Click here to switch to the map view.

The map label for this gene is clcA [H]

Identifier: 18310390

GI number: 18310390

Start: 1659846

End: 1661417

Strand: Reverse

Name: clcA [H]

Synonym: CPE1408

Alternate gene names: 18310390

Gene position: 1661417-1659846 (Counterclockwise)

Preceding gene: 18310393

Following gene: 18310387

Centisome position: 54.81

GC content: 31.23

Gene sequence:

>1572_bases
TTGAGTAATGAGAGTACGAAAAAAGTACTGTCACATAGAAAGGATTTAAGATTTAAATTAGTTCTAGAAGGTGCTGCCAT
AGGACTTTTATGTTCTTTAGTTTTAGTGCTAAATAGAATTATTGTTAATTACTTATTTCCACTTTTTAAAAAGCTTTATG
CATGGGCAGCATTAAGTATAACTAATATGATTATAGTTTTAGTTATATTAGCTATTTTAGGAGCACTTGTTGGATTTATG
GTTAGAAGAGAACCTATGATTTCAGGAAGTGGTATTCCTCAAGTTGAAGGAGAATTAATTGGTAAACTTAAAATGAATTG
GCTAAAGATTTTAATTTATAAGTTCTTAGGAGGAGTAATTTCCTTAGGAGCTGGATTGTCTTTAGGTAGAGAAGGTCCAT
CAGTACAAATGGGAGCCGCTGTAGGAGAAGGATTTAGTAATAGTTTAAAAAGAATAAATATAGAGAAAAAATATTTAATA
ACCTCAGGTGCTTCAGCTGGTTTAGCAGCAGCATTTAATGCACCTTTATCAGGGGTAATATTTGCCCTAGAAGAGGTACA
TAAGAGTTTCTCACCTTTAGTTTTAGTTTCTGCAATGGCAGCATCCTTAGTATCTGATTTTGTTTCAAAACAATTTTTAG
GAATGAATCCTAGTTTAGGAATAGAAAATGTTCCTGTATTACCTTTAAAATATTACTGGGTATTAATAATATTAGGAGTA
ATTTTAGGTATAGGTGGTGCAATATTCTCAAAGGGAATTTTAAAAGTACAAAGTTTATATGGAAAGTTTAAAAAGGTTCC
TGTAGAAGTTAAGGTAATGATTCCTTTCTTATTAACAGGTATATTAGGTATTTTCGCACCAATAATACTAGGTGGTGGAC
ATGAACTTATAATGGATTTAGCAACTAAGAGCTTTCCAATAAAGCTTCTTTTAGCTGTGCTTTTAGTTAAATTTTTATTA
ACTATTATAAGTTTTGGTGCAGGTACACCAGGTGGTATATTCTTCCCACTATTACTTTTAGGTGCAGTAGTAGGAAATAT
AGTTGGAATAGTAAGTTGTAATGCATTTGGAGTTCCAAACCAATATATAATAGATTTTATAATATTAGCCATGGCAGGTA
ACTTTGCTTCAATAGTAAAGGCACCTATTACAGGTATAATACTTATTACAGAGATGACTGGTTCTTTTGAACATATGCTA
GCTTTATCTGTAGTTGTAATAATTTCCTATGTAACATCTGACTTACTAAAAAGTGAACCAATATATGAATCTTTATTAGA
AAGATGGATAGAAAAGGTTGGTTCAGAAGTAGAAGAACCTTCTAATAATAAAACTTTACTAGAAGTTGGAGTAGAACTTG
GTAGTGAAGCAGAAGGAAAAGAAATAAAAGATGTTAATTGGCCAGAAACAGCTCTTTTAGTTGCAATAAAAAGAGGAAAT
AACGAAATAATCCCTAAGGGTTCTATTGAAATACAAAGTGGAGATTATTTAGTGGTTATGGTTGATGAGAGCAGAGCAAG
CTCTGTTTTAGAAGAAATTCAATTCTTAACCTCTGCTAAAGAAGAAATTTAA

Upstream 100 bases:

>100_bases
AAATAATTTGAAATTGAAGTTTAATTAAATTTGAATCTGTAAAAACATAAGGGTATAATAAATATGTTAATAAAATGTTA
AGTGTAAGGAGGGGAAATCT

Downstream 100 bases:

>100_bases
TTATACATATGAAAATATAATAATAAACTTTATAAAAATTTTATTATATAAGAATTTAAAAAAAGACACTAGGAGAATTT
GTAAAAATAAATTTTCTTAG

Product: hypothetical protein

Products: Cl Ion [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 523; Mature: 522

Protein sequence:

>523_residues
MSNESTKKVLSHRKDLRFKLVLEGAAIGLLCSLVLVLNRIIVNYLFPLFKKLYAWAALSITNMIIVLVILAILGALVGFM
VRREPMISGSGIPQVEGELIGKLKMNWLKILIYKFLGGVISLGAGLSLGREGPSVQMGAAVGEGFSNSLKRINIEKKYLI
TSGASAGLAAAFNAPLSGVIFALEEVHKSFSPLVLVSAMAASLVSDFVSKQFLGMNPSLGIENVPVLPLKYYWVLIILGV
ILGIGGAIFSKGILKVQSLYGKFKKVPVEVKVMIPFLLTGILGIFAPIILGGGHELIMDLATKSFPIKLLLAVLLVKFLL
TIISFGAGTPGGIFFPLLLLGAVVGNIVGIVSCNAFGVPNQYIIDFIILAMAGNFASIVKAPITGIILITEMTGSFEHML
ALSVVVIISYVTSDLLKSEPIYESLLERWIEKVGSEVEEPSNNKTLLEVGVELGSEAEGKEIKDVNWPETALLVAIKRGN
NEIIPKGSIEIQSGDYLVVMVDESRASSVLEEIQFLTSAKEEI

Sequences:

>Translated_523_residues
MSNESTKKVLSHRKDLRFKLVLEGAAIGLLCSLVLVLNRIIVNYLFPLFKKLYAWAALSITNMIIVLVILAILGALVGFM
VRREPMISGSGIPQVEGELIGKLKMNWLKILIYKFLGGVISLGAGLSLGREGPSVQMGAAVGEGFSNSLKRINIEKKYLI
TSGASAGLAAAFNAPLSGVIFALEEVHKSFSPLVLVSAMAASLVSDFVSKQFLGMNPSLGIENVPVLPLKYYWVLIILGV
ILGIGGAIFSKGILKVQSLYGKFKKVPVEVKVMIPFLLTGILGIFAPIILGGGHELIMDLATKSFPIKLLLAVLLVKFLL
TIISFGAGTPGGIFFPLLLLGAVVGNIVGIVSCNAFGVPNQYIIDFIILAMAGNFASIVKAPITGIILITEMTGSFEHML
ALSVVVIISYVTSDLLKSEPIYESLLERWIEKVGSEVEEPSNNKTLLEVGVELGSEAEGKEIKDVNWPETALLVAIKRGN
NEIIPKGSIEIQSGDYLVVMVDESRASSVLEEIQFLTSAKEEI
>Mature_522_residues
SNESTKKVLSHRKDLRFKLVLEGAAIGLLCSLVLVLNRIIVNYLFPLFKKLYAWAALSITNMIIVLVILAILGALVGFMV
RREPMISGSGIPQVEGELIGKLKMNWLKILIYKFLGGVISLGAGLSLGREGPSVQMGAAVGEGFSNSLKRINIEKKYLIT
SGASAGLAAAFNAPLSGVIFALEEVHKSFSPLVLVSAMAASLVSDFVSKQFLGMNPSLGIENVPVLPLKYYWVLIILGVI
LGIGGAIFSKGILKVQSLYGKFKKVPVEVKVMIPFLLTGILGIFAPIILGGGHELIMDLATKSFPIKLLLAVLLVKFLLT
IISFGAGTPGGIFFPLLLLGAVVGNIVGIVSCNAFGVPNQYIIDFIILAMAGNFASIVKAPITGIILITEMTGSFEHMLA
LSVVVIISYVTSDLLKSEPIYESLLERWIEKVGSEVEEPSNNKTLLEVGVELGSEAEGKEIKDVNWPETALLVAIKRGNN
EIIPKGSIEIQSGDYLVVMVDESRASSVLEEIQFLTSAKEEI

Specific function: Proton-coupled chloride transporter. Functions as antiport system and exchanges two chloride ions for 1 proton. Probably acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation, as part of the extreme

COG id: COG0038

COG function: function code P; Chloride channel protein EriC

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chloride channel (TC 2.A.49) family. ClcA subfamily [H]

Homologues:

Organism=Homo sapiens, GI55770838, Length=404, Percent_Identity=27.7227722772277, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI55770840, Length=404, Percent_Identity=27.7227722772277, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI153252026, Length=427, Percent_Identity=25.0585480093677, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI4557473, Length=440, Percent_Identity=24.7727272727273, Blast_Score=86, Evalue=7e-17,
Organism=Homo sapiens, GI189217923, Length=440, Percent_Identity=24.7727272727273, Blast_Score=86, Evalue=9e-17,
Organism=Homo sapiens, GI189217921, Length=440, Percent_Identity=24.7727272727273, Blast_Score=86, Evalue=9e-17,
Organism=Escherichia coli, GI1786350, Length=392, Percent_Identity=32.6530612244898, Blast_Score=158, Evalue=7e-40,
Organism=Escherichia coli, GI87081943, Length=321, Percent_Identity=27.4143302180685, Blast_Score=77, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17532615, Length=397, Percent_Identity=25.4408060453401, Blast_Score=95, Evalue=7e-20,
Organism=Caenorhabditis elegans, GI17559050, Length=413, Percent_Identity=27.3607748184019, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71985148, Length=427, Percent_Identity=24.1217798594848, Blast_Score=76, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI71985141, Length=427, Percent_Identity=24.1217798594848, Blast_Score=75, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI71980828, Length=159, Percent_Identity=29.559748427673, Blast_Score=68, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71980820, Length=159, Percent_Identity=29.559748427673, Blast_Score=68, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71980824, Length=159, Percent_Identity=29.559748427673, Blast_Score=68, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6322500, Length=407, Percent_Identity=25.0614250614251, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24665008, Length=460, Percent_Identity=27.1739130434783, Blast_Score=110, Evalue=3e-24,
Organism=Drosophila melanogaster, GI45551566, Length=435, Percent_Identity=29.4252873563218, Blast_Score=108, Evalue=1e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014743
- InterPro:   IPR001807 [H]

Pfam domain/function: PF00654 Voltage_CLC [H]

EC number: NA

Molecular weight: Translated: 56186; Mature: 56055

Theoretical pI: Translated: 8.16; Mature: 8.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNESTKKVLSHRKDLRFKLVLEGAAIGLLCSLVLVLNRIIVNYLFPLFKKLYAWAALSI
CCCHHHHHHHHHHHCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TNMIIVLVILAILGALVGFMVRREPMISGSGIPQVEGELIGKLKMNWLKILIYKFLGGVI
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
SLGAGLSLGREGPSVQMGAAVGEGFSNSLKRINIEKKYLITSGASAGLAAAFNAPLSGVI
HHCCCCCCCCCCCCEEEHHHHCCCHHHHHHHCCCCHHEEEECCCCCCHHHHHCCCHHHHH
FALEEVHKSFSPLVLVSAMAASLVSDFVSKQFLGMNPSLGIENVPVLPLKYYWVLIILGV
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHH
ILGIGGAIFSKGILKVQSLYGKFKKVPVEVKVMIPFLLTGILGIFAPIILGGGHELIMDL
HHHCCHHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
ATKSFPIKLLLAVLLVKFLLTIISFGAGTPGGIFFPLLLLGAVVGNIVGIVSCNAFGVPN
HCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCH
QYIIDFIILAMAGNFASIVKAPITGIILITEMTGSFEHMLALSVVVIISYVTSDLLKSEP
HHHHHHHHHHHHCCHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCC
IYESLLERWIEKVGSEVEEPSNNKTLLEVGVELGSEAEGKEIKDVNWPETALLVAIKRGN
HHHHHHHHHHHHHCHHHCCCCCCCCHHEEEHHCCCCCCCCCCCCCCCCCCEEEEEEECCC
NEIIPKGSIEIQSGDYLVVMVDESRASSVLEEIQFLTSAKEEI
CCCCCCCCEEEECCCEEEEEECCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SNESTKKVLSHRKDLRFKLVLEGAAIGLLCSLVLVLNRIIVNYLFPLFKKLYAWAALSI
CCHHHHHHHHHHHCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TNMIIVLVILAILGALVGFMVRREPMISGSGIPQVEGELIGKLKMNWLKILIYKFLGGVI
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
SLGAGLSLGREGPSVQMGAAVGEGFSNSLKRINIEKKYLITSGASAGLAAAFNAPLSGVI
HHCCCCCCCCCCCCEEEHHHHCCCHHHHHHHCCCCHHEEEECCCCCCHHHHHCCCHHHHH
FALEEVHKSFSPLVLVSAMAASLVSDFVSKQFLGMNPSLGIENVPVLPLKYYWVLIILGV
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHH
ILGIGGAIFSKGILKVQSLYGKFKKVPVEVKVMIPFLLTGILGIFAPIILGGGHELIMDL
HHHCCHHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
ATKSFPIKLLLAVLLVKFLLTIISFGAGTPGGIFFPLLLLGAVVGNIVGIVSCNAFGVPN
HCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCH
QYIIDFIILAMAGNFASIVKAPITGIILITEMTGSFEHMLALSVVVIISYVTSDLLKSEP
HHHHHHHHHHHHCCHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCC
IYESLLERWIEKVGSEVEEPSNNKTLLEVGVELGSEAEGKEIKDVNWPETALLVAIKRGN
HHHHHHHHHHHHHCHHHCCCCCCCCHHEEEHHCCCCCCCCCCCCCCCCCCEEEEEEECCC
NEIIPKGSIEIQSGDYLVVMVDESRASSVLEEIQFLTSAKEEI
CCCCCCCCEEEECCCEEEEEECCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Cl Ion [Periplasm] [C]

Specific reaction: Cl Ion [Periplasm] = Cl Ion [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA