Click here to switch to the map view.

The map label for this gene is folA/folK [H]

Identifier: 18310004

GI number: 18310004

Start: 1224445

End: 1225266

Strand: Direct

Name: folA/folK [H]

Synonym: CPE1022

Alternate gene names: 18310004

Gene position: 1224445-1225266 (Clockwise)

Preceding gene: 18310003

Following gene: 18310006

Centisome position: 40.39

GC content: 28.1

Gene sequence:

>822_bases
ATGGATAAAATTATTATTAAAGATTTTGAGGTTTTTGGTAATCATGGAGTCTTTGAAGAGGAGAAGAGACTTGGACAAAA
ATTTGTTTTAAGTATAGAACTTTTCTTAGATACTAGAGAGGCGGGAGTTACTGGAGATTTAAGCAAATCTGTTCATTATG
GAGAACTTGCACATAAGGTTGAGGAAGAGTTTAAAAAGCAAAGCTATGATTTAATAGAAACTGCAGCTGAAAAATTATGT
GAGTTTATATTATTAGAATATCCTCTTGTAAAAAAAGTGAAAGTTTCTTTAAAGAAACCATGGGCACCTATATTAAGAAG
TTTAGATACTGTATCTATAGAAATAGAGAGAGGATGGAATGAGGCATACCTTTCATATGGTTCTAATATAGGAGATAAAA
AATATTATATAGAAGAAGCTTTAAAGGAAATAAATAAGGCTTATCATACTGAAATTATAAAAAAATCTAATTTAATTGAG
ACAGAACCTTGGGGATATACTGAGCAGGATGAATTTTTAAATGGTGCTTGTAAAATAAAAACTCTTTTAAACCCTAAGGA
ATTAATAAAATTTTTATTAAGTATAGAACAAAAGCTTAAAAGAGAGAGAAAGATTAAGTGGGGTCCTAGAACTATAGACT
TAGATGTAATATTTTTTAATGATTTAATAAGTGAAGATGAAGAAATCATACTTCCACATCCTAGAATGCATGAAAGAAGT
TTTGTTTTAGAGCCATTAAATGAAATTGCTCCATATAAGATTCATCCCTTATATAGAAAGCGTGTATTTGAACTTTTAGA
AGAATTAAATAAAAATAAATAA

Upstream 100 bases:

>100_bases
AATTAAAGGGTGCGAATTTGTAAGAGTTCATGATGTTTTAGAAAACAAGAGAACTGCCCTTATGACTGATGCTATGGTAA
GAAGATAGGAGTTAGATTTC

Downstream 100 bases:

>100_bases
ATATAAACAATCTATTATTAATAAAGATATAGAATTTAGTATAAATCACTACTAAATCCTATATCTTTTTTTATTGTTTT
TTATTAAAAACATACTGGCA

Product: dihydroneopterin aldolase/ 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase

Products: NA

Alternate protein names: Dihydroneopterin aldolase; DHNA; 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; PPPK; 7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase; HPPK [H]

Number of amino acids: Translated: 273; Mature: 273

Protein sequence:

>273_residues
MDKIIIKDFEVFGNHGVFEEEKRLGQKFVLSIELFLDTREAGVTGDLSKSVHYGELAHKVEEEFKKQSYDLIETAAEKLC
EFILLEYPLVKKVKVSLKKPWAPILRSLDTVSIEIERGWNEAYLSYGSNIGDKKYYIEEALKEINKAYHTEIIKKSNLIE
TEPWGYTEQDEFLNGACKIKTLLNPKELIKFLLSIEQKLKRERKIKWGPRTIDLDVIFFNDLISEDEEIILPHPRMHERS
FVLEPLNEIAPYKIHPLYRKRVFELLEELNKNK

Sequences:

>Translated_273_residues
MDKIIIKDFEVFGNHGVFEEEKRLGQKFVLSIELFLDTREAGVTGDLSKSVHYGELAHKVEEEFKKQSYDLIETAAEKLC
EFILLEYPLVKKVKVSLKKPWAPILRSLDTVSIEIERGWNEAYLSYGSNIGDKKYYIEEALKEINKAYHTEIIKKSNLIE
TEPWGYTEQDEFLNGACKIKTLLNPKELIKFLLSIEQKLKRERKIKWGPRTIDLDVIFFNDLISEDEEIILPHPRMHERS
FVLEPLNEIAPYKIHPLYRKRVFELLEELNKNK
>Mature_273_residues
MDKIIIKDFEVFGNHGVFEEEKRLGQKFVLSIELFLDTREAGVTGDLSKSVHYGELAHKVEEEFKKQSYDLIETAAEKLC
EFILLEYPLVKKVKVSLKKPWAPILRSLDTVSIEIERGWNEAYLSYGSNIGDKKYYIEEALKEINKAYHTEIIKKSNLIE
TEPWGYTEQDEFLNGACKIKTLLNPKELIKFLLSIEQKLKRERKIKWGPRTIDLDVIFFNDLISEDEEIILPHPRMHERS
FVLEPLNEIAPYKIHPLYRKRVFELLEELNKNK

Specific function: Dihydrofolate biosynthesis; first step. [C]

COG id: COG0801

COG function: function code H; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the HPPK family [H]

Homologues:

Organism=Escherichia coli, GI1786335, Length=136, Percent_Identity=36.7647058823529, Blast_Score=96, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6324073, Length=172, Percent_Identity=38.3720930232558, Blast_Score=125, Evalue=6e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006156
- InterPro:   IPR006157
- InterPro:   IPR000550 [H]

Pfam domain/function: PF02152 FolB; PF01288 HPPK [H]

EC number: =4.1.2.25; =2.7.6.3 [H]

Molecular weight: Translated: 32117; Mature: 32117

Theoretical pI: Translated: 5.97; Mature: 5.97

Prosite motif: PS00794 HPPK

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKIIIKDFEVFGNHGVFEEEKRLGQKFVLSIELFLDTREAGVTGDLSKSVHYGELAHKV
CCCEEEEHHHHHCCCCCCHHHHHCCHHHEEEEEEEEECHHCCCCCCHHHCCHHHHHHHHH
EEEFKKQSYDLIETAAEKLCEFILLEYPLVKKVKVSLKKPWAPILRSLDTVSIEIERGWN
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHCCCCEEEEEECCCC
EAYLSYGSNIGDKKYYIEEALKEINKAYHTEIIKKSNLIETEPWGYTEQDEFLNGACKIK
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHCCHHEEH
TLLNPKELIKFLLSIEQKLKRERKIKWGPRTIDLDVIFFNDLISEDEEIILPHPRMHERS
CCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEEEHHHHCCCCCEECCCCCCCCHH
FVLEPLNEIAPYKIHPLYRKRVFELLEELNKNK
HHHCCHHHCCCCEECHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MDKIIIKDFEVFGNHGVFEEEKRLGQKFVLSIELFLDTREAGVTGDLSKSVHYGELAHKV
CCCEEEEHHHHHCCCCCCHHHHHCCHHHEEEEEEEEECHHCCCCCCHHHCCHHHHHHHHH
EEEFKKQSYDLIETAAEKLCEFILLEYPLVKKVKVSLKKPWAPILRSLDTVSIEIERGWN
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHCCCCEEEEEECCCC
EAYLSYGSNIGDKKYYIEEALKEINKAYHTEIIKKSNLIETEPWGYTEQDEFLNGACKIK
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHCCHHEEH
TLLNPKELIKFLLSIEQKLKRERKIKWGPRTIDLDVIFFNDLISEDEEIILPHPRMHERS
CCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEEEHHHHCCCCCEECCCCCCCCHH
FVLEPLNEIAPYKIHPLYRKRVFELLEELNKNK
HHHCCHHHCCCCEECHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2168367; 7798151; 11463916; 8385663 [H]