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The map label for this gene is mtaD1 [H]

Identifier: 18310249

GI number: 18310249

Start: 1486429

End: 1487763

Strand: Reverse

Name: mtaD1 [H]

Synonym: CPE1267

Alternate gene names: 18310249

Gene position: 1487763-1486429 (Counterclockwise)

Preceding gene: 18310250

Following gene: 18310248

Centisome position: 49.08

GC content: 28.84

Gene sequence:

>1335_bases
ATGAGTAAAATAGTAACTTTAATAAAAAATGTTACAGTTATTACTATGAATGAACATAAAGAAATTATAGAAAATGGTTT
AGTTGTTTTTGAAAAAAATAAAATAGTATATGTTGGAACTGATGTAAGGACAGAAGAAAAATTAAAAAGAAGTGGATATA
AAGTTGAGGTAATAGATGGTGAAGAGGGAATATTAATGCCAGGTATGATAAACTGTCATACTCATGGGTCTATGGTTCCT
TTTAGAAGTTTAGCTGACGATTGTAAGGATAGATTAAAGAGATATTTATTTCCCTTAGAACAAAGATTAGTTGATAAAGA
ATTGACTTATATAGGAGCAAAGTATGCTATAGCAGAAATGTTATTAGGTGGAGTAACTACCTTTTGTGATATGTATTATT
TTGAAGATGAGGTAGCGAAAGCTGCTAAAGAATTAAATATGAGAGGAGTGCTTTGTGAGACAATAGTAGATTTTCCTTCG
CCAGATTCAGAAAAGGCTTTTGGAGGTTTAGATTATTCCATAAAATTTATAGAAAAATGGAAAAATGATGATTTGATAAC
TCCAGGAATAGCTCCTCATGCACCTTATACAAATACAGAGGAATCATTAAAGGAAGCATATAAAATTAGTAAAAAATATG
ATGTTCCTATAACTATGCATTTAGCAGAAATGGACTATGAGTTAGAGGAATGTAAAGATAAATATAATCTTACCCCAGTT
GCTTATTTAGATAAGCTTGGAATTTTAGACTCTAATTTTATAGCAGCCCATGCAGTTTTAGTTAATGAAGAAGATATAGA
AATTCTAAGGAAGAATAATGTTAATATATCTCATAATATAGGAGCAAATTCTAAAGGAGCTAAAGGAATAGCACCAATAT
TAAAGATGAGAGAAAAAGGAATAAATATTGGGCTTGGAACAGATGGTCCTATGAGTGGAAATACTTTAGATATATTAAGC
CAGATGTCACAAGTAGGAAAAATTCATAAATTATTTAATAAAGATAGAACTTTACTACCATCAATAGATTTAATAGAAAT
GGGAACCATAGGTGGAGCTAAAGTTTTAGGAATTGATAAAGAAGTTGGATCTATAGAGATTGGTAAGAAAGCTGATTTAA
CTTTAATAGAAACAAAATCAGTAAATATGCAACCTATATATGATTATTATGCAACAATAGTATATTCTGCTAATTCTAGC
AATGTAGAATTAGTAGTTGTTGATGGTAAGATTGTTGTTAAGGATAAAAAATTAGTAAGTGCTAGCTTTTCTGAAGTAAG
AAAAGATTTACTAAGTTTAACAGAGAAAATAAAGAAAATTTCTAAAGAACTTTAG

Upstream 100 bases:

>100_bases
ATTACGCAAAGTAATATAAAAGGAAAGTAAGGGGATGTATCGTAGTAGATATAGCCTCTTATTTTTAGCTATATTTTAGG
TGGATTTTGGAGGGGATAAT

Downstream 100 bases:

>100_bases
GGGTTTATATAATAAGAAAGCTTAATTAAACTTAATAAAATAAAAACACATTGAGTTTTTCAATGTGTTTTTTTAGTTAT
AATTTTTATTATTTACTACT

Product: hypothetical protein

Products: NA

Alternate protein names: MTA/SAH deaminase 1 [H]

Number of amino acids: Translated: 444; Mature: 443

Protein sequence:

>444_residues
MSKIVTLIKNVTVITMNEHKEIIENGLVVFEKNKIVYVGTDVRTEEKLKRSGYKVEVIDGEEGILMPGMINCHTHGSMVP
FRSLADDCKDRLKRYLFPLEQRLVDKELTYIGAKYAIAEMLLGGVTTFCDMYYFEDEVAKAAKELNMRGVLCETIVDFPS
PDSEKAFGGLDYSIKFIEKWKNDDLITPGIAPHAPYTNTEESLKEAYKISKKYDVPITMHLAEMDYELEECKDKYNLTPV
AYLDKLGILDSNFIAAHAVLVNEEDIEILRKNNVNISHNIGANSKGAKGIAPILKMREKGINIGLGTDGPMSGNTLDILS
QMSQVGKIHKLFNKDRTLLPSIDLIEMGTIGGAKVLGIDKEVGSIEIGKKADLTLIETKSVNMQPIYDYYATIVYSANSS
NVELVVVDGKIVVKDKKLVSASFSEVRKDLLSLTEKIKKISKEL

Sequences:

>Translated_444_residues
MSKIVTLIKNVTVITMNEHKEIIENGLVVFEKNKIVYVGTDVRTEEKLKRSGYKVEVIDGEEGILMPGMINCHTHGSMVP
FRSLADDCKDRLKRYLFPLEQRLVDKELTYIGAKYAIAEMLLGGVTTFCDMYYFEDEVAKAAKELNMRGVLCETIVDFPS
PDSEKAFGGLDYSIKFIEKWKNDDLITPGIAPHAPYTNTEESLKEAYKISKKYDVPITMHLAEMDYELEECKDKYNLTPV
AYLDKLGILDSNFIAAHAVLVNEEDIEILRKNNVNISHNIGANSKGAKGIAPILKMREKGINIGLGTDGPMSGNTLDILS
QMSQVGKIHKLFNKDRTLLPSIDLIEMGTIGGAKVLGIDKEVGSIEIGKKADLTLIETKSVNMQPIYDYYATIVYSANSS
NVELVVVDGKIVVKDKKLVSASFSEVRKDLLSLTEKIKKISKEL
>Mature_443_residues
SKIVTLIKNVTVITMNEHKEIIENGLVVFEKNKIVYVGTDVRTEEKLKRSGYKVEVIDGEEGILMPGMINCHTHGSMVPF
RSLADDCKDRLKRYLFPLEQRLVDKELTYIGAKYAIAEMLLGGVTTFCDMYYFEDEVAKAAKELNMRGVLCETIVDFPSP
DSEKAFGGLDYSIKFIEKWKNDDLITPGIAPHAPYTNTEESLKEAYKISKKYDVPITMHLAEMDYELEECKDKYNLTPVA
YLDKLGILDSNFIAAHAVLVNEEDIEILRKNNVNISHNIGANSKGAKGIAPILKMREKGINIGLGTDGPMSGNTLDILSQ
MSQVGKIHKLFNKDRTLLPSIDLIEMGTIGGAKVLGIDKEVGSIEIGKKADLTLIETKSVNMQPIYDYYATIVYSANSSN
VELVVVDGKIVVKDKKLVSASFSEVRKDLLSLTEKIKKISKEL

Specific function: Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine [H]

COG id: COG0402

COG function: function code FR; Cytosine deaminase and related metal-dependent hydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MTA/SAH deaminase family [H]

Homologues:

Organism=Homo sapiens, GI4758426, Length=428, Percent_Identity=25, Blast_Score=111, Evalue=1e-24,
Organism=Escherichia coli, GI1789249, Length=412, Percent_Identity=24.5145631067961, Blast_Score=115, Evalue=8e-27,
Organism=Escherichia coli, GI87082177, Length=469, Percent_Identity=23.2409381663113, Blast_Score=76, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17540282, Length=340, Percent_Identity=25.2941176470588, Blast_Score=74, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6319963, Length=335, Percent_Identity=24.1791044776119, Blast_Score=105, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24643849, Length=426, Percent_Identity=24.4131455399061, Blast_Score=110, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.4.28 [H]

Molecular weight: Translated: 49521; Mature: 49390

Theoretical pI: Translated: 5.75; Mature: 5.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKIVTLIKNVTVITMNEHKEIIENGLVVFEKNKIVYVGTDVRTEEKLKRSGYKVEVIDG
CHHHHHHHCCCEEEEECCHHHHHHCCCEEEECCEEEEEECCCCCHHHHHHCCCEEEEEEC
EEGILMPGMINCHTHGSMVPFRSLADDCKDRLKRYLFPLEQRLVDKELTYIGAKYAIAEM
CCCEECCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLGGVTTFCDMYYFEDEVAKAAKELNMRGVLCETIVDFPSPDSEKAFGGLDYSIKFIEKW
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCCCCCEEHHHHHC
KNDDLITPGIAPHAPYTNTEESLKEAYKISKKYDVPITMHLAEMDYELEECKDKYNLTPV
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHCCCCHH
AYLDKLGILDSNFIAAHAVLVNEEDIEILRKNNVNISHNIGANSKGAKGIAPILKMREKG
HHHHHHCCCCCCCCEEEEEEECCHHHHHHHCCCCCEEECCCCCCCCCCHHHHHHHHHHCC
INIGLGTDGPMSGNTLDILSQMSQVGKIHKLFNKDRTLLPSIDLIEMGTIGGAKVLGIDK
CEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCEEEEEECC
EVGSIEIGKKADLTLIETKSVNMQPIYDYYATIVYSANSSNVELVVVDGKIVVKDKKLVS
CCCCEECCCCCCEEEEEECCCCCCHHHHEEEEEEEECCCCCEEEEEECCEEEEECCHHHH
ASFSEVRKDLLSLTEKIKKISKEL
HHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SKIVTLIKNVTVITMNEHKEIIENGLVVFEKNKIVYVGTDVRTEEKLKRSGYKVEVIDG
HHHHHHHCCCEEEEECCHHHHHHCCCEEEECCEEEEEECCCCCHHHHHHCCCEEEEEEC
EEGILMPGMINCHTHGSMVPFRSLADDCKDRLKRYLFPLEQRLVDKELTYIGAKYAIAEM
CCCEECCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLGGVTTFCDMYYFEDEVAKAAKELNMRGVLCETIVDFPSPDSEKAFGGLDYSIKFIEKW
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCCCCCEEHHHHHC
KNDDLITPGIAPHAPYTNTEESLKEAYKISKKYDVPITMHLAEMDYELEECKDKYNLTPV
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHCCCCHH
AYLDKLGILDSNFIAAHAVLVNEEDIEILRKNNVNISHNIGANSKGAKGIAPILKMREKG
HHHHHHCCCCCCCCEEEEEEECCHHHHHHHCCCCCEEECCCCCCCCCCHHHHHHHHHHCC
INIGLGTDGPMSGNTLDILSQMSQVGKIHKLFNKDRTLLPSIDLIEMGTIGGAKVLGIDK
CEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCEEEEEECC
EVGSIEIGKKADLTLIETKSVNMQPIYDYYATIVYSANSSNVELVVVDGKIVVKDKKLVS
CCCCEECCCCCCEEEEEECCCCCCHHHHEEEEEEEECCCCCEEEEEECCEEEEECCHHHH
ASFSEVRKDLLSLTEKIKKISKEL
HHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA