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The map label for this gene is cobD [H]

Identifier: 18310022

GI number: 18310022

Start: 1240580

End: 1241644

Strand: Direct

Name: cobD [H]

Synonym: CPE1040

Alternate gene names: 18310022

Gene position: 1240580-1241644 (Clockwise)

Preceding gene: 18310021

Following gene: 18310023

Centisome position: 40.92

GC content: 26.29

Gene sequence:

>1065_bases
ATGAATTTAGGACATGGTGGTAATGTAGAAGAAATTAAGAGGATTTATGGCTTAAAAGAAAATGAAATTATTGATTTTTC
AGCTAATATAAACCCTCTAGGAATCTCTGAAAGAGTAAAAGAGGCTATGGTAAGAGGAATAAATTCTATAGAGAGATATC
CAGATATAACTTATTATGAGCTTAAAAAGGGGATTTCAAACTTTGAAAAGGTAGCTTTAGAAAATATAGTTATAGGAAAT
GGTGCAGCAGAGGTTATTTTTAATATAGTAAGAGGAATAAAACCTAAAAAGGCCCTTATAGTAGCACCAACCTTTTCAGA
GTATGAGGATGCTTTAAATTCTGTTGAGTGTGAAGTTAACCATTATATATTAAAAGATAATTATTCAGTAGATAATGGAT
TTTTAGAAGAAATCAAGGAAGAATTAGATATTATATTTTTATGTAATCCCAATAATCCTACAGGGGCTTTAATAGAAAAA
GATTTTTCATTAAAAGTATTAGAAAAAGCAAAAAAAATGAATATTACAGTTGTTTTTGATGAATCCTTCTTAGACTTTGT
TGAAGATAATGATAGATATTCTCTTATTAAAGAACTTAATAATTTCCAAAATTTAATTATAGTAAAATCTTTAACTAAAT
TATTTGCCTTTCCTGGAATAAGATTAGGTTATGGATTAAGTTCTAATAATAATTTTATAGAAAAAATAAATTCAGTAGTA
ACTCCTTGGAGTGTAAATACCGTAGCAGACTATGCCGGAAGAGAAGCATTAAAAGATGTTGAGTATATTAAAAACAGCGT
AGCTTACATAAAAAAAGAAAATGAATTTTTATATAATGGCCTAGAGAATTTTAAAGATATTACTACTTTTAAAGGTGCAG
TAAATTTTGTATTTTTTAAATTAAATAAAAATATAAATTTAAGAGAAGAATTAATTAGAAGAGGTATTATAATAAGAAGT
TGTAGTAATTATATTGGCTTAGACAATAGCTTCTATAGGGTGGCAGTTAGAACAAGGGAAGAAAACAAAAAGCTTTTAGA
AGAACTTTCAAAGGTTTTAAAATAA

Upstream 100 bases:

>100_bases
AAATTTCAGATGTTTATAAGACTAATAATATATTAGGAATGGTTTCTTTTTTAGGAATGGTAGTAGCACTTATTATTAGA
TGTATTTTAGAGGTGATTAT

Downstream 100 bases:

>100_bases
GCCTTATACTATTACTTTTATTATTAATAGGTTTTATATTAAATTAAGAAGTTTGACAATGATAAAATATAATAATATAA
TCAAGTTGATTAACTAATAA

Product: threonine-phosphate decarboxylase

Products: NA

Alternate protein names: L-threonine-O-3-phosphate decarboxylase [H]

Number of amino acids: Translated: 354; Mature: 354

Protein sequence:

>354_residues
MNLGHGGNVEEIKRIYGLKENEIIDFSANINPLGISERVKEAMVRGINSIERYPDITYYELKKGISNFEKVALENIVIGN
GAAEVIFNIVRGIKPKKALIVAPTFSEYEDALNSVECEVNHYILKDNYSVDNGFLEEIKEELDIIFLCNPNNPTGALIEK
DFSLKVLEKAKKMNITVVFDESFLDFVEDNDRYSLIKELNNFQNLIIVKSLTKLFAFPGIRLGYGLSSNNNFIEKINSVV
TPWSVNTVADYAGREALKDVEYIKNSVAYIKKENEFLYNGLENFKDITTFKGAVNFVFFKLNKNINLREELIRRGIIIRS
CSNYIGLDNSFYRVAVRTREENKKLLEELSKVLK

Sequences:

>Translated_354_residues
MNLGHGGNVEEIKRIYGLKENEIIDFSANINPLGISERVKEAMVRGINSIERYPDITYYELKKGISNFEKVALENIVIGN
GAAEVIFNIVRGIKPKKALIVAPTFSEYEDALNSVECEVNHYILKDNYSVDNGFLEEIKEELDIIFLCNPNNPTGALIEK
DFSLKVLEKAKKMNITVVFDESFLDFVEDNDRYSLIKELNNFQNLIIVKSLTKLFAFPGIRLGYGLSSNNNFIEKINSVV
TPWSVNTVADYAGREALKDVEYIKNSVAYIKKENEFLYNGLENFKDITTFKGAVNFVFFKLNKNINLREELIRRGIIIRS
CSNYIGLDNSFYRVAVRTREENKKLLEELSKVLK
>Mature_354_residues
MNLGHGGNVEEIKRIYGLKENEIIDFSANINPLGISERVKEAMVRGINSIERYPDITYYELKKGISNFEKVALENIVIGN
GAAEVIFNIVRGIKPKKALIVAPTFSEYEDALNSVECEVNHYILKDNYSVDNGFLEEIKEELDIIFLCNPNNPTGALIEK
DFSLKVLEKAKKMNITVVFDESFLDFVEDNDRYSLIKELNNFQNLIIVKSLTKLFAFPGIRLGYGLSSNNNFIEKINSVV
TPWSVNTVADYAGREALKDVEYIKNSVAYIKKENEFLYNGLENFKDITTFKGAVNFVFFKLNKNINLREELIRRGIIIRS
CSNYIGLDNSFYRVAVRTREENKKLLEELSKVLK

Specific function: Decarboxylates L-threonine-O-3-phosphate to yield (R)-1- amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin [H]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=312, Percent_Identity=27.2435897435897, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI1788627, Length=194, Percent_Identity=24.2268041237113, Blast_Score=63, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6322075, Length=339, Percent_Identity=23.8938053097345, Blast_Score=84, Evalue=4e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR005860
- InterPro:   IPR004838
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =4.1.1.81 [H]

Molecular weight: Translated: 40480; Mature: 40480

Theoretical pI: Translated: 5.41; Mature: 5.41

Prosite motif: PS00105 AA_TRANSFER_CLASS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLGHGGNVEEIKRIYGLKENEIIDFSANINPLGISERVKEAMVRGINSIERYPDITYYE
CCCCCCCCHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHH
LKKGISNFEKVALENIVIGNGAAEVIFNIVRGIKPKKALIVAPTFSEYEDALNSVECEVN
HHHHHHHHHHHHHHHEEECCCHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHCEEEEEE
HYILKDNYSVDNGFLEEIKEELDIIFLCNPNNPTGALIEKDFSLKVLEKAKKMNITVVFD
EEEEECCCCCCHHHHHHHHHHCCEEEEECCCCCCCCEEECCCCHHHHHHHHHCEEEEEEC
ESFLDFVEDNDRYSLIKELNNFQNLIIVKSLTKLFAFPGIRLGYGLSSNNNFIEKINSVV
CHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHHC
TPWSVNTVADYAGREALKDVEYIKNSVAYIKKENEFLYNGLENFKDITTFKGAVNFVFFK
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCEEEEEEE
LNKNINLREELIRRGIIIRSCSNYIGLDNSFYRVAVRTREENKKLLEELSKVLK
ECCCCCHHHHHHHCCHHEEECCCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHC
>Mature Secondary Structure
MNLGHGGNVEEIKRIYGLKENEIIDFSANINPLGISERVKEAMVRGINSIERYPDITYYE
CCCCCCCCHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHH
LKKGISNFEKVALENIVIGNGAAEVIFNIVRGIKPKKALIVAPTFSEYEDALNSVECEVN
HHHHHHHHHHHHHHHEEECCCHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHCEEEEEE
HYILKDNYSVDNGFLEEIKEELDIIFLCNPNNPTGALIEKDFSLKVLEKAKKMNITVVFD
EEEEECCCCCCHHHHHHHHHHCCEEEEECCCCCCCCEEECCCCHHHHHHHHHCEEEEEEC
ESFLDFVEDNDRYSLIKELNNFQNLIIVKSLTKLFAFPGIRLGYGLSSNNNFIEKINSVV
CHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHHC
TPWSVNTVADYAGREALKDVEYIKNSVAYIKKENEFLYNGLENFKDITTFKGAVNFVFFK
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCEEEEEEE
LNKNINLREELIRRGIIIRSCSNYIGLDNSFYRVAVRTREENKKLLEELSKVLK
ECCCCCHHHHHHHCCHHEEECCCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]