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The map label for this gene is rnz [H]

Identifier: 18310345

GI number: 18310345

Start: 1606130

End: 1607080

Strand: Reverse

Name: rnz [H]

Synonym: CPE1363

Alternate gene names: 18310345

Gene position: 1607080-1606130 (Counterclockwise)

Preceding gene: 18310346

Following gene: 18310344

Centisome position: 53.01

GC content: 30.28

Gene sequence:

>951_bases
ATGTTAAATGTAACCTTGTTAGGAACAGGGGGAGGCATGCCTATGCCAAATAGATTTTTATCATCAGTTGTTATGAATTT
CAATGGGAGAAAAATTCTTTTAGACTGTGGAGAGGGAACGCAGGTTTCTATGAGGGTAAATGGAACTGGATTTAAAAGTA
TAGATATTATTTGTATAAGTCATCTTCATGGAGATCATATATATGGATTACCAGGTTTACTTTCTACAATTGGGAATAGT
GGAAGAGTAGAGGATATATATATAATAGGACCTAATGGAATAAAAGAGGTTATAGAGGGATTTCTAATAACTCTTCCATA
TCTTCCATATAAACTTAACATACTAGAAGATGCAAGTAATTTAGAATTCATGGTTAAAAAAGAAAAAATAGAATTAGTTG
AATTGAATGAAAAAATAAGTTCAGATTTAACTATAGAGACTTTAGGATTAGATCATTCCTCTCCTTGTTTAGGATACTCT
TTTAATATAAGGAGAGGAAGAAAATTTAATGTAGAAAAAGCTTTAATGAATAAAGTTCCAAAGGAGTTGTGGTCTAAACT
TCAAAGAAATGAGGAAGTTAGTTTAAATGGAGTTAAATATTATAGTTACATGGTCTTAGGAGATGAAAGAAAGGGAATAA
AACTAAGTTACACAACAGATACAAGACCTACAGAGGATATACCAGGTTTTATAAAGGAAAGTGATTTATACATATGTGAG
GGGACTTATGGAAGTGAAGAGGATATGCATAAGGCCATAAAGAATAAACATATGACTTTTAAGGAAGCAGCTAATTTAGC
TAAAAAGGGTCAGGTAAAGGAATTATTATTAACTCATTTTAGTCCATCTATTAATGATCCAAAGGAATTTATAAATAATG
CAAGAGAAGTATTTGAAAATTTACATGCTGGAAGTGATGGAGAAGAAAGAGTTTTAAATTTTAAAGAATAA

Upstream 100 bases:

>100_bases
ATAAGAAAAAGACCAGAATCTTTGATTTTGGTCTTTTTTTATAATAAATATTATTTTGCTATATAATATAATTAGTTATA
GAAAGAGAGGATTGATTAAA

Downstream 100 bases:

>100_bases
TTAAAATAAGATATTTAAAACTTCCAATAAATGTTATAATTAATATGTAATCTTATAACTAAGAAAGGGATTGAGAATAT
GAAGGGGTTAATAGTTTTTG

Product: ribonuclease Z

Products: NA

Alternate protein names: RNase Z; tRNA 3 endonuclease; tRNase Z [H]

Number of amino acids: Translated: 316; Mature: 316

Protein sequence:

>316_residues
MLNVTLLGTGGGMPMPNRFLSSVVMNFNGRKILLDCGEGTQVSMRVNGTGFKSIDIICISHLHGDHIYGLPGLLSTIGNS
GRVEDIYIIGPNGIKEVIEGFLITLPYLPYKLNILEDASNLEFMVKKEKIELVELNEKISSDLTIETLGLDHSSPCLGYS
FNIRRGRKFNVEKALMNKVPKELWSKLQRNEEVSLNGVKYYSYMVLGDERKGIKLSYTTDTRPTEDIPGFIKESDLYICE
GTYGSEEDMHKAIKNKHMTFKEAANLAKKGQVKELLLTHFSPSINDPKEFINNAREVFENLHAGSDGEERVLNFKE

Sequences:

>Translated_316_residues
MLNVTLLGTGGGMPMPNRFLSSVVMNFNGRKILLDCGEGTQVSMRVNGTGFKSIDIICISHLHGDHIYGLPGLLSTIGNS
GRVEDIYIIGPNGIKEVIEGFLITLPYLPYKLNILEDASNLEFMVKKEKIELVELNEKISSDLTIETLGLDHSSPCLGYS
FNIRRGRKFNVEKALMNKVPKELWSKLQRNEEVSLNGVKYYSYMVLGDERKGIKLSYTTDTRPTEDIPGFIKESDLYICE
GTYGSEEDMHKAIKNKHMTFKEAANLAKKGQVKELLLTHFSPSINDPKEFINNAREVFENLHAGSDGEERVLNFKE
>Mature_316_residues
MLNVTLLGTGGGMPMPNRFLSSVVMNFNGRKILLDCGEGTQVSMRVNGTGFKSIDIICISHLHGDHIYGLPGLLSTIGNS
GRVEDIYIIGPNGIKEVIEGFLITLPYLPYKLNILEDASNLEFMVKKEKIELVELNEKISSDLTIETLGLDHSSPCLGYS
FNIRRGRKFNVEKALMNKVPKELWSKLQRNEEVSLNGVKYYSYMVLGDERKGIKLSYTTDTRPTEDIPGFIKESDLYICE
GTYGSEEDMHKAIKNKHMTFKEAANLAKKGQVKELLLTHFSPSINDPKEFINNAREVFENLHAGSDGEERVLNFKE

Specific function: Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA [H]

COG id: COG1234

COG function: function code R; Metal-dependent hydrolases of the beta-lactamase superfamily III

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the RNase Z family [H]

Homologues:

Organism=Homo sapiens, GI8922122, Length=314, Percent_Identity=31.8471337579618, Blast_Score=107, Evalue=2e-23,
Organism=Escherichia coli, GI87082078, Length=321, Percent_Identity=27.4143302180685, Blast_Score=105, Evalue=4e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001279
- InterPro:   IPR013471 [H]

Pfam domain/function: PF00753 Lactamase_B [H]

EC number: =3.1.26.11 [H]

Molecular weight: Translated: 35487; Mature: 35487

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNVTLLGTGGGMPMPNRFLSSVVMNFNGRKILLDCGEGTQVSMRVNGTGFKSIDIICIS
CEEEEEEECCCCCCCCHHHHHHHHHCCCCCEEEEECCCCCEEEEEECCCCCCEEEEEEEE
HLHGDHIYGLPGLLSTIGNSGRVEDIYIIGPNGIKEVIEGFLITLPYLPYKLNILEDASN
ECCCCEEECCHHHHHHCCCCCCEEEEEEECCCHHHHHHHHHHHHCCCCCEEEEEECCCCC
LEFMVKKEKIELVELNEKISSDLTIETLGLDHSSPCLGYSFNIRRGRKFNVEKALMNKVP
CEEEEEECCEEEEEHHHHHCCCCEEEEECCCCCCCCEEEEEECCCCCCCCHHHHHHHHHH
KELWSKLQRNEEVSLNGVKYYSYMVLGDERKGIKLSYTTDTRPTEDIPGFIKESDLYICE
HHHHHHHHCCCCCEECCEEEEEEEEECCCCCCEEEEEECCCCCCCCCCCCEECCCEEEEE
GTYGSEEDMHKAIKNKHMTFKEAANLAKKGQVKELLLTHFSPSINDPKEFINNAREVFEN
CCCCCHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHH
LHAGSDGEERVLNFKE
HCCCCCCHHHCCCCCC
>Mature Secondary Structure
MLNVTLLGTGGGMPMPNRFLSSVVMNFNGRKILLDCGEGTQVSMRVNGTGFKSIDIICIS
CEEEEEEECCCCCCCCHHHHHHHHHCCCCCEEEEECCCCCEEEEEECCCCCCEEEEEEEE
HLHGDHIYGLPGLLSTIGNSGRVEDIYIIGPNGIKEVIEGFLITLPYLPYKLNILEDASN
ECCCCEEECCHHHHHHCCCCCCEEEEEEECCCHHHHHHHHHHHHCCCCCEEEEEECCCCC
LEFMVKKEKIELVELNEKISSDLTIETLGLDHSSPCLGYSFNIRRGRKFNVEKALMNKVP
CEEEEEECCEEEEEHHHHHCCCCEEEEECCCCCCCCEEEEEECCCCCCCCHHHHHHHHHH
KELWSKLQRNEEVSLNGVKYYSYMVLGDERKGIKLSYTTDTRPTEDIPGFIKESDLYICE
HHHHHHHHCCCCCEECCEEEEEEEEECCCCCCEEEEEECCCCCCCCCCCCEECCCEEEEE
GTYGSEEDMHKAIKNKHMTFKEAANLAKKGQVKELLLTHFSPSINDPKEFINNAREVFEN
CCCCCHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHH
LHAGSDGEERVLNFKE
HCCCCCCHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA