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The map label for this gene is algC [H]

Identifier: 182680479

GI number: 182680479

Start: 4058998

End: 4060497

Strand: Reverse

Name: algC [H]

Synonym: Bind_3580

Alternate gene names: 182680479

Gene position: 4060497-4058998 (Counterclockwise)

Preceding gene: 182680480

Following gene: 182680478

Centisome position: 97.37

GC content: 57.47

Gene sequence:

>1500_bases
ATGTTCCCGAAGCCCGTGCCTTTCCTGCAGACCAACACTTACGCCTATGAATCTTCCCCCATGGTCAAGCCCACCGGCTT
TCGCGAATATGACGCGCGTTGGCTCTTCGAGAAGGAGATCAACCTCATGGGTGTCCAGGCCCTGGGGCTTGGCCTTGGAA
CCTTGCTGGCCGAAATGGGCGTCAAACCGGAAGTCGTCACGGGTCATGATTTCCGCTCCTATTCCGCTTCGATCAAGCTC
GCCATGGTGACCGGGCTGATGGCGGCCGGTGTGCGCGTGCATGATATCGGCCTCGCTCTTTCGCCCATGGCCTATTTCGC
GCAATTCGATCTCGACGTTCCGGCCGTCGCCATGGTGACGGCCTCCCATAATGATAATGGTTGGACCGGCGTGAAAATGG
GCGCGCAGCGGCCGGTCACCTTCGGTCCCGATGAAATGGGCCGACTCAAGGAGATCGTGCTTTCAGGCAGCTACCGCTAT
GCCGATGGCGGCTCCTATCGTTTTGTCGAGGATTTCCCTTCCCATTATATCAATGATCTGACTAATCGTGCGCCGATCAA
GCGCAAGCTCAAGGTCGTCGTCGCTTGCGGCAATGGCACTGCCGGCGCCTTCGCGCCTAAAATCATCGAAAAGCTCGGCT
GCGAAGTCGTTCCCCTCGATACCGATCTCGATTTCAATTTCCCGCATTACAATCCCAATCCCGAAGACCTGCACATGCTG
CACGCCATGGCGGACAAGGTGCGTGAGAGCGGCGCCGATCTCGGCCTCGGCTTTGACGGCGACGGCGACCGTTGCGGCGT
CGTCGATAATCACGGCGAGGAAATTTTTGCCGACAAGATCGGTGTCATGCTCGCCCGCGATCTCTCGAAATTGCATCCCG
GCGCGACCTTCGTCGTCGATGTCAAATCGACGGGCCTGTTCGCCACCGATCCGGATTTGCTGAAACAAAACGTCAAAGCC
GATTATTGGAAGACTGGCCATTCCTATATCAAGCGCCGAGTGACTGATCTGAAGGCGCTCGCCGGCTTCGAGAAATCTGG
CCATTTCTTCTTCAACGCGCCGGTTGGACGCGGTTATGACGATGGACTCGTCACGGCGATCCATATTCTCGACATGCTCG
ACCGCAATCCTGATAAGTCCATGGCCGAGCTCTATGAGGCCCTGCCGAAAACCTGGGGTTCGCCAACCATGTCGCCCCAT
TGCGACGACGAAAAGAAATATGGCGTCGTGGACAAGGTCGTCGAACGGTTCAAGGCCATGCAGGCTAAAGGTGAAACGCT
GACGGGCCAGAAAATCCGCGATCTCGTGACGGTCAATGGCGTCCGCGTTACGACAGAGGATGGAACCTGGGGCCTAGTCC
GCGCTTCATCCAACAAGCCGGAATTGGTGGTCGTTGTCGAAAGCCCCGCCTCGGAAGCCAGAATGCGGGAAATGTTCGCC
GCCGTGGACGGTGTTTTGCGGGAAAACCCCGAAGTTGGCGCCTATAACCAAACCATCTGA

Upstream 100 bases:

>100_bases
GAAAAATAGCTCTAGGTCTTTGACATTCAGCAAATAGCCTTGCAGCAAATAGCCTCGCCAAAAGTCTGACTGTGCGTGAA
GCTCAATCGAAGGATGATTC

Downstream 100 bases:

>100_bases
TATTAATGGAAACCAGAGTCTTCCCCATGAACTCATGGGGAAGACTCTATGCTTATCGATCAAGCCATGGCCGATGTCGA
AATAGCGATCCGGGTCACAC

Product: phosphoglucomutase/phosphomannomutase subunit alpha/beta

Products: NA

Alternate protein names: PMM / PGM [H]

Number of amino acids: Translated: 499; Mature: 499

Protein sequence:

>499_residues
MFPKPVPFLQTNTYAYESSPMVKPTGFREYDARWLFEKEINLMGVQALGLGLGTLLAEMGVKPEVVTGHDFRSYSASIKL
AMVTGLMAAGVRVHDIGLALSPMAYFAQFDLDVPAVAMVTASHNDNGWTGVKMGAQRPVTFGPDEMGRLKEIVLSGSYRY
ADGGSYRFVEDFPSHYINDLTNRAPIKRKLKVVVACGNGTAGAFAPKIIEKLGCEVVPLDTDLDFNFPHYNPNPEDLHML
HAMADKVRESGADLGLGFDGDGDRCGVVDNHGEEIFADKIGVMLARDLSKLHPGATFVVDVKSTGLFATDPDLLKQNVKA
DYWKTGHSYIKRRVTDLKALAGFEKSGHFFFNAPVGRGYDDGLVTAIHILDMLDRNPDKSMAELYEALPKTWGSPTMSPH
CDDEKKYGVVDKVVERFKAMQAKGETLTGQKIRDLVTVNGVRVTTEDGTWGLVRASSNKPELVVVVESPASEARMREMFA
AVDGVLRENPEVGAYNQTI

Sequences:

>Translated_499_residues
MFPKPVPFLQTNTYAYESSPMVKPTGFREYDARWLFEKEINLMGVQALGLGLGTLLAEMGVKPEVVTGHDFRSYSASIKL
AMVTGLMAAGVRVHDIGLALSPMAYFAQFDLDVPAVAMVTASHNDNGWTGVKMGAQRPVTFGPDEMGRLKEIVLSGSYRY
ADGGSYRFVEDFPSHYINDLTNRAPIKRKLKVVVACGNGTAGAFAPKIIEKLGCEVVPLDTDLDFNFPHYNPNPEDLHML
HAMADKVRESGADLGLGFDGDGDRCGVVDNHGEEIFADKIGVMLARDLSKLHPGATFVVDVKSTGLFATDPDLLKQNVKA
DYWKTGHSYIKRRVTDLKALAGFEKSGHFFFNAPVGRGYDDGLVTAIHILDMLDRNPDKSMAELYEALPKTWGSPTMSPH
CDDEKKYGVVDKVVERFKAMQAKGETLTGQKIRDLVTVNGVRVTTEDGTWGLVRASSNKPELVVVVESPASEARMREMFA
AVDGVLRENPEVGAYNQTI
>Mature_499_residues
MFPKPVPFLQTNTYAYESSPMVKPTGFREYDARWLFEKEINLMGVQALGLGLGTLLAEMGVKPEVVTGHDFRSYSASIKL
AMVTGLMAAGVRVHDIGLALSPMAYFAQFDLDVPAVAMVTASHNDNGWTGVKMGAQRPVTFGPDEMGRLKEIVLSGSYRY
ADGGSYRFVEDFPSHYINDLTNRAPIKRKLKVVVACGNGTAGAFAPKIIEKLGCEVVPLDTDLDFNFPHYNPNPEDLHML
HAMADKVRESGADLGLGFDGDGDRCGVVDNHGEEIFADKIGVMLARDLSKLHPGATFVVDVKSTGLFATDPDLLKQNVKA
DYWKTGHSYIKRRVTDLKALAGFEKSGHFFFNAPVGRGYDDGLVTAIHILDMLDRNPDKSMAELYEALPKTWGSPTMSPH
CDDEKKYGVVDKVVERFKAMQAKGETLTGQKIRDLVTVNGVRVTTEDGTWGLVRASSNKPELVVVVESPASEARMREMFA
AVDGVLRENPEVGAYNQTI

Specific function: The phosphomannomutase activity produces a precursor for alginate polymerization. The alginate layer causes a mucoid phenotype and provides a protective barrier against host immune defenses and antibiotics. Also involved in core-LPS biosynthesis due to it

COG id: COG1109

COG function: function code G; Phosphomannomutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphohexose mutase family [H]

Homologues:

Organism=Escherichia coli, GI1788361, Length=488, Percent_Identity=28.8934426229508, Blast_Score=126, Evalue=3e-30,
Organism=Escherichia coli, GI1789566, Length=346, Percent_Identity=26.3005780346821, Blast_Score=75, Evalue=9e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005844
- InterPro:   IPR016055
- InterPro:   IPR005845
- InterPro:   IPR005846
- InterPro:   IPR005843
- InterPro:   IPR016066
- InterPro:   IPR005841 [H]

Pfam domain/function: PF02878 PGM_PMM_I; PF02879 PGM_PMM_II; PF02880 PGM_PMM_III; PF00408 PGM_PMM_IV [H]

EC number: =5.4.2.2; =5.4.2.8 [H]

Molecular weight: Translated: 54724; Mature: 54724

Theoretical pI: Translated: 5.93; Mature: 5.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFPKPVPFLQTNTYAYESSPMVKPTGFREYDARWLFEKEINLMGVQALGLGLGTLLAEMG
CCCCCCCCEECCCEEECCCCCCCCCCCCCCCCEEEEECCCCEEEHHHHHHHHHHHHHHHC
VKPEVVTGHDFRSYSASIKLAMVTGLMAAGVRVHDIGLALSPMAYFAQFDLDVPAVAMVT
CCCEEECCCCCCCHHCEEEHHHHHHHHHCCCEEEECCEEHHHHHHHHHCCCCCCEEEEEE
ASHNDNGWTGVKMGAQRPVTFGPDEMGRLKEIVLSGSYRYADGGSYRFVEDFPSHYINDL
ECCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHCCCEEECCCCCEEHHHHHHHHHHHHH
TNRAPIKRKLKVVVACGNGTAGAFAPKIIEKLGCEVVPLDTDLDFNFPHYNPNPEDLHML
HCCCCCCEEEEEEEEECCCCCCHHHHHHHHHHCCEEEECCCCCCCCCCCCCCCHHHHHHH
HAMADKVRESGADLGLGFDGDGDRCGVVDNHGEEIFADKIGVMLARDLSKLHPGATFVVD
HHHHHHHHHCCCCCCCCCCCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEE
VKSTGLFATDPDLLKQNVKADYWKTGHSYIKRRVTDLKALAGFEKSGHFFFNAPVGRGYD
ECCCCCEECCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCC
DGLVTAIHILDMLDRNPDKSMAELYEALPKTWGSPTMSPHCDDEKKYGVVDKVVERFKAM
CHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
QAKGETLTGQKIRDLVTVNGVRVTTEDGTWGLVRASSNKPELVVVVESPASEARMREMFA
HHCCCCCCHHHHHHHEEECCEEEEECCCCEEEEEECCCCCCEEEEECCCCHHHHHHHHHH
AVDGVLRENPEVGAYNQTI
HHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MFPKPVPFLQTNTYAYESSPMVKPTGFREYDARWLFEKEINLMGVQALGLGLGTLLAEMG
CCCCCCCCEECCCEEECCCCCCCCCCCCCCCCEEEEECCCCEEEHHHHHHHHHHHHHHHC
VKPEVVTGHDFRSYSASIKLAMVTGLMAAGVRVHDIGLALSPMAYFAQFDLDVPAVAMVT
CCCEEECCCCCCCHHCEEEHHHHHHHHHCCCEEEECCEEHHHHHHHHHCCCCCCEEEEEE
ASHNDNGWTGVKMGAQRPVTFGPDEMGRLKEIVLSGSYRYADGGSYRFVEDFPSHYINDL
ECCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHCCCEEECCCCCEEHHHHHHHHHHHHH
TNRAPIKRKLKVVVACGNGTAGAFAPKIIEKLGCEVVPLDTDLDFNFPHYNPNPEDLHML
HCCCCCCEEEEEEEEECCCCCCHHHHHHHHHHCCEEEECCCCCCCCCCCCCCCHHHHHHH
HAMADKVRESGADLGLGFDGDGDRCGVVDNHGEEIFADKIGVMLARDLSKLHPGATFVVD
HHHHHHHHHCCCCCCCCCCCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEE
VKSTGLFATDPDLLKQNVKADYWKTGHSYIKRRVTDLKALAGFEKSGHFFFNAPVGRGYD
ECCCCCEECCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCC
DGLVTAIHILDMLDRNPDKSMAELYEALPKTWGSPTMSPHCDDEKKYGVVDKVVERFKAM
CHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
QAKGETLTGQKIRDLVTVNGVRVTTEDGTWGLVRASSNKPELVVVVESPASEARMREMFA
HHCCCCCCHHHHHHHEEECCEEEEECCCCEEEEEECCCCCCEEEEECCCCHHHHHHHHHH
AVDGVLRENPEVGAYNQTI
HHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12928499 [H]