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The map label for this gene is pyrD [H]

Identifier: 18310160

GI number: 18310160

Start: 1374440

End: 1375339

Strand: Reverse

Name: pyrD [H]

Synonym: CPE1178

Alternate gene names: 18310160

Gene position: 1375339-1374440 (Counterclockwise)

Preceding gene: 18310161

Following gene: 18310159

Centisome position: 45.37

GC content: 32.56

Gene sequence:

>900_bases
ATGTTAAAAACAGTTATAAATGGAGTAGATTTTAAAAACCCTGTTATAGCAGCATCAGGTACTTTCGGCTTTGGAGCTGA
GTATAATAACTTCTATGATGTGGGAGAATTAGGAGGAATAAGTTCAAAAGGACTAACTCTTAATAGTAGAGAAGGTAATG
AAGGAATAAGAATATATGAAACTCCTCAAGGAATAATGAATTCAGTAGGACTTCAAAATCCAGGTGTAGAGAAATTTATA
GAAGTAGAACTCCCTAAAATGTTAGAACTAGGAACAAATATAATAGCAAATGTAGGGGGAGCTACTATAGAGGATTATGA
AAAAGCAGTATCTCTTTTAAATAAAGAAAAGATAGACATGATAGAGTTAAATATATCTTGTCCTAATGTAAAATCTGGTG
GAATGGCCTTTGGTATACAATCAGATGTGGCATATGAGGTGGTTTCTAAGGTTAGAAAAATATGTGATAAACCTTTAATG
GTAAAATTATCACCAAATGCTGAAAATATATGCAATATGGCATATAGATGTGCAGAGGCAGGAGCAGATTCAATCTCCCT
AATAAATACATTAAAAGGAATGGCAATAGATATAAAAAATAGAAAGCCAGTATTTAATAATGTGTATGCAGGACTTTCTG
GCCCAGCTGTAAAACCTATAGCACTTAGAATGGTTCATGAAGTAGCTAAAACTGTAGACATTCCAGTAATAGGATTAGGC
GGAATTTCTACAGCAGAAGATGCCATAGAATTTATGATGGCAGGAGCATCAGCTATACAAATAGGTACAATAAACTTTGT
AAATCCTAAAGCAGGTATAGAAATAATAAAAGGCTTGGAAGACTTTTGCAAAAAAGAAGGATTAAAAAATATTAATGAAA
TTGTAGGATGCATAAAGTAA

Upstream 100 bases:

>100_bases
TGTATATGTAAAACAAAGTCAGGAAATAAGAGAACTTGTAAAGATGGTCCAGTATTTAATGGATTAGAAGTTGAATTCTA
ATTTAGGAGGGGTTAAAAGT

Downstream 100 bases:

>100_bases
TAAAAGATTAAATAGCTAATAAAGATTATAAATATATTTTAAAGATTATTAAATCACAAAATTTATCTTCATATTAATAT
AGTGATTTTTATAAAAAGTA

Product: dihydroorotate dehydrogenase 1B

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase [H]

Number of amino acids: Translated: 299; Mature: 299

Protein sequence:

>299_residues
MLKTVINGVDFKNPVIAASGTFGFGAEYNNFYDVGELGGISSKGLTLNSREGNEGIRIYETPQGIMNSVGLQNPGVEKFI
EVELPKMLELGTNIIANVGGATIEDYEKAVSLLNKEKIDMIELNISCPNVKSGGMAFGIQSDVAYEVVSKVRKICDKPLM
VKLSPNAENICNMAYRCAEAGADSISLINTLKGMAIDIKNRKPVFNNVYAGLSGPAVKPIALRMVHEVAKTVDIPVIGLG
GISTAEDAIEFMMAGASAIQIGTINFVNPKAGIEIIKGLEDFCKKEGLKNINEIVGCIK

Sequences:

>Translated_299_residues
MLKTVINGVDFKNPVIAASGTFGFGAEYNNFYDVGELGGISSKGLTLNSREGNEGIRIYETPQGIMNSVGLQNPGVEKFI
EVELPKMLELGTNIIANVGGATIEDYEKAVSLLNKEKIDMIELNISCPNVKSGGMAFGIQSDVAYEVVSKVRKICDKPLM
VKLSPNAENICNMAYRCAEAGADSISLINTLKGMAIDIKNRKPVFNNVYAGLSGPAVKPIALRMVHEVAKTVDIPVIGLG
GISTAEDAIEFMMAGASAIQIGTINFVNPKAGIEIIKGLEDFCKKEGLKNINEIVGCIK
>Mature_299_residues
MLKTVINGVDFKNPVIAASGTFGFGAEYNNFYDVGELGGISSKGLTLNSREGNEGIRIYETPQGIMNSVGLQNPGVEKFI
EVELPKMLELGTNIIANVGGATIEDYEKAVSLLNKEKIDMIELNISCPNVKSGGMAFGIQSDVAYEVVSKVRKICDKPLM
VKLSPNAENICNMAYRCAEAGADSISLINTLKGMAIDIKNRKPVFNNVYAGLSGPAVKPIALRMVHEVAKTVDIPVIGLG
GISTAEDAIEFMMAGASAIQIGTINFVNPKAGIEIIKGLEDFCKKEGLKNINEIVGCIK

Specific function: Unknown

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily [H]

Homologues:

Organism=Homo sapiens, GI119943098, Length=222, Percent_Identity=27.9279279279279, Blast_Score=92, Evalue=7e-19,
Organism=Homo sapiens, GI45006951, Length=322, Percent_Identity=25.1552795031056, Blast_Score=89, Evalue=5e-18,
Organism=Escherichia coli, GI87082059, Length=315, Percent_Identity=29.8412698412698, Blast_Score=113, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI71984108, Length=154, Percent_Identity=32.4675324675325, Blast_Score=86, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6322633, Length=300, Percent_Identity=30.3333333333333, Blast_Score=99, Evalue=6e-22,
Organism=Drosophila melanogaster, GI24640763, Length=173, Percent_Identity=32.3699421965318, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI18858217, Length=173, Percent_Identity=32.3699421965318, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI281361352, Length=318, Percent_Identity=27.0440251572327, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI17137316, Length=318, Percent_Identity=27.0440251572327, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005720
- InterPro:   IPR012135 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: =1.3.3.1 [H]

Molecular weight: Translated: 31923; Mature: 31923

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: PS00012 PHOSPHOPANTETHEINE ; PS00912 DHODEHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKTVINGVDFKNPVIAASGTFGFGAEYNNFYDVGELGGISSKGLTLNSREGNEGIRIYE
CCCHHCCCCCCCCCEEEECCCCCCCCCCCCCCCCHHCCCCCCCCEEEECCCCCCCEEEEE
TPQGIMNSVGLQNPGVEKFIEVELPKMLELGTNIIANVGGATIEDYEKAVSLLNKEKIDM
CCHHHHHHCCCCCCCHHHHEEECCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCEE
IELNISCPNVKSGGMAFGIQSDVAYEVVSKVRKICDKPLMVKLSPNAENICNMAYRCAEA
EEEEEECCCCCCCCEEEECCHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHC
GADSISLINTLKGMAIDIKNRKPVFNNVYAGLSGPAVKPIALRMVHEVAKTVDIPVIGLG
CCCHHHHHHHHCCCEEEECCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCEEECC
GISTAEDAIEFMMAGASAIQIGTINFVNPKAGIEIIKGLEDFCKKEGLKNINEIVGCIK
CCCHHHHHHHHHHCCCCEEEEEEEEEECCHHHHHHHHHHHHHHHHHCHHHHHHHHHHCC
>Mature Secondary Structure
MLKTVINGVDFKNPVIAASGTFGFGAEYNNFYDVGELGGISSKGLTLNSREGNEGIRIYE
CCCHHCCCCCCCCCEEEECCCCCCCCCCCCCCCCHHCCCCCCCCEEEECCCCCCCEEEEE
TPQGIMNSVGLQNPGVEKFIEVELPKMLELGTNIIANVGGATIEDYEKAVSLLNKEKIDM
CCHHHHHHCCCCCCCHHHHEEECCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCEE
IELNISCPNVKSGGMAFGIQSDVAYEVVSKVRKICDKPLMVKLSPNAENICNMAYRCAEA
EEEEEECCCCCCCCEEEECCHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHC
GADSISLINTLKGMAIDIKNRKPVFNNVYAGLSGPAVKPIALRMVHEVAKTVDIPVIGLG
CCCHHHHHHHHCCCEEEECCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCEEECC
GISTAEDAIEFMMAGASAIQIGTINFVNPKAGIEIIKGLEDFCKKEGLKNINEIVGCIK
CCCHHHHHHHHHHCCCCEEEEEEEEEECCHHHHHHHHHHHHHHHHHCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA