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The map label for this gene is accC [H]

Identifier: 18310056

GI number: 18310056

Start: 1279310

End: 1280662

Strand: Direct

Name: accC [H]

Synonym: CPE1074

Alternate gene names: 18310056

Gene position: 1279310-1280662 (Clockwise)

Preceding gene: 18310055

Following gene: 18310057

Centisome position: 42.2

GC content: 31.41

Gene sequence:

>1353_bases
ATGTTTAAAAAGATATTAATAGCAAATAGAGGTGAAATAGCTGTTAGAATAATACGTGCTTGTAGAGAATTAGGAATTCT
TACTGTAGCTGTTTATTCTGAAATAGACAAAGATGCACTACATGTGCAGTTAGCTGATGAAGCAGTTTGTATAGGTCCAT
GGAATTCTAAAGAAAGTTACTTAAATATTCAAAATATATTAAGTGCTTGTGTTCTAACTGGGGCTGAAGCTATTCATCCT
GGATTTGGTTTTTTATCTGAGAATCCAAGATTTGCTAAGATGTGTGAAGAGTGTAATATTGAGTTTATTGGCCCTAATTG
GAGAGCTATAGAACTTATGGGAAACAAAGCTATGGCAAGAGAAATAATGAAAAAGGCTGATGTTCCTGTTGTACCTGGAT
ATGAAGGTGAAATTGAAAGTCCAGAGTTTGCTTTAAAGATAGCTAAAAAAATAGGATTTCCTGTAATAGTAAAGGCTTCC
TCAGGTGGTGGTGGAAAAGGAATAAGAATAGTTTATAAAGAAGATGATTTTATTTCAAATTACAACACAGCTAAATCAGA
GGCTCAAGCAAACTTTGGTGATGATAAAATTTACATTGAGAGATTTGTTGAAAATCCTAAACATATAGAAGTACAATTAT
TATGCGATAAGCATGGAAATGCCCTTCACCTTTTTGAGCGAGATTGTTCAGCTCAAAGAAAAAATCAAAAAGTTTTAGAA
GAAGCTCCTTCATCAATTTTAAGTGATGAACAAAGGGATAAACTTGGTAAGATTGCAGTTAAAGCAGCTAAAGCTGTAAA
CTATAGCAATGTTGGAACAATTGAATTTTTATTAGATAAAAATGGTGAATTTTATTTTATGGAAATGAACACAAGAATAC
AAGTTGAACATCCTATAACTGAAATGATAACAGGTGTTGATCTTGTTAAGGAACAAATAAAAGTTGCATTTGGTAAGGAG
TTAGAAATAACTCAAGATGATTTAAAGATAAATGGTCATTCCATAGAATGCAGAATAAATGCTGAAGATCCAAGCAAAAA
CTTTATGCCATGCCCTGGTTTAATAAAGGAAATTAATTTCCCAGGAGGATTTGGAGTTCGTTTAGATACAGCAATTTATT
CTGGATATAAGATACCCCATTGTTATGATTCAATGATTGGTAAGCTAATAGTTCATGGTAAAGATAGAGAAGAGGCAATT
TCTAAAATGAAAAGGGCTTTAGATGAATTTGCTATTGATGGTATAACAACTAACATAGACTATCACTTTTTAATATTGGA
TCATGAAGATTTTAAAAATGGTACTTATAATACTTCATTTTTATCTGAAAAGTTGGTGAATAAGTATGATTAA

Upstream 100 bases:

>100_bases
TTAGAGGAAGCATTGGATTTGGTAAAGCTACGGCTACTGTAGATGGAAAAATCGCTTGTTCTGGAGAAATTATGTTTGCA
ATAGGTTAGGTGATTTAATT

Downstream 100 bases:

>100_bases
GAATTTATTAAATAAAAGAAAGTATATAACTGTTAGTTCAGTTGAATTAAATGATACTGAATTAAGTGAAGATGAAAAAC
CAAATATACCCTCTGGGTAT

Product: biotin carboxylase

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A; ACC [H]

Number of amino acids: Translated: 450; Mature: 450

Protein sequence:

>450_residues
MFKKILIANRGEIAVRIIRACRELGILTVAVYSEIDKDALHVQLADEAVCIGPWNSKESYLNIQNILSACVLTGAEAIHP
GFGFLSENPRFAKMCEECNIEFIGPNWRAIELMGNKAMAREIMKKADVPVVPGYEGEIESPEFALKIAKKIGFPVIVKAS
SGGGGKGIRIVYKEDDFISNYNTAKSEAQANFGDDKIYIERFVENPKHIEVQLLCDKHGNALHLFERDCSAQRKNQKVLE
EAPSSILSDEQRDKLGKIAVKAAKAVNYSNVGTIEFLLDKNGEFYFMEMNTRIQVEHPITEMITGVDLVKEQIKVAFGKE
LEITQDDLKINGHSIECRINAEDPSKNFMPCPGLIKEINFPGGFGVRLDTAIYSGYKIPHCYDSMIGKLIVHGKDREEAI
SKMKRALDEFAIDGITTNIDYHFLILDHEDFKNGTYNTSFLSEKLVNKYD

Sequences:

>Translated_450_residues
MFKKILIANRGEIAVRIIRACRELGILTVAVYSEIDKDALHVQLADEAVCIGPWNSKESYLNIQNILSACVLTGAEAIHP
GFGFLSENPRFAKMCEECNIEFIGPNWRAIELMGNKAMAREIMKKADVPVVPGYEGEIESPEFALKIAKKIGFPVIVKAS
SGGGGKGIRIVYKEDDFISNYNTAKSEAQANFGDDKIYIERFVENPKHIEVQLLCDKHGNALHLFERDCSAQRKNQKVLE
EAPSSILSDEQRDKLGKIAVKAAKAVNYSNVGTIEFLLDKNGEFYFMEMNTRIQVEHPITEMITGVDLVKEQIKVAFGKE
LEITQDDLKINGHSIECRINAEDPSKNFMPCPGLIKEINFPGGFGVRLDTAIYSGYKIPHCYDSMIGKLIVHGKDREEAI
SKMKRALDEFAIDGITTNIDYHFLILDHEDFKNGTYNTSFLSEKLVNKYD
>Mature_450_residues
MFKKILIANRGEIAVRIIRACRELGILTVAVYSEIDKDALHVQLADEAVCIGPWNSKESYLNIQNILSACVLTGAEAIHP
GFGFLSENPRFAKMCEECNIEFIGPNWRAIELMGNKAMAREIMKKADVPVVPGYEGEIESPEFALKIAKKIGFPVIVKAS
SGGGGKGIRIVYKEDDFISNYNTAKSEAQANFGDDKIYIERFVENPKHIEVQLLCDKHGNALHLFERDCSAQRKNQKVLE
EAPSSILSDEQRDKLGKIAVKAAKAVNYSNVGTIEFLLDKNGEFYFMEMNTRIQVEHPITEMITGVDLVKEQIKVAFGKE
LEITQDDLKINGHSIECRINAEDPSKNFMPCPGLIKEINFPGGFGVRLDTAIYSGYKIPHCYDSMIGKLIVHGKDREEAI
SKMKRALDEFAIDGITTNIDYHFLILDHEDFKNGTYNTSFLSEKLVNKYD

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI116805327, Length=441, Percent_Identity=48.2993197278912, Blast_Score=456, Evalue=1e-128,
Organism=Homo sapiens, GI189095269, Length=444, Percent_Identity=49.7747747747748, Blast_Score=446, Evalue=1e-125,
Organism=Homo sapiens, GI65506442, Length=444, Percent_Identity=49.7747747747748, Blast_Score=446, Evalue=1e-125,
Organism=Homo sapiens, GI295821183, Length=444, Percent_Identity=49.7747747747748, Blast_Score=445, Evalue=1e-125,
Organism=Homo sapiens, GI106049528, Length=446, Percent_Identity=46.8609865470852, Blast_Score=404, Evalue=1e-113,
Organism=Homo sapiens, GI106049295, Length=446, Percent_Identity=46.8609865470852, Blast_Score=404, Evalue=1e-113,
Organism=Homo sapiens, GI106049292, Length=446, Percent_Identity=46.8609865470852, Blast_Score=404, Evalue=1e-113,
Organism=Homo sapiens, GI38679960, Length=508, Percent_Identity=31.2992125984252, Blast_Score=263, Evalue=3e-70,
Organism=Homo sapiens, GI38679977, Length=508, Percent_Identity=31.2992125984252, Blast_Score=263, Evalue=3e-70,
Organism=Homo sapiens, GI38679967, Length=508, Percent_Identity=31.2992125984252, Blast_Score=263, Evalue=3e-70,
Organism=Homo sapiens, GI38679971, Length=508, Percent_Identity=31.2992125984252, Blast_Score=262, Evalue=4e-70,
Organism=Homo sapiens, GI38679974, Length=508, Percent_Identity=31.2992125984252, Blast_Score=262, Evalue=4e-70,
Organism=Homo sapiens, GI134142062, Length=509, Percent_Identity=29.4695481335953, Blast_Score=248, Evalue=8e-66,
Organism=Escherichia coli, GI1789654, Length=446, Percent_Identity=54.0358744394619, Blast_Score=476, Evalue=1e-135,
Organism=Escherichia coli, GI1786216, Length=238, Percent_Identity=26.0504201680672, Blast_Score=69, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17567343, Length=444, Percent_Identity=49.5495495495495, Blast_Score=447, Evalue=1e-126,
Organism=Caenorhabditis elegans, GI71987519, Length=442, Percent_Identity=47.5113122171946, Blast_Score=427, Evalue=1e-120,
Organism=Caenorhabditis elegans, GI17562816, Length=447, Percent_Identity=44.5190156599553, Blast_Score=375, Evalue=1e-104,
Organism=Caenorhabditis elegans, GI133931226, Length=491, Percent_Identity=30.3462321792261, Blast_Score=236, Evalue=2e-62,
Organism=Caenorhabditis elegans, GI71997168, Length=511, Percent_Identity=30.1369863013699, Blast_Score=231, Evalue=8e-61,
Organism=Caenorhabditis elegans, GI71997163, Length=511, Percent_Identity=30.1369863013699, Blast_Score=230, Evalue=1e-60,
Organism=Saccharomyces cerevisiae, GI6319685, Length=443, Percent_Identity=45.372460496614, Blast_Score=381, Evalue=1e-106,
Organism=Saccharomyces cerevisiae, GI6319695, Length=447, Percent_Identity=46.3087248322148, Blast_Score=367, Evalue=1e-102,
Organism=Saccharomyces cerevisiae, GI6321376, Length=447, Percent_Identity=47.427293064877, Blast_Score=359, Evalue=1e-100,
Organism=Saccharomyces cerevisiae, GI6324343, Length=516, Percent_Identity=32.3643410852713, Blast_Score=265, Evalue=8e-72,
Organism=Saccharomyces cerevisiae, GI6323863, Length=469, Percent_Identity=33.4754797441365, Blast_Score=263, Evalue=3e-71,
Organism=Drosophila melanogaster, GI24651757, Length=444, Percent_Identity=46.6216216216216, Blast_Score=431, Evalue=1e-121,
Organism=Drosophila melanogaster, GI281363050, Length=446, Percent_Identity=47.5336322869955, Blast_Score=400, Evalue=1e-112,
Organism=Drosophila melanogaster, GI24652224, Length=446, Percent_Identity=47.5336322869955, Blast_Score=400, Evalue=1e-112,
Organism=Drosophila melanogaster, GI24652222, Length=446, Percent_Identity=47.5336322869955, Blast_Score=400, Evalue=1e-112,
Organism=Drosophila melanogaster, GI24652220, Length=446, Percent_Identity=47.5336322869955, Blast_Score=400, Evalue=1e-112,
Organism=Drosophila melanogaster, GI24652218, Length=446, Percent_Identity=47.5336322869955, Blast_Score=400, Evalue=1e-112,
Organism=Drosophila melanogaster, GI24652212, Length=446, Percent_Identity=47.5336322869955, Blast_Score=400, Evalue=1e-112,
Organism=Drosophila melanogaster, GI24652210, Length=446, Percent_Identity=47.5336322869955, Blast_Score=400, Evalue=1e-112,
Organism=Drosophila melanogaster, GI24652214, Length=446, Percent_Identity=47.5336322869955, Blast_Score=400, Evalue=1e-112,
Organism=Drosophila melanogaster, GI19921944, Length=446, Percent_Identity=47.5336322869955, Blast_Score=400, Evalue=1e-112,
Organism=Drosophila melanogaster, GI24652216, Length=446, Percent_Identity=47.5336322869955, Blast_Score=400, Evalue=1e-112,
Organism=Drosophila melanogaster, GI24651759, Length=408, Percent_Identity=45.343137254902, Blast_Score=386, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24586458, Length=496, Percent_Identity=30.4435483870968, Blast_Score=253, Evalue=1e-67,
Organism=Drosophila melanogaster, GI161076407, Length=496, Percent_Identity=30.4435483870968, Blast_Score=253, Evalue=1e-67,
Organism=Drosophila melanogaster, GI24586460, Length=496, Percent_Identity=30.4435483870968, Blast_Score=253, Evalue=1e-67,
Organism=Drosophila melanogaster, GI161076409, Length=496, Percent_Identity=30.4435483870968, Blast_Score=253, Evalue=2e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 50473; Mature: 50473

Theoretical pI: Translated: 5.68; Mature: 5.68

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFKKILIANRGEIAVRIIRACRELGILTVAVYSEIDKDALHVQLADEAVCIGPWNSKESY
CCCEEEEECCCHHHHHHHHHHHHCCEEEEEEHHHCCCCEEEEEEECCEEEECCCCCCCCE
LNIQNILSACVLTGAEAIHPGFGFLSENPRFAKMCEECNIEFIGPNWRAIELMGNKAMAR
EEHHHHHHHHHHCCHHHCCCCCCCCCCCCHHHHHHHHCCEEEECCCCEEEEEECCHHHHH
EIMKKADVPVVPGYEGEIESPEFALKIAKKIGFPVIVKASSGGGGKGIRIVYKEDDFISN
HHHHHCCCCCCCCCCCCCCCCHHHHHHHHHCCCEEEEEECCCCCCCCEEEEEECCCCCCC
YNTAKSEAQANFGDDKIYIERFVENPKHIEVQLLCDKHGNALHLFERDCSAQRKNQKVLE
CCCCHHHHCCCCCCCHHHHHHHHCCCCEEEEEEEECCCCCEEEEECCCHHHHHHHHHHHH
EAPSSILSDEQRDKLGKIAVKAAKAVNYSNVGTIEFLLDKNGEFYFMEMNTRIQVEHPIT
HHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCEEEEEECCEEEEECCHH
EMITGVDLVKEQIKVAFGKELEITQDDLKINGHSIECRINAEDPSKNFMPCPGLIKEINF
HHHHHHHHHHHHHHHHCCCCEEEECCCEEECCEEEEEEEECCCCCCCCCCCCHHHHHCCC
PGGFGVRLDTAIYSGYKIPHCYDSMIGKLIVHGKDREEAISKMKRALDEFAIDGITTNID
CCCCCEEEEHHHHCCCCCCHHHHHHHHHEEECCCCHHHHHHHHHHHHHHHHHCCEEECCE
YHFLILDHEDFKNGTYNTSFLSEKLVNKYD
EEEEEEECCCCCCCCCCHHHHHHHHHHCCC
>Mature Secondary Structure
MFKKILIANRGEIAVRIIRACRELGILTVAVYSEIDKDALHVQLADEAVCIGPWNSKESY
CCCEEEEECCCHHHHHHHHHHHHCCEEEEEEHHHCCCCEEEEEEECCEEEECCCCCCCCE
LNIQNILSACVLTGAEAIHPGFGFLSENPRFAKMCEECNIEFIGPNWRAIELMGNKAMAR
EEHHHHHHHHHHCCHHHCCCCCCCCCCCCHHHHHHHHCCEEEECCCCEEEEEECCHHHHH
EIMKKADVPVVPGYEGEIESPEFALKIAKKIGFPVIVKASSGGGGKGIRIVYKEDDFISN
HHHHHCCCCCCCCCCCCCCCCHHHHHHHHHCCCEEEEEECCCCCCCCEEEEEECCCCCCC
YNTAKSEAQANFGDDKIYIERFVENPKHIEVQLLCDKHGNALHLFERDCSAQRKNQKVLE
CCCCHHHHCCCCCCCHHHHHHHHCCCCEEEEEEEECCCCCEEEEECCCHHHHHHHHHHHH
EAPSSILSDEQRDKLGKIAVKAAKAVNYSNVGTIEFLLDKNGEFYFMEMNTRIQVEHPIT
HHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCEEEEEECCEEEEECCHH
EMITGVDLVKEQIKVAFGKELEITQDDLKINGHSIECRINAEDPSKNFMPCPGLIKEINF
HHHHHHHHHHHHHHHHCCCCEEEECCCEEECCEEEEEEEECCCCCCCCCCCCHHHHHCCC
PGGFGVRLDTAIYSGYKIPHCYDSMIGKLIVHGKDREEAISKMKRALDEFAIDGITTNID
CCCCCEEEEHHHHCCCCCCHHHHHHHHHEEECCCCHHHHHHHHHHHHHHHHHCCEEECCE
YHFLILDHEDFKNGTYNTSFLSEKLVNKYD
EEEEEEECCCCCCCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8102363; 11759840 [H]