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The map label for this gene is glyA [H]

Identifier: 18310911

GI number: 18310911

Start: 2210573

End: 2211805

Strand: Reverse

Name: glyA [H]

Synonym: CPE1929

Alternate gene names: 18310911

Gene position: 2211805-2210573 (Counterclockwise)

Preceding gene: 18310914

Following gene: 18310910

Centisome position: 72.96

GC content: 31.47

Gene sequence:

>1233_bases
ATGAATTTTGACAACTTAGAAAGAGAAGATGAGCAAATTGCACATCTTGTTCAAAAGGAAAAGGAAAGGCAAGAAAATAG
TATAGAGCTTATAGCTTCAGAAAACTTTGTTAGCAAAGCTGTTATGGAAGCTATGGGATCATATTTAACAAATAAATATG
CTGAGGGTTATCCTTCAAAAAGATACTATGGTGGATGTCACGTAGTAGATGAGGTTGAAGATTTAGCAAGAGAAAGAGTA
AAAAAATTATTTGGGGCTGAGCATGCTAATGTACAACCACATTCAGGATCACAAGCTAATATGGCTGTTTATTTTTCAAT
ATTAGAGCCAGGTGATACTGTATTAGGAATGGATTTAAGCCATGGAGGACACTTAACTCATGGTTCATCAGTTAACTTTT
CAGGTAGATTATTTAATTTCGTGTCATATGGTGTAGATAAAGAAACAGAAACAATAAACTATGAAACTGTAAGAGAATTA
GCTCTTAAACATAAACCTAAATTAATAGTTGCAGGAGCTAGTGCATATTCAAGAATTATAGATTTTAAAACTTTAAGAGA
GATAGCAGATGAGGTAGGAGCATACTTAATGGTTGATATAGCTCACATTGCAGGGCTTGTAGCTACAGGCTTACATCCAT
CACCAGTTCCTTATGCTGATTTTGTTACATCAACAACTCATAAAACTTTAAGAGGACCAAGAGGAGGATTAATACTTTGT
AAAGAAAAATTTGCAAAAGTATTAGATAAAAATATTTTCCCAGGAATACAAGGTGGTCCTTTAATGCATATAATAGCTGC
AAAGGCTGTTTGTTTTAAAGAAGCATTAGAACCAAGTTTTAAAACATATATGGAGCAAGTTGTTAAAAATGCACATGTTT
TAGCAGAAGCTTTAGAAGCTTATGGATTTAAATTAGTTTCAAATGGAACTGATAACCATTTAATACTTGTTGATTTAACT
AATAAAGATATAACTGGTAAAGATGCAGAAATTCTTTTAGATAGTATAGGAATAACTTTAAATAAAAATACTGTACCAAA
TGAAACAAGAAGCCCATTTGTTACTAGTGGTGTTAGAATAGGAACTCCTGCTATAACAACTAGAGGATTTAAAGAAGAAG
AAATGAAAGAAATAGCTTCTATAATAAATGATGCTATTAAAGAAAAAGATGGAGATTTAGAACCATTAAAAGCAAGAGTT
AAAGCTTTATGTGCTAAGTATCCTTTATATTAA

Upstream 100 bases:

>100_bases
TATTAGTTTAATCAAAATATAAACAAATTATTTTTTGTTGCTAAAAATAATTAATAAATTTATAATAAGTAATATACATT
TTACGTTTGGGGTGAAGAAA

Downstream 100 bases:

>100_bases
TAATTAAAAATAGTTTTTAAGGGGAGTATTAAAATTTTGCTTTGGTGAATTTAGTATTCTCTTTAAGAAATACTGAATAG
AGAATTAAAGTCATGTTGCA

Product: serine hydroxymethyltransferase

Products: NA

Alternate protein names: SHMT; Serine methylase [H]

Number of amino acids: Translated: 410; Mature: 410

Protein sequence:

>410_residues
MNFDNLEREDEQIAHLVQKEKERQENSIELIASENFVSKAVMEAMGSYLTNKYAEGYPSKRYYGGCHVVDEVEDLARERV
KKLFGAEHANVQPHSGSQANMAVYFSILEPGDTVLGMDLSHGGHLTHGSSVNFSGRLFNFVSYGVDKETETINYETVREL
ALKHKPKLIVAGASAYSRIIDFKTLREIADEVGAYLMVDIAHIAGLVATGLHPSPVPYADFVTSTTHKTLRGPRGGLILC
KEKFAKVLDKNIFPGIQGGPLMHIIAAKAVCFKEALEPSFKTYMEQVVKNAHVLAEALEAYGFKLVSNGTDNHLILVDLT
NKDITGKDAEILLDSIGITLNKNTVPNETRSPFVTSGVRIGTPAITTRGFKEEEMKEIASIINDAIKEKDGDLEPLKARV
KALCAKYPLY

Sequences:

>Translated_410_residues
MNFDNLEREDEQIAHLVQKEKERQENSIELIASENFVSKAVMEAMGSYLTNKYAEGYPSKRYYGGCHVVDEVEDLARERV
KKLFGAEHANVQPHSGSQANMAVYFSILEPGDTVLGMDLSHGGHLTHGSSVNFSGRLFNFVSYGVDKETETINYETVREL
ALKHKPKLIVAGASAYSRIIDFKTLREIADEVGAYLMVDIAHIAGLVATGLHPSPVPYADFVTSTTHKTLRGPRGGLILC
KEKFAKVLDKNIFPGIQGGPLMHIIAAKAVCFKEALEPSFKTYMEQVVKNAHVLAEALEAYGFKLVSNGTDNHLILVDLT
NKDITGKDAEILLDSIGITLNKNTVPNETRSPFVTSGVRIGTPAITTRGFKEEEMKEIASIINDAIKEKDGDLEPLKARV
KALCAKYPLY
>Mature_410_residues
MNFDNLEREDEQIAHLVQKEKERQENSIELIASENFVSKAVMEAMGSYLTNKYAEGYPSKRYYGGCHVVDEVEDLARERV
KKLFGAEHANVQPHSGSQANMAVYFSILEPGDTVLGMDLSHGGHLTHGSSVNFSGRLFNFVSYGVDKETETINYETVREL
ALKHKPKLIVAGASAYSRIIDFKTLREIADEVGAYLMVDIAHIAGLVATGLHPSPVPYADFVTSTTHKTLRGPRGGLILC
KEKFAKVLDKNIFPGIQGGPLMHIIAAKAVCFKEALEPSFKTYMEQVVKNAHVLAEALEAYGFKLVSNGTDNHLILVDLT
NKDITGKDAEILLDSIGITLNKNTVPNETRSPFVTSGVRIGTPAITTRGFKEEEMKEIASIINDAIKEKDGDLEPLKARV
KALCAKYPLY

Specific function: Interconversion of serine and glycine [H]

COG id: COG0112

COG function: function code E; Glycine/serine hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SHMT family [H]

Homologues:

Organism=Homo sapiens, GI19923315, Length=425, Percent_Identity=44.4705882352941, Blast_Score=366, Evalue=1e-101,
Organism=Homo sapiens, GI261862352, Length=425, Percent_Identity=44.4705882352941, Blast_Score=365, Evalue=1e-101,
Organism=Homo sapiens, GI261862350, Length=425, Percent_Identity=44.4705882352941, Blast_Score=365, Evalue=1e-101,
Organism=Homo sapiens, GI261862348, Length=425, Percent_Identity=44.4705882352941, Blast_Score=365, Evalue=1e-101,
Organism=Homo sapiens, GI261862346, Length=425, Percent_Identity=44, Blast_Score=353, Evalue=2e-97,
Organism=Homo sapiens, GI22547186, Length=406, Percent_Identity=45.320197044335, Blast_Score=338, Evalue=7e-93,
Organism=Homo sapiens, GI22547189, Length=391, Percent_Identity=44.5012787723785, Blast_Score=311, Evalue=7e-85,
Organism=Escherichia coli, GI1788902, Length=411, Percent_Identity=59.6107055961071, Blast_Score=493, Evalue=1e-141,
Organism=Caenorhabditis elegans, GI25144732, Length=407, Percent_Identity=44.2260442260442, Blast_Score=354, Evalue=4e-98,
Organism=Caenorhabditis elegans, GI25144729, Length=407, Percent_Identity=44.2260442260442, Blast_Score=354, Evalue=5e-98,
Organism=Saccharomyces cerevisiae, GI6319739, Length=429, Percent_Identity=44.988344988345, Blast_Score=369, Evalue=1e-103,
Organism=Saccharomyces cerevisiae, GI6323087, Length=402, Percent_Identity=45.0248756218905, Blast_Score=352, Evalue=5e-98,
Organism=Drosophila melanogaster, GI24640005, Length=405, Percent_Identity=46.1728395061728, Blast_Score=377, Evalue=1e-105,
Organism=Drosophila melanogaster, GI221329721, Length=405, Percent_Identity=46.1728395061728, Blast_Score=376, Evalue=1e-104,

Paralogues:

None

Copy number: 3180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 12,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR001085
- InterPro:   IPR019798 [H]

Pfam domain/function: PF00464 SHMT [H]

EC number: =2.1.2.1 [H]

Molecular weight: Translated: 45189; Mature: 45189

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: PS00096 SHMT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFDNLEREDEQIAHLVQKEKERQENSIELIASENFVSKAVMEAMGSYLTNKYAEGYPSK
CCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCC
RYYGGCHVVDEVEDLARERVKKLFGAEHANVQPHSGSQANMAVYFSILEPGDTVLGMDLS
CCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEEECCCCEEEEEEEC
HGGHLTHGSSVNFSGRLFNFVSYGVDKETETINYETVRELALKHKPKLIVAGASAYSRII
CCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCEEEECCHHHHHHH
DFKTLREIADEVGAYLMVDIAHIAGLVATGLHPSPVPYADFVTSTTHKTLRGPRGGLILC
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEE
KEKFAKVLDKNIFPGIQGGPLMHIIAAKAVCFKEALEPSFKTYMEQVVKNAHVLAEALEA
HHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHH
YGFKLVSNGTDNHLILVDLTNKDITGKDAEILLDSIGITLNKNTVPNETRSPFVTSGVRI
HCEEEECCCCCCEEEEEEECCCCCCCCHHHHHHHHHCEEECCCCCCCCCCCCCEECCEEE
GTPAITTRGFKEEEMKEIASIINDAIKEKDGDLEPLKARVKALCAKYPLY
CCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MNFDNLEREDEQIAHLVQKEKERQENSIELIASENFVSKAVMEAMGSYLTNKYAEGYPSK
CCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCC
RYYGGCHVVDEVEDLARERVKKLFGAEHANVQPHSGSQANMAVYFSILEPGDTVLGMDLS
CCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEEECCCCEEEEEEEC
HGGHLTHGSSVNFSGRLFNFVSYGVDKETETINYETVRELALKHKPKLIVAGASAYSRII
CCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCEEEECCHHHHHHH
DFKTLREIADEVGAYLMVDIAHIAGLVATGLHPSPVPYADFVTSTTHKTLRGPRGGLILC
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEE
KEKFAKVLDKNIFPGIQGGPLMHIIAAKAVCFKEALEPSFKTYMEQVVKNAHVLAEALEA
HHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHH
YGFKLVSNGTDNHLILVDLTNKDITGKDAEILLDSIGITLNKNTVPNETRSPFVTSGVRI
HCEEEECCCCCCEEEEEEECCCCCCCCHHHHHHHHHCEEECCCCCCCCCCCCCEECCEEE
GTPAITTRGFKEEEMKEIASIINDAIKEKDGDLEPLKARVKALCAKYPLY
CCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA