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The map label for this gene is thiD [H]

Identifier: 18310320

GI number: 18310320

Start: 1580067

End: 1580861

Strand: Reverse

Name: thiD [H]

Synonym: CPE1338

Alternate gene names: 18310320

Gene position: 1580861-1580067 (Counterclockwise)

Preceding gene: 18310322

Following gene: 18310319

Centisome position: 52.15

GC content: 31.45

Gene sequence:

>795_bases
ATGAGTAAATTATTTAATGCATTAACAATTGCAGGGTCAGATAGTTCAGGGGGAGCAGGAATACAGGCTGATATAAAAGC
TTTTTCCGCTAATGGAGTTTACGGAATGAGTATAATAACTGCCATAACAGCTCAGAATACTCAAGGAGTTTTTGGAATAA
TGGATGTTACTCCTGAAATTATAGAAAAACAAATAGATGTTATTTTTAATGATATAGAAGTAGGTGCCATAAAAATAGGT
ATGGTATCTAAAATTGAATCAATAAAAGCCATAAGTAATGCTTTAGGAAGAGTAGAAAAATTGCCTCAAATAGTATTAGA
TCCTGTTATGATTTCAAAAAGTGGATTTAAGCTTTTATCAGATGATGCAAAAAATACTTTAATAGAGAAGTTAATACCGA
TAGCTACTTTGATAACTCCAAATTTACCAGAGACAGAAGAATTATTAGGCAGAGAAATACTTACAATAGAAGATATGAAA
AAGGCAGCCTGTGACCTTAAAAAATTAGGAGCAAAAAATGTTTTAATTAAGGGTGGACATTTAGAAGGCGAGGCCACAGA
TATTTTATATGATGGTGAAAACTTTACTCTTTTTAATGAAGAGAGAATAAATACAAAGCATACTCATGGAACAGGATGTA
CCTTATCATCAGCTATTACAGCTAATTTATCAAAGGGAATGAATATAGTTGATTCTGTTAGAAGTGGAAAAGAATATATT
ACAGGTGCTATAAAAAATGGCTTTGAACTTGGAAAGGGTGTTGGACCAACACATCATTTCTATAAATTTTACTAG

Upstream 100 bases:

>100_bases
CGTAGGGAAGCCCAAGAGACAAATATATTTAAATTGATTTTAAAGCATATATAGCCTTAGGGCTGTATATGCTTTTTCTT
TTTTAGAAGGAGTGAAAAAT

Downstream 100 bases:

>100_bases
GAGGAATAAAAATGGAAGTTTTGAAAAGAGAAAATCCTTTAATACATATGATAACTAATTATGTTACAGTTAATGATTTA
GCACAAGTAACTATTAATTA

Product: phosphomethylpyrimidine kinase

Products: NA

Alternate protein names: Hydroxymethylpyrimidine kinase; HMP kinase; Hydroxymethylpyrimidine phosphate kinase; HMP-P kinase; HMP-phosphate kinase; HMPP kinase [H]

Number of amino acids: Translated: 264; Mature: 263

Protein sequence:

>264_residues
MSKLFNALTIAGSDSSGGAGIQADIKAFSANGVYGMSIITAITAQNTQGVFGIMDVTPEIIEKQIDVIFNDIEVGAIKIG
MVSKIESIKAISNALGRVEKLPQIVLDPVMISKSGFKLLSDDAKNTLIEKLIPIATLITPNLPETEELLGREILTIEDMK
KAACDLKKLGAKNVLIKGGHLEGEATDILYDGENFTLFNEERINTKHTHGTGCTLSSAITANLSKGMNIVDSVRSGKEYI
TGAIKNGFELGKGVGPTHHFYKFY

Sequences:

>Translated_264_residues
MSKLFNALTIAGSDSSGGAGIQADIKAFSANGVYGMSIITAITAQNTQGVFGIMDVTPEIIEKQIDVIFNDIEVGAIKIG
MVSKIESIKAISNALGRVEKLPQIVLDPVMISKSGFKLLSDDAKNTLIEKLIPIATLITPNLPETEELLGREILTIEDMK
KAACDLKKLGAKNVLIKGGHLEGEATDILYDGENFTLFNEERINTKHTHGTGCTLSSAITANLSKGMNIVDSVRSGKEYI
TGAIKNGFELGKGVGPTHHFYKFY
>Mature_263_residues
SKLFNALTIAGSDSSGGAGIQADIKAFSANGVYGMSIITAITAQNTQGVFGIMDVTPEIIEKQIDVIFNDIEVGAIKIGM
VSKIESIKAISNALGRVEKLPQIVLDPVMISKSGFKLLSDDAKNTLIEKLIPIATLITPNLPETEELLGREILTIEDMKK
AACDLKKLGAKNVLIKGGHLEGEATDILYDGENFTLFNEERINTKHTHGTGCTLSSAITANLSKGMNIVDSVRSGKEYIT
GAIKNGFELGKGVGPTHHFYKFY

Specific function: Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P [H]

COG id: COG0351

COG function: function code H; Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiD family [H]

Homologues:

Organism=Escherichia coli, GI1788420, Length=266, Percent_Identity=43.984962406015, Blast_Score=229, Evalue=1e-61,
Organism=Saccharomyces cerevisiae, GI6325378, Length=274, Percent_Identity=37.2262773722628, Blast_Score=180, Evalue=2e-46,
Organism=Saccharomyces cerevisiae, GI6324997, Length=275, Percent_Identity=39.2727272727273, Blast_Score=161, Evalue=1e-40,
Organism=Saccharomyces cerevisiae, GI6324517, Length=275, Percent_Identity=37.8181818181818, Blast_Score=155, Evalue=7e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013749
- InterPro:   IPR004399 [H]

Pfam domain/function: PF08543 Phos_pyr_kin [H]

EC number: =2.7.1.49; =2.7.4.7 [H]

Molecular weight: Translated: 28303; Mature: 28172

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKLFNALTIAGSDSSGGAGIQADIKAFSANGVYGMSIITAITAQNTQGVFGIMDVTPEI
CCCHHCEEEEECCCCCCCCCEEEEHEEECCCCEEHHHHHHHHHCCCCCCEEEEECCCHHH
IEKQIDVIFNDIEVGAIKIGMVSKIESIKAISNALGRVEKLPQIVLDPVMISKSGFKLLS
HHHHHHHHHCCCEECEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHCCCCCCCHHH
DDAKNTLIEKLIPIATLITPNLPETEELLGREILTIEDMKKAACDLKKLGAKNVLIKGGH
CHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCEECHHHHHHHHHHHHHCCCCCEEEECCC
LEGEATDILYDGENFTLFNEERINTKHTHGTGCTLSSAITANLSKGMNIVDSVRSGKEYI
CCCCCEEEEECCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHCCHHHH
TGAIKNGFELGKGVGPTHHFYKFY
HHHHHCCHHHCCCCCCCCCCEEEC
>Mature Secondary Structure 
SKLFNALTIAGSDSSGGAGIQADIKAFSANGVYGMSIITAITAQNTQGVFGIMDVTPEI
CCHHCEEEEECCCCCCCCCEEEEHEEECCCCEEHHHHHHHHHCCCCCCEEEEECCCHHH
IEKQIDVIFNDIEVGAIKIGMVSKIESIKAISNALGRVEKLPQIVLDPVMISKSGFKLLS
HHHHHHHHHCCCEECEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHCCCCCCCHHH
DDAKNTLIEKLIPIATLITPNLPETEELLGREILTIEDMKKAACDLKKLGAKNVLIKGGH
CHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCEECHHHHHHHHHHHHHCCCCCEEEECCC
LEGEATDILYDGENFTLFNEERINTKHTHGTGCTLSSAITANLSKGMNIVDSVRSGKEYI
CCCCCEEEEECCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHCCHHHH
TGAIKNGFELGKGVGPTHHFYKFY
HHHHHCCHHHCCCCCCCCCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11481431; 8246891 [H]