Click here to switch to the map view.

The map label for this gene is gpo [H]

Identifier: 18309936

GI number: 18309936

Start: 1152358

End: 1152894

Strand: Direct

Name: gpo [H]

Synonym: CPE0954

Alternate gene names: 18309936

Gene position: 1152358-1152894 (Clockwise)

Preceding gene: 18309935

Following gene: 18309940

Centisome position: 38.01

GC content: 29.98

Gene sequence:

>537_bases
ATGCTATATGATTTTAAAGTTAAGGATATTGAAGGAAATGAGGTTTCTTTAGGGGAGTATAAAGGAAAGGTTCTTTTAAT
AGTTAATACTGCAACAGGATGTGGATTTACTCCTCAATATGAAGGATTAGAAGTGCTTTATAAAAAATACCATGATAAAG
GGTTTGAAATATTAGATTTTCCATGTAATCAGTTCTTTGAGCAAGCACCAGGAAGCAATGAAGAAATCGTTGGATTTTGC
AAATTAAACTATGGAACTACATTTAAGACCTTTGCAAAAGTAGAGGTTAATGGAGAGAATGCTTGTGAATTATACAAATT
TTTAAAGAAAGAAGCTCCAATGGCAAAGGAAGATGAAACATCTTTAGGATTTTATGATAAATTAAAAGGCTTAGGATTTA
CTACAGAAGGAGAAGAAATAAAGTGGAATTTCACTAAGTTTTTAATAGATAAAAATGGTGAAGTTGTTGCTAGATTTGCA
CCTACATTTGAACCTGAAAAGTTAGATGAATTAATAGAAGAATTATTAGAAGAATAA

Upstream 100 bases:

>100_bases
TTATATAATTTTAAAAAATTTTCAGTATTTTTGGATTAAAAAAATTTTTATAGGATAAATTAAAAAGGTATTAAAATACA
TTAAAAGGAGAGATTTAATT

Downstream 100 bases:

>100_bases
TACAGTTTTTAAGGAAAAGACCTATGATTAGATTTTTAATACTAATCATAGGTCTTTTAATGTTTTAATGTGAATTTAAT
AAATTAAAGTTAACTAATTA

Product: glutathione peroxidase

Products: glutathione disulfide; H2O

Alternate protein names: NA

Number of amino acids: Translated: 178; Mature: 178

Protein sequence:

>178_residues
MLYDFKVKDIEGNEVSLGEYKGKVLLIVNTATGCGFTPQYEGLEVLYKKYHDKGFEILDFPCNQFFEQAPGSNEEIVGFC
KLNYGTTFKTFAKVEVNGENACELYKFLKKEAPMAKEDETSLGFYDKLKGLGFTTEGEEIKWNFTKFLIDKNGEVVARFA
PTFEPEKLDELIEELLEE

Sequences:

>Translated_178_residues
MLYDFKVKDIEGNEVSLGEYKGKVLLIVNTATGCGFTPQYEGLEVLYKKYHDKGFEILDFPCNQFFEQAPGSNEEIVGFC
KLNYGTTFKTFAKVEVNGENACELYKFLKKEAPMAKEDETSLGFYDKLKGLGFTTEGEEIKWNFTKFLIDKNGEVVARFA
PTFEPEKLDELIEELLEE
>Mature_178_residues
MLYDFKVKDIEGNEVSLGEYKGKVLLIVNTATGCGFTPQYEGLEVLYKKYHDKGFEILDFPCNQFFEQAPGSNEEIVGFC
KLNYGTTFKTFAKVEVNGENACELYKFLKKEAPMAKEDETSLGFYDKLKGLGFTTEGEEIKWNFTKFLIDKNGEVVARFA
PTFEPEKLDELIEELLEE

Specific function: Important in the cellular metabolism or defense processes particular to this pathogen [H]

COG id: COG0386

COG function: function code O; Glutathione peroxidase

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutathione peroxidase family [H]

Homologues:

Organism=Homo sapiens, GI90903240, Length=165, Percent_Identity=43.030303030303, Blast_Score=120, Evalue=6e-28,
Organism=Homo sapiens, GI75709200, Length=165, Percent_Identity=43.030303030303, Blast_Score=120, Evalue=7e-28,
Organism=Homo sapiens, GI15618997, Length=177, Percent_Identity=36.1581920903955, Blast_Score=117, Evalue=6e-27,
Organism=Homo sapiens, GI192455698, Length=160, Percent_Identity=35.625, Blast_Score=102, Evalue=1e-22,
Organism=Homo sapiens, GI41406084, Length=184, Percent_Identity=34.7826086956522, Blast_Score=99, Evalue=1e-21,
Organism=Homo sapiens, GI90903238, Length=147, Percent_Identity=40.1360544217687, Blast_Score=98, Evalue=5e-21,
Organism=Homo sapiens, GI4557629, Length=165, Percent_Identity=36.3636363636364, Blast_Score=96, Evalue=2e-20,
Organism=Homo sapiens, GI6006001, Length=164, Percent_Identity=35.9756097560976, Blast_Score=87, Evalue=6e-18,
Organism=Homo sapiens, GI32967607, Length=181, Percent_Identity=32.0441988950276, Blast_Score=84, Evalue=6e-17,
Organism=Homo sapiens, GI33186887, Length=184, Percent_Identity=29.8913043478261, Blast_Score=80, Evalue=1e-15,
Organism=Escherichia coli, GI1788003, Length=172, Percent_Identity=47.093023255814, Blast_Score=158, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI17506887, Length=178, Percent_Identity=41.0112359550562, Blast_Score=125, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI71993584, Length=176, Percent_Identity=38.6363636363636, Blast_Score=124, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI193209493, Length=186, Percent_Identity=36.5591397849462, Blast_Score=123, Evalue=6e-29,
Organism=Caenorhabditis elegans, GI17550320, Length=186, Percent_Identity=34.9462365591398, Blast_Score=119, Evalue=8e-28,
Organism=Caenorhabditis elegans, GI17535473, Length=177, Percent_Identity=38.9830508474576, Blast_Score=119, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI193210707, Length=178, Percent_Identity=39.3258426966292, Blast_Score=116, Evalue=6e-27,
Organism=Caenorhabditis elegans, GI71999642, Length=77, Percent_Identity=40.2597402597403, Blast_Score=75, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI193210709, Length=73, Percent_Identity=49.3150684931507, Blast_Score=72, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71993573, Length=95, Percent_Identity=37.8947368421053, Blast_Score=71, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6319721, Length=177, Percent_Identity=49.7175141242938, Blast_Score=167, Evalue=1e-42,
Organism=Saccharomyces cerevisiae, GI6322228, Length=177, Percent_Identity=48.5875706214689, Blast_Score=157, Evalue=1e-39,
Organism=Saccharomyces cerevisiae, GI6322826, Length=177, Percent_Identity=38.9830508474576, Blast_Score=122, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24656772, Length=177, Percent_Identity=44.6327683615819, Blast_Score=135, Evalue=1e-32,
Organism=Drosophila melanogaster, GI24656767, Length=177, Percent_Identity=44.6327683615819, Blast_Score=134, Evalue=3e-32,
Organism=Drosophila melanogaster, GI24656777, Length=177, Percent_Identity=44.6327683615819, Blast_Score=134, Evalue=3e-32,
Organism=Drosophila melanogaster, GI85726443, Length=177, Percent_Identity=36.7231638418079, Blast_Score=111, Evalue=2e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000889
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00255 GSHPx [H]

EC number: 1.11.1.9

Molecular weight: Translated: 20343; Mature: 20343

Theoretical pI: Translated: 4.33; Mature: 4.33

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00460 GLUTATHIONE_PEROXID_1 ; PS00763 GLUTATHIONE_PEROXID_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLYDFKVKDIEGNEVSLGEYKGKVLLIVNTATGCGFTPQYEGLEVLYKKYHDKGFEILDF
CCEEEEEECCCCCEEECCCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHCCCCCEEEEC
PCNQFFEQAPGSNEEIVGFCKLNYGTTFKTFAKVEVNGENACELYKFLKKEAPMAKEDET
CHHHHHHHCCCCCCCEEEEEEECCCCCEEEEEEEEECCCCHHHHHHHHHHHCCCCCCCCC
SLGFYDKLKGLGFTTEGEEIKWNFTKFLIDKNGEVVARFAPTFEPEKLDELIEELLEE
CCCHHHHHCCCCCCCCCCEEEEEEEEEEECCCCCEEEEECCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MLYDFKVKDIEGNEVSLGEYKGKVLLIVNTATGCGFTPQYEGLEVLYKKYHDKGFEILDF
CCEEEEEECCCCCEEECCCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHCCCCCEEEEC
PCNQFFEQAPGSNEEIVGFCKLNYGTTFKTFAKVEVNGENACELYKFLKKEAPMAKEDET
CHHHHHHHCCCCCCCEEEEEEECCCCCEEEEEEEEECCCCHHHHHHHHHHHCCCCCCCCC
SLGFYDKLKGLGFTTEGEEIKWNFTKFLIDKNGEVVARFAPTFEPEKLDELIEELLEE
CCCHHHHHCCCCCCCCCCEEEEEEEEEEECCCCCEEEEECCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: glutathione; H2O2

Specific reaction: 2 glutathione + H2O2 = glutathione disulfide + 2 H2O

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10722605; 10761919 [H]