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The map label for this gene is pyrE

Identifier: 18310159

GI number: 18310159

Start: 1373711

End: 1374289

Strand: Reverse

Name: pyrE

Synonym: CPE1177

Alternate gene names: 18310159

Gene position: 1374289-1373711 (Counterclockwise)

Preceding gene: 18310160

Following gene: 18310158

Centisome position: 45.33

GC content: 33.85

Gene sequence:

>579_bases
ATGAAAAATACAGACGCTATGGTTATAGATACATTAAAAGAGGTTGGAGCATTATTAGAAGGACATTTCTTATTATCATC
AGGAAGACACTCAAATAGATATTGCCAATGTGCTCAATTATTAAAATACCCAGAAAAAGCTGAGAAAGTATTAAAGGTTG
TAGCTGATCAATTAAAAGATATAGACTTTGACTTAGTTGTAGGACCAGCTATGGGAGGAGTTATAGTAGCTTACGAATTA
GGAAGACAATTAGGTAAGCCTGCAATCTTTACTGAAAGAGAAAATGGAGAAATGACTCTAAGAAGAGGATTTACTATAGA
AAAAGGACAAAAAGTAGTAATAACAGAGGATGTTGTAACTACAGGTAAGAGCTTTAAGGAAGCTGCAAAGGTAATTGAAG
AACAAGGGGGAGAAGTTGTTGCAGTAGTTTGTATAGTAGATAGAACTCCAGGCAATGTAACAGATTTCCCAATGTATAGT
TCAATAAAACTTGATATAGAAAGCTTTGAAGCAGAAAATTGCCCACTATGTAAAGAAGGAGTGCCTTACATAAAACCAGG
AAGCAGAAATATAAAATAA

Upstream 100 bases:

>100_bases
AAATCACAAAATTTATCTTCATATTAATATAGTGATTTTTATAAAAAGTAATTTTGAAGATATTAAGAAAATAAATAAGA
AAGTTTTGGAGGAATTAAAT

Downstream 100 bases:

>100_bases
TCCGATAAATTTTAAAAAAACTCTAGTTATAAAGCTAGAGTTTTTTATTTTAGAAAATATATTCTAAAAACTTATTTAAA
TCAATTGATTCTCATCACTT

Product: orotate phosphoribosyltransferase

Products: NA

Alternate protein names: OPRT; OPRTase

Number of amino acids: Translated: 192; Mature: 192

Protein sequence:

>192_residues
MKNTDAMVIDTLKEVGALLEGHFLLSSGRHSNRYCQCAQLLKYPEKAEKVLKVVADQLKDIDFDLVVGPAMGGVIVAYEL
GRQLGKPAIFTERENGEMTLRRGFTIEKGQKVVITEDVVTTGKSFKEAAKVIEEQGGEVVAVVCIVDRTPGNVTDFPMYS
SIKLDIESFEAENCPLCKEGVPYIKPGSRNIK

Sequences:

>Translated_192_residues
MKNTDAMVIDTLKEVGALLEGHFLLSSGRHSNRYCQCAQLLKYPEKAEKVLKVVADQLKDIDFDLVVGPAMGGVIVAYEL
GRQLGKPAIFTERENGEMTLRRGFTIEKGQKVVITEDVVTTGKSFKEAAKVIEEQGGEVVAVVCIVDRTPGNVTDFPMYS
SIKLDIESFEAENCPLCKEGVPYIKPGSRNIK
>Mature_192_residues
MKNTDAMVIDTLKEVGALLEGHFLLSSGRHSNRYCQCAQLLKYPEKAEKVLKVVADQLKDIDFDLVVGPAMGGVIVAYEL
GRQLGKPAIFTERENGEMTLRRGFTIEKGQKVVITEDVVTTGKSFKEAAKVIEEQGGEVVAVVCIVDRTPGNVTDFPMYS
SIKLDIESFEAENCPLCKEGVPYIKPGSRNIK

Specific function: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)

COG id: COG0461

COG function: function code F; Orotate phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRE_CLOP1 (Q0TRB3)

Other databases:

- EMBL:   CP000246
- RefSeq:   YP_695827.1
- ProteinModelPortal:   Q0TRB3
- SMR:   Q0TRB3
- STRING:   Q0TRB3
- GeneID:   4201573
- GenomeReviews:   CP000246_GR
- KEGG:   cpf:CPF_1381
- TIGR:   CPF_1381
- eggNOG:   COG0461
- HOGENOM:   HBG404341
- OMA:   FYLQSAK
- ProtClustDB:   PRK00455
- BioCyc:   CPER195103:CPF_1381-MONOMER
- HAMAP:   MF_01208
- InterPro:   IPR023031
- InterPro:   IPR006273
- InterPro:   IPR000836
- TIGRFAMs:   TIGR01367

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.10

Molecular weight: Translated: 21112; Mature: 21112

Theoretical pI: Translated: 5.41; Mature: 5.41

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: BINDING 120-120 BINDING 148-148

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNTDAMVIDTLKEVGALLEGHFLLSSGRHSNRYCQCAQLLKYPEKAEKVLKVVADQLKD
CCCCCHHHHHHHHHHHHHHHCHHEEECCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHC
IDFDLVVGPAMGGVIVAYELGRQLGKPAIFTERENGEMTLRRGFTIEKGQKVVITEDVVT
CCCEEEECCCCCCCHHHHHHHHHHCCCCEEEECCCCCEEEECCCEECCCCEEEEEHHHHH
TGKSFKEAAKVIEEQGGEVVAVVCIVDRTPGNVTDFPMYSSIKLDIESFEAENCPLCKEG
CCHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCCCCCCCCEEEEEHHHCCCCCCCCCCCC
VPYIKPGSRNIK
CCCCCCCCCCCC
>Mature Secondary Structure
MKNTDAMVIDTLKEVGALLEGHFLLSSGRHSNRYCQCAQLLKYPEKAEKVLKVVADQLKD
CCCCCHHHHHHHHHHHHHHHCHHEEECCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHC
IDFDLVVGPAMGGVIVAYELGRQLGKPAIFTERENGEMTLRRGFTIEKGQKVVITEDVVT
CCCEEEECCCCCCCHHHHHHHHHHCCCCEEEECCCCCEEEECCCEECCCCEEEEEHHHHH
TGKSFKEAAKVIEEQGGEVVAVVCIVDRTPGNVTDFPMYSSIKLDIESFEAENCPLCKEG
CCHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCCCCCCCCEEEEEHHHCCCCCCCCCCCC
VPYIKPGSRNIK
CCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA