGVGFYEINDKANNLLAEACVRLGLIEDKKDYRKYYFHSIGHSLGLDTHDVGKRDIILE
CCCCCEEEECCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEE
EGMVYTVEPGLYIEEEAIGIRIEDDVLVTKDGCEVLTKECIKSVEDIEKFMSNR
CCEEEEECCCCEEECCCEEEEEECCEEEECCCHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2659585; 1339425; 9278503; 9520390 [H]