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The map label for this gene is ntpD [H]

Identifier: 18310618

GI number: 18310618

Start: 1908420

End: 1909064

Strand: Reverse

Name: ntpD [H]

Synonym: CPE1636

Alternate gene names: 18310618

Gene position: 1909064-1908420 (Counterclockwise)

Preceding gene: 18310619

Following gene: 18310617

Centisome position: 62.98

GC content: 32.4

Gene sequence:

>645_bases
ATGGCACAAAGATTAAATGTCAATCCTACTAGAATGGAACTCTCAAAGCTAAAGAAAAGATTAGCAACAGCAACAAGAGG
ACATAAATTATTAAAAGATAAGCAAGATGAGTTAATGAGACAATTCATAAATCTTATCAAATATAATAATCAATTAAGAG
ATGAAGTTGAAAAGGAACTAGGAAGTTCCTTAAAAGACTTCGTTATGGCTAGAGCTGTTATGAGTTCAGAGTTCCTAGAG
GAAGCTATAGCATACCCTAAAGAAGAAATTGAGGTTGAAGTGGGAAATAAAAACATAATGAGTGTAAATGTGCCTATAAT
GAACTTCAAAAGAAAATTAGAAGGTGATGAAGGTAGTATTTATCCTTATGGCTTTATGAATACTTCAGCTGAACTTGATG
ATGCAATTTCTAAACTATATGGAATTTTACCAAAGTTATTAGAACTTGCAGAAGTTGAGAAATCTGGTCAGCTTATGGCA
GACGAGATAGAGAAGACAAGAAGAAGAGTTAACGCTCTTGAATATATGACAATTCCTCAATTAAAAGAAACTATCAGATA
CATCAGAATGAAGCTTGATGAAAATGAGAGAAGTGCCTTAACAAGACTTATGAAAGTTAAGTCTATGATAGAGCAAAGAG
GATAA

Upstream 100 bases:

>100_bases
TTGGATGGAAATTACTTAAGATCTTACCTAGAACAGAGCTTAAGAGAATTAGAGATGAATATCTTGAAAAGTATATGCCT
GTTGGAGAGGATGAGTAAGA

Downstream 100 bases:

>100_bases
TATATTTAAATTAATAAAAAAGGCAATCTTATGTTAATAAAACATCAAGATTTGCCTTTTTTCTTTACTATTTTCAAAAT
AAAATGTATAATCTTATTAA

Product: V-type ATP synthase subunit D

Products: ADP; phosphate; H+

Alternate protein names: V-ATPase subunit D [H]

Number of amino acids: Translated: 214; Mature: 213

Protein sequence:

>214_residues
MAQRLNVNPTRMELSKLKKRLATATRGHKLLKDKQDELMRQFINLIKYNNQLRDEVEKELGSSLKDFVMARAVMSSEFLE
EAIAYPKEEIEVEVGNKNIMSVNVPIMNFKRKLEGDEGSIYPYGFMNTSAELDDAISKLYGILPKLLELAEVEKSGQLMA
DEIEKTRRRVNALEYMTIPQLKETIRYIRMKLDENERSALTRLMKVKSMIEQRG

Sequences:

>Translated_214_residues
MAQRLNVNPTRMELSKLKKRLATATRGHKLLKDKQDELMRQFINLIKYNNQLRDEVEKELGSSLKDFVMARAVMSSEFLE
EAIAYPKEEIEVEVGNKNIMSVNVPIMNFKRKLEGDEGSIYPYGFMNTSAELDDAISKLYGILPKLLELAEVEKSGQLMA
DEIEKTRRRVNALEYMTIPQLKETIRYIRMKLDENERSALTRLMKVKSMIEQRG
>Mature_213_residues
AQRLNVNPTRMELSKLKKRLATATRGHKLLKDKQDELMRQFINLIKYNNQLRDEVEKELGSSLKDFVMARAVMSSEFLEE
AIAYPKEEIEVEVGNKNIMSVNVPIMNFKRKLEGDEGSIYPYGFMNTSAELDDAISKLYGILPKLLELAEVEKSGQLMAD
EIEKTRRRVNALEYMTIPQLKETIRYIRMKLDENERSALTRLMKVKSMIEQRG

Specific function: Produces ATP from ADP in the presence of a proton gradient across the membrane [H]

COG id: COG1394

COG function: function code C; Archaeal/vacuolar-type H+-ATPase subunit D

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the V-ATPase D subunit family [H]

Homologues:

Organism=Homo sapiens, GI7706757, Length=208, Percent_Identity=29.8076923076923, Blast_Score=75, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17553636, Length=209, Percent_Identity=28.2296650717703, Blast_Score=72, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6320784, Length=210, Percent_Identity=27.6190476190476, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI20128937, Length=208, Percent_Identity=31.7307692307692, Blast_Score=78, Evalue=4e-15,
Organism=Drosophila melanogaster, GI21355551, Length=210, Percent_Identity=30.952380952381, Blast_Score=73, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002699 [H]

Pfam domain/function: PF01813 ATP-synt_D [H]

EC number: 3.6.3.14

Molecular weight: Translated: 24837; Mature: 24706

Theoretical pI: Translated: 9.44; Mature: 9.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
6.1 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
5.6 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQRLNVNPTRMELSKLKKRLATATRGHKLLKDKQDELMRQFINLIKYNNQLRDEVEKEL
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCHHHHHHHHHHH
GSSLKDFVMARAVMSSEFLEEAIAYPKEEIEVEVGNKNIMSVNVPIMNFKRKLEGDEGSI
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHEEEEECCCEEEEECCHHHHHHHHHCCCCCCC
YPYGFMNTSAELDDAISKLYGILPKLLELAEVEKSGQLMADEIEKTRRRVNALEYMTIPQ
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
LKETIRYIRMKLDENERSALTRLMKVKSMIEQRG
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AQRLNVNPTRMELSKLKKRLATATRGHKLLKDKQDELMRQFINLIKYNNQLRDEVEKEL
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCHHHHHHHHHHH
GSSLKDFVMARAVMSSEFLEEAIAYPKEEIEVEVGNKNIMSVNVPIMNFKRKLEGDEGSI
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHEEEEECCCEEEEECCHHHHHHHHHCCCCCCC
YPYGFMNTSAELDDAISKLYGILPKLLELAEVEKSGQLMADEIEKTRRRVNALEYMTIPQ
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
LKETIRYIRMKLDENERSALTRLMKVKSMIEQRG
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; H2O; H+

Specific reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out)

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA