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The map label for this gene is ispA [C]

Identifier: 18310802

GI number: 18310802

Start: 2099104

End: 2100009

Strand: Reverse

Name: ispA [C]

Synonym: CPE1820

Alternate gene names: 18310802

Gene position: 2100009-2099104 (Counterclockwise)

Preceding gene: 18310803

Following gene: 18310801

Centisome position: 69.27

GC content: 28.59

Gene sequence:

>906_bases
ATGAAAAAGAGGAAGACTTTGGAGGATACAGCAATGAATATTAATAGCTTAAAAGAGGAAGTTGATCAATCTTTAAAAGC
TTATTTTAATAAAGATAGAGAATACAATAAAGTTTTATATGATTCAATGGCATATAGCATAAATGTAGGGGGAAAAAGAA
TAAGACCAATCTTAATGCTTTTATCTTACTATATTTATAAAAGTGATTATAAAAAAATATTAACACCTGCAATGGCCATA
GAAATGATACACACTTATTCTTTAATACATGATGATTTACCATGTATGGACAATGATGATTTAAGAAGAGGAAAACCTAC
AAATCATAAGGTTTTTGGAGAAGCTATTGCTGTTTTAGCTGGAGATGCCCTTTTAAATGAAGCTATGAAAATTTTAGTTG
ATTATTCTTTAGAAGAAGGAAAAAGTGCATTAAAGGCAACTAAAATAATTGCAGATGCAGCAGGATCAGATGGAATGATT
GGTGGGCAAATTGTTGATATAATAAATGAAGATAAGGAAGAAATTTCTTTAAAAGAATTAGATTATATGCATTTAAAGAA
AACTGGAGAACTTATAAAAGCTTCAATAATGTCTGGAGCGGTTTTAGCAGAAGCTTCAGAGGGAGATATTAAAAAATTAG
AGGGTTTTGGATATAAGTTAGGCTTAGCATTTCAAATAAAAGATGATATATTAGATGTAGTGGGAAATGCAAAAGATTTA
GGGAAGAATGTTCACAAAGACCAAGAAAGCAATAAAAATAATTATATAACCATTTTTGGATTAGAAGAATGTAAGAAAAA
ATGCGTGAATATAACTGAGGAATGTATAGAGATATTAAGTTCAATAAAAGGAAATACAGAGCCTCTAAAAGTTTTAACCA
TGAAACTTTTAGAGAGAAAATTTTAA

Upstream 100 bases:

>100_bases
TTAGAAGAGTCTATAAAAAGCTATGAAAATGGAGTTAAAATAGTAAATAAACTATATAAGAAGCTAAGCACTTTAGAAGG
CAAAATAAAGGTTGTTGAAG

Downstream 100 bases:

>100_bases
TAATAAAGGATTTGGTTTAAATGAGTGAAGTTCTACAGAGAATAACTGATCCTAAAGAAATAAAGGATTTAGATGAGAAA
GAATTAGAAATATTAGCTGA

Product: geranyltranstransferase

Products: NA

Alternate protein names: FPP synthase; (2E,6E)-farnesyl diphosphate synthase; Geranyltranstransferase [H]

Number of amino acids: Translated: 301; Mature: 301

Protein sequence:

>301_residues
MKKRKTLEDTAMNINSLKEEVDQSLKAYFNKDREYNKVLYDSMAYSINVGGKRIRPILMLLSYYIYKSDYKKILTPAMAI
EMIHTYSLIHDDLPCMDNDDLRRGKPTNHKVFGEAIAVLAGDALLNEAMKILVDYSLEEGKSALKATKIIADAAGSDGMI
GGQIVDIINEDKEEISLKELDYMHLKKTGELIKASIMSGAVLAEASEGDIKKLEGFGYKLGLAFQIKDDILDVVGNAKDL
GKNVHKDQESNKNNYITIFGLEECKKKCVNITEECIEILSSIKGNTEPLKVLTMKLLERKF

Sequences:

>Translated_301_residues
MKKRKTLEDTAMNINSLKEEVDQSLKAYFNKDREYNKVLYDSMAYSINVGGKRIRPILMLLSYYIYKSDYKKILTPAMAI
EMIHTYSLIHDDLPCMDNDDLRRGKPTNHKVFGEAIAVLAGDALLNEAMKILVDYSLEEGKSALKATKIIADAAGSDGMI
GGQIVDIINEDKEEISLKELDYMHLKKTGELIKASIMSGAVLAEASEGDIKKLEGFGYKLGLAFQIKDDILDVVGNAKDL
GKNVHKDQESNKNNYITIFGLEECKKKCVNITEECIEILSSIKGNTEPLKVLTMKLLERKF
>Mature_301_residues
MKKRKTLEDTAMNINSLKEEVDQSLKAYFNKDREYNKVLYDSMAYSINVGGKRIRPILMLLSYYIYKSDYKKILTPAMAI
EMIHTYSLIHDDLPCMDNDDLRRGKPTNHKVFGEAIAVLAGDALLNEAMKILVDYSLEEGKSALKATKIIADAAGSDGMI
GGQIVDIINEDKEEISLKELDYMHLKKTGELIKASIMSGAVLAEASEGDIKKLEGFGYKLGLAFQIKDDILDVVGNAKDL
GKNVHKDQESNKNNYITIFGLEECKKKCVNITEECIEILSSIKGNTEPLKVLTMKLLERKF

Specific function: Unknown

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI50659086, Length=210, Percent_Identity=31.4285714285714, Blast_Score=80, Evalue=3e-15,
Organism=Escherichia coli, GI1786623, Length=301, Percent_Identity=37.2093023255814, Blast_Score=168, Evalue=4e-43,
Organism=Escherichia coli, GI1789578, Length=235, Percent_Identity=30.2127659574468, Blast_Score=108, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI17505681, Length=175, Percent_Identity=31.4285714285714, Blast_Score=80, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6322294, Length=266, Percent_Identity=28.1954887218045, Blast_Score=63, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24651612, Length=212, Percent_Identity=26.4150943396226, Blast_Score=82, Evalue=6e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.10 [H]

Molecular weight: Translated: 33761; Mature: 33761

Theoretical pI: Translated: 6.08; Mature: 6.08

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1 ; PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKRKTLEDTAMNINSLKEEVDQSLKAYFNKDREYNKVLYDSMAYSINVGGKRIRPILML
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHEEEECCCHHHHHHHHH
LSYYIYKSDYKKILTPAMAIEMIHTYSLIHDDLPCMDNDDLRRGKPTNHKVFGEAIAVLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
GDALLNEAMKILVDYSLEEGKSALKATKIIADAAGSDGMIGGQIVDIINEDKEEISLKEL
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCHHHHHHHHH
DYMHLKKTGELIKASIMSGAVLAEASEGDIKKLEGFGYKLGLAFQIKDDILDVVGNAKDL
HHHHHHHHHHHHHHHHHHCHHEEECCCCCHHHHHCCCEEEEEEEEEHHHHHHHHCCHHHH
GKNVHKDQESNKNNYITIFGLEECKKKCVNITEECIEILSSIKGNTEPLKVLTMKLLERK
HHHHHCCCCCCCCCEEEEEEHHHHHHHHHCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHC
F
C
>Mature Secondary Structure
MKKRKTLEDTAMNINSLKEEVDQSLKAYFNKDREYNKVLYDSMAYSINVGGKRIRPILML
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHEEEECCCHHHHHHHHH
LSYYIYKSDYKKILTPAMAIEMIHTYSLIHDDLPCMDNDDLRRGKPTNHKVFGEAIAVLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
GDALLNEAMKILVDYSLEEGKSALKATKIIADAAGSDGMIGGQIVDIINEDKEEISLKEL
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCHHHHHHHHH
DYMHLKKTGELIKASIMSGAVLAEASEGDIKKLEGFGYKLGLAFQIKDDILDVVGNAKDL
HHHHHHHHHHHHHHHHHHCHHEEECCCCCHHHHHCCCEEEEEEEEEHHHHHHHHCCHHHH
GKNVHKDQESNKNNYITIFGLEECKKKCVNITEECIEILSSIKGNTEPLKVLTMKLLERK
HHHHHCCCCCCCCCEEEEEEHHHHHHHHHCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHC
F
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8486607; 7918490 [H]