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The map label for this gene is galK [H]

Identifier: 18310327

GI number: 18310327

Start: 1588332

End: 1589495

Strand: Direct

Name: galK [H]

Synonym: CPE1345

Alternate gene names: 18310327

Gene position: 1588332-1589495 (Clockwise)

Preceding gene: 18310325

Following gene: 18310328

Centisome position: 52.4

GC content: 29.98

Gene sequence:

>1164_bases
ATGGAATTAAATACACTTAAATCAACTTTTATTAATAATTTTGGTAAAGAACCTAATTCATTATTCTTCTCGCCAGGAAG
AATAAATCTTATAGGTGAACATATTGACTACAATGGGGGATTCGTATTTCCTTGCCCAATAACTCTTGGAACTTTTGCAG
CAGCAAGCTTAAGAGATGATAGAATTTGTAGAGCTTACTCTCTTAACTTTGAATCTCTTGGAGTAATAGAGTTTTCTTTA
GATGATTTATCTTATAAAAAAGAGGATAATTGGACAAACTATCTTAAAGGAGTACTAAAAGTACTTATAGAAAAAGGATA
TAAAATAGATAAGGGTATTGACTTAGTTATCAATGGAAATCTTCCAAACGGAGCTGGTCTTTCCTCTTCAGCATCTTTAG
AAATGTTAATAGTAAAAATTTTAGATACTTTCTTTTCTCTTAATATTTCAAAGGTAGATGCTGCACTAATAGGTAAAGAG
GTAGAAAATACTTATATAGGTGTTAATAGTGGTATAATGGATCAATTTGCTATTTCTCTAGGAGAAAAGGATAAGGCAAT
TTTACTTGATTGTAATAGCTTATATTATGAATATGTTCCTTTAAACTTAGGAGATAATTCAATAATTATAATGAACACTA
ATAAAAGACGTGAACTTGCAGATTCTAAATATAATGAAAGAAGAAAAGAATGTGATGATTCTTTAGACACTTTAAAGAAA
TATACTAATATTTCTTCTCTTTGTGAACTAACTTCCTTAGAATTTGAAACATATAAAGATAAAATAGAAGATTCTAATAA
ATTACGTAGATGTGTACATGCTATTTCTGAAAATGAAAGAGTAAAAGATGCTGTAAAAGCTTTAAAAGAAAATAATCTTG
AATTATTTGGACAACTTATGAATCAGTCTCATATTTCCCTTAGAGATGATTATGAAGTTACTGGTAAAGAATTAGATACC
CTAGCTGAAAACGCTTGGAAACAACCTGGAGTTTTAGGTGCTCGTATGACTGGGGCTGGCTTTGGTGGATGTGCCATAGC
AATAGTTAATAATGCTCATGTTGATGAATTTATTAAAAATGTTGGACAGGCTTATAAGGATGCTATAGGATATGAAGCAT
CATTCTATGTTGCTTCTATAGGTAATGGTCCTACTGAACTTTAA

Upstream 100 bases:

>100_bases
TAACTTAACAAAAAATTAGTAAAATTTTTAGTAAAACAATTGATTTTTATTTTTTGTAATCGTATAATTAAGTTACAGAT
TTTCTATTTGGAGGTATATC

Downstream 100 bases:

>100_bases
AATAAAACCTTTGGGCTGTATCAAAATATAATAATAAAACTTACAAACACATACTCTTTGTAAGTTTTATAAAAACCTAT
TTTGATACATGCCCTCTTCA

Product: galactokinase

Products: NA

Alternate protein names: Galactose kinase [H]

Number of amino acids: Translated: 387; Mature: 387

Protein sequence:

>387_residues
MELNTLKSTFINNFGKEPNSLFFSPGRINLIGEHIDYNGGFVFPCPITLGTFAAASLRDDRICRAYSLNFESLGVIEFSL
DDLSYKKEDNWTNYLKGVLKVLIEKGYKIDKGIDLVINGNLPNGAGLSSSASLEMLIVKILDTFFSLNISKVDAALIGKE
VENTYIGVNSGIMDQFAISLGEKDKAILLDCNSLYYEYVPLNLGDNSIIIMNTNKRRELADSKYNERRKECDDSLDTLKK
YTNISSLCELTSLEFETYKDKIEDSNKLRRCVHAISENERVKDAVKALKENNLELFGQLMNQSHISLRDDYEVTGKELDT
LAENAWKQPGVLGARMTGAGFGGCAIAIVNNAHVDEFIKNVGQAYKDAIGYEASFYVASIGNGPTEL

Sequences:

>Translated_387_residues
MELNTLKSTFINNFGKEPNSLFFSPGRINLIGEHIDYNGGFVFPCPITLGTFAAASLRDDRICRAYSLNFESLGVIEFSL
DDLSYKKEDNWTNYLKGVLKVLIEKGYKIDKGIDLVINGNLPNGAGLSSSASLEMLIVKILDTFFSLNISKVDAALIGKE
VENTYIGVNSGIMDQFAISLGEKDKAILLDCNSLYYEYVPLNLGDNSIIIMNTNKRRELADSKYNERRKECDDSLDTLKK
YTNISSLCELTSLEFETYKDKIEDSNKLRRCVHAISENERVKDAVKALKENNLELFGQLMNQSHISLRDDYEVTGKELDT
LAENAWKQPGVLGARMTGAGFGGCAIAIVNNAHVDEFIKNVGQAYKDAIGYEASFYVASIGNGPTEL
>Mature_387_residues
MELNTLKSTFINNFGKEPNSLFFSPGRINLIGEHIDYNGGFVFPCPITLGTFAAASLRDDRICRAYSLNFESLGVIEFSL
DDLSYKKEDNWTNYLKGVLKVLIEKGYKIDKGIDLVINGNLPNGAGLSSSASLEMLIVKILDTFFSLNISKVDAALIGKE
VENTYIGVNSGIMDQFAISLGEKDKAILLDCNSLYYEYVPLNLGDNSIIIMNTNKRRELADSKYNERRKECDDSLDTLKK
YTNISSLCELTSLEFETYKDKIEDSNKLRRCVHAISENERVKDAVKALKENNLELFGQLMNQSHISLRDDYEVTGKELDT
LAENAWKQPGVLGARMTGAGFGGCAIAIVNNAHVDEFIKNVGQAYKDAIGYEASFYVASIGNGPTEL

Specific function: Galactose metabolism; first step. [C]

COG id: COG0153

COG function: function code G; Galactokinase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. GalK subfamily [H]

Homologues:

Organism=Homo sapiens, GI4503895, Length=389, Percent_Identity=35.73264781491, Blast_Score=236, Evalue=2e-62,
Organism=Homo sapiens, GI4503897, Length=414, Percent_Identity=30.1932367149758, Blast_Score=136, Evalue=3e-32,
Organism=Homo sapiens, GI48527957, Length=414, Percent_Identity=29.7101449275362, Blast_Score=136, Evalue=4e-32,
Organism=Escherichia coli, GI1786972, Length=379, Percent_Identity=39.3139841688654, Blast_Score=268, Evalue=4e-73,
Organism=Caenorhabditis elegans, GI71989053, Length=407, Percent_Identity=29.97542997543, Blast_Score=119, Evalue=4e-27,
Organism=Saccharomyces cerevisiae, GI6319494, Length=255, Percent_Identity=29.4117647058824, Blast_Score=79, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6320212, Length=241, Percent_Identity=29.4605809128631, Blast_Score=76, Evalue=8e-15,
Organism=Drosophila melanogaster, GI24661292, Length=428, Percent_Identity=27.1028037383178, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI21355577, Length=428, Percent_Identity=27.1028037383178, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24661285, Length=428, Percent_Identity=27.1028037383178, Blast_Score=110, Evalue=1e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000705
- InterPro:   IPR022963
- InterPro:   IPR019741
- InterPro:   IPR019539
- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR006206
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF10509 GalKase_gal_bdg; PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N [H]

EC number: =2.7.1.6 [H]

Molecular weight: Translated: 43003; Mature: 43003

Theoretical pI: Translated: 4.72; Mature: 4.72

Prosite motif: PS00106 GALACTOKINASE ; PS00627 GHMP_KINASES_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELNTLKSTFINNFGKEPNSLFFSPGRINLIGEHIDYNGGFVFPCPITLGTFAAASLRDD
CCCHHHHHHHHHHHCCCCCCEEECCCEEEEEEEEEECCCCEEEECCCHHHHHHHHHCCCC
RICRAYSLNFESLGVIEFSLDDLSYKKEDNWTNYLKGVLKVLIEKGYKIDKGIDLVINGN
CEEHEEECCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCEECCCEEEEEECC
LPNGAGLSSSASLEMLIVKILDTFFSLNISKVDAALIGKEVENTYIGVNSGIMDQFAISL
CCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCEEECCCCHHHHHHHHC
GEKDKAILLDCNSLYYEYVPLNLGDNSIIIMNTNKRRELADSKYNERRKECDDSLDTLKK
CCCCCEEEEECCCEEEEEEEEECCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHH
YTNISSLCELTSLEFETYKDKIEDSNKLRRCVHAISENERVKDAVKALKENNLELFGQLM
HHCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHH
NQSHISLRDDYEVTGKELDTLAENAWKQPGVLGARMTGAGFGGCAIAIVNNAHVDEFIKN
CCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCCCEEEEEECCCHHHHHHHH
VGQAYKDAIGYEASFYVASIGNGPTEL
HHHHHHHHHCCCCEEEEEECCCCCCCC
>Mature Secondary Structure
MELNTLKSTFINNFGKEPNSLFFSPGRINLIGEHIDYNGGFVFPCPITLGTFAAASLRDD
CCCHHHHHHHHHHHCCCCCCEEECCCEEEEEEEEEECCCCEEEECCCHHHHHHHHHCCCC
RICRAYSLNFESLGVIEFSLDDLSYKKEDNWTNYLKGVLKVLIEKGYKIDKGIDLVINGN
CEEHEEECCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCEECCCEEEEEECC
LPNGAGLSSSASLEMLIVKILDTFFSLNISKVDAALIGKEVENTYIGVNSGIMDQFAISL
CCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCEEECCCCHHHHHHHHC
GEKDKAILLDCNSLYYEYVPLNLGDNSIIIMNTNKRRELADSKYNERRKECDDSLDTLKK
CCCCCEEEEECCCEEEEEEEEECCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHH
YTNISSLCELTSLEFETYKDKIEDSNKLRRCVHAISENERVKDAVKALKENNLELFGQLM
HHCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHH
NQSHISLRDDYEVTGKELDTLAENAWKQPGVLGARMTGAGFGGCAIAIVNNAHVDEFIKN
CCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCCCEEEEEECCCHHHHHHHH
VGQAYKDAIGYEASFYVASIGNGPTEL
HHHHHHHHHCCCCEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA