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The map label for this gene is parE [H]

Identifier: 18311051

GI number: 18311051

Start: 2368714

End: 2370666

Strand: Reverse

Name: parE [H]

Synonym: CPE2069

Alternate gene names: 18311051

Gene position: 2370666-2368714 (Counterclockwise)

Preceding gene: 18311052

Following gene: 18311050

Centisome position: 78.2

GC content: 31.49

Gene sequence:

>1953_bases
ATGTATATGAGCAATAAAAATAACAATTATGATGTTACCTCTTTAACTTCTTTAGAAAAGTTAGAACCAGTAAGAGTAAG
ACCAGGAATGTACATAGGTTCTACAGGAAGCAAGGGACTTCATCATTGTATATGGGAAATATTAGATAACTCTATAGACG
AAATATCAAATGGATATGGAAATAAGGCTAAGGTTATTTTAAATAAAGATAAAAGTGTAACTGTAATAGATAATGGAAGA
GGAATTCCTACGGGAATGCATCCAATAAAGAAAAAAACTGGTGTTGAAATGGTATTTACAGAGCTTCACACTGGGGGTAA
GTTTAATAACCAAAACTATAAGACTTCAGGAGGACTTCATGGTGTTGGAGCAGCCGTTGTTAATGCCTTATCAAGATGGC
TAGAAGTTGAAGTAAAACAAAATGGAAAGATATATAGACAAAGATTTGAATATGCTTATGACAAAGAGCTTAAAAAAGAT
ATGCCAGGAACACCAGTAACTCCATTAGAAGTAGTAGGAGAATCTAAGGAAACTGGAACAAAGGTTACTTTTTTACCAGA
TAGAGAAGTATTTTCAACATCAGATTTTAAATTTGACATAATAGATGAAAGATTACAAGAATTAGCTTTCCAAAATAAAG
GAATAAGATTAGAACTTATTGATAATAGAAAAGAAGAAAGTGTAAGTAAAGAATATTATTCTGAAAGAGGACTTTTAGAT
TTTATAGATTATTTAAATGAAAGTAAAACCCCTCTTCATCCAACTCCTGTTTTATTTGAAGGAGAAAAAGAAGTAAACAA
CATACAAATGTATGGAGAGATATGTCTTCAATTTACTGATTCAACAACAGAGAATATAGTTAGTTACGTAAATAATATCC
CTACTACAGAAGCTGGTACTCATGAGACTGGTTTTAAAACAGGAATGACTCGTGCTTTTAAGGAATGGGCTAAAAAGCTT
AACCTTATAAAAGAAAAAGATAAGGAATTTGAAGGTGATGATTTAAGAGAAGGTATGACAGCTATTGTCAGAATAAAAAT
CACAAATCCAGTCTTTGAAGGGCAAACAAAAACTAAGCTTGGGAATAATGAAGCTTACACAATGATGAATGATTTAGCTT
ACACTAAATTTGGTCATTGGATAGAGGATAATAAAGAAGTTGCAACTATGATTATAAATAATGCCTTAGATGCAGCTGCT
AGAAGAGAGAAAATTAAAAAGATTAATGATGCAGAGAGAAAGAAAATAGGAAAAGGAACAGCACCTTTAGCAGGAAAGGT
TGCAGTATGCACATTAAAAAATAAAGAAGCTAATGAATTCATAGTAGTTGAAGGAGATTCTGCAGGTGGATCAGCTAAGC
AAGCTAGAGATAGAAGATTCCAAACAATAATGCCTTCAAAAGGTAAAATAATGAATACAGAAAAACAAAAGTTAGAAAAT
GTTATAGCTTCTGAGGAATTAAAAATCTTTAATACTGCCATAGGTACAGGAATTTTAGATAATTATAATGAAGAAGATTT
AAAATATGACAAAATAATAATAATGAGTGATGCTGACGTAGATGGATATCATATAAGAACTCTTTGGATGACATATATCT
ATAGATACATGAGACCTCTTATAGCTAATGGTCATCTTTATTTAGCACAACCACCTCTTTATAAAGTTGCTAAATCAGGT
AAGGGTAAAGATAAGATTCTTTATGCTTATAGTGATGACGAATTAGAAGAAGTTAAAAAGAAGGTAGGAAAGGGAGCAAC
TATTCAAAGATTTAAAGGACTTGGAGAAATGAATCCAGACCAATTATGGGAGACAACTTTAAATCCAGAAACAAGAACTT
TAGTACAAGTTACTATAGAAGATGCCGCTAAGGCTGAAAAAATGGTTTCTTTATTAATGGGTGATGTTGTTCAGCCTAGA
AAGAACTATATGTATAAGTATGCTGAGTTCTAA

Upstream 100 bases:

>100_bases
AAAAAAACATTTAGAAATGAATTAGAGATAAATGACATAGAAAATGAATTATTTAAATTAGAGGAAATATATAAAGAGAT
TTCAGAGGAATTAAGGGAGG

Downstream 100 bases:

>100_bases
AGGAGGAGATTAAATGGCTAAGAAGAATATTGAAATACCTAAGGATAATAATATTATCAGAATGCCTCTTGAAGAGGTTA
TGCCTGATAACTATTTACCT

Product: DNA topoisomerase IV subunit B

Products: NA

Alternate protein names: Topoisomerase IV subunit B [H]

Number of amino acids: Translated: 650; Mature: 650

Protein sequence:

>650_residues
MYMSNKNNNYDVTSLTSLEKLEPVRVRPGMYIGSTGSKGLHHCIWEILDNSIDEISNGYGNKAKVILNKDKSVTVIDNGR
GIPTGMHPIKKKTGVEMVFTELHTGGKFNNQNYKTSGGLHGVGAAVVNALSRWLEVEVKQNGKIYRQRFEYAYDKELKKD
MPGTPVTPLEVVGESKETGTKVTFLPDREVFSTSDFKFDIIDERLQELAFQNKGIRLELIDNRKEESVSKEYYSERGLLD
FIDYLNESKTPLHPTPVLFEGEKEVNNIQMYGEICLQFTDSTTENIVSYVNNIPTTEAGTHETGFKTGMTRAFKEWAKKL
NLIKEKDKEFEGDDLREGMTAIVRIKITNPVFEGQTKTKLGNNEAYTMMNDLAYTKFGHWIEDNKEVATMIINNALDAAA
RREKIKKINDAERKKIGKGTAPLAGKVAVCTLKNKEANEFIVVEGDSAGGSAKQARDRRFQTIMPSKGKIMNTEKQKLEN
VIASEELKIFNTAIGTGILDNYNEEDLKYDKIIIMSDADVDGYHIRTLWMTYIYRYMRPLIANGHLYLAQPPLYKVAKSG
KGKDKILYAYSDDELEEVKKKVGKGATIQRFKGLGEMNPDQLWETTLNPETRTLVQVTIEDAAKAEKMVSLLMGDVVQPR
KNYMYKYAEF

Sequences:

>Translated_650_residues
MYMSNKNNNYDVTSLTSLEKLEPVRVRPGMYIGSTGSKGLHHCIWEILDNSIDEISNGYGNKAKVILNKDKSVTVIDNGR
GIPTGMHPIKKKTGVEMVFTELHTGGKFNNQNYKTSGGLHGVGAAVVNALSRWLEVEVKQNGKIYRQRFEYAYDKELKKD
MPGTPVTPLEVVGESKETGTKVTFLPDREVFSTSDFKFDIIDERLQELAFQNKGIRLELIDNRKEESVSKEYYSERGLLD
FIDYLNESKTPLHPTPVLFEGEKEVNNIQMYGEICLQFTDSTTENIVSYVNNIPTTEAGTHETGFKTGMTRAFKEWAKKL
NLIKEKDKEFEGDDLREGMTAIVRIKITNPVFEGQTKTKLGNNEAYTMMNDLAYTKFGHWIEDNKEVATMIINNALDAAA
RREKIKKINDAERKKIGKGTAPLAGKVAVCTLKNKEANEFIVVEGDSAGGSAKQARDRRFQTIMPSKGKIMNTEKQKLEN
VIASEELKIFNTAIGTGILDNYNEEDLKYDKIIIMSDADVDGYHIRTLWMTYIYRYMRPLIANGHLYLAQPPLYKVAKSG
KGKDKILYAYSDDELEEVKKKVGKGATIQRFKGLGEMNPDQLWETTLNPETRTLVQVTIEDAAKAEKMVSLLMGDVVQPR
KNYMYKYAEF
>Mature_650_residues
MYMSNKNNNYDVTSLTSLEKLEPVRVRPGMYIGSTGSKGLHHCIWEILDNSIDEISNGYGNKAKVILNKDKSVTVIDNGR
GIPTGMHPIKKKTGVEMVFTELHTGGKFNNQNYKTSGGLHGVGAAVVNALSRWLEVEVKQNGKIYRQRFEYAYDKELKKD
MPGTPVTPLEVVGESKETGTKVTFLPDREVFSTSDFKFDIIDERLQELAFQNKGIRLELIDNRKEESVSKEYYSERGLLD
FIDYLNESKTPLHPTPVLFEGEKEVNNIQMYGEICLQFTDSTTENIVSYVNNIPTTEAGTHETGFKTGMTRAFKEWAKKL
NLIKEKDKEFEGDDLREGMTAIVRIKITNPVFEGQTKTKLGNNEAYTMMNDLAYTKFGHWIEDNKEVATMIINNALDAAA
RREKIKKINDAERKKIGKGTAPLAGKVAVCTLKNKEANEFIVVEGDSAGGSAKQARDRRFQTIMPSKGKIMNTEKQKLEN
VIASEELKIFNTAIGTGILDNYNEEDLKYDKIIIMSDADVDGYHIRTLWMTYIYRYMRPLIANGHLYLAQPPLYKVAKSG
KGKDKILYAYSDDELEEVKKKVGKGATIQRFKGLGEMNPDQLWETTLNPETRTLVQVTIEDAAKAEKMVSLLMGDVVQPR
KNYMYKYAEF

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0187

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the type II topoisomerase family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=621, Percent_Identity=26.0869565217391, Blast_Score=121, Evalue=2e-27,
Organism=Homo sapiens, GI19913406, Length=639, Percent_Identity=23.943661971831, Blast_Score=115, Evalue=1e-25,
Organism=Escherichia coli, GI48994957, Length=587, Percent_Identity=41.396933560477, Blast_Score=451, Evalue=1e-128,
Organism=Escherichia coli, GI1789408, Length=646, Percent_Identity=37.3065015479876, Blast_Score=398, Evalue=1e-112,
Organism=Caenorhabditis elegans, GI17535065, Length=621, Percent_Identity=25.1207729468599, Blast_Score=134, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI212645845, Length=549, Percent_Identity=26.2295081967213, Blast_Score=128, Evalue=8e-30,
Organism=Saccharomyces cerevisiae, GI6324241, Length=639, Percent_Identity=24.8826291079812, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI17136538, Length=629, Percent_Identity=25.1192368839428, Blast_Score=116, Evalue=4e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR020568
- InterPro:   IPR014721
- InterPro:   IPR001241
- InterPro:   IPR013759
- InterPro:   IPR002288
- InterPro:   IPR013506
- InterPro:   IPR013760
- InterPro:   IPR018522
- InterPro:   IPR005740 [H]

Pfam domain/function: PF00204 DNA_gyraseB; PF00986 DNA_gyraseB_C; PF02518 HATPase_c [H]

EC number: 5.99.1.-

Molecular weight: Translated: 73597; Mature: 73597

Theoretical pI: Translated: 7.67; Mature: 7.67

Prosite motif: PS00177 TOPOISOMERASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYMSNKNNNYDVTSLTSLEKLEPVRVRPGMYIGSTGSKGLHHCIWEILDNSIDEISNGYG
CCCCCCCCCCCEEEECHHHHCCCEEECCCEEECCCCCCHHHHHHHHHHHHHHHHHHCCCC
NKAKVILNKDKSVTVIDNGRGIPTGMHPIKKKTGVEMVFTELHTGGKFNNQNYKTSGGLH
CCEEEEEECCCEEEEEECCCCCCCCCCCHHHHCCHHEEEEHHHCCCCCCCCCCCCCCCCC
GVGAAVVNALSRWLEVEVKQNGKIYRQRFEYAYDKELKKDMPGTPVTPLEVVGESKETGT
HHHHHHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCCCCC
KVTFLPDREVFSTSDFKFDIIDERLQELAFQNKGIRLELIDNRKEESVSKEYYSERGLLD
EEEEECCCCCCCCCCCEEHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHCCHHH
FIDYLNESKTPLHPTPVLFEGEKEVNNIQMYGEICLQFTDSTTENIVSYVNNIPTTEAGT
HHHHHCCCCCCCCCCCEEEECCCCCCHHHEEEHHHEEECCCCHHHHHHHHHCCCCCCCCC
HETGFKTGMTRAFKEWAKKLNLIKEKDKEFEGDDLREGMTAIVRIKITNPVFEGQTKTKL
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCEEEEEEEEECCCCCCCCCCCC
GNNEAYTMMNDLAYTKFGHWIEDNKEVATMIINNALDAAARREKIKKINDAERKKIGKGT
CCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCC
APLAGKVAVCTLKNKEANEFIVVEGDSAGGSAKQARDRRFQTIMPSKGKIMNTEKQKLEN
CCCCCCEEEEEECCCCCCEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCEECCHHHHHHH
VIASEELKIFNTAIGTGILDNYNEEDLKYDKIIIMSDADVDGYHIRTLWMTYIYRYMRPL
HHHHHHHHHHHHHHHCCHHCCCCCCCCCCCEEEEEECCCCCCEEHHHHHHHHHHHHHHHH
IANGHLYLAQPPLYKVAKSGKGKDKILYAYSDDELEEVKKKVGKGATIQRFKGLGEMNPD
HCCCEEEEECCCHHHHHHCCCCCCEEEEEECCHHHHHHHHHHCCCCHHHHHHCCCCCCHH
QLWETTLNPETRTLVQVTIEDAAKAEKMVSLLMGDVVQPRKNYMYKYAEF
HHHHCCCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHCCCHHHHCEECCCC
>Mature Secondary Structure
MYMSNKNNNYDVTSLTSLEKLEPVRVRPGMYIGSTGSKGLHHCIWEILDNSIDEISNGYG
CCCCCCCCCCCEEEECHHHHCCCEEECCCEEECCCCCCHHHHHHHHHHHHHHHHHHCCCC
NKAKVILNKDKSVTVIDNGRGIPTGMHPIKKKTGVEMVFTELHTGGKFNNQNYKTSGGLH
CCEEEEEECCCEEEEEECCCCCCCCCCCHHHHCCHHEEEEHHHCCCCCCCCCCCCCCCCC
GVGAAVVNALSRWLEVEVKQNGKIYRQRFEYAYDKELKKDMPGTPVTPLEVVGESKETGT
HHHHHHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCCCCC
KVTFLPDREVFSTSDFKFDIIDERLQELAFQNKGIRLELIDNRKEESVSKEYYSERGLLD
EEEEECCCCCCCCCCCEEHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHCCHHH
FIDYLNESKTPLHPTPVLFEGEKEVNNIQMYGEICLQFTDSTTENIVSYVNNIPTTEAGT
HHHHHCCCCCCCCCCCEEEECCCCCCHHHEEEHHHEEECCCCHHHHHHHHHCCCCCCCCC
HETGFKTGMTRAFKEWAKKLNLIKEKDKEFEGDDLREGMTAIVRIKITNPVFEGQTKTKL
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCEEEEEEEEECCCCCCCCCCCC
GNNEAYTMMNDLAYTKFGHWIEDNKEVATMIINNALDAAARREKIKKINDAERKKIGKGT
CCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCC
APLAGKVAVCTLKNKEANEFIVVEGDSAGGSAKQARDRRFQTIMPSKGKIMNTEKQKLEN
CCCCCCEEEEEECCCCCCEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCEECCHHHHHHH
VIASEELKIFNTAIGTGILDNYNEEDLKYDKIIIMSDADVDGYHIRTLWMTYIYRYMRPL
HHHHHHHHHHHHHHHCCHHCCCCCCCCCCCEEEEEECCCCCCEEHHHHHHHHHHHHHHHH
IANGHLYLAQPPLYKVAKSGKGKDKILYAYSDDELEEVKKKVGKGATIQRFKGLGEMNPD
HCCCEEEEECCCHHHHHHCCCCCCEEEEEECCHHHHHHHHHHCCCCHHHHHHCCCCCCHH
QLWETTLNPETRTLVQVTIEDAAKAEKMVSLLMGDVVQPRKNYMYKYAEF
HHHHCCCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHCCCHHHHCEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969507; 9539793; 9384377 [H]