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The map label for this gene is dut [H]

Identifier: 18309660

GI number: 18309660

Start: 842638

End: 843288

Strand: Direct

Name: dut [H]

Synonym: CPE0678

Alternate gene names: 18309660

Gene position: 842638-843288 (Clockwise)

Preceding gene: 18309659

Following gene: 18309661

Centisome position: 27.8

GC content: 29.34

Gene sequence:

>651_bases
ATGGCGGGAGAACAAAGAATAAGAGATGTATATATTCAATACGATAAAAATGGAGAAACACCTAAATATGAAACACCCTT
GGCCGCAGGAGCAGACCTTTTTGCAGCAGAGGATATGGTTATAAGACCTTTTGAAAAGGTTGCAATTCCACTAGGGTTAA
AGTTTGCAATTTCTGATAATATGGAGCTTCAAATTAGGGCTAGAAGTGGACTTTCTTTAAGAACAAACTTAAAAATTTCA
AACTCAATAGGAACTATTGATGCTGATTCAGTTAGTGATATATCAGTAATTTTAGAAAATAATTATAATATAGCTAATCT
TCCTTATGAGATAGCTAATGATATAAGTATATTAGATGATTTAAAAAATAATTATACTGAAGTAAGATTAAGCGACTATT
TAGAAGCTAAAGGACATGATGTAAGTTCTTATGAGGATGAAGGAAAAAAAGCTTATAAAAAATTATTAAAGACATATATT
TATTTAGATAAGAACGGAAATCCATATGGAACTATATACATAAAAAAAGGAAATAGAATTGCTCAGATGGTTTTAGCAAA
ATATTATAAAGCTAATTTTATAAAAACAGATGACGTTTCTAAACTTAAAAGTGTAAATAGAGGCGGTGGATTTGGTCATA
CAGGCTTTTAA

Upstream 100 bases:

>100_bases
GTTAATAATACAACTTTCAATTAAGAATATGGATGATTTACACATTTGTTAATAGGGGGATTTTAAAATATAATTTTTAC
TAAAGATGGAGGTGAATTTT

Downstream 100 bases:

>100_bases
AATTCCATTGTTTTGTAGAGAAAACTTAAATTATAATATATAAATCGGAATAGTTAGGAAAGTTTTAGAATGAGATAGGA
ACTTATTCTAAAGCTTTTTT

Product: deoxyuridine 5`-triphosphate nucleotidohydrolase

Products: NA

Alternate protein names: dUTPase; dUTP pyrophosphatase [H]

Number of amino acids: Translated: 216; Mature: 215

Protein sequence:

>216_residues
MAGEQRIRDVYIQYDKNGETPKYETPLAAGADLFAAEDMVIRPFEKVAIPLGLKFAISDNMELQIRARSGLSLRTNLKIS
NSIGTIDADSVSDISVILENNYNIANLPYEIANDISILDDLKNNYTEVRLSDYLEAKGHDVSSYEDEGKKAYKKLLKTYI
YLDKNGNPYGTIYIKKGNRIAQMVLAKYYKANFIKTDDVSKLKSVNRGGGFGHTGF

Sequences:

>Translated_216_residues
MAGEQRIRDVYIQYDKNGETPKYETPLAAGADLFAAEDMVIRPFEKVAIPLGLKFAISDNMELQIRARSGLSLRTNLKIS
NSIGTIDADSVSDISVILENNYNIANLPYEIANDISILDDLKNNYTEVRLSDYLEAKGHDVSSYEDEGKKAYKKLLKTYI
YLDKNGNPYGTIYIKKGNRIAQMVLAKYYKANFIKTDDVSKLKSVNRGGGFGHTGF
>Mature_215_residues
AGEQRIRDVYIQYDKNGETPKYETPLAAGADLFAAEDMVIRPFEKVAIPLGLKFAISDNMELQIRARSGLSLRTNLKISN
SIGTIDADSVSDISVILENNYNIANLPYEIANDISILDDLKNNYTEVRLSDYLEAKGHDVSSYEDEGKKAYKKLLKTYIY
LDKNGNPYGTIYIKKGNRIAQMVLAKYYKANFIKTDDVSKLKSVNRGGGFGHTGF

Specific function: This enzyme is involved in nucleotide metabolism:it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA [H]

COG id: COG0756

COG function: function code F; dUTPase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dUTPase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008180
- InterPro:   IPR008181 [H]

Pfam domain/function: PF00692 dUTPase [H]

EC number: =3.6.1.23 [H]

Molecular weight: Translated: 24199; Mature: 24068

Theoretical pI: Translated: 7.60; Mature: 7.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGEQRIRDVYIQYDKNGETPKYETPLAAGADLFAAEDMVIRPFEKVAIPLGLKFAISDN
CCCHHCEEEEEEEECCCCCCCCCCCCCCCCCCCEECCCCEECCHHHEEECCCEEEEECCC
MELQIRARSGLSLRTNLKISNSIGTIDADSVSDISVILENNYNIANLPYEIANDISILDD
CEEEEEECCCCEEEEEEEECCCCCCCCCCCCCEEEEEEECCCCEEECCHHHHCHHHHHHH
LKNNYTEVRLSDYLEAKGHDVSSYEDEGKKAYKKLLKTYIYLDKNGNPYGTIYIKKGNRI
HHCCCEEEEHHHHHHCCCCCCCCHHHHHHHHHHHHHHHEEEECCCCCEEEEEEEECCCHH
AQMVLAKYYKANFIKTDDVSKLKSVNRGGGFGHTGF
HHHHHHHHHHCCCCCCCCHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
AGEQRIRDVYIQYDKNGETPKYETPLAAGADLFAAEDMVIRPFEKVAIPLGLKFAISDN
CCHHCEEEEEEEECCCCCCCCCCCCCCCCCCCEECCCCEECCHHHEEECCCEEEEECCC
MELQIRARSGLSLRTNLKISNSIGTIDADSVSDISVILENNYNIANLPYEIANDISILDD
CEEEEEECCCCEEEEEEEECCCCCCCCCCCCCEEEEEEECCCCEEECCHHHHCHHHHHHH
LKNNYTEVRLSDYLEAKGHDVSSYEDEGKKAYKKLLKTYIYLDKNGNPYGTIYIKKGNRI
HHCCCEEEEHHHHHHCCCCCCCCHHHHHHHHHHHHHHHEEEECCCCCEEEEEEEECCCHH
AQMVLAKYYKANFIKTDDVSKLKSVNRGGGFGHTGF
HHHHHHHHHHCCCCCCCCHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362 [H]