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The map label for this gene is oxyR [H]

Identifier: 182681336

GI number: 182681336

Start: 931213

End: 932148

Strand: Direct

Name: oxyR [H]

Synonym: XfasM23_0783

Alternate gene names: 182681336

Gene position: 931213-932148 (Clockwise)

Preceding gene: 182681335

Following gene: 182681337

Centisome position: 36.72

GC content: 52.24

Gene sequence:

>936_bases
ATGAACCTGCGTGACTTGAAATATCTGATTGCTCTGGCCGATTACAAGCACTTTGGCCGTGCTGCAACTGCATGTTTTGT
CAGTCAGCCGACGCTATCTACGCAAATCAAGAAGTTGGAAGGCGAGCTTGGCGTGTCGTTAGTCGAGCGTGCGCCGCGTA
AGGTCATGATGACCCCGGCTGGGCGCGAAGCGGCGATCCGTGCGCGTAGCATTGTTGCCGAGGTTGAGGAAATGAAGGAA
GCTGCGCGGCGTAGCCGTGATCCGGAGGCTGGTGCCGTGCGTTTGGGTATTTTCCCAACCCTCGGTCCGTATTTGTTGCC
CCACGTAGTACCGAGTATCCGTTATCGTTTTCCACAATTGGAACTGTTGCTGGTTGAGGAGAAAAGTGACGAATTGCTCG
CACAGTTGCGTGAAGGTAAGTTGGATGCAGCGTTGTTGGCATTGCCGTTACATGATGAACAATTGCACACAGAATTTTTG
TTTGAGGAGCCGTTCGTGTTGGCAGTCCCAGAGGGGCATCCGTTGGCTACACGTCGTGAGATGACGATGGAAGAATTAGC
CGACGAACGTTTGTTGTTACTGCAAGATGGCCACTGTCTGCGTGAGCAGGCATTAGATGTGTGCCATATGACGGGTGCAT
CGGAGAAGTCGGAGTTTCAGGCTACGAGCTTGGAGACTTTGCGACAGATGGTCGTTGCTAATGTGGGTATCACGCTGCTG
CCGTTGCTCTCAGTCAAGCCGCCGGTAGTCTGTTCGGAAAGTATTCGTCTGATTAATTTTCCTTTGGACAAACAGCCTAG
TCGCCGAATCGCCATGGTGTGGCGACGCAGTTCTGCGATGACGACATTTCTGGAGAGGTTTTCTAGCATGTTCAAGGAAT
TGCCAAAGGAGTTGTTTGACTTGCCTCAGACCGCGGTACTGTACAAAGGTCGGTAG

Upstream 100 bases:

>100_bases
ATGCAGTACAGCGGTTTAACTTTATGTTGCTTAGTCTTGATGTTGTTGCAATACCTAAGTGTGGAATTACATTCCCTCCT
TTGCCGCGAGGTTTGGCTTT

Downstream 100 bases:

>100_bases
CTTTTCCGGTCGTGTCGGAGTTAAGCGCGAGTCTGTGGGTTACTTACCCGTTGTTATTTTGGAGTCAGGGATGCTTAGAT
GTTGGTGTTAAGATTGCGGA

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: Morphology and auto-aggregation control protein [H]

Number of amino acids: Translated: 311; Mature: 311

Protein sequence:

>311_residues
MNLRDLKYLIALADYKHFGRAATACFVSQPTLSTQIKKLEGELGVSLVERAPRKVMMTPAGREAAIRARSIVAEVEEMKE
AARRSRDPEAGAVRLGIFPTLGPYLLPHVVPSIRYRFPQLELLLVEEKSDELLAQLREGKLDAALLALPLHDEQLHTEFL
FEEPFVLAVPEGHPLATRREMTMEELADERLLLLQDGHCLREQALDVCHMTGASEKSEFQATSLETLRQMVVANVGITLL
PLLSVKPPVVCSESIRLINFPLDKQPSRRIAMVWRRSSAMTTFLERFSSMFKELPKELFDLPQTAVLYKGR

Sequences:

>Translated_311_residues
MNLRDLKYLIALADYKHFGRAATACFVSQPTLSTQIKKLEGELGVSLVERAPRKVMMTPAGREAAIRARSIVAEVEEMKE
AARRSRDPEAGAVRLGIFPTLGPYLLPHVVPSIRYRFPQLELLLVEEKSDELLAQLREGKLDAALLALPLHDEQLHTEFL
FEEPFVLAVPEGHPLATRREMTMEELADERLLLLQDGHCLREQALDVCHMTGASEKSEFQATSLETLRQMVVANVGITLL
PLLSVKPPVVCSESIRLINFPLDKQPSRRIAMVWRRSSAMTTFLERFSSMFKELPKELFDLPQTAVLYKGR
>Mature_311_residues
MNLRDLKYLIALADYKHFGRAATACFVSQPTLSTQIKKLEGELGVSLVERAPRKVMMTPAGREAAIRARSIVAEVEEMKE
AARRSRDPEAGAVRLGIFPTLGPYLLPHVVPSIRYRFPQLELLLVEEKSDELLAQLREGKLDAALLALPLHDEQLHTEFL
FEEPFVLAVPEGHPLATRREMTMEELADERLLLLQDGHCLREQALDVCHMTGASEKSEFQATSLETLRQMVVANVGITLL
PLLSVKPPVVCSESIRLINFPLDKQPSRRIAMVWRRSSAMTTFLERFSSMFKELPKELFDLPQTAVLYKGR

Specific function: Hydrogen peroxide sensor. Activates the expression of a regulon of hydrogen peroxide-inducible genes such as katG, gor, ahpC, ahpF, oxyS (a regulatory RNA), dps, fur and grxA. OxyR expression is negatively autoregulated by binding to a 43 bp region upstre

COG id: COG0583

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790399, Length=301, Percent_Identity=46.843853820598, Blast_Score=262, Evalue=2e-71,
Organism=Escherichia coli, GI157672245, Length=241, Percent_Identity=31.9502074688797, Blast_Score=116, Evalue=2e-27,
Organism=Escherichia coli, GI1787879, Length=251, Percent_Identity=33.0677290836653, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI1788887, Length=245, Percent_Identity=31.8367346938775, Blast_Score=105, Evalue=3e-24,
Organism=Escherichia coli, GI1787530, Length=295, Percent_Identity=25.4237288135593, Blast_Score=104, Evalue=8e-24,
Organism=Escherichia coli, GI145693105, Length=315, Percent_Identity=26.3492063492064, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI2367136, Length=251, Percent_Identity=29.8804780876494, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI1788748, Length=314, Percent_Identity=24.8407643312102, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1789506, Length=283, Percent_Identity=26.5017667844523, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1787806, Length=308, Percent_Identity=24.6753246753247, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1788296, Length=244, Percent_Identity=27.4590163934426, Blast_Score=78, Evalue=8e-16,
Organism=Escherichia coli, GI87082132, Length=291, Percent_Identity=24.0549828178694, Blast_Score=78, Evalue=8e-16,
Organism=Escherichia coli, GI1788481, Length=202, Percent_Identity=26.7326732673267, Blast_Score=78, Evalue=9e-16,
Organism=Escherichia coli, GI1788297, Length=242, Percent_Identity=25.6198347107438, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1790208, Length=288, Percent_Identity=25.6944444444444, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1786401, Length=256, Percent_Identity=26.171875, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1787601, Length=164, Percent_Identity=27.4390243902439, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI87081904, Length=253, Percent_Identity=24.5059288537549, Blast_Score=65, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 35100; Mature: 35100

Theoretical pI: Translated: 6.88; Mature: 6.88

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLRDLKYLIALADYKHFGRAATACFVSQPTLSTQIKKLEGELGVSLVERAPRKVMMTPA
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEECCC
GREAAIRARSIVAEVEEMKEAARRSRDPEAGAVRLGIFPTLGPYLLPHVVPSIRYRFPQL
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCE
ELLLVEEKSDELLAQLREGKLDAALLALPLHDEQLHTEFLFEEPFVLAVPEGHPLATRRE
EEEEEECCCHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHCCCEEEECCCCCCCCHHHH
MTMEELADERLLLLQDGHCLREQALDVCHMTGASEKSEFQATSLETLRQMVVANVGITLL
HHHHHHCCCCEEEEECCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCHHHH
PLLSVKPPVVCSESIRLINFPLDKQPSRRIAMVWRRSSAMTTFLERFSSMFKELPKELFD
HHHCCCCCCEECCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
LPQTAVLYKGR
CCCHHEEECCC
>Mature Secondary Structure
MNLRDLKYLIALADYKHFGRAATACFVSQPTLSTQIKKLEGELGVSLVERAPRKVMMTPA
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEECCC
GREAAIRARSIVAEVEEMKEAARRSRDPEAGAVRLGIFPTLGPYLLPHVVPSIRYRFPQL
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCE
ELLLVEEKSDELLAQLREGKLDAALLALPLHDEQLHTEFLFEEPFVLAVPEGHPLATRRE
EEEEEECCCHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHCCCEEEECCCCCCCCHHHH
MTMEELADERLLLLQDGHCLREQALDVCHMTGASEKSEFQATSLETLRQMVVANVGITLL
HHHHHHCCCCEEEEECCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCHHHH
PLLSVKPPVVCSESIRLINFPLDKQPSRRIAMVWRRSSAMTTFLERFSSMFKELPKELFD
HHHCCCCCCEECCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
LPQTAVLYKGR
CCCHHEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]