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The map label for this gene is manB [H]

Identifier: 18310855

GI number: 18310855

Start: 2143173

End: 2144900

Strand: Reverse

Name: manB [H]

Synonym: CPE1873

Alternate gene names: 18310855

Gene position: 2144900-2143173 (Counterclockwise)

Preceding gene: 18310856

Following gene: 18310854

Centisome position: 70.76

GC content: 29.51

Gene sequence:

>1728_bases
GTGTATAGAGAAAAATATGAAGAATGGCTAAATTCTGATATTATTTCTGAGGAAATAAAGGCGGAATTAAGAGACGTAAA
AGAAGATAAGGAAATAGAAGATAGATTTTATAAGGAATTAGATTTTGGTACTGGTGGATTAAGAGGTGTTATTGGTGCTG
GGACTAATAGAATGAATATCTATACTGTAGGAAAAGCTACTCAAGGATTTGCAGATTATTTAAATGATAATTATGCGGGG
GAAAAATCTGTTGCAATAGCTTATGACTCAAGAAATATGTCTAAGGAGTTTGCAAAAGCGGCTGCTTTAACTCTTTGTGC
AAATGGAATAAAGGTTAATCTTTTTGAATCTTTAAGACCAACTCCAATGTTATCCTTTGCAGTAAGAGAATTAAATTGTA
AGGGTGGTATTGTTATAACAGCATCACATAATCCAAAACAATATAATGGATATAAAGTTTATGGAGATGATGGATGTCAA
TTAACAGATGCTCCTGCAAAAGCTGTTATTGGATATGTTAACAAAGTTACAGATTACGCAAACATAAAGACAATGAGTGA
AGAAAAGGCTTTAGAAGAAGGTCTTTTAGTTTATATTGGTGAAGAAATAGATAAAAAATATATAGATGATTTAAAAACTT
TAACTATAAGAGAAGATTTAGTTAAGAAGCATGCTAAAGATTTAAAAATAATTTATACTCCAATTCATGGTTCAGGAAAT
GTTCCTGTAAGAAGAATATTAAAAGAGTTAGGATATGAGAATGTATTTGTTGTTAAAGAACAAGAAATGCCAGATGGAAA
TTTCCCAACAGCTCCATATCCAAATCCAGAAGATCCAAAGGTATTTAAATTAGCTTTAGACATGGCTAAAGAAATTCAAC
CTGATATAATATTTGGAACAGATCCAGACTGTGATAGAATAGGTGTTGTTGTTAAAGACAATAATGGAGAGTACCAAGTA
TTAAGTGGTAACCAAACAGGAATGTTACTAACTAACTATATATTAAGTTCATTAAAGGAAATGAATAAATTACCTGAAAA
TGGTGCAGTTATAAAAACTATAGTTACTACAGAGTCAGTAAGAAAAATGACTGAGGAATATGGGGTAACTTTAATAGATA
CATTAACAGGATTTAAATATATAGGTGAAAAGATAAGAGAATTTGAAGAATCAGGTTCAAATGAATATTTATTTGGTTTT
GAAGAAAGCTATGGTTACTTAGCTGGAACTTTTGCTAGAGATAAGGATGCTGTTGTAGCTTCAATGTTAATAGCTGAAAT
GACTTTATATTATAAAGAACAAGGAAAAACTCTTTATGATGGTTTAATAGAACTTTATAATAAATATGGTTACTTCAAAG
AAAGCTTAGTATCAATAGAGCTTGCAGGAAAAGAAGGACAAGAACAAATAGCTAAGTGTATAGATGGCTTAAGAAATGAT
GCTTTAAAAGAAATGAACGGAGTTAAAGTTATTACATCTTTCGATTATAAGTTAAGCAAAGAATTAAATAACTTAACTGG
AGAAGAAAAAGAAATCAAACTTCCAAAATCAAATGTTTTAAAATATGTTTTAGAAGATGATTCTTGGTTTGTTGTAAGAC
CATCAGGTACAGAGCCTAAGATGAAAATCTACTTATCAGTAAAAGGTTCAAGTTTAGAAGATTCAAAAGAAAAAACTGAA
AACTTTAAAAATGCAATAATGGAAGTAATTAATGCTAAATTAAAATAG

Upstream 100 bases:

>100_bases
TTTTACTTTTTTTTGTTTTCAAATTTCAAAATATTGTAGTATAATATCTGTGAAAATAAAATATAAAATCCTTATAGAGA
TTTAAAGGGGAGATAGTGCA

Downstream 100 bases:

>100_bases
TTTAAGTTAAACAAAGAGCTATGTTAATATAACTTATATAAAACTTATAAGTTATAAATATAGCTCTTTTTATATTTTTA
GAGCTTAATGCACAAAAGAG

Product: phosphomannomutase

Products: NA

Alternate protein names: PGM; Alpha-phosphoglucomutase; Glucose phosphomutase [H]

Number of amino acids: Translated: 575; Mature: 575

Protein sequence:

>575_residues
MYREKYEEWLNSDIISEEIKAELRDVKEDKEIEDRFYKELDFGTGGLRGVIGAGTNRMNIYTVGKATQGFADYLNDNYAG
EKSVAIAYDSRNMSKEFAKAAALTLCANGIKVNLFESLRPTPMLSFAVRELNCKGGIVITASHNPKQYNGYKVYGDDGCQ
LTDAPAKAVIGYVNKVTDYANIKTMSEEKALEEGLLVYIGEEIDKKYIDDLKTLTIREDLVKKHAKDLKIIYTPIHGSGN
VPVRRILKELGYENVFVVKEQEMPDGNFPTAPYPNPEDPKVFKLALDMAKEIQPDIIFGTDPDCDRIGVVVKDNNGEYQV
LSGNQTGMLLTNYILSSLKEMNKLPENGAVIKTIVTTESVRKMTEEYGVTLIDTLTGFKYIGEKIREFEESGSNEYLFGF
EESYGYLAGTFARDKDAVVASMLIAEMTLYYKEQGKTLYDGLIELYNKYGYFKESLVSIELAGKEGQEQIAKCIDGLRND
ALKEMNGVKVITSFDYKLSKELNNLTGEEKEIKLPKSNVLKYVLEDDSWFVVRPSGTEPKMKIYLSVKGSSLEDSKEKTE
NFKNAIMEVINAKLK

Sequences:

>Translated_575_residues
MYREKYEEWLNSDIISEEIKAELRDVKEDKEIEDRFYKELDFGTGGLRGVIGAGTNRMNIYTVGKATQGFADYLNDNYAG
EKSVAIAYDSRNMSKEFAKAAALTLCANGIKVNLFESLRPTPMLSFAVRELNCKGGIVITASHNPKQYNGYKVYGDDGCQ
LTDAPAKAVIGYVNKVTDYANIKTMSEEKALEEGLLVYIGEEIDKKYIDDLKTLTIREDLVKKHAKDLKIIYTPIHGSGN
VPVRRILKELGYENVFVVKEQEMPDGNFPTAPYPNPEDPKVFKLALDMAKEIQPDIIFGTDPDCDRIGVVVKDNNGEYQV
LSGNQTGMLLTNYILSSLKEMNKLPENGAVIKTIVTTESVRKMTEEYGVTLIDTLTGFKYIGEKIREFEESGSNEYLFGF
EESYGYLAGTFARDKDAVVASMLIAEMTLYYKEQGKTLYDGLIELYNKYGYFKESLVSIELAGKEGQEQIAKCIDGLRND
ALKEMNGVKVITSFDYKLSKELNNLTGEEKEIKLPKSNVLKYVLEDDSWFVVRPSGTEPKMKIYLSVKGSSLEDSKEKTE
NFKNAIMEVINAKLK
>Mature_575_residues
MYREKYEEWLNSDIISEEIKAELRDVKEDKEIEDRFYKELDFGTGGLRGVIGAGTNRMNIYTVGKATQGFADYLNDNYAG
EKSVAIAYDSRNMSKEFAKAAALTLCANGIKVNLFESLRPTPMLSFAVRELNCKGGIVITASHNPKQYNGYKVYGDDGCQ
LTDAPAKAVIGYVNKVTDYANIKTMSEEKALEEGLLVYIGEEIDKKYIDDLKTLTIREDLVKKHAKDLKIIYTPIHGSGN
VPVRRILKELGYENVFVVKEQEMPDGNFPTAPYPNPEDPKVFKLALDMAKEIQPDIIFGTDPDCDRIGVVVKDNNGEYQV
LSGNQTGMLLTNYILSSLKEMNKLPENGAVIKTIVTTESVRKMTEEYGVTLIDTLTGFKYIGEKIREFEESGSNEYLFGF
EESYGYLAGTFARDKDAVVASMLIAEMTLYYKEQGKTLYDGLIELYNKYGYFKESLVSIELAGKEGQEQIAKCIDGLRND
ALKEMNGVKVITSFDYKLSKELNNLTGEEKEIKLPKSNVLKYVLEDDSWFVVRPSGTEPKMKIYLSVKGSSLEDSKEKTE
NFKNAIMEVINAKLK

Specific function: Catalyzes the interconversion between glucose-6- phosphate and alpha-glucose-1-phosphate. This is the first step in the biosynthesis of diglucosyl-diacylglycerol (Glc2-DAG), i.e. the predominant glycolipid found in B.subtilis membrane, which is also used

COG id: COG1109

COG function: function code G; Phosphomannomutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphohexose mutase family [H]

Homologues:

Organism=Homo sapiens, GI63055049, Length=558, Percent_Identity=32.078853046595, Blast_Score=272, Evalue=5e-73,
Organism=Homo sapiens, GI31377548, Length=568, Percent_Identity=31.6901408450704, Blast_Score=249, Evalue=4e-66,
Organism=Caenorhabditis elegans, GI71993870, Length=553, Percent_Identity=32.5497287522604, Blast_Score=246, Evalue=3e-65,
Organism=Caenorhabditis elegans, GI71993878, Length=310, Percent_Identity=33.8709677419355, Blast_Score=158, Evalue=8e-39,
Organism=Saccharomyces cerevisiae, GI6323934, Length=441, Percent_Identity=34.2403628117914, Blast_Score=243, Evalue=6e-65,
Organism=Drosophila melanogaster, GI20129809, Length=593, Percent_Identity=30.35413153457, Blast_Score=249, Evalue=3e-66,
Organism=Drosophila melanogaster, GI24651977, Length=464, Percent_Identity=31.6810344827586, Blast_Score=234, Evalue=2e-61,
Organism=Drosophila melanogaster, GI24653722, Length=486, Percent_Identity=32.3045267489712, Blast_Score=227, Evalue=2e-59,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005844
- InterPro:   IPR016055
- InterPro:   IPR005845
- InterPro:   IPR005846
- InterPro:   IPR005843
- InterPro:   IPR016066
- InterPro:   IPR005841 [H]

Pfam domain/function: PF02878 PGM_PMM_I; PF02879 PGM_PMM_II; PF02880 PGM_PMM_III; PF00408 PGM_PMM_IV [H]

EC number: =5.4.2.2 [H]

Molecular weight: Translated: 64704; Mature: 64704

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: PS00710 PGM_PMM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYREKYEEWLNSDIISEEIKAELRDVKEDKEIEDRFYKELDFGTGGLRGVIGAGTNRMNI
CCHHHHHHHHCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCEEEECCCCEEEE
YTVGKATQGFADYLNDNYAGEKSVAIAYDSRNMSKEFAKAAALTLCANGIKVNLFESLRP
EEECCCCHHHHHHHCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCEEEEEHHCCC
TPMLSFAVRELNCKGGIVITASHNPKQYNGYKVYGDDGCQLTDAPAKAVIGYVNKVTDYA
CHHHHHHHHHCCCCCCEEEEECCCCCCCCCEEEECCCCCEECCCHHHHHHHHHHHHHHHH
NIKTMSEEKALEEGLLVYIGEEIDKKYIDDLKTLTIREDLVKKHAKDLKIIYTPIHGSGN
HHECCHHHHHHHCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCC
VPVRRILKELGYENVFVVKEQEMPDGNFPTAPYPNPEDPKVFKLALDMAKEIQPDIIFGT
CHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEECC
DPDCDRIGVVVKDNNGEYQVLSGNQTGMLLTNYILSSLKEMNKLPENGAVIKTIVTTESV
CCCCCCEEEEEECCCCCEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEECHHHH
RKMTEEYGVTLIDTLTGFKYIGEKIREFEESGSNEYLFGFEESYGYLAGTFARDKDAVVA
HHHHHHHCCEEEHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCEEEECCCCHHHHHH
SMLIAEMTLYYKEQGKTLYDGLIELYNKYGYFKESLVSIELAGKEGQEQIAKCIDGLRND
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHCHHHHHEEEEEECCCCCHHHHHHHHHHHHHH
ALKEMNGVKVITSFDYKLSKELNNLTGEEKEIKLPKSNVLKYVLEDDSWFVVRPSGTEPK
HHHHCCCEEEEEECCHHHHHHHHHCCCCCCEEECCHHHHEEEEEECCCEEEEECCCCCCC
MKIYLSVKGSSLEDSKEKTENFKNAIMEVINAKLK
EEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MYREKYEEWLNSDIISEEIKAELRDVKEDKEIEDRFYKELDFGTGGLRGVIGAGTNRMNI
CCHHHHHHHHCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCEEEECCCCEEEE
YTVGKATQGFADYLNDNYAGEKSVAIAYDSRNMSKEFAKAAALTLCANGIKVNLFESLRP
EEECCCCHHHHHHHCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCEEEEEHHCCC
TPMLSFAVRELNCKGGIVITASHNPKQYNGYKVYGDDGCQLTDAPAKAVIGYVNKVTDYA
CHHHHHHHHHCCCCCCEEEEECCCCCCCCCEEEECCCCCEECCCHHHHHHHHHHHHHHHH
NIKTMSEEKALEEGLLVYIGEEIDKKYIDDLKTLTIREDLVKKHAKDLKIIYTPIHGSGN
HHECCHHHHHHHCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCC
VPVRRILKELGYENVFVVKEQEMPDGNFPTAPYPNPEDPKVFKLALDMAKEIQPDIIFGT
CHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEECC
DPDCDRIGVVVKDNNGEYQVLSGNQTGMLLTNYILSSLKEMNKLPENGAVIKTIVTTESV
CCCCCCEEEEEECCCCCEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEECHHHH
RKMTEEYGVTLIDTLTGFKYIGEKIREFEESGSNEYLFGFEESYGYLAGTFARDKDAVVA
HHHHHHHCCEEEHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCEEEECCCCHHHHHH
SMLIAEMTLYYKEQGKTLYDGLIELYNKYGYFKESLVSIELAGKEGQEQIAKCIDGLRND
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHCHHHHHEEEEEECCCCCHHHHHHHHHHHHHH
ALKEMNGVKVITSFDYKLSKELNNLTGEEKEIKLPKSNVLKYVLEDDSWFVVRPSGTEPK
HHHHCCCEEEEEECCHHHHHHHHHCCCCCCEEECCHHHHEEEEEECCCEEEEECCCCCCC
MKIYLSVKGSSLEDSKEKTENFKNAIMEVINAKLK
EEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377; 2127799 [H]