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The map label for this gene is norM [H]

Identifier: 18311487

GI number: 18311487

Start: 2868217

End: 2869608

Strand: Reverse

Name: norM [H]

Synonym: CPE2505

Alternate gene names: 18311487

Gene position: 2869608-2868217 (Counterclockwise)

Preceding gene: 18311488

Following gene: 18311485

Centisome position: 94.66

GC content: 30.03

Gene sequence:

>1392_bases
ATGAAAGGTTTTAAGAACAAGGAATTTTTACCTACTATGATAATGATGGCTGTTCCTATAACAATTCAGAGTTTCATTAC
ATCGTCATTAAATCTAGTAGATAATTTAATGGTAGGAAAGCTAGGAGAAGAGTCAATAGCCTCAGTTGGGTTAGCTAACC
AATATATATTTATTTTTACTTTATGTATTCTTGGGATAAATGCTGGAGCTAGTGTTTTCATGTCTCAGTTTTGGGGCAAA
AAAGATTTGAAAAATATTAAAAAAGTTTTGGGACTAGATATATCTATTGGACTTATAGTTTCAACTCTTTTTGCCTTAGG
TTCTGGATTTTTTTCTTATGAAATTATGGAGATTCTTTCTAATGATTTAAATGTTATAGAATTAGGAGCTAAATATCTAC
AGATTGTTTCTGTAAGTTGCATATTTACTAATTTTACTCAAGCTTATTCTTCAGTTTTAAGAAGTACAGAGCAACCTAGT
GTTCCTATGTATGCAAGTATAGTTGGAGTCTTGATAAATGCATTTTTAAACTGGGTATTTATATTTGGAAATTTAGGCTT
TGAGCCTATGGGAGTTAATGGAGCAGCTTTAGCAACCACTATTGCAAGATTAGTAGAGATGATATTTATAGTTTCCTTTG
TTTATTTTAGAAAGAATAAGGTGGCATCAAGATTAAATGAGCTTATATCCTTTGATTTAAATTTTGTAAAAATATACTTT
AGAACATCTTGGTCAGTTATAGTAAATGAAATAGTATGGTCTTTAGGTATGACTGCATATTCAATAGCCTATGCTAGAAT
AGGAACAAACGCTGTTGCTAGCATGCAGATTGCTACCACATTAAATAATATGTTTATGGTATTACTAATAGGTTTAGCTA
CAGCTTCTTCTATAATGATAGGGAATAAAATTGGCTCTAATGAGGAAGAAATAGCAAGAGAATATGCTAAGGATATAGCT
GTAATAGCTGTTTTAGTAGGATTTATTTTAGGAATTTTAATATGGATAACAGCACCATTAGCATTAAAGCCTTTTAATGT
AAGTGAAGGAACTTATTTAGATACAGTTAAAGTTTTAAGAATAATAGGATTGTTCTTTACAATAAGAGCTTTTAATATGG
TTATGATTGTTGGTGTATTTAGAGGTGGTGGAGATACTACTTACTCTATGTTAGTACAATGTGGAACAATATGGCTTTAT
GCTGTACCAATGGCTTTCCTTGGAGCTACAGTATTTTCTTTACCTGTATATGGAGTATATTTCTTAATTTGTACAGAGGA
ATTCTTAAAGATAATCTTTGAGGCAGTAAGATTAAAATCAGGAAAATGGATAAAGAATGTTATAAGTGATATTGAAGAAG
ATGAATCTGATGATAATTTAATTACAGTATAA

Upstream 100 bases:

>100_bases
TTTATTAGACAATTAATAGGATTTAAAAGCAGATGGGCGGCTAAAGACTACCCATTTGCTTTTATTTTTTTGTATTTTTT
TAAAAGGGGGATTAAATTTC

Downstream 100 bases:

>100_bases
ATAAAAAAGGTTATATTAATAGTTTCAAAATAAGATTCTATTAATATAACCTTTTATTTATACTATTATTTCTTTTAATG
GTAAGCAGGTTTTACTAGAC

Product: MATE efflux family protein

Products: NA

Alternate protein names: Multidrug-efflux transporter [H]

Number of amino acids: Translated: 463; Mature: 463

Protein sequence:

>463_residues
MKGFKNKEFLPTMIMMAVPITIQSFITSSLNLVDNLMVGKLGEESIASVGLANQYIFIFTLCILGINAGASVFMSQFWGK
KDLKNIKKVLGLDISIGLIVSTLFALGSGFFSYEIMEILSNDLNVIELGAKYLQIVSVSCIFTNFTQAYSSVLRSTEQPS
VPMYASIVGVLINAFLNWVFIFGNLGFEPMGVNGAALATTIARLVEMIFIVSFVYFRKNKVASRLNELISFDLNFVKIYF
RTSWSVIVNEIVWSLGMTAYSIAYARIGTNAVASMQIATTLNNMFMVLLIGLATASSIMIGNKIGSNEEEIAREYAKDIA
VIAVLVGFILGILIWITAPLALKPFNVSEGTYLDTVKVLRIIGLFFTIRAFNMVMIVGVFRGGGDTTYSMLVQCGTIWLY
AVPMAFLGATVFSLPVYGVYFLICTEEFLKIIFEAVRLKSGKWIKNVISDIEEDESDDNLITV

Sequences:

>Translated_463_residues
MKGFKNKEFLPTMIMMAVPITIQSFITSSLNLVDNLMVGKLGEESIASVGLANQYIFIFTLCILGINAGASVFMSQFWGK
KDLKNIKKVLGLDISIGLIVSTLFALGSGFFSYEIMEILSNDLNVIELGAKYLQIVSVSCIFTNFTQAYSSVLRSTEQPS
VPMYASIVGVLINAFLNWVFIFGNLGFEPMGVNGAALATTIARLVEMIFIVSFVYFRKNKVASRLNELISFDLNFVKIYF
RTSWSVIVNEIVWSLGMTAYSIAYARIGTNAVASMQIATTLNNMFMVLLIGLATASSIMIGNKIGSNEEEIAREYAKDIA
VIAVLVGFILGILIWITAPLALKPFNVSEGTYLDTVKVLRIIGLFFTIRAFNMVMIVGVFRGGGDTTYSMLVQCGTIWLY
AVPMAFLGATVFSLPVYGVYFLICTEEFLKIIFEAVRLKSGKWIKNVISDIEEDESDDNLITV
>Mature_463_residues
MKGFKNKEFLPTMIMMAVPITIQSFITSSLNLVDNLMVGKLGEESIASVGLANQYIFIFTLCILGINAGASVFMSQFWGK
KDLKNIKKVLGLDISIGLIVSTLFALGSGFFSYEIMEILSNDLNVIELGAKYLQIVSVSCIFTNFTQAYSSVLRSTEQPS
VPMYASIVGVLINAFLNWVFIFGNLGFEPMGVNGAALATTIARLVEMIFIVSFVYFRKNKVASRLNELISFDLNFVKIYF
RTSWSVIVNEIVWSLGMTAYSIAYARIGTNAVASMQIATTLNNMFMVLLIGLATASSIMIGNKIGSNEEEIAREYAKDIA
VIAVLVGFILGILIWITAPLALKPFNVSEGTYLDTVKVLRIIGLFFTIRAFNMVMIVGVFRGGGDTTYSMLVQCGTIWLY
AVPMAFLGATVFSLPVYGVYFLICTEEFLKIIFEAVRLKSGKWIKNVISDIEEDESDDNLITV

Specific function: Multidrug efflux pump [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family [H]

Homologues:

Organism=Escherichia coli, GI226510954, Length=450, Percent_Identity=21.7777777777778, Blast_Score=81, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 51101; Mature: 51101

Theoretical pI: Translated: 5.25; Mature: 5.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGFKNKEFLPTMIMMAVPITIQSFITSSLNLVDNLMVGKLGEESIASVGLANQYIFIFT
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHH
LCILGINAGASVFMSQFWGKKDLKNIKKVLGLDISIGLIVSTLFALGSGFFSYEIMEILS
HHHHHCCCCHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCHHHHHHHHHHH
NDLNVIELGAKYLQIVSVSCIFTNFTQAYSSVLRSTEQPSVPMYASIVGVLINAFLNWVF
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHH
IFGNLGFEPMGVNGAALATTIARLVEMIFIVSFVYFRKNKVASRLNELISFDLNFVKIYF
HHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEE
RTSWSVIVNEIVWSLGMTAYSIAYARIGTNAVASMQIATTLNNMFMVLLIGLATASSIMI
HHHHHHHHHHHHHHHCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEE
GNKIGSNEEEIAREYAKDIAVIAVLVGFILGILIWITAPLALKPFNVSEGTYLDTVKVLR
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCCCHHHHHHHHH
IIGLFFTIRAFNMVMIVGVFRGGGDTTYSMLVQCGTIWLYAVPMAFLGATVFSLPVYGVY
HHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FLICTEEFLKIIFEAVRLKSGKWIKNVISDIEEDESDDNLITV
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCEEEC
>Mature Secondary Structure
MKGFKNKEFLPTMIMMAVPITIQSFITSSLNLVDNLMVGKLGEESIASVGLANQYIFIFT
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHH
LCILGINAGASVFMSQFWGKKDLKNIKKVLGLDISIGLIVSTLFALGSGFFSYEIMEILS
HHHHHCCCCHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCHHHHHHHHHHH
NDLNVIELGAKYLQIVSVSCIFTNFTQAYSSVLRSTEQPSVPMYASIVGVLINAFLNWVF
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHH
IFGNLGFEPMGVNGAALATTIARLVEMIFIVSFVYFRKNKVASRLNELISFDLNFVKIYF
HHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEE
RTSWSVIVNEIVWSLGMTAYSIAYARIGTNAVASMQIATTLNNMFMVLLIGLATASSIMI
HHHHHHHHHHHHHHHCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEE
GNKIGSNEEEIAREYAKDIAVIAVLVGFILGILIWITAPLALKPFNVSEGTYLDTVKVLR
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCCCHHHHHHHHH
IIGLFFTIRAFNMVMIVGVFRGGGDTTYSMLVQCGTIWLYAVPMAFLGATVFSLPVYGVY
HHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FLICTEEFLKIIFEAVRLKSGKWIKNVISDIEEDESDDNLITV
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10360571 [H]