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The map label for this gene is hisC [H]

Identifier: 18310355

GI number: 18310355

Start: 1624315

End: 1625391

Strand: Direct

Name: hisC [H]

Synonym: CPE1373

Alternate gene names: 18310355

Gene position: 1624315-1625391 (Clockwise)

Preceding gene: 18310354

Following gene: 18310363

Centisome position: 53.58

GC content: 24.61

Gene sequence:

>1077_bases
ATGAGTATTAATCATGGTGCTAATTTATTTGATTTATCAAATGAATTAGGTATAAATAAAAAAGATATTAAAGATTTTAG
TTCAAATATAAATCCCTTTGGAGCATCTAAAAAAGCTAAAGATGCAATTTTAAATAATATTGACATGGTTTCTATATACC
CAGATCCTAAATATACAGATTTAAAGGAGTCAATTTCTCAATATTGTCATTGCAAAAAAGAAAATATTATAGTTGGTAGT
GGAGCTACAGAGCTAATATCCTCTTTTATAAGTGTTATAAACCCTAAAAAAGCTTTATTACTTTCTCCATCTTATTCAGA
ATATGAAAGTGAACTTGAAAAGATAAATTGTGAAATAACTAAGTTTTTTTCTAAAGAAGAAGATAACTTTAAAATAGATG
TTAACAAATTAATAGATAGCATAAACTCTTCAAAATTTGATTTAGTTATAATTTGTAATCCTAATAATCCTACTGGATTT
GCCTTTTCAAAGGATGAAATTTCTTTATTATTAAAGAATACTTCATCACTATTCATGGTTGATGAAACCTATGTTGAGTT
TACAGAGCCTGAAATTTACTCTTCTACTCCACTAGTAGATATTTTTAATAATCTATTTGTAATTAGAGGAACTTCTAAAT
TTTTCTCAACTCCAGGCATAAGATTAGGTTATGGACTTATTTCTAATAAAGAAATTAAAAAGTCAATGGTTGAAAAACTT
GATTTGTGGAATATAAATATCTTTGCTACAACAATGGGAGAAATTATGTTTAAGGATAAAGAGTATATTCTTTCAAATAC
CTCTAAGTTAAAAGAAGAAAGAGATTATCTATTTAGAGAATTAAGTTCAATAAAGGACTTAAAGGTATATGAAAGTTACA
GTAACTTTATACTTTGTAAAATTACATCTAAAAAGTTCACTGCTAACAAACTTTATAATAAACTTTTAGAAAAAGGATTA
ATAATAAGAAACTGTTCTTCTTTTGAAGGTTTAAATGAATATTTCTTTAGGGTTTGTGTCTTAAAACCTGAAGATAATAA
ACTTCTTATAGAAAATCTTAAAAATTTATTTTTATAA

Upstream 100 bases:

>100_bases
AAGGTCTAGATTTCATTAAAATCTAGACCTTTTTATTTTTTAATTAAAGAATTATACTATAGATAAGAGATAAAAAGTTA
TATAAACTTAGGAGGTACTT

Downstream 100 bases:

>100_bases
TTTAAAAAATTAATAGGTTGCATATACATAATTTTTATTATTAATTATATATGCAACCTCTTAATTTTTGAAATTATATC
TTATAAGTACTTTTTAAAAT

Product: aminotransferase family protein

Products: NA

Alternate protein names: L-threonine-O-3-phosphate decarboxylase [H]

Number of amino acids: Translated: 358; Mature: 357

Protein sequence:

>358_residues
MSINHGANLFDLSNELGINKKDIKDFSSNINPFGASKKAKDAILNNIDMVSIYPDPKYTDLKESISQYCHCKKENIIVGS
GATELISSFISVINPKKALLLSPSYSEYESELEKINCEITKFFSKEEDNFKIDVNKLIDSINSSKFDLVIICNPNNPTGF
AFSKDEISLLLKNTSSLFMVDETYVEFTEPEIYSSTPLVDIFNNLFVIRGTSKFFSTPGIRLGYGLISNKEIKKSMVEKL
DLWNINIFATTMGEIMFKDKEYILSNTSKLKEERDYLFRELSSIKDLKVYESYSNFILCKITSKKFTANKLYNKLLEKGL
IIRNCSSFEGLNEYFFRVCVLKPEDNKLLIENLKNLFL

Sequences:

>Translated_358_residues
MSINHGANLFDLSNELGINKKDIKDFSSNINPFGASKKAKDAILNNIDMVSIYPDPKYTDLKESISQYCHCKKENIIVGS
GATELISSFISVINPKKALLLSPSYSEYESELEKINCEITKFFSKEEDNFKIDVNKLIDSINSSKFDLVIICNPNNPTGF
AFSKDEISLLLKNTSSLFMVDETYVEFTEPEIYSSTPLVDIFNNLFVIRGTSKFFSTPGIRLGYGLISNKEIKKSMVEKL
DLWNINIFATTMGEIMFKDKEYILSNTSKLKEERDYLFRELSSIKDLKVYESYSNFILCKITSKKFTANKLYNKLLEKGL
IIRNCSSFEGLNEYFFRVCVLKPEDNKLLIENLKNLFL
>Mature_357_residues
SINHGANLFDLSNELGINKKDIKDFSSNINPFGASKKAKDAILNNIDMVSIYPDPKYTDLKESISQYCHCKKENIIVGSG
ATELISSFISVINPKKALLLSPSYSEYESELEKINCEITKFFSKEEDNFKIDVNKLIDSINSSKFDLVIICNPNNPTGFA
FSKDEISLLLKNTSSLFMVDETYVEFTEPEIYSSTPLVDIFNNLFVIRGTSKFFSTPGIRLGYGLISNKEIKKSMVEKLD
LWNINIFATTMGEIMFKDKEYILSNTSKLKEERDYLFRELSSIKDLKVYESYSNFILCKITSKKFTANKLYNKLLEKGLI
IRNCSSFEGLNEYFFRVCVLKPEDNKLLIENLKNLFL

Specific function: Decarboxylates L-threonine-O-3-phosphate to yield (R)-1- amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin [H]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=310, Percent_Identity=24.8387096774194, Blast_Score=96, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6322075, Length=336, Percent_Identity=27.9761904761905, Blast_Score=88, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR005860
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =4.1.1.81 [H]

Molecular weight: Translated: 40978; Mature: 40846

Theoretical pI: Translated: 6.00; Mature: 6.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSINHGANLFDLSNELGINKKDIKDFSSNINPFGASKKAKDAILNNIDMVSIYPDPKYTD
CCCCCCCCEEECCHHCCCCHHHHHHHHCCCCCCCCCCHHHHHHHCCCEEEEECCCCCCCH
LKESISQYCHCKKENIIVGSGATELISSFISVINPKKALLLSPSYSEYESELEKINCEIT
HHHHHHHHHCCCCCCEEEECCHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHCHHHH
KFFSKEEDNFKIDVNKLIDSINSSKFDLVIICNPNNPTGFAFSKDEISLLLKNTSSLFMV
HHHCCCCCCEEEEHHHHHHHCCCCCEEEEEEECCCCCCCCEECHHHHEEEEECCCCEEEE
DETYVEFTEPEIYSSTPLVDIFNNLFVIRGTSKFFSTPGIRLGYGLISNKEIKKSMVEKL
ECCEEEECCCCCCCCCCHHHHHCCEEEEEECHHHHCCCCCEEECCCCCCHHHHHHHHHHH
DLWNINIFATTMGEIMFKDKEYILSNTSKLKEERDYLFRELSSIKDLKVYESYSNFILCK
CCCEEEEEEEEHHHHHCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEE
ITSKKFTANKLYNKLLEKGLIIRNCSSFEGLNEYFFRVCVLKPEDNKLLIENLKNLFL
EECCCHHHHHHHHHHHHCCCEEECCCCCCHHHHHEEEEEEECCCCCCHHHHHHHHHCC
>Mature Secondary Structure 
SINHGANLFDLSNELGINKKDIKDFSSNINPFGASKKAKDAILNNIDMVSIYPDPKYTD
CCCCCCCEEECCHHCCCCHHHHHHHHCCCCCCCCCCHHHHHHHCCCEEEEECCCCCCCH
LKESISQYCHCKKENIIVGSGATELISSFISVINPKKALLLSPSYSEYESELEKINCEIT
HHHHHHHHHCCCCCCEEEECCHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHCHHHH
KFFSKEEDNFKIDVNKLIDSINSSKFDLVIICNPNNPTGFAFSKDEISLLLKNTSSLFMV
HHHCCCCCCEEEEHHHHHHHCCCCCEEEEEEECCCCCCCCEECHHHHEEEEECCCCEEEE
DETYVEFTEPEIYSSTPLVDIFNNLFVIRGTSKFFSTPGIRLGYGLISNKEIKKSMVEKL
ECCEEEECCCCCCCCCCHHHHHCCEEEEEECHHHHCCCCCEEECCCCCCHHHHHHHHHHH
DLWNINIFATTMGEIMFKDKEYILSNTSKLKEERDYLFRELSSIKDLKVYESYSNFILCK
CCCEEEEEEEEHHHHHCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEE
ITSKKFTANKLYNKLLEKGLIIRNCSSFEGLNEYFFRVCVLKPEDNKLLIENLKNLFL
EECCCHHHHHHHHHHHHCCCEEECCCCCCHHHHHEEEEEEECCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]