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The map label for this gene is yclK [H]

Identifier: 18311469

GI number: 18311469

Start: 2847777

End: 2849186

Strand: Reverse

Name: yclK [H]

Synonym: CPE2487

Alternate gene names: 18311469

Gene position: 2849186-2847777 (Counterclockwise)

Preceding gene: 18311470

Following gene: 18311468

Centisome position: 93.99

GC content: 26.88

Gene sequence:

>1410_bases
ATGAGATGTCGTGGCTTAGTTCCAAAGTTAATCTTAACACTAAGCGTAACAATATGCATTACTTTCTTTATTGTAGGTAT
AATACTTTCTAGCTTGTTTAGAGAAGAATATTATCAAGAAAGATTAAAAACTTTATCTGGAGAAGCGGAAGTTATAGAAC
AAGTTGTAAATTCATTTATGAATAGTGAAACTACTTTAGGTGAATTAGATAAATCTATATCATTTATAGGAGATTCATTA
AAAGCAGATATTTATTTAATTGATAGTTATGGTTACATATATTCAGTTTCTAATGAAAAATATGATTATTTAAAACGCAC
AAAAATAGATGATAATGATATGAAAACATTAAAGGAAAATATTCCTATAGAGCAGAAGAAAAAAAATGAATTTATATATT
CTAAACCTATCTTCTACAAGGGGGTATTTACAGGAGCTGTTTCAATAGTTACTCCTTTAAGTGCTTTATCAGATTCTCTT
GTTAGAATTAATCAAATTGTATGGATGTGTGTAGCTATAGCTATAATTTTTTCTGGATTAGCAATATATTTTATTTCAAA
AAAGATAATCATAAAACCTTTAAAAGTTATAAATAATGCTGCTAAAAAGATTGCTAACGGAGAAATTGGAAATAGAGTTA
ATGTTTCTTATGATGATGAGGTCGGTGAGTTAGCTGAATCATTTAATATAATGGCAACTTCTATTGAGGAGGCAGAACTA
AATAGAAGGGAATTTATATCTAATGTATCTCATGAGTTAAGATCACCAATGACATCGATTAAGGGCTTCATAACTGCCAT
ATTAGATGGAGTTATTCCTAAAGATAAAGAAGAATATTATCTTGTTATAGTAAATGATGAGATAAGTAGATTAACTAGAC
TTATAAATGACTTACTAGATTTATCTGCTATGCAAGCTGGAAAACTAGAGTTTAATATAAGTGAGTTAGAATTAAATAGA
ATTATAGAGACAACTGTATTAAAGATGAATCAAAAGGCTGCAAGTAAAAATATAAAAATTGAAGTTCTCTTAGAGAGCGA
AAAATTATATGTTTATGGAGATAATGATAGATTAATACAGGTTGTTACTAATTTAGTTGATAATGCTATAAAATACTGTG
ATGAAAATGGTGAAGTTAAAATATCAACTAAAACAAAGGGAAGTAAGATTATTGTTAGCATATTTAACACTAGTAAAGGA
ATAGATGAATATGATTTAACTCATATTTGGGATATATTTTATAAAGTTGACAAGGCAAGAAGTAATAAAACTAGTACAGG
GTTAGGATTATCTATTGTGAGAAATATAATACTGCAACTAGAAGAAGATATTTGGGCTGAAAATGTCAAAGATAAAAATG
GTGAAATAAAAGGTGTTAGATTTAATTTTACTTTAACTAAAGTTAAATAA

Upstream 100 bases:

>100_bases
TTGATGTTCACATAAAGAGATTAAGAGAAAAATTAAACGGTGGAGAAGACTGGCAACTTGAAACTGTTTGGGGTGTTGGG
TATAAATTTGAGGTGAAATA

Downstream 100 bases:

>100_bases
GTATTGCATAGGGGGTCTTTATGGGGAATTTTTTTAAGAACTCTAAAAAGGGGAAGGATCTCCATGGAGTAAATGAAAAA
AACTATGACAATATAGTGAT

Product: two-component sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 469; Mature: 469

Protein sequence:

>469_residues
MRCRGLVPKLILTLSVTICITFFIVGIILSSLFREEYYQERLKTLSGEAEVIEQVVNSFMNSETTLGELDKSISFIGDSL
KADIYLIDSYGYIYSVSNEKYDYLKRTKIDDNDMKTLKENIPIEQKKKNEFIYSKPIFYKGVFTGAVSIVTPLSALSDSL
VRINQIVWMCVAIAIIFSGLAIYFISKKIIIKPLKVINNAAKKIANGEIGNRVNVSYDDEVGELAESFNIMATSIEEAEL
NRREFISNVSHELRSPMTSIKGFITAILDGVIPKDKEEYYLVIVNDEISRLTRLINDLLDLSAMQAGKLEFNISELELNR
IIETTVLKMNQKAASKNIKIEVLLESEKLYVYGDNDRLIQVVTNLVDNAIKYCDENGEVKISTKTKGSKIIVSIFNTSKG
IDEYDLTHIWDIFYKVDKARSNKTSTGLGLSIVRNIILQLEEDIWAENVKDKNGEIKGVRFNFTLTKVK

Sequences:

>Translated_469_residues
MRCRGLVPKLILTLSVTICITFFIVGIILSSLFREEYYQERLKTLSGEAEVIEQVVNSFMNSETTLGELDKSISFIGDSL
KADIYLIDSYGYIYSVSNEKYDYLKRTKIDDNDMKTLKENIPIEQKKKNEFIYSKPIFYKGVFTGAVSIVTPLSALSDSL
VRINQIVWMCVAIAIIFSGLAIYFISKKIIIKPLKVINNAAKKIANGEIGNRVNVSYDDEVGELAESFNIMATSIEEAEL
NRREFISNVSHELRSPMTSIKGFITAILDGVIPKDKEEYYLVIVNDEISRLTRLINDLLDLSAMQAGKLEFNISELELNR
IIETTVLKMNQKAASKNIKIEVLLESEKLYVYGDNDRLIQVVTNLVDNAIKYCDENGEVKISTKTKGSKIIVSIFNTSKG
IDEYDLTHIWDIFYKVDKARSNKTSTGLGLSIVRNIILQLEEDIWAENVKDKNGEIKGVRFNFTLTKVK
>Mature_469_residues
MRCRGLVPKLILTLSVTICITFFIVGIILSSLFREEYYQERLKTLSGEAEVIEQVVNSFMNSETTLGELDKSISFIGDSL
KADIYLIDSYGYIYSVSNEKYDYLKRTKIDDNDMKTLKENIPIEQKKKNEFIYSKPIFYKGVFTGAVSIVTPLSALSDSL
VRINQIVWMCVAIAIIFSGLAIYFISKKIIIKPLKVINNAAKKIANGEIGNRVNVSYDDEVGELAESFNIMATSIEEAEL
NRREFISNVSHELRSPMTSIKGFITAILDGVIPKDKEEYYLVIVNDEISRLTRLINDLLDLSAMQAGKLEFNISELELNR
IIETTVLKMNQKAASKNIKIEVLLESEKLYVYGDNDRLIQVVTNLVDNAIKYCDENGEVKISTKTKGSKIIVSIFNTSKG
IDEYDLTHIWDIFYKVDKARSNKTSTGLGLSIVRNIILQLEEDIWAENVKDKNGEIKGVRFNFTLTKVK

Specific function: Could be member of the two-component regulatory system yclK/yclJ. Potentially phosphorylates yclJ [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788393, Length=310, Percent_Identity=30, Blast_Score=155, Evalue=5e-39,
Organism=Escherichia coli, GI1787894, Length=362, Percent_Identity=22.9281767955801, Blast_Score=102, Evalue=5e-23,
Organism=Escherichia coli, GI87082128, Length=288, Percent_Identity=25, Blast_Score=101, Evalue=9e-23,
Organism=Escherichia coli, GI1786600, Length=239, Percent_Identity=27.6150627615063, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1789149, Length=326, Percent_Identity=26.0736196319018, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI145693157, Length=224, Percent_Identity=27.2321428571429, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1790346, Length=283, Percent_Identity=27.9151943462898, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI87081816, Length=200, Percent_Identity=29.5, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI1790436, Length=209, Percent_Identity=27.2727272727273, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI48994928, Length=239, Percent_Identity=26.3598326359833, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1790861, Length=344, Percent_Identity=21.8023255813953, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1789808, Length=268, Percent_Identity=25.3731343283582, Blast_Score=79, Evalue=9e-16,
Organism=Escherichia coli, GI1788713, Length=236, Percent_Identity=23.728813559322, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1786783, Length=305, Percent_Identity=22.6229508196721, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1786912, Length=236, Percent_Identity=25.8474576271186, Blast_Score=75, Evalue=9e-15,
Organism=Escherichia coli, GI1789403, Length=218, Percent_Identity=28.4403669724771, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1788549, Length=202, Percent_Identity=26.7326732673267, Blast_Score=73, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 53151; Mature: 53151

Theoretical pI: Translated: 5.48; Mature: 5.48

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRCRGLVPKLILTLSVTICITFFIVGIILSSLFREEYYQERLKTLSGEAEVIEQVVNSFM
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
NSETTLGELDKSISFIGDSLKADIYLIDSYGYIYSVSNEKYDYLKRTKIDDNDMKTLKEN
CCCCHHHHHHHHHHHHCCCCCCCEEEEECCCEEEEECCCCHHHHHHCCCCCHHHHHHHHC
IPIEQKKKNEFIYSKPIFYKGVFTGAVSIVTPLSALSDSLVRINQIVWMCVAIAIIFSGL
CCCCCCCCCCEEEECCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AIYFISKKIIIKPLKVINNAAKKIANGEIGNRVNVSYDDEVGELAESFNIMATSIEEAEL
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCHHHHHHHHHHHHHCCHHHHHH
NRREFISNVSHELRSPMTSIKGFITAILDGVIPKDKEEYYLVIVNDEISRLTRLINDLLD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCHHHHHHHHHHHHHH
LSAMQAGKLEFNISELELNRIIETTVLKMNQKAASKNIKIEVLLESEKLYVYGDNDRLIQ
HHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCEEEEEECCCHHHH
VVTNLVDNAIKYCDENGEVKISTKTKGSKIIVSIFNTSKGIDEYDLTHIWDIFYKVDKAR
HHHHHHHHHHHHCCCCCCEEEEECCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHC
SNKTSTGLGLSIVRNIILQLEEDIWAENVKDKNGEIKGVRFNFTLTKVK
CCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEEEEEECC
>Mature Secondary Structure
MRCRGLVPKLILTLSVTICITFFIVGIILSSLFREEYYQERLKTLSGEAEVIEQVVNSFM
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
NSETTLGELDKSISFIGDSLKADIYLIDSYGYIYSVSNEKYDYLKRTKIDDNDMKTLKEN
CCCCHHHHHHHHHHHHCCCCCCCEEEEECCCEEEEECCCCHHHHHHCCCCCHHHHHHHHC
IPIEQKKKNEFIYSKPIFYKGVFTGAVSIVTPLSALSDSLVRINQIVWMCVAIAIIFSGL
CCCCCCCCCCEEEECCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AIYFISKKIIIKPLKVINNAAKKIANGEIGNRVNVSYDDEVGELAESFNIMATSIEEAEL
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCHHHHHHHHHHHHHCCHHHHHH
NRREFISNVSHELRSPMTSIKGFITAILDGVIPKDKEEYYLVIVNDEISRLTRLINDLLD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCHHHHHHHHHHHHHH
LSAMQAGKLEFNISELELNRIIETTVLKMNQKAASKNIKIEVLLESEKLYVYGDNDRLIQ
HHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCEEEEEECCCHHHH
VVTNLVDNAIKYCDENGEVKISTKTKGSKIIVSIFNTSKGIDEYDLTHIWDIFYKVDKAR
HHHHHHHHHHHHCCCCCCEEEEECCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHC
SNKTSTGLGLSIVRNIILQLEEDIWAENVKDKNGEIKGVRFNFTLTKVK
CCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8969502; 9384377 [H]