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The map label for this gene is ggt [H]

Identifier: 182680528

GI number: 182680528

Start: 4116949

End: 4118718

Strand: Reverse

Name: ggt [H]

Synonym: Bind_3633

Alternate gene names: 182680528

Gene position: 4118718-4116949 (Counterclockwise)

Preceding gene: 182680529

Following gene: 182680526

Centisome position: 98.77

GC content: 61.81

Gene sequence:

>1770_bases
ATGCGTGATGGTGCAAGACCGATGCGGCGGCGTGGTTCACGGATCTGGTGTTCGCTCGCTTTATTGCTCTGGTTCGTCGG
TCCCGTCACCGCACCCGTCCTTGCCGAACAGCCACCGCGTCTTGCGCGTGAGGGGCGGTTCCTCCCAGTCCTCGCGACGC
ATGGCATGGTGGTCGCGCAAGAAAGCATGGCCGCCCGCATCGGGGTGGATATTCTGCAACGGGGCGGCAATGCAGTCGAT
GCGGCCGTGGCGGTGGCCTTTGCCCTCGCGGTCACTTTGCCGCGCGCCGGTAATCTGGGCGGGGGCGGCTTCATGCTGGT
CCATCTCGCCAAATCCGGCAAGACGATCGCGATTGATTATCGCGAAATGGCCGCGGCCGCGACCACGCCTGAAACGTTTC
TGAATGCCGAAGGCCAAGCCGATCCCGAACGGTCACGTCACGGCGGGCTCGCTGTCGGCGTGCCGGGCACGGTCGCAGGC
CTCGCTCTGGCGCATCGGCGCTATGGCTCCGGGCGCCTCAGCCTGGCAGAACTCGCGGCCCCCGCCATCACTCTCGCCCA
AGATGGGTTCGTCGTTGGCCAGGACCTCTCAGATTCCCTTTATTATAATCTCAACGGATTGCGGCGCTGGCCATCGAGCA
CGCGGATTTTCCTCGACCCCGAGGGCCGGCCGTTGGAACCCGGCCAAAGGCTCGTGCAAAAGGATCTTGCCGCCACCCTG
ACAGCCATCGGACGCGATGGCGAGGCGGCTTTCTACCAGGGCCCGATAGCGGAAAAAATCGTGACGAGTGTCCGTAAGGC
CGGGGGCGAGATGGAGCTCAAGGATCTTGCCGCCTATCGCGCGGTGGAGCGTGAGCCGGTTTCAGGCACTTATCACGGCC
ATAAAATCGTCTCCATGCCGCCGCCCTCCGCGGGTGGTTCTCACCTTATCGAAATCCTGAATATTCTCGAAGGGTTCTCC
CTTGCCAATTACGGCCCGGATTCCGCGCGCACCATTCATCTGACCGGCGAGGCCATGCGGCGCGCCTATGCCGACCGCGC
GAAATATCTCGGCGATCCTGACAGCGTCACCATTCCGCTGAACAATCTCTTGTCCAAGACCTATGCATCCCGGCTGAGAA
AGGAAATCGACGCCGATCATGCGACCCCATCGGACGCACTCCAGCCGCTCGCACCCCTCCCCCATGAGAGCGACCAGACC
ACGCATTTTTCGGTCGTCGATGCGGAAGGCAATGCCGTTTCGAATACATATACGCTGAATTTTTCCTTTGGCCTTGGCCT
TGTCGCCGAAGGCACCGGCGTCCTTCTCAACAATGAGCTCGATGATTTTGCTGCCAAACCCGGTGCGCCCAATGCCTACG
GGCTTGTCGGTGGCAACGCCAATGCGCCGGGCCCACGCAAACGGCCTCTCTCTTCCATGACACCGACCATGGTCTTTGGC
GAGAATGGCGCGCTCGAACTCGTCACCGGCTCGCCGGGCGGCTCGCGCATTATCACCATCGTCCTCGGTCTCATTCTCGA
TATGGTGGATTTCAAGATGAATATCGCGGAGGCCACCGCCATGCCGCGTGTGCATCATCAATGGCTGCCGGATCAGCTCC
AGGTCGAACGCGGCCTCTCGACCGATACGATCGAAAAGCTCCAGGAGCTGGGCCATCACGTCAAGGTCATCGACGCCTGG
GGCTCGGCGCAGAGCATTGCCCTTGTGCCCGGTTTCCTGATGGGCGCTGCGGATACACGTCAACGCGGTCCCTTAGCGAT
TGGCTATTAA

Upstream 100 bases:

>100_bases
CGAGCGCCGAGCGAGCAGCGGCACATCTGATGGTCGTTCTCTACGACGATCGATACCAGCGTGGACCGAATGTCTTTTGA
TGCAGGATGGTGCATGGCTT

Downstream 100 bases:

>100_bases
GGCCAACAGCCGCAAAGAACGGTCCAACGGTCAGTTCTCGTGATCGTTGGAATAATGGTCGATATAGCGCTCGCCCAATT
GAGCCAGCGGCAGGATGGTA

Product: gamma-glutamyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 589; Mature: 589

Protein sequence:

>589_residues
MRDGARPMRRRGSRIWCSLALLLWFVGPVTAPVLAEQPPRLAREGRFLPVLATHGMVVAQESMAARIGVDILQRGGNAVD
AAVAVAFALAVTLPRAGNLGGGGFMLVHLAKSGKTIAIDYREMAAAATTPETFLNAEGQADPERSRHGGLAVGVPGTVAG
LALAHRRYGSGRLSLAELAAPAITLAQDGFVVGQDLSDSLYYNLNGLRRWPSSTRIFLDPEGRPLEPGQRLVQKDLAATL
TAIGRDGEAAFYQGPIAEKIVTSVRKAGGEMELKDLAAYRAVEREPVSGTYHGHKIVSMPPPSAGGSHLIEILNILEGFS
LANYGPDSARTIHLTGEAMRRAYADRAKYLGDPDSVTIPLNNLLSKTYASRLRKEIDADHATPSDALQPLAPLPHESDQT
THFSVVDAEGNAVSNTYTLNFSFGLGLVAEGTGVLLNNELDDFAAKPGAPNAYGLVGGNANAPGPRKRPLSSMTPTMVFG
ENGALELVTGSPGGSRIITIVLGLILDMVDFKMNIAEATAMPRVHHQWLPDQLQVERGLSTDTIEKLQELGHHVKVIDAW
GSAQSIALVPGFLMGAADTRQRGPLAIGY

Sequences:

>Translated_589_residues
MRDGARPMRRRGSRIWCSLALLLWFVGPVTAPVLAEQPPRLAREGRFLPVLATHGMVVAQESMAARIGVDILQRGGNAVD
AAVAVAFALAVTLPRAGNLGGGGFMLVHLAKSGKTIAIDYREMAAAATTPETFLNAEGQADPERSRHGGLAVGVPGTVAG
LALAHRRYGSGRLSLAELAAPAITLAQDGFVVGQDLSDSLYYNLNGLRRWPSSTRIFLDPEGRPLEPGQRLVQKDLAATL
TAIGRDGEAAFYQGPIAEKIVTSVRKAGGEMELKDLAAYRAVEREPVSGTYHGHKIVSMPPPSAGGSHLIEILNILEGFS
LANYGPDSARTIHLTGEAMRRAYADRAKYLGDPDSVTIPLNNLLSKTYASRLRKEIDADHATPSDALQPLAPLPHESDQT
THFSVVDAEGNAVSNTYTLNFSFGLGLVAEGTGVLLNNELDDFAAKPGAPNAYGLVGGNANAPGPRKRPLSSMTPTMVFG
ENGALELVTGSPGGSRIITIVLGLILDMVDFKMNIAEATAMPRVHHQWLPDQLQVERGLSTDTIEKLQELGHHVKVIDAW
GSAQSIALVPGFLMGAADTRQRGPLAIGY
>Mature_589_residues
MRDGARPMRRRGSRIWCSLALLLWFVGPVTAPVLAEQPPRLAREGRFLPVLATHGMVVAQESMAARIGVDILQRGGNAVD
AAVAVAFALAVTLPRAGNLGGGGFMLVHLAKSGKTIAIDYREMAAAATTPETFLNAEGQADPERSRHGGLAVGVPGTVAG
LALAHRRYGSGRLSLAELAAPAITLAQDGFVVGQDLSDSLYYNLNGLRRWPSSTRIFLDPEGRPLEPGQRLVQKDLAATL
TAIGRDGEAAFYQGPIAEKIVTSVRKAGGEMELKDLAAYRAVEREPVSGTYHGHKIVSMPPPSAGGSHLIEILNILEGFS
LANYGPDSARTIHLTGEAMRRAYADRAKYLGDPDSVTIPLNNLLSKTYASRLRKEIDADHATPSDALQPLAPLPHESDQT
THFSVVDAEGNAVSNTYTLNFSFGLGLVAEGTGVLLNNELDDFAAKPGAPNAYGLVGGNANAPGPRKRPLSSMTPTMVFG
ENGALELVTGSPGGSRIITIVLGLILDMVDFKMNIAEATAMPRVHHQWLPDQLQVERGLSTDTIEKLQELGHHVKVIDAW
GSAQSIALVPGFLMGAADTRQRGPLAIGY

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=538, Percent_Identity=33.8289962825279, Blast_Score=266, Evalue=3e-71,
Organism=Homo sapiens, GI73915090, Length=538, Percent_Identity=33.8289962825279, Blast_Score=266, Evalue=3e-71,
Organism=Homo sapiens, GI73915096, Length=538, Percent_Identity=33.8289962825279, Blast_Score=266, Evalue=3e-71,
Organism=Homo sapiens, GI73915094, Length=538, Percent_Identity=33.8289962825279, Blast_Score=266, Evalue=3e-71,
Organism=Homo sapiens, GI113429324, Length=539, Percent_Identity=32.8385899814471, Blast_Score=239, Evalue=4e-63,
Organism=Homo sapiens, GI113429326, Length=544, Percent_Identity=32.1691176470588, Blast_Score=231, Evalue=1e-60,
Organism=Homo sapiens, GI109148539, Length=543, Percent_Identity=34.2541436464088, Blast_Score=222, Evalue=6e-58,
Organism=Homo sapiens, GI153266885, Length=482, Percent_Identity=31.5352697095436, Blast_Score=179, Evalue=5e-45,
Organism=Homo sapiens, GI153266901, Length=485, Percent_Identity=31.7525773195876, Blast_Score=177, Evalue=2e-44,
Organism=Homo sapiens, GI153266907, Length=482, Percent_Identity=29.253112033195, Blast_Score=155, Evalue=1e-37,
Organism=Homo sapiens, GI30581157, Length=222, Percent_Identity=32.8828828828829, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI30581155, Length=222, Percent_Identity=32.8828828828829, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI218505805, Length=222, Percent_Identity=30.6306306306306, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI310124095, Length=223, Percent_Identity=30.4932735426009, Blast_Score=87, Evalue=4e-17,
Organism=Escherichia coli, GI1789856, Length=549, Percent_Identity=52.4590163934426, Blast_Score=554, Evalue=1e-159,
Organism=Caenorhabditis elegans, GI17506189, Length=531, Percent_Identity=33.1450094161959, Blast_Score=260, Evalue=2e-69,
Organism=Caenorhabditis elegans, GI72000294, Length=542, Percent_Identity=30.4428044280443, Blast_Score=222, Evalue=5e-58,
Organism=Caenorhabditis elegans, GI212646519, Length=542, Percent_Identity=30.4428044280443, Blast_Score=222, Evalue=5e-58,
Organism=Caenorhabditis elegans, GI193208245, Length=555, Percent_Identity=29.7297297297297, Blast_Score=215, Evalue=5e-56,
Organism=Caenorhabditis elegans, GI193208247, Length=555, Percent_Identity=29.7297297297297, Blast_Score=214, Evalue=8e-56,
Organism=Caenorhabditis elegans, GI17542894, Length=554, Percent_Identity=30.14440433213, Blast_Score=209, Evalue=3e-54,
Organism=Caenorhabditis elegans, GI17564448, Length=434, Percent_Identity=27.1889400921659, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI72001497, Length=234, Percent_Identity=28.2051282051282, Blast_Score=82, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI72001495, Length=234, Percent_Identity=28.2051282051282, Blast_Score=81, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6323330, Length=571, Percent_Identity=29.7723292469352, Blast_Score=186, Evalue=9e-48,
Organism=Drosophila melanogaster, GI45551474, Length=546, Percent_Identity=30.952380952381, Blast_Score=214, Evalue=1e-55,
Organism=Drosophila melanogaster, GI24642670, Length=546, Percent_Identity=30.952380952381, Blast_Score=214, Evalue=1e-55,
Organism=Drosophila melanogaster, GI24642666, Length=546, Percent_Identity=30.952380952381, Blast_Score=214, Evalue=1e-55,
Organism=Drosophila melanogaster, GI161077878, Length=546, Percent_Identity=30.952380952381, Blast_Score=214, Evalue=2e-55,
Organism=Drosophila melanogaster, GI161077880, Length=546, Percent_Identity=30.952380952381, Blast_Score=214, Evalue=2e-55,
Organism=Drosophila melanogaster, GI18859893, Length=520, Percent_Identity=32.3076923076923, Blast_Score=213, Evalue=2e-55,
Organism=Drosophila melanogaster, GI161077496, Length=570, Percent_Identity=30.5263157894737, Blast_Score=209, Evalue=4e-54,
Organism=Drosophila melanogaster, GI18859741, Length=516, Percent_Identity=30.0387596899225, Blast_Score=205, Evalue=7e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 62559; Mature: 62559

Theoretical pI: Translated: 6.94; Mature: 6.94

Prosite motif: PS00462 G_GLU_TRANSPEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRDGARPMRRRGSRIWCSLALLLWFVGPVTAPVLAEQPPRLAREGRFLPVLATHGMVVAQ
CCCCCCHHHHCCCHHHHHHHHHHHHHHHHCCCHHCCCCCHHHHCCCEEEEEECCCEEEEH
ESMAARIGVDILQRGGNAVDAAVAVAFALAVTLPRAGNLGGGGFMLVHLAKSGKTIAIDY
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCEEEEEH
REMAAAATTPETFLNAEGQADPERSRHGGLAVGVPGTVAGLALAHRRYGSGRLSLAELAA
HHHHHHCCCCHHHHCCCCCCCCCHHHCCCEEEECCHHHHHHHHHHHHCCCCCCCHHHHHC
PAITLAQDGFVVGQDLSDSLYYNLNGLRRWPSSTRIFLDPEGRPLEPGQRLVQKDLAATL
CCEEEECCCEEECCCCCCCEEEECCHHHCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHH
TAIGRDGEAAFYQGPIAEKIVTSVRKAGGEMELKDLAAYRAVEREPVSGTYHGHKIVSMP
HHHCCCCCCEEECCCHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCCCEEEECC
PPSAGGSHLIEILNILEGFSLANYGPDSARTIHLTGEAMRRAYADRAKYLGDPDSVTIPL
CCCCCHHHHHHHHHHHHCCCCCCCCCCCCEEEEECHHHHHHHHHHHHHHCCCCCCEEEEH
NNLLSKTYASRLRKEIDADHATPSDALQPLAPLPHESDQTTHFSVVDAEGNAVSNTYTLN
HHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCCCCCCCCEEEEEEECCCCEECEEEEEE
FSFGLGLVAEGTGVLLNNELDDFAAKPGAPNAYGLVGGNANAPGPRKRPLSSMTPTMVFG
EECCCCEEECCCEEEECCCCHHHHCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCEEEEC
ENGALELVTGSPGGSRIITIVLGLILDMVDFKMNIAEATAMPRVHHQWLPDQLQVERGLS
CCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCHHHHHHCCCC
TDTIEKLQELGHHVKVIDAWGSAQSIALVPGFLMGAADTRQRGPLAIGY
HHHHHHHHHCCCEEEEEECCCCCCEEEECCHHHHCCCCCCCCCCEECCC
>Mature Secondary Structure
MRDGARPMRRRGSRIWCSLALLLWFVGPVTAPVLAEQPPRLAREGRFLPVLATHGMVVAQ
CCCCCCHHHHCCCHHHHHHHHHHHHHHHHCCCHHCCCCCHHHHCCCEEEEEECCCEEEEH
ESMAARIGVDILQRGGNAVDAAVAVAFALAVTLPRAGNLGGGGFMLVHLAKSGKTIAIDY
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCEEEEEH
REMAAAATTPETFLNAEGQADPERSRHGGLAVGVPGTVAGLALAHRRYGSGRLSLAELAA
HHHHHHCCCCHHHHCCCCCCCCCHHHCCCEEEECCHHHHHHHHHHHHCCCCCCCHHHHHC
PAITLAQDGFVVGQDLSDSLYYNLNGLRRWPSSTRIFLDPEGRPLEPGQRLVQKDLAATL
CCEEEECCCEEECCCCCCCEEEECCHHHCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHH
TAIGRDGEAAFYQGPIAEKIVTSVRKAGGEMELKDLAAYRAVEREPVSGTYHGHKIVSMP
HHHCCCCCCEEECCCHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCCCEEEECC
PPSAGGSHLIEILNILEGFSLANYGPDSARTIHLTGEAMRRAYADRAKYLGDPDSVTIPL
CCCCCHHHHHHHHHHHHCCCCCCCCCCCCEEEEECHHHHHHHHHHHHHHCCCCCCEEEEH
NNLLSKTYASRLRKEIDADHATPSDALQPLAPLPHESDQTTHFSVVDAEGNAVSNTYTLN
HHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCCCCCCCCEEEEEEECCCCEECEEEEEE
FSFGLGLVAEGTGVLLNNELDDFAAKPGAPNAYGLVGGNANAPGPRKRPLSSMTPTMVFG
EECCCCEEECCCEEEECCCCHHHHCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCEEEEC
ENGALELVTGSPGGSRIITIVLGLILDMVDFKMNIAEATAMPRVHHQWLPDQLQVERGLS
CCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCHHHHHHCCCC
TDTIEKLQELGHHVKVIDAWGSAQSIALVPGFLMGAADTRQRGPLAIGY
HHHHHHHHHCCCEEEEEECCCCCCEEEECCHHHHCCCCCCCCCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2570061; 9278503; 8041620; 1360205 [H]