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The map label for this gene is sdhA [H]

Identifier: 18309971

GI number: 18309971

Start: 1192185

End: 1193063

Strand: Direct

Name: sdhA [H]

Synonym: CPE0989

Alternate gene names: 18309971

Gene position: 1192185-1193063 (Clockwise)

Preceding gene: 18309970

Following gene: 18309973

Centisome position: 39.33

GC content: 35.95

Gene sequence:

>879_bases
ATGAGAGTTGCAAAAACTGGAGAAGAACTTTTAGATATATGTAAAGAAGAAGGGATTAAGCTTAGTGAATATGCCTTAAG
ATGTGAAATGCAAAGTAAAAATCTTTCTAAAGAAGAAGTTTTAGAGAAACTTTCAAAAACTTTAGAGGTTATGAAAAAAT
CATCATCAAAAGGAAGAGAAGAAGAAGTATATTCACTTAGTGGATTAATAGGAGGAGATGCTTTTAAACTTCAAAAGTAT
TTAGAATCTGGAAAATCTTTCACAGGTAATGGAGCTATATTAGCTATGGCTATGGCTATTTCTTCATCTGAAGTAAATGC
TTCTATGGGAAAAATAATTGCTTGTCCAACAGCGGGCTCTTGTGGAATTCTTCCAGCGGTAATGTTAACAGCTAAGGAAA
GATTAAATCTTCAAGATGAAGATTTATTATATGGACTTTTAGCAGCATCAGCTATTGAGCTTATAATTGGGAAAAATGCT
ACATTTTCAGGAGCAGAAGGTGGATGTCAAGCAGAATGTGGCTCAGCATCTGCCATGGCAGCTGGTGGTCTTGTAGAACT
TATGGGAGGGACAACAGAAATGTCATTAAATGCCGCTGCAATAGTAATAAAGAATATATTAGGTCTTGTTTGTGATCCTG
TTGCAGGCCTTGTTGAAATTCCTTGTGCTAAAAGAAATGCTTCAGGTGCCGTAAATGCTATATGTGCAGCAGATCTTGTA
ATGGCTGGAATAGAATCAAAAATACCTTTTGATGATACAGTAAGTGCTATGGCTCAAGTTGGAAAGGCTCTTCCAGAGAC
CTTAAGAGAAACAGCACTTGGAGGAGTAGCTATTACAAAAACAGGGCTTATGTTGAAGAAAAAAGTATTTGGTAAGTAA

Upstream 100 bases:

>100_bases
AGATAATAAGATTGATGAATCTGTTATAAAGAGAATGGAAGAAATAGATGGAATAAAAAAAGTTATACTTATAAATTTAG
AAGAAGAGGGTGAATAACAT

Downstream 100 bases:

>100_bases
TTTTAATAATATAAATTTATATTATGTATTTACAAAAAAAGTGTACAAGTATTAACTTGTACACTTTTTACATTTTCTTT
ACTATTTCTTTATCCCATAC

Product: L-serine dehydratase alpha subunit

Products: NA

Alternate protein names: SDH; L-serine deaminase; L-SD [H]

Number of amino acids: Translated: 292; Mature: 292

Protein sequence:

>292_residues
MRVAKTGEELLDICKEEGIKLSEYALRCEMQSKNLSKEEVLEKLSKTLEVMKKSSSKGREEEVYSLSGLIGGDAFKLQKY
LESGKSFTGNGAILAMAMAISSSEVNASMGKIIACPTAGSCGILPAVMLTAKERLNLQDEDLLYGLLAASAIELIIGKNA
TFSGAEGGCQAECGSASAMAAGGLVELMGGTTEMSLNAAAIVIKNILGLVCDPVAGLVEIPCAKRNASGAVNAICAADLV
MAGIESKIPFDDTVSAMAQVGKALPETLRETALGGVAITKTGLMLKKKVFGK

Sequences:

>Translated_292_residues
MRVAKTGEELLDICKEEGIKLSEYALRCEMQSKNLSKEEVLEKLSKTLEVMKKSSSKGREEEVYSLSGLIGGDAFKLQKY
LESGKSFTGNGAILAMAMAISSSEVNASMGKIIACPTAGSCGILPAVMLTAKERLNLQDEDLLYGLLAASAIELIIGKNA
TFSGAEGGCQAECGSASAMAAGGLVELMGGTTEMSLNAAAIVIKNILGLVCDPVAGLVEIPCAKRNASGAVNAICAADLV
MAGIESKIPFDDTVSAMAQVGKALPETLRETALGGVAITKTGLMLKKKVFGK
>Mature_292_residues
MRVAKTGEELLDICKEEGIKLSEYALRCEMQSKNLSKEEVLEKLSKTLEVMKKSSSKGREEEVYSLSGLIGGDAFKLQKY
LESGKSFTGNGAILAMAMAISSSEVNASMGKIIACPTAGSCGILPAVMLTAKERLNLQDEDLLYGLLAASAIELIIGKNA
TFSGAEGGCQAECGSASAMAAGGLVELMGGTTEMSLNAAAIVIKNILGLVCDPVAGLVEIPCAKRNASGAVNAICAADLV
MAGIESKIPFDDTVSAMAQVGKALPETLRETALGGVAITKTGLMLKKKVFGK

Specific function: Anaerobic degradation of L-threonine to propionate. [C]

COG id: COG1760

COG function: function code E; L-serine deaminase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-sulfur dependent L-serine dehydratase family [H]

Homologues:

Organism=Escherichia coli, GI48994925, Length=281, Percent_Identity=36.2989323843416, Blast_Score=153, Evalue=1e-38,
Organism=Escherichia coli, GI1788116, Length=285, Percent_Identity=35.0877192982456, Blast_Score=146, Evalue=2e-36,
Organism=Escherichia coli, GI1789161, Length=281, Percent_Identity=35.9430604982206, Blast_Score=142, Evalue=3e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005130
- InterPro:   IPR004642 [H]

Pfam domain/function: PF03313 SDH_alpha [H]

EC number: =4.3.1.17 [H]

Molecular weight: Translated: 30267; Mature: 30267

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.1 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
7.5 %Cys+Met (Translated Protein)
3.1 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
7.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVAKTGEELLDICKEEGIKLSEYALRCEMQSKNLSKEEVLEKLSKTLEVMKKSSSKGRE
CCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCH
EEVYSLSGLIGGDAFKLQKYLESGKSFTGNGAILAMAMAISSSEVNASMGKIIACPTAGS
HHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCHHHHHCCCCEEECCCCCC
CGILPAVMLTAKERLNLQDEDLLYGLLAASAIELIIGKNATFSGAEGGCQAECGSASAMA
CHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHH
AGGLVELMGGTTEMSLNAAAIVIKNILGLVCDPVAGLVEIPCAKRNASGAVNAICAADLV
HCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHH
MAGIESKIPFDDTVSAMAQVGKALPETLRETALGGVAITKTGLMLKKKVFGK
HHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRVAKTGEELLDICKEEGIKLSEYALRCEMQSKNLSKEEVLEKLSKTLEVMKKSSSKGRE
CCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCH
EEVYSLSGLIGGDAFKLQKYLESGKSFTGNGAILAMAMAISSSEVNASMGKIIACPTAGS
HHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCHHHHHCCCCEEECCCCCC
CGILPAVMLTAKERLNLQDEDLLYGLLAASAIELIIGKNATFSGAEGGCQAECGSASAMA
CHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHH
AGGLVELMGGTTEMSLNAAAIVIKNILGLVCDPVAGLVEIPCAKRNASGAVNAICAADLV
HCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHH
MAGIESKIPFDDTVSAMAQVGKALPETLRETALGGVAITKTGLMLKKKVFGK
HHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9244285; 2065681 [H]