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The map label for this gene is maeB [C]

Identifier: 18310133

GI number: 18310133

Start: 1344643

End: 1345788

Strand: Direct

Name: maeB [C]

Synonym: CPE1151

Alternate gene names: 18310133

Gene position: 1344643-1345788 (Clockwise)

Preceding gene: 18310132

Following gene: 18310134

Centisome position: 44.36

GC content: 32.02

Gene sequence:

>1146_bases
ATGACTAAGGACGAATTGTTAAAACAAAGAGAATTAGCTCATGGATTAATAAGTATAAACCCTAATTTCGATATAAATAA
TAGAGAACAATTATCTCAAATATATACTCCAGGAGTATCAACTATTTGTAAAGAAGTTGAGCATCATCATAATATGGTAA
AAACACTAACTTCTGTTGGAAATTCAATAGCTGTTATAACAGATGGTACGGCGGTTTTAGGTCTTGGAAATATAGGAACC
CTTGCAGGATATCCTATAGTAGAGGCTAAAGCTCTAGTTTATAAAGACCTAGCTGGTGTAAACGCTATACCTTTATGTGT
TGATCAAATAGGATGTAATGAACTGATTAAAACTATAAAAAGTATATCTCCAAGTTTTAGTGGAATTCATCTTGAAGATA
TAAAGGCACCAGAATGTTTTTATATAGAAGAGGAACTTAAAAAGACTTTAAACATTCCAGTTTATCATGATGATCAACAT
GGTACTGCCATTGCTGTTTTAGGTGCTCTTTATAATGGAGCTAAGGTGGTTAATAAGGATTTTTTAAAATTAAAGGTATT
AATTTTAGGGGCAGGAGCTTCAGGGATTGCAACAGCAAAATTATTATTAAAGGCTGGAATAGAAGATATTATATTAGTTG
ACAAAAATGGTGCTTTAGTTAATGGGGATGAAACTCTTAATGCTCCTCAAAAGGAAATGGCTAAAATAACAAATAAAGAA
TTTAAAAAAGGAACTTTGAAAGAGGTAATTAAAGGACGAGATGTGTTTATAGGTTTATCAGAAGGAAATCTTGTAACTAA
GGAAATGGTAGAAAGTATGAATGAGGATCCTATAATATTTGCTTTAGCTAATCCAACACCAGAGATAAAACCTGAAATTG
CAAAGGAAGCTGGTGCAAGGGTTATTGCAACAGGTGGACCTTCTTATCCAAATCAGATTAATAATATATTAGTATTCCCA
GGATTATTTAAAGGCTTATTAGAAGCTAAGGCAACTGATGTAACTTGTGATGTAATGATAGCAGTTGGCAAAAAACTAGC
TTCCTTAGTTGAAAATCCAACTGCTGAAAAAATAATACCTGGAGTATTTGATGGTGATATAGTTAAGTCTGTTTCTGAAA
CTGTGGTTAAAAATATTGAGAATTAG

Upstream 100 bases:

>100_bases
TACGAGCTTACTTCAAGTATAAAAGAAAAAATACTTAAGTATAAAAACAGTAAAAATTAATTAGTATAAAATATTTAATA
GTTTGAAGAGAGGTAATAAT

Downstream 100 bases:

>100_bases
TTAATTTAGGGGGAGTTTATATGGAATTACAAAATAAAAAGATAGATGGTAAAGAAGAGAGCTTACTTAAAAAGTTTTTT
AATATAAATCTTTTTGGGGT

Product: malate oxidoreductase

Products: NA

Alternate protein names: NAD-ME [H]

Number of amino acids: Translated: 381; Mature: 380

Protein sequence:

>381_residues
MTKDELLKQRELAHGLISINPNFDINNREQLSQIYTPGVSTICKEVEHHHNMVKTLTSVGNSIAVITDGTAVLGLGNIGT
LAGYPIVEAKALVYKDLAGVNAIPLCVDQIGCNELIKTIKSISPSFSGIHLEDIKAPECFYIEEELKKTLNIPVYHDDQH
GTAIAVLGALYNGAKVVNKDFLKLKVLILGAGASGIATAKLLLKAGIEDIILVDKNGALVNGDETLNAPQKEMAKITNKE
FKKGTLKEVIKGRDVFIGLSEGNLVTKEMVESMNEDPIIFALANPTPEIKPEIAKEAGARVIATGGPSYPNQINNILVFP
GLFKGLLEAKATDVTCDVMIAVGKKLASLVENPTAEKIIPGVFDGDIVKSVSETVVKNIEN

Sequences:

>Translated_381_residues
MTKDELLKQRELAHGLISINPNFDINNREQLSQIYTPGVSTICKEVEHHHNMVKTLTSVGNSIAVITDGTAVLGLGNIGT
LAGYPIVEAKALVYKDLAGVNAIPLCVDQIGCNELIKTIKSISPSFSGIHLEDIKAPECFYIEEELKKTLNIPVYHDDQH
GTAIAVLGALYNGAKVVNKDFLKLKVLILGAGASGIATAKLLLKAGIEDIILVDKNGALVNGDETLNAPQKEMAKITNKE
FKKGTLKEVIKGRDVFIGLSEGNLVTKEMVESMNEDPIIFALANPTPEIKPEIAKEAGARVIATGGPSYPNQINNILVFP
GLFKGLLEAKATDVTCDVMIAVGKKLASLVENPTAEKIIPGVFDGDIVKSVSETVVKNIEN
>Mature_380_residues
TKDELLKQRELAHGLISINPNFDINNREQLSQIYTPGVSTICKEVEHHHNMVKTLTSVGNSIAVITDGTAVLGLGNIGTL
AGYPIVEAKALVYKDLAGVNAIPLCVDQIGCNELIKTIKSISPSFSGIHLEDIKAPECFYIEEELKKTLNIPVYHDDQHG
TAIAVLGALYNGAKVVNKDFLKLKVLILGAGASGIATAKLLLKAGIEDIILVDKNGALVNGDETLNAPQKEMAKITNKEF
KKGTLKEVIKGRDVFIGLSEGNLVTKEMVESMNEDPIIFALANPTPEIKPEIAKEAGARVIATGGPSYPNQINNILVFPG
LFKGLLEAKATDVTCDVMIAVGKKLASLVENPTAEKIIPGVFDGDIVKSVSETVVKNIEN

Specific function: In addition to the NAD-dependent oxidative decarboxylation of L-malate, the enzyme catalyzes the decarboxylation of oxaloacetate [H]

COG id: COG0281

COG function: function code C; Malic enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the malic enzymes family [H]

Homologues:

Organism=Homo sapiens, GI4505145, Length=396, Percent_Identity=24.7474747474747, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI270265879, Length=369, Percent_Identity=25.4742547425474, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI4505143, Length=381, Percent_Identity=24.6719160104987, Blast_Score=76, Evalue=4e-14,
Organism=Escherichia coli, GI1788806, Length=373, Percent_Identity=40.2144772117962, Blast_Score=283, Evalue=2e-77,
Organism=Escherichia coli, GI87081919, Length=410, Percent_Identity=23.4146341463415, Blast_Score=84, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6322823, Length=362, Percent_Identity=24.8618784530387, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI21356279, Length=402, Percent_Identity=25.8706467661692, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI281362672, Length=402, Percent_Identity=25.8706467661692, Blast_Score=93, Evalue=3e-19,
Organism=Drosophila melanogaster, GI281362674, Length=402, Percent_Identity=25.8706467661692, Blast_Score=93, Evalue=3e-19,
Organism=Drosophila melanogaster, GI78707240, Length=373, Percent_Identity=24.9329758713137, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI78707242, Length=373, Percent_Identity=24.9329758713137, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI78707238, Length=373, Percent_Identity=24.9329758713137, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24646386, Length=395, Percent_Identity=25.3164556962025, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24646388, Length=395, Percent_Identity=25.3164556962025, Blast_Score=79, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015884
- InterPro:   IPR012301
- InterPro:   IPR012302
- InterPro:   IPR001891
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00390 malic; PF03949 Malic_M [H]

EC number: =1.1.1.38 [H]

Molecular weight: Translated: 40826; Mature: 40695

Theoretical pI: Translated: 5.48; Mature: 5.48

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKDELLKQRELAHGLISINPNFDINNREQLSQIYTPGVSTICKEVEHHHNMVKTLTSVG
CCHHHHHHHHHHHCCEEEECCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCC
NSIAVITDGTAVLGLGNIGTLAGYPIVEAKALVYKDLAGVNAIPLCVDQIGCNELIKTIK
CEEEEEECCCEEEECCCCHHHCCCCHHHHHHHHHHHHCCCCCHHHHHHHCCHHHHHHHHH
SISPSFSGIHLEDIKAPECFYIEEELKKTLNIPVYHDDQHGTAIAVLGALYNGAKVVNKD
HCCCCCCCEEEECCCCCCEEEEHHHHHHHCCCCEEECCCCCHHHHHHHHHHCCHHHHCCH
FLKLKVLILGAGASGIATAKLLLKAGIEDIILVDKNGALVNGDETLNAPQKEMAKITNKE
HEEEEEEEEECCCCHHHHHHHHHHCCCCEEEEECCCCCEECCCHHCCCCHHHHHHHHHHH
FKKGTLKEVIKGRDVFIGLSEGNLVTKEMVESMNEDPIIFALANPTPEIKPEIAKEAGAR
HCCCHHHHHHCCCCEEEEECCCCCHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHCCCE
VIATGGPSYPNQINNILVFPGLFKGLLEAKATDVTCDVMIAVGKKLASLVENPTAEKIIP
EEECCCCCCCHHHCCEEECHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCHHHHCC
GVFDGDIVKSVSETVVKNIEN
CCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TKDELLKQRELAHGLISINPNFDINNREQLSQIYTPGVSTICKEVEHHHNMVKTLTSVG
CHHHHHHHHHHHCCEEEECCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCC
NSIAVITDGTAVLGLGNIGTLAGYPIVEAKALVYKDLAGVNAIPLCVDQIGCNELIKTIK
CEEEEEECCCEEEECCCCHHHCCCCHHHHHHHHHHHHCCCCCHHHHHHHCCHHHHHHHHH
SISPSFSGIHLEDIKAPECFYIEEELKKTLNIPVYHDDQHGTAIAVLGALYNGAKVVNKD
HCCCCCCCEEEECCCCCCEEEEHHHHHHHCCCCEEECCCCCHHHHHHHHHHCCHHHHCCH
FLKLKVLILGAGASGIATAKLLLKAGIEDIILVDKNGALVNGDETLNAPQKEMAKITNKE
HEEEEEEEEECCCCHHHHHHHHHHCCCCEEEEECCCCCEECCCHHCCCCHHHHHHHHHHH
FKKGTLKEVIKGRDVFIGLSEGNLVTKEMVESMNEDPIIFALANPTPEIKPEIAKEAGAR
HCCCHHHHHHCCCCEEEEECCCCCHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHCCCE
VIATGGPSYPNQINNILVFPGLFKGLLEAKATDVTCDVMIAVGKKLASLVENPTAEKIIP
EEECCCCCCCHHHCCEEECHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCHHHHCC
GVFDGDIVKSVSETVVKNIEN
CCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2644282 [H]