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The map label for this gene is secD [H]

Identifier: 18310924

GI number: 18310924

Start: 2224435

End: 2225694

Strand: Reverse

Name: secD [H]

Synonym: CPE1942

Alternate gene names: 18310924

Gene position: 2225694-2224435 (Counterclockwise)

Preceding gene: 18310925

Following gene: 18310923

Centisome position: 73.42

GC content: 31.75

Gene sequence:

>1260_bases
ATGAAATCAAAATTAGGTAGCTTCATATTATTTTTTATCTCCATAGCAGTGATAAGTTTTTTAGCTCTAGCAGGGTTCAA
AGGATTTACATTAGGGGACTATCAATTTAAAACGTTTAATGAGGTTATAACTAAAGGATTGGATTTACAAGGTGGAGTTT
CTGTTCTTATGGAAATCCAAAGTGATGATGTAACAGTAGATCAATTAAACACAACAAAGGAACTTCTATCTTTAAGGGTT
AATAAGGTTGGAGTTTCAGAAACTGTAGTAACGACAGAGGGAAATAATAGAATAAGAATTGATATTCCAGGACAATACGA
TTCAAAAACTATAGTGGATTCTCTTCAAAAAACAGGGGAGTTAACATTTGTAGGACCTGAGGATGATGTTATTTTAACAG
GTAAAGATGTTGAAAAGTCAAGTGTATATATAGACCCTCAAACAGGTAAGCCAGTTATAAAATTAGAGCTTAACGAAGAA
GGTAAGCAAAAGTTTGCTGAGGCAACAAAAAAATATAAAGGCCAAAAAATAGCTATAAAAATGGATAATGAAACATTAAC
AGATCCAGTAGTAAATGACATAATTTCTAATGGTGAAGCTATTATTTCAGGAAATAGATCAATGGAAGAAGCTGAAAAGG
TATCTGGAATAATAAATGCTGGTGCATTACCAGTTCCAGTTAAGGCAGTTTCAGTTGAGACTGTAGGTGCTCAATTAGGT
GCAAATGCTCTTCCAAATGCTCTGAAAGCAGGAGCAATAGGTGTAGCTATAATATTCTTATTTATGATACTATACTATAG
AGTTCCAGGATTTATTGCATGTATGTCACTAAGTGTTTATATATTATTAGTGCTTTATATATTTGCATTAGTAGGAGTAA
CTCTTACTTTACCAGGTATAGCAGCTTTCTTATTAACAGTAGGTATGGCAGTAGATGCTAACGTACTTATATTTGAAAGA
ATCAAAGAAGAACTTGGAAATGGTAGAAGTATAACATCAGCTATGAAAATAGGTTTTAGTAATGCTTTAAGATCAATAAT
GGATTCTAATATAACAACTCTTATTGCTGGTTTAGTTCTATACTTCTTTGGATCAGGACCAGTTAAAGGATTTGCTTTAA
CATTATTAATAGGTATTGTAATAAGTATGTTTACCGCTATAATAATGACAAGATTCTTTATGAATTTAGGATTCAACATG
GGAATATTAAATAAGCCTTCAATGTTTGGTCGTATAAAAGGAGGTAGACATAATGCTTAA

Upstream 100 bases:

>100_bases
TAAAAATATAATATTAATAATTGTTGCCATATATTGACTATATGGCAACATATTAATATAATTTAGTTTATCAGAGAAAA
TTTTACAGAGGGGGATAACC

Downstream 100 bases:

>100_bases
AATTGTAGAGAAGAAGAAAATATGGTTTACTATATCAATTCTTATAATTGTTATAGGTTTTGGATTTATGTTTACTAAAG
GTATGAACTTTGGAATCGAC

Product: preprotein translocase subunit SecD

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 419; Mature: 419

Protein sequence:

>419_residues
MKSKLGSFILFFISIAVISFLALAGFKGFTLGDYQFKTFNEVITKGLDLQGGVSVLMEIQSDDVTVDQLNTTKELLSLRV
NKVGVSETVVTTEGNNRIRIDIPGQYDSKTIVDSLQKTGELTFVGPEDDVILTGKDVEKSSVYIDPQTGKPVIKLELNEE
GKQKFAEATKKYKGQKIAIKMDNETLTDPVVNDIISNGEAIISGNRSMEEAEKVSGIINAGALPVPVKAVSVETVGAQLG
ANALPNALKAGAIGVAIIFLFMILYYRVPGFIACMSLSVYILLVLYIFALVGVTLTLPGIAAFLLTVGMAVDANVLIFER
IKEELGNGRSITSAMKIGFSNALRSIMDSNITTLIAGLVLYFFGSGPVKGFALTLLIGIVISMFTAIIMTRFFMNLGFNM
GILNKPSMFGRIKGGRHNA

Sequences:

>Translated_419_residues
MKSKLGSFILFFISIAVISFLALAGFKGFTLGDYQFKTFNEVITKGLDLQGGVSVLMEIQSDDVTVDQLNTTKELLSLRV
NKVGVSETVVTTEGNNRIRIDIPGQYDSKTIVDSLQKTGELTFVGPEDDVILTGKDVEKSSVYIDPQTGKPVIKLELNEE
GKQKFAEATKKYKGQKIAIKMDNETLTDPVVNDIISNGEAIISGNRSMEEAEKVSGIINAGALPVPVKAVSVETVGAQLG
ANALPNALKAGAIGVAIIFLFMILYYRVPGFIACMSLSVYILLVLYIFALVGVTLTLPGIAAFLLTVGMAVDANVLIFER
IKEELGNGRSITSAMKIGFSNALRSIMDSNITTLIAGLVLYFFGSGPVKGFALTLLIGIVISMFTAIIMTRFFMNLGFNM
GILNKPSMFGRIKGGRHNA
>Mature_419_residues
MKSKLGSFILFFISIAVISFLALAGFKGFTLGDYQFKTFNEVITKGLDLQGGVSVLMEIQSDDVTVDQLNTTKELLSLRV
NKVGVSETVVTTEGNNRIRIDIPGQYDSKTIVDSLQKTGELTFVGPEDDVILTGKDVEKSSVYIDPQTGKPVIKLELNEE
GKQKFAEATKKYKGQKIAIKMDNETLTDPVVNDIISNGEAIISGNRSMEEAEKVSGIINAGALPVPVKAVSVETVGAQLG
ANALPNALKAGAIGVAIIFLFMILYYRVPGFIACMSLSVYILLVLYIFALVGVTLTLPGIAAFLLTVGMAVDANVLIFER
IKEELGNGRSITSAMKIGFSNALRSIMDSNITTLIAGLVLYFFGSGPVKGFALTLLIGIVISMFTAIIMTRFFMNLGFNM
GILNKPSMFGRIKGGRHNA

Specific function: Required for efficient translocation of secretory pre- proteins under conditions of hypersecretion but is not required for the release of mature proteins from the membrane [H]

COG id: COG0342

COG function: function code U; Preprotein translocase subunit SecD

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the secD/secF family. SecF subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786609, Length=372, Percent_Identity=34.1397849462366, Blast_Score=180, Evalue=2e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005791
- InterPro:   IPR022813
- InterPro:   IPR022646
- InterPro:   IPR022645
- InterPro:   IPR005665 [H]

Pfam domain/function: PF07549 Sec_GG; PF02355 SecD_SecF [H]

EC number: NA

Molecular weight: Translated: 45127; Mature: 45127

Theoretical pI: Translated: 8.34; Mature: 8.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSKLGSFILFFISIAVISFLALAGFKGFTLGDYQFKTFNEVITKGLDLQGGVSVLMEIQ
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCHHHHHHHHHHCCCCCCCCCEEEEEEC
SDDVTVDQLNTTKELLSLRVNKVGVSETVVTTEGNNRIRIDIPGQYDSKTIVDSLQKTGE
CCCEEHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCEEEEEECCCCCCHHHHHHHHHCCC
LTFVGPEDDVILTGKDVEKSSVYIDPQTGKPVIKLELNEEGKQKFAEATKKYKGQKIAIK
EEEECCCCCEEEECCCCCCCEEEECCCCCCCEEEEEECCHHHHHHHHHHHHHCCCEEEEE
MDNETLTDPVVNDIISNGEAIISGNRSMEEAEKVSGIINAGALPVPVKAVSVETVGAQLG
ECCCCCCHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHCCCCCCCCEEEEEHHHHHHHHC
ANALPNALKAGAIGVAIIFLFMILYYRVPGFIACMSLSVYILLVLYIFALVGVTLTLPGI
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AAFLLTVGMAVDANVLIFERIKEELGNGRSITSAMKIGFSNALRSIMDSNITTLIAGLVL
HHHHHHHHHHCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
YFFGSGPVKGFALTLLIGIVISMFTAIIMTRFFMNLGFNMGILNKPSMFGRIKGGRHNA
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHEECCCCCCCC
>Mature Secondary Structure
MKSKLGSFILFFISIAVISFLALAGFKGFTLGDYQFKTFNEVITKGLDLQGGVSVLMEIQ
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCHHHHHHHHHHCCCCCCCCCEEEEEEC
SDDVTVDQLNTTKELLSLRVNKVGVSETVVTTEGNNRIRIDIPGQYDSKTIVDSLQKTGE
CCCEEHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCEEEEEECCCCCCHHHHHHHHHCCC
LTFVGPEDDVILTGKDVEKSSVYIDPQTGKPVIKLELNEEGKQKFAEATKKYKGQKIAIK
EEEECCCCCEEEECCCCCCCEEEECCCCCCCEEEEEECCHHHHHHHHHHHHHCCCEEEEE
MDNETLTDPVVNDIISNGEAIISGNRSMEEAEKVSGIINAGALPVPVKAVSVETVGAQLG
ECCCCCCHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHCCCCCCCCEEEEEHHHHHHHHC
ANALPNALKAGAIGVAIIFLFMILYYRVPGFIACMSLSVYILLVLYIFALVGVTLTLPGI
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AAFLLTVGMAVDANVLIFERIKEELGNGRSITSAMKIGFSNALRSIMDSNITTLIAGLVL
HHHHHHHHHHCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
YFFGSGPVKGFALTLLIGIVISMFTAIIMTRFFMNLGFNMGILNKPSMFGRIKGGRHNA
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9694879; 9384377 [H]