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The map label for this gene is dxs [H]

Identifier: 18310801

GI number: 18310801

Start: 2097224

End: 2099083

Strand: Reverse

Name: dxs [H]

Synonym: CPE1819

Alternate gene names: 18310801

Gene position: 2099083-2097224 (Counterclockwise)

Preceding gene: 18310802

Following gene: 18310800

Centisome position: 69.24

GC content: 29.68

Gene sequence:

>1860_bases
ATGAGTGAAGTTCTACAGAGAATAACTGATCCTAAAGAAATAAAGGATTTAGATGAGAAAGAATTAGAAATATTAGCTGA
AGATTTAAGAGAATTTTTAATTGAAAGTGTTTCAAACACTGGGGGACATTTTGCTTCAAACTTAGGAGTTATTGATTTAA
CAGTAGCTTTATTTAAAAATTTTGATTTTAGTGAAGATAGAATAATATGGGATGTTGGACATCAATCTTATGCTTATAAG
ATATTAACAGGAAGAAAAGATAAATTTAATACTTTAAGACAATATGGTGGATTGTGTGGATTTCCTAAGAGAACAGAAAG
TGAATATGATTTTTTTGCCACTGGACATAGTAGTACATCACTATCTTCAGCAGCAGGTATGGCTAGAGCACAGAGGCTAC
TTGGAAAAGATAATAAGGTCATAGCAGTTATAGGTGATGGAGCCTTAACTGGAGGTATGGCCTTAGAAGCCTTAAATGAT
ATTGGATATAGAAAAGATAATCTTATAATAATATTAAATGATAATCAAATGTCTATATGTAAAAATGTTGGAGGACTTGC
AACCTATTTAAATAAGCTTAGAATGGGTGTAGGTTATAATAAATTAAAATCAGATATTGGATCAACTTTAGATACAACTT
CTTTGGGGAAAAGAGTAAAGAACTCTCTTTCAAAATTAAAAGATGGTATTAAAAAAATTGTTGTACCAAGTATGTACTTT
GAAGATATTGGATTAAAATATTTTGGTATAGTAGATGGACATAATATTAGAGAATTAAATGAAGTTTTAAGCATAGCTAA
AAATATAAAAGGACCAGTTATAATACATACAGTTACTAAAAAAGGAAAAGGCTATGAATTAGCAGAAAAAAATCCTAATA
AATATCATGGAGTATCTCCTTTTGATTTAGGGGAAGGAGTAATTTCAAAGTTTTCAAGTAGAAATTATTCTTCTACCTTT
GGAGAAGAAATGATTAAATTAGCTAAAAATGATGATAAAGTTGTTGCAATTACTGCTGCTATGCCAGATGGAACAGGATT
AAAAGATTTTAGAGAAGAATTTCCTGATAGATTTTTTGATGTAGGAATAGCAGAACAACACGCTGTTACCTTAGCTGCTG
GAATGGCAGCAGAGGGTTTAAAACCATTTTTTGCAGTTTATTCCACTTTCCTACAAAGAGCTTATGACCAAGTTTTACAT
GATGTATGCATACAAAAACTACCTGTTACACTTTGTTTAGATAGAGCTGGCTTAGTTGGAGAAGATGGAGAAACTCATCA
AGGTATATTCGACATTTCATTTTTATCTCCAATGCCTAATATGACTATTGTTGCACCTAAGTGTATAGATGAAATGGAAG
TTATCTTAAAATGGGCAAGTAATTTTAATGCACCTTTAGCTATAAGATATCCAAGAGGTGGAGATATTGATGTTAATTTA
AAACCATTAAGTAAAATAGAATATGGAAAATGGGAAAAGGTTCAAGAGGGAGAGAAGATAGCAATAGTTGCTACTGGTAA
AATGGTTCAACATGCTATGATTGCTGCACAAAAAATAAAAGAAGAAAAAAATATAGATATTTTAATTATAAATGCAACCT
TTATAAAACCAATAGATAAAGAATTATTAAATTCCTTATCAAAGGATGGATTTAAGATTGTAACTATTGAAGATAATATT
AAAAAAGGTGGCTTTGGAGAAGGCGTTCTAGAGTATTTAAATGAAATTGGACATAAAGAAAAAATTGTTACATTAGCATT
TAATGATAAGTTTATAGAACATGGCAAGCCTGATATTTTATATAAAATTAATGGGTTAGATGCAGAGGGAATAAAAAACA
CATTAATTGAATTACTTTAA

Upstream 100 bases:

>100_bases
TAGAGATATTAAGTTCAATAAAAGGAAATACAGAGCCTCTAAAAGTTTTAACCATGAAACTTTTAGAGAGAAAATTTTAA
TAATAAAGGATTTGGTTTAA

Downstream 100 bases:

>100_bases
AGGAGAAAATTATGGCAGAAAAAAAAGAGAAAAAAGAAAGACTTGACGTACTTCTTGTTGAACAAGGTATTGCTGAGTCA
AGAGAAAAAGCTAAAAGATA

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS [H]

Number of amino acids: Translated: 619; Mature: 618

Protein sequence:

>619_residues
MSEVLQRITDPKEIKDLDEKELEILAEDLREFLIESVSNTGGHFASNLGVIDLTVALFKNFDFSEDRIIWDVGHQSYAYK
ILTGRKDKFNTLRQYGGLCGFPKRTESEYDFFATGHSSTSLSSAAGMARAQRLLGKDNKVIAVIGDGALTGGMALEALND
IGYRKDNLIIILNDNQMSICKNVGGLATYLNKLRMGVGYNKLKSDIGSTLDTTSLGKRVKNSLSKLKDGIKKIVVPSMYF
EDIGLKYFGIVDGHNIRELNEVLSIAKNIKGPVIIHTVTKKGKGYELAEKNPNKYHGVSPFDLGEGVISKFSSRNYSSTF
GEEMIKLAKNDDKVVAITAAMPDGTGLKDFREEFPDRFFDVGIAEQHAVTLAAGMAAEGLKPFFAVYSTFLQRAYDQVLH
DVCIQKLPVTLCLDRAGLVGEDGETHQGIFDISFLSPMPNMTIVAPKCIDEMEVILKWASNFNAPLAIRYPRGGDIDVNL
KPLSKIEYGKWEKVQEGEKIAIVATGKMVQHAMIAAQKIKEEKNIDILIINATFIKPIDKELLNSLSKDGFKIVTIEDNI
KKGGFGEGVLEYLNEIGHKEKIVTLAFNDKFIEHGKPDILYKINGLDAEGIKNTLIELL

Sequences:

>Translated_619_residues
MSEVLQRITDPKEIKDLDEKELEILAEDLREFLIESVSNTGGHFASNLGVIDLTVALFKNFDFSEDRIIWDVGHQSYAYK
ILTGRKDKFNTLRQYGGLCGFPKRTESEYDFFATGHSSTSLSSAAGMARAQRLLGKDNKVIAVIGDGALTGGMALEALND
IGYRKDNLIIILNDNQMSICKNVGGLATYLNKLRMGVGYNKLKSDIGSTLDTTSLGKRVKNSLSKLKDGIKKIVVPSMYF
EDIGLKYFGIVDGHNIRELNEVLSIAKNIKGPVIIHTVTKKGKGYELAEKNPNKYHGVSPFDLGEGVISKFSSRNYSSTF
GEEMIKLAKNDDKVVAITAAMPDGTGLKDFREEFPDRFFDVGIAEQHAVTLAAGMAAEGLKPFFAVYSTFLQRAYDQVLH
DVCIQKLPVTLCLDRAGLVGEDGETHQGIFDISFLSPMPNMTIVAPKCIDEMEVILKWASNFNAPLAIRYPRGGDIDVNL
KPLSKIEYGKWEKVQEGEKIAIVATGKMVQHAMIAAQKIKEEKNIDILIINATFIKPIDKELLNSLSKDGFKIVTIEDNI
KKGGFGEGVLEYLNEIGHKEKIVTLAFNDKFIEHGKPDILYKINGLDAEGIKNTLIELL
>Mature_618_residues
SEVLQRITDPKEIKDLDEKELEILAEDLREFLIESVSNTGGHFASNLGVIDLTVALFKNFDFSEDRIIWDVGHQSYAYKI
LTGRKDKFNTLRQYGGLCGFPKRTESEYDFFATGHSSTSLSSAAGMARAQRLLGKDNKVIAVIGDGALTGGMALEALNDI
GYRKDNLIIILNDNQMSICKNVGGLATYLNKLRMGVGYNKLKSDIGSTLDTTSLGKRVKNSLSKLKDGIKKIVVPSMYFE
DIGLKYFGIVDGHNIRELNEVLSIAKNIKGPVIIHTVTKKGKGYELAEKNPNKYHGVSPFDLGEGVISKFSSRNYSSTFG
EEMIKLAKNDDKVVAITAAMPDGTGLKDFREEFPDRFFDVGIAEQHAVTLAAGMAAEGLKPFFAVYSTFLQRAYDQVLHD
VCIQKLPVTLCLDRAGLVGEDGETHQGIFDISFLSPMPNMTIVAPKCIDEMEVILKWASNFNAPLAIRYPRGGDIDVNLK
PLSKIEYGKWEKVQEGEKIAIVATGKMVQHAMIAAQKIKEEKNIDILIINATFIKPIDKELLNSLSKDGFKIVTIEDNIK
KGGFGEGVLEYLNEIGHKEKIVTLAFNDKFIEHGKPDILYKINGLDAEGIKNTLIELL

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) [H]

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=675, Percent_Identity=24.4444444444444, Blast_Score=142, Evalue=7e-34,
Organism=Homo sapiens, GI4507521, Length=675, Percent_Identity=24.4444444444444, Blast_Score=142, Evalue=7e-34,
Organism=Homo sapiens, GI133778974, Length=617, Percent_Identity=22.0421393841167, Blast_Score=102, Evalue=1e-21,
Organism=Homo sapiens, GI225637463, Length=365, Percent_Identity=23.8356164383562, Blast_Score=90, Evalue=5e-18,
Organism=Homo sapiens, GI225637461, Length=365, Percent_Identity=23.8356164383562, Blast_Score=90, Evalue=5e-18,
Organism=Homo sapiens, GI225637459, Length=365, Percent_Identity=23.8356164383562, Blast_Score=90, Evalue=6e-18,
Organism=Escherichia coli, GI1786622, Length=612, Percent_Identity=43.9542483660131, Blast_Score=513, Evalue=1e-146,
Organism=Caenorhabditis elegans, GI17539652, Length=657, Percent_Identity=24.9619482496195, Blast_Score=105, Evalue=6e-23,
Organism=Drosophila melanogaster, GI24666278, Length=636, Percent_Identity=25.1572327044025, Blast_Score=136, Evalue=3e-32,
Organism=Drosophila melanogaster, GI45551847, Length=633, Percent_Identity=24.6445497630332, Blast_Score=126, Evalue=5e-29,
Organism=Drosophila melanogaster, GI45550715, Length=633, Percent_Identity=24.6445497630332, Blast_Score=126, Evalue=5e-29,
Organism=Drosophila melanogaster, GI24645119, Length=581, Percent_Identity=24.9569707401033, Blast_Score=122, Evalue=5e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005477
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; PF00456 Transketolase_N [H]

EC number: =2.2.1.7 [H]

Molecular weight: Translated: 68497; Mature: 68366

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: PS00801 TRANSKETOLASE_1 ; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEVLQRITDPKEIKDLDEKELEILAEDLREFLIESVSNTGGHFASNLGVIDLTVALFKN
CHHHHHHCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCHHHHHHHHHHC
FDFSEDRIIWDVGHQSYAYKILTGRKDKFNTLRQYGGLCGFPKRTESEYDFFATGHSSTS
CCCCCCCEEEEECCCCEEEEEECCCCHHHHHHHHHCCCCCCCCCCCCCCCEEEECCCCCC
LSSAAGMARAQRLLGKDNKVIAVIGDGALTGGMALEALNDIGYRKDNLIIILNDNQMSIC
HHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHCCCCCCCEEEEECCCCHHHH
KNVGGLATYLNKLRMGVGYNKLKSDIGSTLDTTSLGKRVKNSLSKLKDGIKKIVVPSMYF
HHCCHHHHHHHHHHHCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
EDIGLKYFGIVDGHNIRELNEVLSIAKNIKGPVIIHTVTKKGKGYELAEKNPNKYHGVSP
HHCCCEEEEEECCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCC
FDLGEGVISKFSSRNYSSTFGEEMIKLAKNDDKVVAITAAMPDGTGLKDFREEFPDRFFD
CCCCHHHHHHHCCCCCCHHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHCCHHHHC
VGIAEQHAVTLAAGMAAEGLKPFFAVYSTFLQRAYDQVLHDVCIQKLPVTLCLDRAGLVG
CCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEECCCCCCC
EDGETHQGIFDISFLSPMPNMTIVAPKCIDEMEVILKWASNFNAPLAIRYPRGGDIDVNL
CCCCCCCCEEEEEECCCCCCCEEECHHHHHHHHHHHHHHHCCCCCEEEECCCCCCEEEEC
KPLSKIEYGKWEKVQEGEKIAIVATGKMVQHAMIAAQKIKEEKNIDILIINATFIKPIDK
CCCCCCCCCCCHHHCCCCEEEEEECCHHHHHHHHHHHHHHHCCCCCEEEEEEHHHCHHHH
ELLNSLSKDGFKIVTIEDNIKKGGFGEGVLEYLNEIGHKEKIVTLAFNDKFIEHGKPDIL
HHHHHHCCCCEEEEEEECCCCCCCCCHHHHHHHHHCCCCCEEEEEEECCHHHHCCCCCEE
YKINGLDAEGIKNTLIELL
EEECCCCHHHHHHHHHHHC
>Mature Secondary Structure 
SEVLQRITDPKEIKDLDEKELEILAEDLREFLIESVSNTGGHFASNLGVIDLTVALFKN
HHHHHHCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCHHHHHHHHHHC
FDFSEDRIIWDVGHQSYAYKILTGRKDKFNTLRQYGGLCGFPKRTESEYDFFATGHSSTS
CCCCCCCEEEEECCCCEEEEEECCCCHHHHHHHHHCCCCCCCCCCCCCCCEEEECCCCCC
LSSAAGMARAQRLLGKDNKVIAVIGDGALTGGMALEALNDIGYRKDNLIIILNDNQMSIC
HHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHCCCCCCCEEEEECCCCHHHH
KNVGGLATYLNKLRMGVGYNKLKSDIGSTLDTTSLGKRVKNSLSKLKDGIKKIVVPSMYF
HHCCHHHHHHHHHHHCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
EDIGLKYFGIVDGHNIRELNEVLSIAKNIKGPVIIHTVTKKGKGYELAEKNPNKYHGVSP
HHCCCEEEEEECCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCC
FDLGEGVISKFSSRNYSSTFGEEMIKLAKNDDKVVAITAAMPDGTGLKDFREEFPDRFFD
CCCCHHHHHHHCCCCCCHHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHCCHHHHC
VGIAEQHAVTLAAGMAAEGLKPFFAVYSTFLQRAYDQVLHDVCIQKLPVTLCLDRAGLVG
CCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEECCCCCCC
EDGETHQGIFDISFLSPMPNMTIVAPKCIDEMEVILKWASNFNAPLAIRYPRGGDIDVNL
CCCCCCCCEEEEEECCCCCCCEEECHHHHHHHHHHHHHHHCCCCCEEEECCCCCCEEEEC
KPLSKIEYGKWEKVQEGEKIAIVATGKMVQHAMIAAQKIKEEKNIDILIINATFIKPIDK
CCCCCCCCCCCHHHCCCCEEEEEECCHHHHHHHHHHHHHHHCCCCCEEEEEEHHHCHHHH
ELLNSLSKDGFKIVTIEDNIKKGGFGEGVLEYLNEIGHKEKIVTLAFNDKFIEHGKPDIL
HHHHHHCCCCEEEEEEECCCCCCCCCHHHHHHHHHCCCCCEEEEEEECCHHHHCCCCCEE
YKINGLDAEGIKNTLIELL
EEECCCCHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA