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The map label for this gene is adhE [H]

Identifier: 18309884

GI number: 18309884

Start: 1103887

End: 1105365

Strand: Direct

Name: adhE [H]

Synonym: CPE0902

Alternate gene names: 18309884

Gene position: 1103887-1105365 (Clockwise)

Preceding gene: 18309883

Following gene: 18309885

Centisome position: 36.41

GC content: 34.96

Gene sequence:

>1479_bases
ATGGAGTTTTTAGATAAAGACTTAGTTTCCATACAGGAAACTAGGGGGCTTATAAGAAAGGCTAAAGAAGCTCAAAGCAA
GTTAGCCCGTATGAGTCAACAAGACATAGACAGAATAGTTAAAGCTATATCTGATGCTGCTTATGAAAATTCTGAAAAAC
TTGCTAAGATGGCAAATGAGGAAACAGGATTTGGTAAATGGGAAGATAAAGTATTAAAAAATGTTTTTGCTGCAAGAACA
GTTTATGAATCAATAAAGGATACAAAAACTGTTGGAATAGTAGAGGAAAATGTTGAGAAAAGAGCATTTAAAATTATGGT
GCCAGTAGGAGTAGTTGCAGGACTTATACCATCAACAAATCCAACTTCAACAGCAATCTACAAAGCTATGATTTCAATAA
AAGCTAGAAATGCAATTGTTTTATCACCACATCCAAGTGCAAAAAAATGTATTATTGAAACAGCTAAGATAATAGCTAAG
GCTGCTGAGAGAGCAGGTTGTCCAGAAGGAGCTATAGGATGCATTACAGTACCTTCAATAGAAGGAACTAATGAACTTAT
GAAGAATAAAGATACTTCATTAATCCTAGCAACAGGTGGAGAAGCAATGGTTAGAGCTGCTTATTCATCAGGAACACCAG
CTATAGGTGTTGGACCAGGAAATGGACCAGCTTTCATAGATAAGAGTGCAGATGTTAAGTTAGCAGTTAAGAGAATATTA
GATTCTAAAACTTTTGATAATGGAACAATATGTGCTTCAGAACAATCAATAGTAGTTGAAAAAGCTATGGAAGATGAAGT
TGTTAGAGAATTAAAAGAACAAGGAGCTTACTTCTTAACTGAAGAACAAGCAAATCAACTATCTAAATTTGTAATGAGAG
CAAATGGAACTATGAACCCACAAATAGTTGGAAAAACTCCACAAGACATAGCTAAGTTAGCTGGTTTAGAAGGAATTCCA
TCTTGGGCAAGAGTTTTAGTTCCAAGAGAGTGCCATGTTGGACATAAGTATCCATTCTCAAGAGAAAAGTTAACAACTAT
TTTAACTTTCTTTGTAGAAGAGAATGTAGATGCTGTATTAAATAGATGTAGAGAAATATTACTAAATGAAGGAGCTGGAC
ATACATTCTGTATGCATGCAAATAATGAGGAGCTTGTTAAGAGATTCGCATTAGAAATGCCAGTTTCAAGAATGGTAGTA
AATTCACCAGGAGCTCTTGGTGGAATAGGAGCTACAATCAACTTAGTACCTGCCTTAACTTTAGGATGTGGTGCAGTTGG
AGGAAGTTCTACATCACACAACATAGGACCATTAGATTTAATGAATACAAGAAATGTAGCTTATGGAATTAGAGAACTTG
AAGATATTAGAGAGTTAGCTGTAGGAGCTACAAAGGAAGTTTCCGCAAGTTTAGACTTAGGCGACAAGGAAGAGTTAATA
AACTTATTAGTTAAGAAGATTATTGAGGAACTTAAGTAA

Upstream 100 bases:

>100_bases
AAGCCTTAAATATGAACATAACTTCTAATAAGCTTAAGTCTCTAAAGAAGAAAGATTTAGTAGATATATTACTAAAATAT
AGTGAAGAAGGTGACAGTTA

Downstream 100 bases:

>100_bases
GTTTTAAGATAATTTGATTCTACTATAAATCAAAGACTTATTTAATATTAAAGATGATTTTCATTACATAGAAATGAAAA
GGTATAAAAAGGCTTAATAT

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: Alcohol dehydrogenase; ADH; Acetaldehyde dehydrogenase [acetylating]; ACDH [H]

Number of amino acids: Translated: 492; Mature: 492

Protein sequence:

>492_residues
MEFLDKDLVSIQETRGLIRKAKEAQSKLARMSQQDIDRIVKAISDAAYENSEKLAKMANEETGFGKWEDKVLKNVFAART
VYESIKDTKTVGIVEENVEKRAFKIMVPVGVVAGLIPSTNPTSTAIYKAMISIKARNAIVLSPHPSAKKCIIETAKIIAK
AAERAGCPEGAIGCITVPSIEGTNELMKNKDTSLILATGGEAMVRAAYSSGTPAIGVGPGNGPAFIDKSADVKLAVKRIL
DSKTFDNGTICASEQSIVVEKAMEDEVVRELKEQGAYFLTEEQANQLSKFVMRANGTMNPQIVGKTPQDIAKLAGLEGIP
SWARVLVPRECHVGHKYPFSREKLTTILTFFVEENVDAVLNRCREILLNEGAGHTFCMHANNEELVKRFALEMPVSRMVV
NSPGALGGIGATINLVPALTLGCGAVGGSSTSHNIGPLDLMNTRNVAYGIRELEDIRELAVGATKEVSASLDLGDKEELI
NLLVKKIIEELK

Sequences:

>Translated_492_residues
MEFLDKDLVSIQETRGLIRKAKEAQSKLARMSQQDIDRIVKAISDAAYENSEKLAKMANEETGFGKWEDKVLKNVFAART
VYESIKDTKTVGIVEENVEKRAFKIMVPVGVVAGLIPSTNPTSTAIYKAMISIKARNAIVLSPHPSAKKCIIETAKIIAK
AAERAGCPEGAIGCITVPSIEGTNELMKNKDTSLILATGGEAMVRAAYSSGTPAIGVGPGNGPAFIDKSADVKLAVKRIL
DSKTFDNGTICASEQSIVVEKAMEDEVVRELKEQGAYFLTEEQANQLSKFVMRANGTMNPQIVGKTPQDIAKLAGLEGIP
SWARVLVPRECHVGHKYPFSREKLTTILTFFVEENVDAVLNRCREILLNEGAGHTFCMHANNEELVKRFALEMPVSRMVV
NSPGALGGIGATINLVPALTLGCGAVGGSSTSHNIGPLDLMNTRNVAYGIRELEDIRELAVGATKEVSASLDLGDKEELI
NLLVKKIIEELK
>Mature_492_residues
MEFLDKDLVSIQETRGLIRKAKEAQSKLARMSQQDIDRIVKAISDAAYENSEKLAKMANEETGFGKWEDKVLKNVFAART
VYESIKDTKTVGIVEENVEKRAFKIMVPVGVVAGLIPSTNPTSTAIYKAMISIKARNAIVLSPHPSAKKCIIETAKIIAK
AAERAGCPEGAIGCITVPSIEGTNELMKNKDTSLILATGGEAMVRAAYSSGTPAIGVGPGNGPAFIDKSADVKLAVKRIL
DSKTFDNGTICASEQSIVVEKAMEDEVVRELKEQGAYFLTEEQANQLSKFVMRANGTMNPQIVGKTPQDIAKLAGLEGIP
SWARVLVPRECHVGHKYPFSREKLTTILTFFVEENVDAVLNRCREILLNEGAGHTFCMHANNEELVKRFALEMPVSRMVV
NSPGALGGIGATINLVPALTLGCGAVGGSSTSHNIGPLDLMNTRNVAYGIRELEDIRELAVGATKEVSASLDLGDKEELI
NLLVKKIIEELK

Specific function: This enzyme has probably two activities:ADH, and ACDH [H]

COG id: COG1012

COG function: function code C; NAD-dependent aldehyde dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the iron- containing alcohol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1787493, Length=445, Percent_Identity=42.247191011236, Blast_Score=341, Evalue=5e-95,
Organism=Escherichia coli, GI1788797, Length=381, Percent_Identity=33.3333333333333, Blast_Score=167, Evalue=1e-42,
Organism=Escherichia coli, GI87081896, Length=253, Percent_Identity=22.5296442687747, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001670
- InterPro:   IPR018211
- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016162
- InterPro:   IPR015590
- InterPro:   IPR012079 [H]

Pfam domain/function: PF00171 Aldedh; PF00465 Fe-ADH [H]

EC number: =1.1.1.1; =1.2.1.10 [H]

Molecular weight: Translated: 53153; Mature: 53153

Theoretical pI: Translated: 6.78; Mature: 6.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEFLDKDLVSIQETRGLIRKAKEAQSKLARMSQQDIDRIVKAISDAAYENSEKLAKMANE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCC
ETGFGKWEDKVLKNVFAARTVYESIKDTKTVGIVEENVEKRAFKIMVPVGVVAGLIPSTN
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEHHHHHHHHHHEEEEEHHHHHHHCCCCCC
PTSTAIYKAMISIKARNAIVLSPHPSAKKCIIETAKIIAKAAERAGCPEGAIGCITVPSI
CCHHHHHHHHHHHEECCEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCC
EGTNELMKNKDTSLILATGGEAMVRAAYSSGTPAIGVGPGNGPAFIDKSADVKLAVKRIL
CCHHHHHCCCCCEEEEEECCHHHHHHHHCCCCCEEEECCCCCCEEECCCCCHHHHHHHHH
DSKTFDNGTICASEQSIVVEKAMEDEVVRELKEQGAYFLTEEQANQLSKFVMRANGTMNP
HCCCCCCCCEECCCCHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHCCCCCCC
QIVGKTPQDIAKLAGLEGIPSWARVLVPRECHVGHKYPFSREKLTTILTFFVEENVDAVL
EEECCCHHHHHHHHCCCCCCHHHHHHCCCHHCCCCCCCCCHHHHHHHHHHHHHCCHHHHH
NRCREILLNEGAGHTFCMHANNEELVKRFALEMPVSRMVVNSPGALGGIGATINLVPALT
HHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHCCHHHHHCCCCCCCCCCCCHHHHHHHHH
LGCGAVGGSSTSHNIGPLDLMNTRNVAYGIRELEDIRELAVGATKEVSASLDLGDKEELI
HHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCHHHHH
NLLVKKIIEELK
HHHHHHHHHHCC
>Mature Secondary Structure
MEFLDKDLVSIQETRGLIRKAKEAQSKLARMSQQDIDRIVKAISDAAYENSEKLAKMANE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCC
ETGFGKWEDKVLKNVFAARTVYESIKDTKTVGIVEENVEKRAFKIMVPVGVVAGLIPSTN
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEHHHHHHHHHHEEEEEHHHHHHHCCCCCC
PTSTAIYKAMISIKARNAIVLSPHPSAKKCIIETAKIIAKAAERAGCPEGAIGCITVPSI
CCHHHHHHHHHHHEECCEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCC
EGTNELMKNKDTSLILATGGEAMVRAAYSSGTPAIGVGPGNGPAFIDKSADVKLAVKRIL
CCHHHHHCCCCCEEEEEECCHHHHHHHHCCCCCEEEECCCCCCEEECCCCCHHHHHHHHH
DSKTFDNGTICASEQSIVVEKAMEDEVVRELKEQGAYFLTEEQANQLSKFVMRANGTMNP
HCCCCCCCCEECCCCHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHCCCCCCC
QIVGKTPQDIAKLAGLEGIPSWARVLVPRECHVGHKYPFSREKLTTILTFFVEENVDAVL
EEECCCHHHHHHHHCCCCCCHHHHHHCCCHHCCCCCCCCCHHHHHHHHHHHHHCCHHHHH
NRCREILLNEGAGHTFCMHANNEELVKRFALEMPVSRMVVNSPGALGGIGATINLVPALT
HHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHCCHHHHHCCCCCCCCCCCCHHHHHHHHH
LGCGAVGGSSTSHNIGPLDLMNTRNVAYGIRELEDIRELAVGATKEVSASLDLGDKEELI
HHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCHHHHH
NLLVKKIIEELK
HHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8226639; 8300540; 11466286 [H]