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The map label for this gene is folP [C]

Identifier: 18310003

GI number: 18310003

Start: 1223623

End: 1224432

Strand: Direct

Name: folP [C]

Synonym: CPE1021

Alternate gene names: 18310003

Gene position: 1223623-1224432 (Clockwise)

Preceding gene: 18310002

Following gene: 18310004

Centisome position: 40.36

GC content: 32.72

Gene sequence:

>810_bases
GTGAAAATAGGAAATAAAGAGTTTGAAATAGGCAAAAGAACATATATAATGGGAATTTTAAATGTGACTCCAGATTCATT
TTCAGATGGTGGAAAATATAATGATATTGAGTTAGCTCTAAAGAGAGCTGAGAAGATGATTAATGATGGCGTTGACATAA
TAGATATTGGAGGAGAGTCAACAAGACCAACTCATACACCAGTAGGAGAAGAAGAAGAATTAAATAGAGTAGTACCTGTA
ATAAAAGCCTTAAGAGAAAAGTTTGATATACCTATATCAGTTGATACATATAAGGGGAAAGTGGCAGAGGAAGCCATAAA
AGCAGGTGCAGATTTAATAAATGATGTATGGGGCTTTAAAAAGGATAAATATATGGCTGCTGTGGCTGCTAAATATGGAG
TACCTTGTTGCATAATGCACAATAGAAATGATAATGAATATGGTGATGACATCATAGAAACTATGAAATCTGATATGGAA
GAATGTATAAAGATAGCCCTAGATGCTGGAGTTAAGAAAGAAAATATAATTTTAGACCCAGGTATAGGTTTTGCAAAGGA
TTATGATCAAAACTTAGAAGTATTAAATAGATTAGATGAGTTTTGCAATATGGACTATCCAGTTTTATTAGGAACATCAA
GAAAATCAGTAATAGGCAATACTTTAAATCTTCCAACAGATGAAAGATTAGAAGGTACTTTAGCTACAACTACTCTTGGA
ATAATTAAAGGGTGCGAATTTGTAAGAGTTCATGATGTTTTAGAAAACAAGAGAACTGCCCTTATGACTGATGCTATGGT
AAGAAGATAG

Upstream 100 bases:

>100_bases
TAAAAAATCAAGAAGCTGTTTTTTATGTAATGCTGAAAAACTTTGTAAGTGGAGCAAAGAAAAAAAGAATTTAGATATAA
TTATTTAAGGGGGAACTTTT

Downstream 100 bases:

>100_bases
GAGTTAGATTTCATGGATAAAATTATTATTAAAGATTTTGAGGTTTTTGGTAATCATGGAGTCTTTGAAGAGGAGAAGAG
ACTTGGACAAAAATTTGTTT

Product: dihydropteroate synthase

Products: NA

Alternate protein names: DHPS; Dihydropteroate pyrophosphorylase [H]

Number of amino acids: Translated: 269; Mature: 269

Protein sequence:

>269_residues
MKIGNKEFEIGKRTYIMGILNVTPDSFSDGGKYNDIELALKRAEKMINDGVDIIDIGGESTRPTHTPVGEEEELNRVVPV
IKALREKFDIPISVDTYKGKVAEEAIKAGADLINDVWGFKKDKYMAAVAAKYGVPCCIMHNRNDNEYGDDIIETMKSDME
ECIKIALDAGVKKENIILDPGIGFAKDYDQNLEVLNRLDEFCNMDYPVLLGTSRKSVIGNTLNLPTDERLEGTLATTTLG
IIKGCEFVRVHDVLENKRTALMTDAMVRR

Sequences:

>Translated_269_residues
MKIGNKEFEIGKRTYIMGILNVTPDSFSDGGKYNDIELALKRAEKMINDGVDIIDIGGESTRPTHTPVGEEEELNRVVPV
IKALREKFDIPISVDTYKGKVAEEAIKAGADLINDVWGFKKDKYMAAVAAKYGVPCCIMHNRNDNEYGDDIIETMKSDME
ECIKIALDAGVKKENIILDPGIGFAKDYDQNLEVLNRLDEFCNMDYPVLLGTSRKSVIGNTLNLPTDERLEGTLATTTLG
IIKGCEFVRVHDVLENKRTALMTDAMVRR
>Mature_269_residues
MKIGNKEFEIGKRTYIMGILNVTPDSFSDGGKYNDIELALKRAEKMINDGVDIIDIGGESTRPTHTPVGEEEELNRVVPV
IKALREKFDIPISVDTYKGKVAEEAIKAGADLINDVWGFKKDKYMAAVAAKYGVPCCIMHNRNDNEYGDDIIETMKSDME
ECIKIALDAGVKKENIILDPGIGFAKDYDQNLEVLNRLDEFCNMDYPVLLGTSRKSVIGNTLNLPTDERLEGTLATTTLG
IIKGCEFVRVHDVLENKRTALMTDAMVRR

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=247, Percent_Identity=44.9392712550607, Blast_Score=216, Evalue=1e-57,
Organism=Saccharomyces cerevisiae, GI6324073, Length=318, Percent_Identity=35.8490566037736, Blast_Score=157, Evalue=1e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 29984; Mature: 29984

Theoretical pI: Translated: 4.70; Mature: 4.70

Prosite motif: PS50972 PTERIN_BINDING ; PS00792 DHPS_1 ; PS00793 DHPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIGNKEFEIGKRTYIMGILNVTPDSFSDGGKYNDIELALKRAEKMINDGVDIIDIGGES
CCCCCCCHHCCCEEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEECCCCC
TRPTHTPVGEEEELNRVVPVIKALREKFDIPISVDTYKGKVAEEAIKAGADLINDVWGFK
CCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHHCCC
KDKYMAAVAAKYGVPCCIMHNRNDNEYGDDIIETMKSDMEECIKIALDAGVKKENIILDP
CHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECC
GIGFAKDYDQNLEVLNRLDEFCNMDYPVLLGTSRKSVIGNTLNLPTDERLEGTLATTTLG
CCCCHHCCCHHHHHHHHHHHHHCCCCCEEEECCCHHHHCCCCCCCCCHHHCCHHHHHHHH
IIKGCEFVRVHDVLENKRTALMTDAMVRR
HHHCCCHHHHHHHHHCCHHHHHHHHHHCC
>Mature Secondary Structure
MKIGNKEFEIGKRTYIMGILNVTPDSFSDGGKYNDIELALKRAEKMINDGVDIIDIGGES
CCCCCCCHHCCCEEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEECCCCC
TRPTHTPVGEEEELNRVVPVIKALREKFDIPISVDTYKGKVAEEAIKAGADLINDVWGFK
CCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHHCCC
KDKYMAAVAAKYGVPCCIMHNRNDNEYGDDIIETMKSDMEECIKIALDAGVKKENIILDP
CHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECC
GIGFAKDYDQNLEVLNRLDEFCNMDYPVLLGTSRKSVIGNTLNLPTDERLEGTLATTTLG
CCCCHHCCCHHHHHHHHHHHHHCCCCCEEEECCCHHHHCCCCCCCCCHHHCCHHHHHHHH
IIKGCEFVRVHDVLENKRTALMTDAMVRR
HHHCCCHHHHHHHHHCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8396545 [H]