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The map label for this gene is thrS

Identifier: 18311304

GI number: 18311304

Start: 2670843

End: 2672774

Strand: Direct

Name: thrS

Synonym: CPE2322

Alternate gene names: 18311304

Gene position: 2670843-2672774 (Clockwise)

Preceding gene: 18311302

Following gene: 18311310

Centisome position: 88.11

GC content: 33.07

Gene sequence:

>1932_bases
ATGATAAAAATTACACTTAAAGATGGTTCAATAAAAGAAGTTGAAGCTGGACTATCAATTTTTGAAATAGCTCAAAGCAT
AAGCCAAGGACTAGCTAGAAATGCTTGTTGTGGTATATTAAACGGAAAAGTTGAGGACTTAAGATTTATAGTTAATGAAG
ATTCTTCATTAGAAATCTGTACTTTTGATTCTAAAGAAGGTCAACATGCTTTTAACCACACTGCTTCTCATGTATTAGCA
GCTGCAGTTAAAAGATTATTCCCTCAAGATAAATTAGCTATAGGACCATCAATAGATAATGGTTTCTATTATGATTTTGA
TACTGAAAAACCATTCTCTGCTGACCAATTAAACAAATTAGAAGAAGAGATGAAAAAAATAATAAAAGAAAATCCTGAAA
TAAAAAGATTTGAACTTCCTAGAAACGAAGCTTTAGAACTTATGAAGGATGAACCTTACAAAGTTGAACTTATAAATGAT
CTTCCAGAAGGTGAAGTAATTTCATTCTACCAAATAGGTGATTTTGTTGACCTTTGTGCAGGACCTCACTTAATGGCTGT
TAAACCAATAAAAGCAGTTAAATTATTAAGATCTACTGGTGCTTACTGGAAAGGTGACGAAAAGAACAAAATGCTTTCAA
GAGTATATGGAACTGCTTTCCCTAAGAAATCAGAATTAGATGCTTATTTAGAAGCTTTAGAAGAAGCTAAGAAAAGAGAC
CATAATAAATTAGGTAGAGAGCTTGGAATCTTTACTACTGATGAAAATGTAGGTCAAGGACTTCCATTATTAATGCCAAA
AGGAGCTAGAATAATCCAAACTCTTCAAAGATGGATAGAAGACGAAGAACAAAGAAGAGGCTATGTTTTAACTAAAACTC
CTTTAATGGCTAAAAGTGACCTTTACAAAATTTCAGGACACTGGGATCACTATAAAGATGGTATGTTCGTTTTAGGTGAT
GAGGAAAAAGATAGTGAAGTATTTGCTTTAAGACCAATGACTTGCCCATTCCAATACGCAATATATAACTCAACTCAACA
CAGTTATAGAGACTTACCAGTAAGATTTGCTGAAACTTCTACTCTATTTAGAAATGAATCTTCAGGAGAAATGCACGGTC
TTATAAGAGTAAGACAATTCACTCTTGCTGATGGACACATAGTATGTACTCCAGAGCAATTAGAAGATGAATTTAAAAAC
ACTGTTGACTTAGTTAAATATGTTATGGAAACTTTAGGAATTGCTGATGATATTACTTACAGATTCTCAAAATGGGATCC
AAACAATACTGAGAAATACATCAATGATCCTGAAGCTTGGGAAAATACTCAAAATATAATGAGAGAAATATTAAACCACT
TAAATATAGACTTTACTGAAGCTGATGATGAAGCTGCTTTCTATGGTCCAAAACTTGATATCCAATTCAAGAATGTTCAT
GGAAAAGAAGATACAATCATCACTATCCAAATAGACTTCGCTTTAGCTGAAAGATTTGGAATGTACTACATCGATAAAGA
TGGAGAAAAGAAACGTCCTTACATCATTCACAGAAGTTCAATTGGATGTTATGAAAGAACACTAGCAATGCTTATAGAAA
AATATGCAGGTGCTCTTCCAACTTGGATAGCTCCAGTTCAAGCTAAAGTTCTTCCTTTATCAGATAAATATGCTGATTAT
GCAAATGAAGTTGTTGAAGAATTAAGAAGAAGAGGAGTTAGAGTTGAAGCTGACCACAGAGCTGAAAAAATCGGTTATAA
AATAAGAGAAGCTAGATTAGAAAGAACTCCTTACATCTTAGTTGTTGGAGAAAAAGAAGCTGAAAACAAAGAAGTTTCTG
TAAGAAGCAGAAAGAACGGTGAGGAAGGTGCTATGCCTTTAGCTGACTTCGTAAACAGAATAGTTCTTGAAATAGCTAAC
AGAGAAAACTAA

Upstream 100 bases:

>100_bases
ATACACTCTCGTCCCTTTTCTATATTTAGAAGAGGGATGAGAGTTTTTATTTTATATGAATGAAAATTAAAAGAAATTTA
TTTTGAAAGGAGAAATTAAT

Downstream 100 bases:

>100_bases
GAAAATACAAAGCCTAATTAACTAAAATATAAATATATTCCGAGGATTAATGTATTTCACTAAGAATTTACAGTAATCAT
TCCAAGAAATTTACTAAAGA

Product: threonyl-tRNA synthetase

Products: NA

Alternate protein names: Threonine--tRNA ligase; ThrRS

Number of amino acids: Translated: 643; Mature: 643

Protein sequence:

>643_residues
MIKITLKDGSIKEVEAGLSIFEIAQSISQGLARNACCGILNGKVEDLRFIVNEDSSLEICTFDSKEGQHAFNHTASHVLA
AAVKRLFPQDKLAIGPSIDNGFYYDFDTEKPFSADQLNKLEEEMKKIIKENPEIKRFELPRNEALELMKDEPYKVELIND
LPEGEVISFYQIGDFVDLCAGPHLMAVKPIKAVKLLRSTGAYWKGDEKNKMLSRVYGTAFPKKSELDAYLEALEEAKKRD
HNKLGRELGIFTTDENVGQGLPLLMPKGARIIQTLQRWIEDEEQRRGYVLTKTPLMAKSDLYKISGHWDHYKDGMFVLGD
EEKDSEVFALRPMTCPFQYAIYNSTQHSYRDLPVRFAETSTLFRNESSGEMHGLIRVRQFTLADGHIVCTPEQLEDEFKN
TVDLVKYVMETLGIADDITYRFSKWDPNNTEKYINDPEAWENTQNIMREILNHLNIDFTEADDEAAFYGPKLDIQFKNVH
GKEDTIITIQIDFALAERFGMYYIDKDGEKKRPYIIHRSSIGCYERTLAMLIEKYAGALPTWIAPVQAKVLPLSDKYADY
ANEVVEELRRRGVRVEADHRAEKIGYKIREARLERTPYILVVGEKEAENKEVSVRSRKNGEEGAMPLADFVNRIVLEIAN
REN

Sequences:

>Translated_643_residues
MIKITLKDGSIKEVEAGLSIFEIAQSISQGLARNACCGILNGKVEDLRFIVNEDSSLEICTFDSKEGQHAFNHTASHVLA
AAVKRLFPQDKLAIGPSIDNGFYYDFDTEKPFSADQLNKLEEEMKKIIKENPEIKRFELPRNEALELMKDEPYKVELIND
LPEGEVISFYQIGDFVDLCAGPHLMAVKPIKAVKLLRSTGAYWKGDEKNKMLSRVYGTAFPKKSELDAYLEALEEAKKRD
HNKLGRELGIFTTDENVGQGLPLLMPKGARIIQTLQRWIEDEEQRRGYVLTKTPLMAKSDLYKISGHWDHYKDGMFVLGD
EEKDSEVFALRPMTCPFQYAIYNSTQHSYRDLPVRFAETSTLFRNESSGEMHGLIRVRQFTLADGHIVCTPEQLEDEFKN
TVDLVKYVMETLGIADDITYRFSKWDPNNTEKYINDPEAWENTQNIMREILNHLNIDFTEADDEAAFYGPKLDIQFKNVH
GKEDTIITIQIDFALAERFGMYYIDKDGEKKRPYIIHRSSIGCYERTLAMLIEKYAGALPTWIAPVQAKVLPLSDKYADY
ANEVVEELRRRGVRVEADHRAEKIGYKIREARLERTPYILVVGEKEAENKEVSVRSRKNGEEGAMPLADFVNRIVLEIAN
REN
>Mature_643_residues
MIKITLKDGSIKEVEAGLSIFEIAQSISQGLARNACCGILNGKVEDLRFIVNEDSSLEICTFDSKEGQHAFNHTASHVLA
AAVKRLFPQDKLAIGPSIDNGFYYDFDTEKPFSADQLNKLEEEMKKIIKENPEIKRFELPRNEALELMKDEPYKVELIND
LPEGEVISFYQIGDFVDLCAGPHLMAVKPIKAVKLLRSTGAYWKGDEKNKMLSRVYGTAFPKKSELDAYLEALEEAKKRD
HNKLGRELGIFTTDENVGQGLPLLMPKGARIIQTLQRWIEDEEQRRGYVLTKTPLMAKSDLYKISGHWDHYKDGMFVLGD
EEKDSEVFALRPMTCPFQYAIYNSTQHSYRDLPVRFAETSTLFRNESSGEMHGLIRVRQFTLADGHIVCTPEQLEDEFKN
TVDLVKYVMETLGIADDITYRFSKWDPNNTEKYINDPEAWENTQNIMREILNHLNIDFTEADDEAAFYGPKLDIQFKNVH
GKEDTIITIQIDFALAERFGMYYIDKDGEKKRPYIIHRSSIGCYERTLAMLIEKYAGALPTWIAPVQAKVLPLSDKYADY
ANEVVEELRRRGVRVEADHRAEKIGYKIREARLERTPYILVVGEKEAENKEVSVRSRKNGEEGAMPLADFVNRIVLEIAN
REN

Specific function: Thrs Is Also A Translational Repressor Protein, It Controls The Translation Of Its Own Gene By Binding To Its mRNA. [C]

COG id: COG0441

COG function: function code J; Threonyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI38202255, Length=637, Percent_Identity=35.4788069073783, Blast_Score=411, Evalue=1e-114,
Organism=Homo sapiens, GI38570111, Length=639, Percent_Identity=34.8982785602504, Blast_Score=407, Evalue=1e-113,
Organism=Homo sapiens, GI20070344, Length=657, Percent_Identity=32.7245053272451, Blast_Score=362, Evalue=1e-100,
Organism=Escherichia coli, GI1788013, Length=644, Percent_Identity=37.2670807453416, Blast_Score=465, Evalue=1e-132,
Organism=Caenorhabditis elegans, GI71984192, Length=636, Percent_Identity=34.2767295597484, Blast_Score=404, Evalue=1e-113,
Organism=Caenorhabditis elegans, GI71984184, Length=636, Percent_Identity=34.2767295597484, Blast_Score=404, Evalue=1e-113,
Organism=Saccharomyces cerevisiae, GI6322112, Length=659, Percent_Identity=33.3839150227618, Blast_Score=387, Evalue=1e-108,
Organism=Saccharomyces cerevisiae, GI6322654, Length=396, Percent_Identity=32.5757575757576, Blast_Score=234, Evalue=4e-62,
Organism=Drosophila melanogaster, GI24583839, Length=638, Percent_Identity=36.9905956112853, Blast_Score=443, Evalue=1e-124,
Organism=Drosophila melanogaster, GI24583842, Length=638, Percent_Identity=36.9905956112853, Blast_Score=442, Evalue=1e-124,
Organism=Drosophila melanogaster, GI28574141, Length=638, Percent_Identity=36.9905956112853, Blast_Score=442, Evalue=1e-124,
Organism=Drosophila melanogaster, GI24664387, Length=236, Percent_Identity=25.4237288135593, Blast_Score=68, Evalue=2e-11,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): SYT_CLOP1 (Q0TMX8)

Other databases:

- EMBL:   CP000246
- RefSeq:   YP_697012.1
- ProteinModelPortal:   Q0TMX8
- SMR:   Q0TMX8
- STRING:   Q0TMX8
- GeneID:   4201920
- GenomeReviews:   CP000246_GR
- KEGG:   cpf:CPF_2631
- TIGR:   CPF_2631
- eggNOG:   COG0441
- HOGENOM:   HBG352811
- OMA:   LFVTPDQ
- ProtClustDB:   PRK00413
- BioCyc:   CPER195103:CPF_2631-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00184_B
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR012675
- InterPro:   IPR004095
- InterPro:   IPR012676
- InterPro:   IPR002320
- InterPro:   IPR018163
- InterPro:   IPR012947
- Gene3D:   G3DSA:3.40.50.800
- Gene3D:   G3DSA:3.10.20.30
- PRINTS:   PR01047
- SMART:   SM00863
- TIGRFAMs:   TIGR00418

Pfam domain/function: PF03129 HGTP_anticodon; PF02824 TGS; PF00587 tRNA-synt_2b; PF07973 tRNA_SAD; SSF52954 Anticodon_bd; SSF81271 TGS-like; SSF55186 Thr/Ala-tRNA-synth_IIc_edit

EC number: =6.1.1.3

Molecular weight: Translated: 73678; Mature: 73678

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKITLKDGSIKEVEAGLSIFEIAQSISQGLARNACCGILNGKVEDLRFIVNEDSSLEIC
CEEEEECCCCHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHEEEEECCCCCEEEE
TFDSKEGQHAFNHTASHVLAAAVKRLFPQDKLAIGPSIDNGFYYDFDTEKPFSADQLNKL
EECCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCEEEECCCCCCCCHHHHHHH
EEEMKKIIKENPEIKRFELPRNEALELMKDEPYKVELINDLPEGEVISFYQIGDFVDLCA
HHHHHHHHHCCCCCEEEECCHHHHHHHHCCCCEEEEEECCCCCCCEEEEEECCCHHHHHC
GPHLMAVKPIKAVKLLRSTGAYWKGDEKNKMLSRVYGTAFPKKSELDAYLEALEEAKKRD
CCCEEEECHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
HNKLGRELGIFTTDENVGQGLPLLMPKGARIIQTLQRWIEDEEQRRGYVLTKTPLMAKSD
HHHHHHHCCCEECCCCCCCCCCEECCCCHHHHHHHHHHHCCHHHHCCEEEECCCCCCCCC
LYKISGHWDHYKDGMFVLGDEEKDSEVFALRPMTCPFQYAIYNSTQHSYRDLPVRFAETS
CEEECCCCCCCCCCEEEECCCCCCCCEEEEECCCCCEEEEEECCCCCHHHCCCEEEEHHH
TLFRNESSGEMHGLIRVRQFTLADGHIVCTPEQLEDEFKNTVDLVKYVMETLGIADDITY
HHHCCCCCCCHHHEEEEEEEEECCCEEEECHHHHHHHHHHHHHHHHHHHHHCCCCCCCEE
RFSKWDPNNTEKYINDPEAWENTQNIMREILNHLNIDFTEADDEAAFYGPKLDIQFKNVH
EEECCCCCCCHHCCCCCHHHHHHHHHHHHHHHHCCCCEECCCCCCEEECCEEEEEECCCC
GKEDTIITIQIDFALAERFGMYYIDKDGEKKRPYIIHRSSIGCYERTLAMLIEKYAGALP
CCCCEEEEEEEEHHHHHHCCEEEECCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHCCCC
TWIAPVQAKVLPLSDKYADYANEVVEELRRRGVRVEADHRAEKIGYKIREARLERTPYIL
HHHCCCEEEEEECCHHHHHHHHHHHHHHHHCCCEEECHHHHHHHHHHHHHHHHCCCCEEE
VVGEKEAENKEVSVRSRKNGEEGAMPLADFVNRIVLEIANREN
EECCCCCCCCCEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MIKITLKDGSIKEVEAGLSIFEIAQSISQGLARNACCGILNGKVEDLRFIVNEDSSLEIC
CEEEEECCCCHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHEEEEECCCCCEEEE
TFDSKEGQHAFNHTASHVLAAAVKRLFPQDKLAIGPSIDNGFYYDFDTEKPFSADQLNKL
EECCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCEEEECCCCCCCCHHHHHHH
EEEMKKIIKENPEIKRFELPRNEALELMKDEPYKVELINDLPEGEVISFYQIGDFVDLCA
HHHHHHHHHCCCCCEEEECCHHHHHHHHCCCCEEEEEECCCCCCCEEEEEECCCHHHHHC
GPHLMAVKPIKAVKLLRSTGAYWKGDEKNKMLSRVYGTAFPKKSELDAYLEALEEAKKRD
CCCEEEECHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
HNKLGRELGIFTTDENVGQGLPLLMPKGARIIQTLQRWIEDEEQRRGYVLTKTPLMAKSD
HHHHHHHCCCEECCCCCCCCCCEECCCCHHHHHHHHHHHCCHHHHCCEEEECCCCCCCCC
LYKISGHWDHYKDGMFVLGDEEKDSEVFALRPMTCPFQYAIYNSTQHSYRDLPVRFAETS
CEEECCCCCCCCCCEEEECCCCCCCCEEEEECCCCCEEEEEECCCCCHHHCCCEEEEHHH
TLFRNESSGEMHGLIRVRQFTLADGHIVCTPEQLEDEFKNTVDLVKYVMETLGIADDITY
HHHCCCCCCCHHHEEEEEEEEECCCEEEECHHHHHHHHHHHHHHHHHHHHHCCCCCCCEE
RFSKWDPNNTEKYINDPEAWENTQNIMREILNHLNIDFTEADDEAAFYGPKLDIQFKNVH
EEECCCCCCCHHCCCCCHHHHHHHHHHHHHHHHCCCCEECCCCCCEEECCEEEEEECCCC
GKEDTIITIQIDFALAERFGMYYIDKDGEKKRPYIIHRSSIGCYERTLAMLIEKYAGALP
CCCCEEEEEEEEHHHHHHCCEEEECCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHCCCC
TWIAPVQAKVLPLSDKYADYANEVVEELRRRGVRVEADHRAEKIGYKIREARLERTPYIL
HHHCCCEEEEEECCHHHHHHHHHHHHHHHHCCCEEECHHHHHHHHHHHHHHHHCCCCEEE
VVGEKEAENKEVSVRSRKNGEEGAMPLADFVNRIVLEIANREN
EECCCCCCCCCEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA