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The map label for this gene is phoR [H]

Identifier: 18309968

GI number: 18309968

Start: 1188307

End: 1190178

Strand: Direct

Name: phoR [H]

Synonym: CPE0986

Alternate gene names: 18309968

Gene position: 1188307-1190178 (Clockwise)

Preceding gene: 18309964

Following gene: 18309969

Centisome position: 39.2

GC content: 25.32

Gene sequence:

>1872_bases
ATGAAGGATTTTAATTTTGAAGAAATATTAGAGTCATGTCCTATGGATTATATTTATGGGAAGCTAAAGAATAAAGATTC
TAGTGATTTATTTGTACTTAAGTCTAGCATAAAAGAATTTAATAGCAAATTGTTAAGTGAAGTACTAGGTAGTGATATAG
ATTTTAAAACTATATTTAGTAAAAGTAATATTCATGGAGAAGGGTATTATAAAGACTTAAATGAAAACCTTAGTTTAAAG
CTTCTTAATAATGATTATGTAATTATTTGGTTTAGTCAATATTTATTGGAGAAATATAATAAACTAGAAATTAATCTAAA
AAAAGAAAAAGACATGTTAGATTTATTTTTAGATTCTTTAACAGATTACGTATTTTTTAAGGACATTGATGGAAGATATA
TAAATTGTAATAAGGCTTTTGAAAATAAAGTTGGAATTGAGAAAAAATATATAATTGGAAAAACTGATAAAGATATATTT
TTTGATGATCCAAGTAAGGTAGAAACATTTATTAAAACAGATAGAGAGGTTATTAATTCAAGAGAAAAGAAAGTTTATGG
TGAAGAATGGGGATTTGAATGTGAAGATGGGTATTTAGAAGAGACTGTAAAATCCCCATATTTTGATGAAAATAATGAAG
TTAAAGGTATAATTGGACTAACAAGGGATATTTCCTATAAAAAAGCTATAGAATATAGGCTTAAGAAAAATGATAAAATG
TTTTTTGAAGTTTTTAATTACTTAGATGATGTTGTAATTATAAAAGAAGGAGAAAAAACTATTTATGTAAACCATGCCTT
TGAAAAATTATATGGATTAAATTGTAAAGAGTTATACAAAGAAAAAAGTATGATTGTGAAATTAGATAGAATTCATCCAG
AGGATAGATATAAGTTTAGTAATATTGATTTTGAGGATTTTTTTATGGAGAAGGCTAGAATTGTTAGAGCAGACAATGAA
GTTAGAAATGTTTTATTTAGAGCAAACTCCATAAAAAATGAAAATGGAGAATCTATAAGGAGAATCATAGTTATAAATGA
TATTACAGATACTATAGAAAAAAGTAATGAGATGGAAAAGCTTAGAATGGAGTTCTTTGCTAATATATCTCATGAATTTA
AGACACCTGTAAATTTAATATACAGTGCACTTCAGCTTTTAGAATTAAAGTTGAAAAATAATATAGATAGGGATGAAGAG
AGTTATATTAATTATATTAAAATGGCTAAGCAGAATGTTTTTAGATTATTAAAGTTAATAAATAATTTAATAGATAGTAC
TAAGCTAGAAGCAGGCTTTTTTAATGTTAATATTAAAAATCATGATATAGTAAGTTGTGTTGAGGATATAACAATGTCTA
TATGTGGTTTTGCTGAAAAAAATAAAATTTCCATAACTTTTGATACAGAAGAGGAAGAAAAAATAATTGCTTTTGATTTG
AATCATTTAGAAAGGATATTATTAAATATTTTATCCAATGCTATAAAATTTAATCGGGAAAATGGTAATATAGATGTCTA
TATGAGTTTTGATGAAAGGTATGCAAATATAAGTATTAAAGACACGGGTATAGGCATACAAAAGGATAAAATAGACTTGC
TTTTTGATAGATTTAAAAAAATAAATAATAGATTAACCAAGGTTAATGAGGGAAGTGGAATAGGACTTTTTATAGCTAAG
GAGCTTGTAAAAATTAATGGGGGTGAGATGATAGTTAATAGTGAACTAGGAGAAGGAACAGAGTTTATAATAAAACTTCC
AATTAAAAAGATGGAAAGTGAAGTTTTAGATGAGATAGCCTTAACATCCTGTGAAAGAGAAAATAGAGAAGAACTTTACA
AAGTGGAGTTATCAGATATTTATAGCCTTTAG

Upstream 100 bases:

>100_bases
TTAAAGTTCCAAAATGAATATAATAAAAATAAAATAAGGGAAAGAATGTTTTAACTTGAAAATAATTGATTTTCATAACT
TAAAGGGGAGTTATACTATT

Downstream 100 bases:

>100_bases
AAGAAAAGCTGTATCAATTGATACAGCTTTTTATTTTTTATTATACTATTAAAAATTTAAATTTAAATATTTATGTTATT
TATTATACAAATTTTTAATA

Product: two-component sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 623; Mature: 623

Protein sequence:

>623_residues
MKDFNFEEILESCPMDYIYGKLKNKDSSDLFVLKSSIKEFNSKLLSEVLGSDIDFKTIFSKSNIHGEGYYKDLNENLSLK
LLNNDYVIIWFSQYLLEKYNKLEINLKKEKDMLDLFLDSLTDYVFFKDIDGRYINCNKAFENKVGIEKKYIIGKTDKDIF
FDDPSKVETFIKTDREVINSREKKVYGEEWGFECEDGYLEETVKSPYFDENNEVKGIIGLTRDISYKKAIEYRLKKNDKM
FFEVFNYLDDVVIIKEGEKTIYVNHAFEKLYGLNCKELYKEKSMIVKLDRIHPEDRYKFSNIDFEDFFMEKARIVRADNE
VRNVLFRANSIKNENGESIRRIIVINDITDTIEKSNEMEKLRMEFFANISHEFKTPVNLIYSALQLLELKLKNNIDRDEE
SYINYIKMAKQNVFRLLKLINNLIDSTKLEAGFFNVNIKNHDIVSCVEDITMSICGFAEKNKISITFDTEEEEKIIAFDL
NHLERILLNILSNAIKFNRENGNIDVYMSFDERYANISIKDTGIGIQKDKIDLLFDRFKKINNRLTKVNEGSGIGLFIAK
ELVKINGGEMIVNSELGEGTEFIIKLPIKKMESEVLDEIALTSCERENREELYKVELSDIYSL

Sequences:

>Translated_623_residues
MKDFNFEEILESCPMDYIYGKLKNKDSSDLFVLKSSIKEFNSKLLSEVLGSDIDFKTIFSKSNIHGEGYYKDLNENLSLK
LLNNDYVIIWFSQYLLEKYNKLEINLKKEKDMLDLFLDSLTDYVFFKDIDGRYINCNKAFENKVGIEKKYIIGKTDKDIF
FDDPSKVETFIKTDREVINSREKKVYGEEWGFECEDGYLEETVKSPYFDENNEVKGIIGLTRDISYKKAIEYRLKKNDKM
FFEVFNYLDDVVIIKEGEKTIYVNHAFEKLYGLNCKELYKEKSMIVKLDRIHPEDRYKFSNIDFEDFFMEKARIVRADNE
VRNVLFRANSIKNENGESIRRIIVINDITDTIEKSNEMEKLRMEFFANISHEFKTPVNLIYSALQLLELKLKNNIDRDEE
SYINYIKMAKQNVFRLLKLINNLIDSTKLEAGFFNVNIKNHDIVSCVEDITMSICGFAEKNKISITFDTEEEEKIIAFDL
NHLERILLNILSNAIKFNRENGNIDVYMSFDERYANISIKDTGIGIQKDKIDLLFDRFKKINNRLTKVNEGSGIGLFIAK
ELVKINGGEMIVNSELGEGTEFIIKLPIKKMESEVLDEIALTSCERENREELYKVELSDIYSL
>Mature_623_residues
MKDFNFEEILESCPMDYIYGKLKNKDSSDLFVLKSSIKEFNSKLLSEVLGSDIDFKTIFSKSNIHGEGYYKDLNENLSLK
LLNNDYVIIWFSQYLLEKYNKLEINLKKEKDMLDLFLDSLTDYVFFKDIDGRYINCNKAFENKVGIEKKYIIGKTDKDIF
FDDPSKVETFIKTDREVINSREKKVYGEEWGFECEDGYLEETVKSPYFDENNEVKGIIGLTRDISYKKAIEYRLKKNDKM
FFEVFNYLDDVVIIKEGEKTIYVNHAFEKLYGLNCKELYKEKSMIVKLDRIHPEDRYKFSNIDFEDFFMEKARIVRADNE
VRNVLFRANSIKNENGESIRRIIVINDITDTIEKSNEMEKLRMEFFANISHEFKTPVNLIYSALQLLELKLKNNIDRDEE
SYINYIKMAKQNVFRLLKLINNLIDSTKLEAGFFNVNIKNHDIVSCVEDITMSICGFAEKNKISITFDTEEEEKIIAFDL
NHLERILLNILSNAIKFNRENGNIDVYMSFDERYANISIKDTGIGIQKDKIDLLFDRFKKINNRLTKVNEGSGIGLFIAK
ELVKINGGEMIVNSELGEGTEFIIKLPIKKMESEVLDEIALTSCERENREELYKVELSDIYSL

Specific function: Member of the two-component regulatory system phoP/phoR involved in the alkaline phosphatase genes regulation. PhoR may function as a membrane-associated protein kinase that phosphorylates phoP in response to environmental signals [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1789149, Length=237, Percent_Identity=28.6919831223629, Blast_Score=107, Evalue=3e-24,
Organism=Escherichia coli, GI1788713, Length=277, Percent_Identity=28.5198555956679, Blast_Score=106, Evalue=5e-24,
Organism=Escherichia coli, GI145693157, Length=246, Percent_Identity=26.4227642276423, Blast_Score=105, Evalue=8e-24,
Organism=Escherichia coli, GI48994928, Length=259, Percent_Identity=27.4131274131274, Blast_Score=97, Evalue=3e-21,
Organism=Escherichia coli, GI1786912, Length=234, Percent_Identity=25.2136752136752, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1786600, Length=247, Percent_Identity=25.1012145748988, Blast_Score=86, Evalue=8e-18,
Organism=Escherichia coli, GI87081816, Length=234, Percent_Identity=25.6410256410256, Blast_Score=83, Evalue=7e-17,
Organism=Escherichia coli, GI87082128, Length=238, Percent_Identity=25.6302521008403, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI1788393, Length=255, Percent_Identity=21.5686274509804, Blast_Score=78, Evalue=2e-15,
Organism=Escherichia coli, GI1790436, Length=228, Percent_Identity=25.8771929824561, Blast_Score=75, Evalue=2e-14,
Organism=Escherichia coli, GI1788549, Length=273, Percent_Identity=23.4432234432234, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI1786783, Length=231, Percent_Identity=28.1385281385281, Blast_Score=74, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 73084; Mature: 73084

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: PS50112 PAS ; PS50113 PAC ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKDFNFEEILESCPMDYIYGKLKNKDSSDLFVLKSSIKEFNSKLLSEVLGSDIDFKTIFS
CCCCCHHHHHHHCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEC
KSNIHGEGYYKDLNENLSLKLLNNDYVIIWFSQYLLEKYNKLEINLKKEKDMLDLFLDSL
CCCCCCCCCHHCCCCCCEEEEECCCEEEEEEHHHHHHCCCEEEEEEECHHHHHHHHHHHH
TDYVFFKDIDGRYINCNKAFENKVGIEKKYIIGKTDKDIFFDDPSKVETFIKTDREVINS
HHEEEEEECCCCEEECCHHHHHCCCCCEEEEECCCCCCCEECCHHHHHHHHHHHHHHHCC
REKKVYGEEWGFECEDGYLEETVKSPYFDENNEVKGIIGLTRDISYKKAIEYRLKKNDKM
HHHHCCCHHCCCCCCCCHHHHHHCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHCCCCHH
FFEVFNYLDDVVIIKEGEKTIYVNHAFEKLYGLNCKELYKEKSMIVKLDRIHPEDRYKFS
HHHHHHHHCCEEEEECCCEEEEEEEHHHHHHCCCHHHHHHHHHHEEEEECCCCCCCCEEC
NIDFEDFFMEKARIVRADNEVRNVLFRANSIKNENGESIRRIIVINDITDTIEKSNEMEK
CCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCEEEEEEEECCHHHHHCCCHHHH
LRMEFFANISHEFKTPVNLIYSALQLLELKLKNNIDRDEESYINYIKMAKQNVFRLLKLI
HHHHHHHCCCHHCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHH
NNLIDSTKLEAGFFNVNIKNHDIVSCVEDITMSICGFAEKNKISITFDTEEEEKIIAFDL
HHHHHCCEECCEEEEEEECCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCEEEEEEH
NHLERILLNILSNAIKFNRENGNIDVYMSFDERYANISIKDTGIGIQKDKIDLLFDRFKK
HHHHHHHHHHHHHHHEECCCCCCEEEEEEECCCEEEEEEEECCCCCCHHHHHHHHHHHHH
INNRLTKVNEGSGIGLFIAKELVKINGGEMIVNSELGEGTEFIIKLPIKKMESEVLDEIA
HHHHHEECCCCCCEEHHHHHHHHHCCCCCEEEECCCCCCCEEEEECCHHHHHHHHHHHHH
LTSCERENREELYKVELSDIYSL
HHHHCCCCHHHHEEEEHHHHHCC
>Mature Secondary Structure
MKDFNFEEILESCPMDYIYGKLKNKDSSDLFVLKSSIKEFNSKLLSEVLGSDIDFKTIFS
CCCCCHHHHHHHCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEC
KSNIHGEGYYKDLNENLSLKLLNNDYVIIWFSQYLLEKYNKLEINLKKEKDMLDLFLDSL
CCCCCCCCCHHCCCCCCEEEEECCCEEEEEEHHHHHHCCCEEEEEEECHHHHHHHHHHHH
TDYVFFKDIDGRYINCNKAFENKVGIEKKYIIGKTDKDIFFDDPSKVETFIKTDREVINS
HHEEEEEECCCCEEECCHHHHHCCCCCEEEEECCCCCCCEECCHHHHHHHHHHHHHHHCC
REKKVYGEEWGFECEDGYLEETVKSPYFDENNEVKGIIGLTRDISYKKAIEYRLKKNDKM
HHHHCCCHHCCCCCCCCHHHHHHCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHCCCCHH
FFEVFNYLDDVVIIKEGEKTIYVNHAFEKLYGLNCKELYKEKSMIVKLDRIHPEDRYKFS
HHHHHHHHCCEEEEECCCEEEEEEEHHHHHHCCCHHHHHHHHHHEEEEECCCCCCCCEEC
NIDFEDFFMEKARIVRADNEVRNVLFRANSIKNENGESIRRIIVINDITDTIEKSNEMEK
CCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCEEEEEEEECCHHHHHCCCHHHH
LRMEFFANISHEFKTPVNLIYSALQLLELKLKNNIDRDEESYINYIKMAKQNVFRLLKLI
HHHHHHHCCCHHCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHH
NNLIDSTKLEAGFFNVNIKNHDIVSCVEDITMSICGFAEKNKISITFDTEEEEKIIAFDL
HHHHHCCEECCEEEEEEECCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCEEEEEEH
NHLERILLNILSNAIKFNRENGNIDVYMSFDERYANISIKDTGIGIQKDKIDLLFDRFKK
HHHHHHHHHHHHHHHEECCCCCCEEEEEEECCCEEEEEEEECCCCCCHHHHHHHHHHHHH
INNRLTKVNEGSGIGLFIAKELVKINGGEMIVNSELGEGTEFIIKLPIKKMESEVLDEIA
HHHHHEECCCCCCEEHHHHHHHHHCCCCCEEEECCCCCCCEEEEECCHHHHHHHHHHHHH
LTSCERENREELYKVELSDIYSL
HHHHCCCCHHHHEEEEHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3142862; 9387221; 9384377 [H]