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The map label for this gene is pyrH

Identifier: 18310680

GI number: 18310680

Start: 1976641

End: 1977354

Strand: Reverse

Name: pyrH

Synonym: CPE1698

Alternate gene names: 18310680

Gene position: 1977354-1976641 (Counterclockwise)

Preceding gene: 18310681

Following gene: 18310679

Centisome position: 65.23

GC content: 34.73

Gene sequence:

>714_bases
ATGGGAACTTGTAAATACAAAAGAGTTATGCTTAAGTTATCAGGTGAGGCTTTAGCAGGCGAAAATGGTTTTGGAATAGA
TTTTAATATAGCAATGAACATAGCAAAGGCTGTAAAAGAGCTTGTTGATATGGGAATAGAAGTAGGCGCAGTTGTAGGTG
GCGGAAACATATGGAGAGGTAGAAGTGGAGAAGGCATGGATAGAACTACTGCTGACTATATGGGAATGTTAGCTACTTCA
ATAAATGCTTTAGCTCTTCAAGATTCATTAGAATCTTTAGGGGTAGACACTAGAGTACAGACTGCTATAGAAATGAAGGA
AATAGCAGAGCCATATATAAGAAGAAGAGCTATGAGACACTTAGAAAAAGGTAGAGTAGTAATATTCGGAGCAGGAACAG
GAAACCCTTATTTTTCAACTGATACAGCAGCAGCATTAAGAGCCGCTGAAATAGAAGCTGATGTAATATTATTAGCTAAA
AAGGTTGATGGAGTTTATGATAAAGATCCACATAAATACGATGATGCTAAAAAATATGATGAATTATCATATATAGAAGT
ACTTGAGCAAGGATTACAAGTAATGGATTCAACTGCAACATCACTTTGTATGGACAACAACATCCCTATATTAGTATTTG
CTTTAGATAATCCTGAAAACATTAAGAGAGTTGTTTTAGGAGAAAATATAGGAACAATAGTAAGCAAAAAATAA

Upstream 100 bases:

>100_bases
GAAAATAATAACATAAGAGAACACATTGTGTTCTCTTTTTTTAGAATATAGATATAAAAAATTAACAAAAATAGAGAATT
CAGCGTTTTGGAGGTTTAAG

Downstream 100 bases:

>100_bases
GGAGGAGTTTTAAATGATTAAGGACGTTATAAAAAAATCAGAAGAAAAAATGAATAAAACTATAAATTCTTTAAATTCAG
AATTAGCTACAATGAAAGCT

Product: uridylate kinase

Products: NA

Alternate protein names: UK; Uridine monophosphate kinase; UMP kinase; UMPK

Number of amino acids: Translated: 237; Mature: 236

Protein sequence:

>237_residues
MGTCKYKRVMLKLSGEALAGENGFGIDFNIAMNIAKAVKELVDMGIEVGAVVGGGNIWRGRSGEGMDRTTADYMGMLATS
INALALQDSLESLGVDTRVQTAIEMKEIAEPYIRRRAMRHLEKGRVVIFGAGTGNPYFSTDTAAALRAAEIEADVILLAK
KVDGVYDKDPHKYDDAKKYDELSYIEVLEQGLQVMDSTATSLCMDNNIPILVFALDNPENIKRVVLGENIGTIVSKK

Sequences:

>Translated_237_residues
MGTCKYKRVMLKLSGEALAGENGFGIDFNIAMNIAKAVKELVDMGIEVGAVVGGGNIWRGRSGEGMDRTTADYMGMLATS
INALALQDSLESLGVDTRVQTAIEMKEIAEPYIRRRAMRHLEKGRVVIFGAGTGNPYFSTDTAAALRAAEIEADVILLAK
KVDGVYDKDPHKYDDAKKYDELSYIEVLEQGLQVMDSTATSLCMDNNIPILVFALDNPENIKRVVLGENIGTIVSKK
>Mature_236_residues
GTCKYKRVMLKLSGEALAGENGFGIDFNIAMNIAKAVKELVDMGIEVGAVVGGGNIWRGRSGEGMDRTTADYMGMLATSI
NALALQDSLESLGVDTRVQTAIEMKEIAEPYIRRRAMRHLEKGRVVIFGAGTGNPYFSTDTAAALRAAEIEADVILLAKK
VDGVYDKDPHKYDDAKKYDELSYIEVLEQGLQVMDSTATSLCMDNNIPILVFALDNPENIKRVVLGENIGTIVSKK

Specific function: Catalyzes the reversible phosphorylation of UMP to UDP

COG id: COG0528

COG function: function code F; Uridylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UMP kinase family

Homologues:

Organism=Escherichia coli, GI1786367, Length=233, Percent_Identity=49.7854077253219, Blast_Score=231, Evalue=3e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRH_CLOP1 (Q0TPQ5)

Other databases:

- EMBL:   CP000246
- RefSeq:   YP_696385.1
- ProteinModelPortal:   Q0TPQ5
- SMR:   Q0TPQ5
- STRING:   Q0TPQ5
- GeneID:   4203637
- GenomeReviews:   CP000246_GR
- KEGG:   cpf:CPF_1952
- TIGR:   CPF_1952
- eggNOG:   COG0528
- HOGENOM:   HBG497552
- OMA:   RHMEKGR
- ProtClustDB:   PRK00358
- BioCyc:   CPER195103:CPF_1952-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01220_B
- InterPro:   IPR001048
- InterPro:   IPR001057
- InterPro:   IPR011817
- InterPro:   IPR015963
- Gene3D:   G3DSA:3.40.1160.10
- PIRSF:   PIRSF005650
- PRINTS:   PR00474
- TIGRFAMs:   TIGR02075

Pfam domain/function: PF00696 AA_kinase; SSF53633 Aa_kinase

EC number: =2.7.4.22

Molecular weight: Translated: 25785; Mature: 25654

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: NA

Important sites: BINDING 54-54 BINDING 55-55 BINDING 59-59 BINDING 72-72 BINDING 166-166 BINDING 169-169

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGTCKYKRVMLKLSGEALAGENGFGIDFNIAMNIAKAVKELVDMGIEVGAVVGGGNIWRG
CCCCHHEEEEEEECCCEECCCCCCCEEHHHHHHHHHHHHHHHHCCCEEEEEEECCCEECC
RSGEGMDRTTADYMGMLATSINALALQDSLESLGVDTRVQTAIEMKEIAEPYIRRRAMRH
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LEKGRVVIFGAGTGNPYFSTDTAAALRAAEIEADVILLAKKVDGVYDKDPHKYDDAKKYD
HHCCCEEEEECCCCCCCCCCCHHHHHHHHHCCCCEEEEEEHHCCCCCCCCCCCCCHHHHH
ELSYIEVLEQGLQVMDSTATSLCMDNNIPILVFALDNPENIKRVVLGENIGTIVSKK
HHHHHHHHHHHHHHHHHHHHHHEECCCCCEEEEEECCCCHHEEEEECCCCCHHCCCC
>Mature Secondary Structure 
GTCKYKRVMLKLSGEALAGENGFGIDFNIAMNIAKAVKELVDMGIEVGAVVGGGNIWRG
CCCHHEEEEEEECCCEECCCCCCCEEHHHHHHHHHHHHHHHHCCCEEEEEEECCCEECC
RSGEGMDRTTADYMGMLATSINALALQDSLESLGVDTRVQTAIEMKEIAEPYIRRRAMRH
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LEKGRVVIFGAGTGNPYFSTDTAAALRAAEIEADVILLAKKVDGVYDKDPHKYDDAKKYD
HHCCCEEEEECCCCCCCCCCCHHHHHHHHHCCCCEEEEEEHHCCCCCCCCCCCCCHHHHH
ELSYIEVLEQGLQVMDSTATSLCMDNNIPILVFALDNPENIKRVVLGENIGTIVSKK
HHHHHHHHHHHHHHHHHHHHHHEECCCCCEEEEEECCCCHHEEEEECCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA