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The map label for this gene is licA [H]

Identifier: 18309609

GI number: 18309609

Start: 786364

End: 788232

Strand: Direct

Name: licA [H]

Synonym: CPE0627

Alternate gene names: 18309609

Gene position: 786364-788232 (Clockwise)

Preceding gene: 18309608

Following gene: 18309610

Centisome position: 25.94

GC content: 27.55

Gene sequence:

>1869_bases
ATGTTATCATATGATATTGAAGTTTTAAAAATTATAAATGATGAAGACAATATAAGTCAAAGAAGATTAGCAGAAATGCT
AAACATTTCTTTAGGTAAAATAAATTCTTTACTTAAGGAACTATTGACTAAAGAATACATAGTTAAAATTGATATAGATA
AGAGAAATGTTAAATATGAATTAACTGAGGCAGGAATTGCATTACTAGAAAATTCATTAGATAAAGTTAAGAGCACAAAG
TTATCCATACATAAGCATAAATTTCATAAAGTTAAACAAGCTGTTATTTTAGGAGCTGGTGGTAAAGGTGATTTTGGAAA
GCCAGCTGGTTTTTTAGAGCTTGAAGAATTCAGAATAATTGATAGAATAATTGATATTTTGAAATCAAATGGTATAGAGA
AGATTGTTATAGTAAATGGATATAAGAAAGAATACTATGAAGAATTAGCTGAAAAAGATTCAACAATTTTTTGTGTAACT
AATTCAAATTATAAATGGACAGGAACAATGAGTTCTTTAGCTTTAGCTAAGGAATATATAGATGATGATTTTATATTGGT
AGAAAATGATCTTGTTTTTGAAAGTAGAGCTGTAGAACAAATTATTAAAAATGATAATAGAGATTGTGTTTTAATTACTA
ATGAAAGTGGATCAGGGGATGAGGCCTTCGTTGAAATAAGGGATGGCTATCTTTTTAAAATGTCAAAAGATGTACACCAA
TTTAATAAGATTGATGGAGAAATGATTGGTATAAGCAAAATATCTTATAAATTATTTAAAATGATGTTAGAAGAATTTAA
ACATAATATAAATCCATATATGAATTATGAGTACACTATGTTAGATGTTGCTAGAAATTATAAGGTTGGTTATGAAAAGA
TAAATGACCTTGTTTGGGGAGAAATTGACAATAAAGATCAATATGAAAAAGTAAAGAAACACATTATACCTATGATAAGA
AGAAAAGAAATGCAATATAAAATAGATCAAGTAAAAAGTGCTATAGTTAATGGATTAAAGGTTTCAGAAGAGGAAGTTAA
AGAAATAGTACCTGTAGGAGGTATGACTAATAAAAACTATAAGGCTTTTGTAAATGACAAAGCCTATATAGTAAGAATAC
CAGGATTAGGTACAAGCTCTATGATTAATAGAAGAGATGAAATGATAAACTCTAAACTAGCAGCAGATGAAGGAATAGAT
GCTAAAATACTTTTCTTTGATGAAGAGTCTGGAGTAAAGATTGCAGAACTTATAGAGGGAGCAGAAACTCTTAATCCTGC
AACGGCTAAAAAGAAAGAAAATATGGAATTAGTGGTAGGGGCATTAAGAACTTTACATAATTCAGAGATAAAAATGGAAA
ATAGATTTAATGTTTTTGAGAAAATTGAGGATTATGAGAGTCTTGTTAAAAAGGTTAGTGGTACTCTTTTTGAAGATTAT
TATGAAATAAAAACAAGAGTATTAAAGTTAGAAAAAGTTTTAGAAGATAATGGAATGGAAATAAAACCATGTCATAATGA
TACCGTTCCAGAAAACTTTGTTAAAGATATTAATGAAAGAATGTATCTAATAGATTGGGAGTACAGTGGATTAAATGATC
CTATGTGGGATTTAGCGGCTCACTCAATTGAATGTGATTTTTCAGAGGATGATGAAGAATTATTCTTAAATCTATATTTT
AACAATTTAATTGAAGATAAGCATAAGATAAGAATTCTTGTTTATAAAATATGTCAGGACTTTTTATGGAGCATATGGAC
TATTTTAAAAGAGGCTCAAGGCGATGATTTTGGAACTTATGGTATAGATAGATATAATAGAGGAAAGAAAAACTTAGAGT
TATTAGATAAAATTTTAATGGGGCAATAA

Upstream 100 bases:

>100_bases
TTAACTTATCTAGGATAAGTTAATACTTTTTTTATTGTAATAAGGAAAATTTTGTGATATTATATTAATGTTCAAAAAAT
GAACGAAGGGAGAGTTGAGG

Downstream 100 bases:

>100_bases
AGTATGAATTTAAAGGAGAGGCAGTATGTTTAAAAGTAATTATAAGGGATATGGTAGTGGAATTATATCTGCTATGGCTT
GGGGGCTAGATACTGTTTTA

Product: choline kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 622; Mature: 622

Protein sequence:

>622_residues
MLSYDIEVLKIINDEDNISQRRLAEMLNISLGKINSLLKELLTKEYIVKIDIDKRNVKYELTEAGIALLENSLDKVKSTK
LSIHKHKFHKVKQAVILGAGGKGDFGKPAGFLELEEFRIIDRIIDILKSNGIEKIVIVNGYKKEYYEELAEKDSTIFCVT
NSNYKWTGTMSSLALAKEYIDDDFILVENDLVFESRAVEQIIKNDNRDCVLITNESGSGDEAFVEIRDGYLFKMSKDVHQ
FNKIDGEMIGISKISYKLFKMMLEEFKHNINPYMNYEYTMLDVARNYKVGYEKINDLVWGEIDNKDQYEKVKKHIIPMIR
RKEMQYKIDQVKSAIVNGLKVSEEEVKEIVPVGGMTNKNYKAFVNDKAYIVRIPGLGTSSMINRRDEMINSKLAADEGID
AKILFFDEESGVKIAELIEGAETLNPATAKKKENMELVVGALRTLHNSEIKMENRFNVFEKIEDYESLVKKVSGTLFEDY
YEIKTRVLKLEKVLEDNGMEIKPCHNDTVPENFVKDINERMYLIDWEYSGLNDPMWDLAAHSIECDFSEDDEELFLNLYF
NNLIEDKHKIRILVYKICQDFLWSIWTILKEAQGDDFGTYGIDRYNRGKKNLELLDKILMGQ

Sequences:

>Translated_622_residues
MLSYDIEVLKIINDEDNISQRRLAEMLNISLGKINSLLKELLTKEYIVKIDIDKRNVKYELTEAGIALLENSLDKVKSTK
LSIHKHKFHKVKQAVILGAGGKGDFGKPAGFLELEEFRIIDRIIDILKSNGIEKIVIVNGYKKEYYEELAEKDSTIFCVT
NSNYKWTGTMSSLALAKEYIDDDFILVENDLVFESRAVEQIIKNDNRDCVLITNESGSGDEAFVEIRDGYLFKMSKDVHQ
FNKIDGEMIGISKISYKLFKMMLEEFKHNINPYMNYEYTMLDVARNYKVGYEKINDLVWGEIDNKDQYEKVKKHIIPMIR
RKEMQYKIDQVKSAIVNGLKVSEEEVKEIVPVGGMTNKNYKAFVNDKAYIVRIPGLGTSSMINRRDEMINSKLAADEGID
AKILFFDEESGVKIAELIEGAETLNPATAKKKENMELVVGALRTLHNSEIKMENRFNVFEKIEDYESLVKKVSGTLFEDY
YEIKTRVLKLEKVLEDNGMEIKPCHNDTVPENFVKDINERMYLIDWEYSGLNDPMWDLAAHSIECDFSEDDEELFLNLYF
NNLIEDKHKIRILVYKICQDFLWSIWTILKEAQGDDFGTYGIDRYNRGKKNLELLDKILMGQ
>Mature_622_residues
MLSYDIEVLKIINDEDNISQRRLAEMLNISLGKINSLLKELLTKEYIVKIDIDKRNVKYELTEAGIALLENSLDKVKSTK
LSIHKHKFHKVKQAVILGAGGKGDFGKPAGFLELEEFRIIDRIIDILKSNGIEKIVIVNGYKKEYYEELAEKDSTIFCVT
NSNYKWTGTMSSLALAKEYIDDDFILVENDLVFESRAVEQIIKNDNRDCVLITNESGSGDEAFVEIRDGYLFKMSKDVHQ
FNKIDGEMIGISKISYKLFKMMLEEFKHNINPYMNYEYTMLDVARNYKVGYEKINDLVWGEIDNKDQYEKVKKHIIPMIR
RKEMQYKIDQVKSAIVNGLKVSEEEVKEIVPVGGMTNKNYKAFVNDKAYIVRIPGLGTSSMINRRDEMINSKLAADEGID
AKILFFDEESGVKIAELIEGAETLNPATAKKKENMELVVGALRTLHNSEIKMENRFNVFEKIEDYESLVKKVSGTLFEDY
YEIKTRVLKLEKVLEDNGMEIKPCHNDTVPENFVKDINERMYLIDWEYSGLNDPMWDLAAHSIECDFSEDDEELFLNLYF
NNLIEDKHKIRILVYKICQDFLWSIWTILKEAQGDDFGTYGIDRYNRGKKNLELLDKILMGQ

Specific function: Mediates phase variation of the LOS 6A2 and 12D9 epitopes. Phase variation of H.influenza LOS epitopes expressed by licA is determined by a translational switch [H]

COG id: COG0510

COG function: function code M; Predicted choline kinase involved in LPS biosynthesis

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S49 family [H]

Homologues:

Organism=Caenorhabditis elegans, GI71997462, Length=292, Percent_Identity=26.7123287671233, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002573
- InterPro:   IPR011009 [H]

Pfam domain/function: PF01633 Choline_kinase [H]

EC number: NA

Molecular weight: Translated: 72048; Mature: 72048

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSYDIEVLKIINDEDNISQRRLAEMLNISLGKINSLLKELLTKEYIVKIDIDKRNVKYE
CCCCCEEEEEEECCCCCHHHHHHHHHHHCCHHHHHHHHHHHHCCCEEEEEEECCCCCEEE
LTEAGIALLENSLDKVKSTKLSIHKHKFHKVKQAVILGAGGKGDFGKPAGFLELEEFRII
EHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCCEEHHHHHHH
DRIIDILKSNGIEKIVIVNGYKKEYYEELAEKDSTIFCVTNSNYKWTGTMSSLALAKEYI
HHHHHHHHCCCCCEEEEEECHHHHHHHHHHCCCCEEEEEECCCEEEECCHHHHHHHHHHC
DDDFILVENDLVFESRAVEQIIKNDNRDCVLITNESGSGDEAFVEIRDGYLFKMSKDVHQ
CCCEEEEECCCHHHHHHHHHHHHCCCCCEEEEECCCCCCCCEEEEEECCEEEEEHHHHHH
FNKIDGEMIGISKISYKLFKMMLEEFKHNINPYMNYEYTMLDVARNYKVGYEKINDLVWG
HHCCCCCEEEHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEHHHCCCCCHHHHHHHHCC
EIDNKDQYEKVKKHIIPMIRRKEMQYKIDQVKSAIVNGLKVSEEEVKEIVPVGGMTNKNY
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCC
KAFVNDKAYIVRIPGLGTSSMINRRDEMINSKLAADEGIDAKILFFDEESGVKIAELIEG
EEEECCCEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCHHHHHHCC
AETLNPATAKKKENMELVVGALRTLHNSEIKMENRFNVFEKIEDYESLVKKVSGTLFEDY
HHHCCCCHHHHHCCHHHHHHHHHHHCCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHHHH
YEIKTRVLKLEKVLEDNGMEIKPCHNDTVPENFVKDINERMYLIDWEYSGLNDPMWDLAA
HHHHHHHHHHHHHHHCCCCEEECCCCCCCCHHHHHHHCCCEEEEEEECCCCCCCHHHHHH
HSIECDFSEDDEELFLNLYFNNLIEDKHKIRILVYKICQDFLWSIWTILKEAQGDDFGTY
CCEECCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
GIDRYNRGKKNLELLDKILMGQ
CCCHHCCCCCHHHHHHHHHCCC
>Mature Secondary Structure
MLSYDIEVLKIINDEDNISQRRLAEMLNISLGKINSLLKELLTKEYIVKIDIDKRNVKYE
CCCCCEEEEEEECCCCCHHHHHHHHHHHCCHHHHHHHHHHHHCCCEEEEEEECCCCCEEE
LTEAGIALLENSLDKVKSTKLSIHKHKFHKVKQAVILGAGGKGDFGKPAGFLELEEFRII
EHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCCEEHHHHHHH
DRIIDILKSNGIEKIVIVNGYKKEYYEELAEKDSTIFCVTNSNYKWTGTMSSLALAKEYI
HHHHHHHHCCCCCEEEEEECHHHHHHHHHHCCCCEEEEEECCCEEEECCHHHHHHHHHHC
DDDFILVENDLVFESRAVEQIIKNDNRDCVLITNESGSGDEAFVEIRDGYLFKMSKDVHQ
CCCEEEEECCCHHHHHHHHHHHHCCCCCEEEEECCCCCCCCEEEEEECCEEEEEHHHHHH
FNKIDGEMIGISKISYKLFKMMLEEFKHNINPYMNYEYTMLDVARNYKVGYEKINDLVWG
HHCCCCCEEEHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEHHHCCCCCHHHHHHHHCC
EIDNKDQYEKVKKHIIPMIRRKEMQYKIDQVKSAIVNGLKVSEEEVKEIVPVGGMTNKNY
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCC
KAFVNDKAYIVRIPGLGTSSMINRRDEMINSKLAADEGIDAKILFFDEESGVKIAELIEG
EEEECCCEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCHHHHHHCC
AETLNPATAKKKENMELVVGALRTLHNSEIKMENRFNVFEKIEDYESLVKKVSGTLFEDY
HHHCCCCHHHHHCCHHHHHHHHHHHCCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHHHH
YEIKTRVLKLEKVLEDNGMEIKPCHNDTVPENFVKDINERMYLIDWEYSGLNDPMWDLAA
HHHHHHHHHHHHHHHCCCCEEECCCCCCCCHHHHHHHCCCEEEEEEECCCCCCCHHHHHH
HSIECDFSEDDEELFLNLYFNNLIEDKHKIRILVYKICQDFLWSIWTILKEAQGDDFGTY
CCEECCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
GIDRYNRGKKNLELLDKILMGQ
CCCHHCCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2479481; 8861214 [H]