Click here to switch to the map view.

The map label for this gene is ygcA [C]

Identifier: 18311096

GI number: 18311096

Start: 2425791

End: 2427146

Strand: Reverse

Name: ygcA [C]

Synonym: CPE2114

Alternate gene names: 18311096

Gene position: 2427146-2425791 (Counterclockwise)

Preceding gene: 18311097

Following gene: 18311095

Centisome position: 80.07

GC content: 31.42

Gene sequence:

>1356_bases
ATGAGAAAAGGTAATGAAATAGAATTATTAGTAGAGGGAATAGAGTTCCCTGCTAAAGGATTCGGCTTTGTAGATGGATT
AAAAGTTTATGCTAAAAATACTTTCCCAGGACAAAAAGTCTTTGGTAGAGTAACTAAGAAAAGAAAAGAGTATGCAGAAA
TTAGAGTTTCTGAAGTAAGAGAAAAAGCTAGTTATGAGGAAGACCAAAAGTGTCCACACTTTGGAGTATGTGGAGGATGT
TCTTCTCAAACAATTCCTTATGAGAAACAATTAGAGCTTAAGGTTGAACAAGTTAAAGATTTATTTAAAGAGGCTGAGGT
TCCAACAGGAGAGTTTTTAGGTATAGAAACTAGTCCAATTCAATGGGAATATAGAAATAAGATGGAATACACTTTTGGAG
ACGAAGAAAAAGGTGGAGAACTTACCCTTGGAATGCATATGAAGGGAAAATCTTTTGGAATAGTGAATGTTGATAAGTGT
GTATTAGTTGATGAAGATTTTAGAAATATACTAGATACAACAGTTAAATATTTCAGAGAAAAAGGATTACCTTTCTATAA
AATAATGCCTAGAACAGGGTATTTAAGATACCTAGTAGTAAGAAAAAGTGTTAAGACAGAAGAAATTCTTGTGAATTTAG
TTACTACAACTCAAATAGATTTTGATTTAACGGAGTTTACTGAACTTATAAAAGGATTAAACTTAAAAGGAAAATTAAAA
TCAATAATACATACAGAAAGTGATGCTTTATCAGAGGCTGTTATACCAGAGAAAGTAAACATTCTATATGGTGATGATTT
TATAACAGAAAATCTTTTAGGATTAAACTTTAAAATATCTCCATTCTCATTCTTCCAAACAAACTCACTAGGAGCTGAAA
AGCTATATAGCATAGTGAGAGATTTTATGGGGGCTGCTGACAATAAAGTAGTATTTGATCTTTATTGCGGAACAGGAACA
ATAGGTCAAATAGCAGCAGGAAAAGCTTCTAAGGTTATTGGAATTGAACTTATAGAAGAGGCAGCTATGGCAGCTAATGA
GAATGCAAAATTAAATGGATTAAATAATTGTAACTTTATAGCTGGAGATGTAGCTGAGGTTATAAAAACAGTTAAGGATA
AACCAGATATAATAATTTTAGATCCACCAAGAAGTGGGGTACATCCAAAGGCATTAGACTACGTTATAAAATTTAATGCT
CCACAAATAATCTATGTTTCATGTAATCCAAAAACTCTAGTAACTGACTTAAAAGTTTTAGAAACTAAGGGATATGAAAT
AGAAAAAACTTTACTTATGGATATGTTCCCTAACACTCCTCACGTAGAGACAGTTGTAAAATTAAATAAGAAATAA

Upstream 100 bases:

>100_bases
CATACTTTACAGAGCTATAATGGAAGGTAGAAAGTTCAAATTAACATTAGGTGAAAAAGTTTTTAGAAAATAAATAATTT
ATTAGTAAGGGAGACAACTA

Downstream 100 bases:

>100_bases
ATTATTTTATAAGCATAGATAGAATGATTTGATAAATAAATTGCTACCAATTTAACAAGATAAAAGTTTATTGGTGGCAA
TTTTTTATTTGTAGAAATAT

Product: 23S rRNA (uracil-5-)-methyltransferase RumA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 451; Mature: 451

Protein sequence:

>451_residues
MRKGNEIELLVEGIEFPAKGFGFVDGLKVYAKNTFPGQKVFGRVTKKRKEYAEIRVSEVREKASYEEDQKCPHFGVCGGC
SSQTIPYEKQLELKVEQVKDLFKEAEVPTGEFLGIETSPIQWEYRNKMEYTFGDEEKGGELTLGMHMKGKSFGIVNVDKC
VLVDEDFRNILDTTVKYFREKGLPFYKIMPRTGYLRYLVVRKSVKTEEILVNLVTTTQIDFDLTEFTELIKGLNLKGKLK
SIIHTESDALSEAVIPEKVNILYGDDFITENLLGLNFKISPFSFFQTNSLGAEKLYSIVRDFMGAADNKVVFDLYCGTGT
IGQIAAGKASKVIGIELIEEAAMAANENAKLNGLNNCNFIAGDVAEVIKTVKDKPDIIILDPPRSGVHPKALDYVIKFNA
PQIIYVSCNPKTLVTDLKVLETKGYEIEKTLLMDMFPNTPHVETVVKLNKK

Sequences:

>Translated_451_residues
MRKGNEIELLVEGIEFPAKGFGFVDGLKVYAKNTFPGQKVFGRVTKKRKEYAEIRVSEVREKASYEEDQKCPHFGVCGGC
SSQTIPYEKQLELKVEQVKDLFKEAEVPTGEFLGIETSPIQWEYRNKMEYTFGDEEKGGELTLGMHMKGKSFGIVNVDKC
VLVDEDFRNILDTTVKYFREKGLPFYKIMPRTGYLRYLVVRKSVKTEEILVNLVTTTQIDFDLTEFTELIKGLNLKGKLK
SIIHTESDALSEAVIPEKVNILYGDDFITENLLGLNFKISPFSFFQTNSLGAEKLYSIVRDFMGAADNKVVFDLYCGTGT
IGQIAAGKASKVIGIELIEEAAMAANENAKLNGLNNCNFIAGDVAEVIKTVKDKPDIIILDPPRSGVHPKALDYVIKFNA
PQIIYVSCNPKTLVTDLKVLETKGYEIEKTLLMDMFPNTPHVETVVKLNKK
>Mature_451_residues
MRKGNEIELLVEGIEFPAKGFGFVDGLKVYAKNTFPGQKVFGRVTKKRKEYAEIRVSEVREKASYEEDQKCPHFGVCGGC
SSQTIPYEKQLELKVEQVKDLFKEAEVPTGEFLGIETSPIQWEYRNKMEYTFGDEEKGGELTLGMHMKGKSFGIVNVDKC
VLVDEDFRNILDTTVKYFREKGLPFYKIMPRTGYLRYLVVRKSVKTEEILVNLVTTTQIDFDLTEFTELIKGLNLKGKLK
SIIHTESDALSEAVIPEKVNILYGDDFITENLLGLNFKISPFSFFQTNSLGAEKLYSIVRDFMGAADNKVVFDLYCGTGT
IGQIAAGKASKVIGIELIEEAAMAANENAKLNGLNNCNFIAGDVAEVIKTVKDKPDIIILDPPRSGVHPKALDYVIKFNA
PQIIYVSCNPKTLVTDLKVLETKGYEIEKTLLMDMFPNTPHVETVVKLNKK

Specific function: Could Be A 23s rRNA (Uracil-5-)-Methyltransferase. [C]

COG id: COG2265

COG function: function code J; SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 TRAM domain

Homologues:

Organism=Homo sapiens, GI34222389, Length=412, Percent_Identity=29.6116504854369, Blast_Score=160, Evalue=3e-39,
Organism=Homo sapiens, GI51173878, Length=412, Percent_Identity=29.6116504854369, Blast_Score=160, Evalue=3e-39,
Organism=Homo sapiens, GI269784680, Length=411, Percent_Identity=26.7639902676399, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI269784676, Length=411, Percent_Identity=26.7639902676399, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI20149688, Length=411, Percent_Identity=26.7639902676399, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI269784678, Length=353, Percent_Identity=27.1954674220963, Blast_Score=129, Evalue=4e-30,
Organism=Escherichia coli, GI1789148, Length=454, Percent_Identity=26.2114537444934, Blast_Score=154, Evalue=8e-39,
Organism=Escherichia coli, GI1787083, Length=380, Percent_Identity=28.1578947368421, Blast_Score=145, Evalue=4e-36,
Organism=Escherichia coli, GI1790403, Length=264, Percent_Identity=26.1363636363636, Blast_Score=82, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI71997438, Length=166, Percent_Identity=28.9156626506024, Blast_Score=80, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6322909, Length=403, Percent_Identity=27.0471464019851, Blast_Score=95, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24666579, Length=465, Percent_Identity=27.3118279569892, Blast_Score=142, Evalue=4e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): Y2114_CLOPE (Q8XIK5)

Other databases:

- EMBL:   BA000016
- RefSeq:   NP_563030.1
- ProteinModelPortal:   Q8XIK5
- SMR:   Q8XIK5
- GeneID:   990429
- GenomeReviews:   BA000016_GR
- KEGG:   cpe:CPE2114
- NMPDR:   fig|195102.1.peg.2177
- HOGENOM:   HBG690163
- OMA:   LNGLNNC
- PhylomeDB:   Q8XIK5
- ProtClustDB:   CLSK882798
- BioCyc:   CPER195102:CPE2114-MONOMER
- InterPro:   IPR016027
- InterPro:   IPR001566
- InterPro:   IPR002792
- InterPro:   IPR010280
- TIGRFAMs:   TIGR00479

Pfam domain/function: PF05958 tRNA_U5-meth_tr; SSF50249 Nucleic_acid_OB

EC number: NA

Molecular weight: Translated: 50647; Mature: 50647

Theoretical pI: Translated: 5.87; Mature: 5.87

Prosite motif: PS50926 TRAM; PS01230 TRMA_1; PS01231 TRMA_2

Important sites: ACT_SITE 408-408 BINDING 286-286 BINDING 315-315 BINDING 336-336 BINDING 381-381

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKGNEIELLVEGIEFPAKGFGFVDGLKVYAKNTFPGQKVFGRVTKKRKEYAEIRVSEVR
CCCCCEEEEEEECCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHH
EKASYEEDQKCPHFGVCGGCSSQTIPYEKQLELKVEQVKDLFKEAEVPTGEFLGIETSPI
HHHCCCHHHCCCCCCCCCCCCCCCCCCHHHHHEEHHHHHHHHHHCCCCCCCEECCCCCCC
QWEYRNKMEYTFGDEEKGGELTLGMHMKGKSFGIVNVDKCVLVDEDFRNILDTTVKYFRE
EEEECCCEEEECCCCCCCCEEEEEEEECCCEECEEECCEEEEECHHHHHHHHHHHHHHHH
KGLPFYKIMPRTGYLRYLVVRKSVKTEEILVNLVTTTQIDFDLTEFTELIKGLNLKGKLK
CCCCEEEECCCCCCEEEEEEHHCCCHHHHEEEEEEEEEECCCHHHHHHHHHCCCCCHHHH
SIIHTESDALSEAVIPEKVNILYGDDFITENLLGLNFKISPFSFFQTNSLGAEKLYSIVR
HHHHCCHHHHHHHCCCCCEEEEECCCHHHCCCCCCEEEECCEEEEECCCCCHHHHHHHHH
DFMGAADNKVVFDLYCGTGTIGQIAAGKASKVIGIELIEEAAMAANENAKLNGLNNCNFI
HHHCCCCCCEEEEEEECCCCCCHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCEE
AGDVAEVIKTVKDKPDIIILDPPRSGVHPKALDYVIKFNAPQIIYVSCNPKTLVTDLKVL
HHHHHHHHHHHCCCCCEEEECCCCCCCCHHHEEEEEEECCCEEEEEECCCCEEHHHHHHH
ETKGYEIEKTLLMDMFPNTPHVETVVKLNKK
HCCCCCHHHHHHHHCCCCCCCEEEHEEECCC
>Mature Secondary Structure
MRKGNEIELLVEGIEFPAKGFGFVDGLKVYAKNTFPGQKVFGRVTKKRKEYAEIRVSEVR
CCCCCEEEEEEECCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHH
EKASYEEDQKCPHFGVCGGCSSQTIPYEKQLELKVEQVKDLFKEAEVPTGEFLGIETSPI
HHHCCCHHHCCCCCCCCCCCCCCCCCCHHHHHEEHHHHHHHHHHCCCCCCCEECCCCCCC
QWEYRNKMEYTFGDEEKGGELTLGMHMKGKSFGIVNVDKCVLVDEDFRNILDTTVKYFRE
EEEECCCEEEECCCCCCCCEEEEEEEECCCEECEEECCEEEEECHHHHHHHHHHHHHHHH
KGLPFYKIMPRTGYLRYLVVRKSVKTEEILVNLVTTTQIDFDLTEFTELIKGLNLKGKLK
CCCCEEEECCCCCCEEEEEEHHCCCHHHHEEEEEEEEEECCCHHHHHHHHHCCCCCHHHH
SIIHTESDALSEAVIPEKVNILYGDDFITENLLGLNFKISPFSFFQTNSLGAEKLYSIVR
HHHHCCHHHHHHHCCCCCEEEEECCCHHHCCCCCCEEEECCEEEEECCCCCHHHHHHHHH
DFMGAADNKVVFDLYCGTGTIGQIAAGKASKVIGIELIEEAAMAANENAKLNGLNNCNFI
HHHCCCCCCEEEEEEECCCCCCHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCEE
AGDVAEVIKTVKDKPDIIILDPPRSGVHPKALDYVIKFNAPQIIYVSCNPKTLVTDLKVL
HHHHHHHHHHHCCCCCEEEECCCCCCCCHHHEEEEEEECCCEEEEEECCCCEEHHHHHHH
ETKGYEIEKTLLMDMFPNTPHVETVVKLNKK
HCCCCCHHHHHHHHCCCCCCCEEEHEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11792842