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The map label for this gene is hemE [H]

Identifier: 182680469

GI number: 182680469

Start: 4048399

End: 4049451

Strand: Reverse

Name: hemE [H]

Synonym: Bind_3569

Alternate gene names: 182680469

Gene position: 4049451-4048399 (Counterclockwise)

Preceding gene: 182680478

Following gene: 182680468

Centisome position: 97.11

GC content: 59.83

Gene sequence:

>1053_bases
TTGAAGCCTGCGGACACTTGTCCTTCTCCCTCGACGGGCAAACCCTTGCTCGATGTCTGTCAGGGAAAAATCTTTTCAAA
GCCACCCGTATGGCTCATGCGCCAGGCCGGACGTTACCTTCCCGAATATCAGGCGATCCGGGCGCAATCGGCGTCCTTTC
TTGATTTCTGCTATAATCCTCTCGCCGCCAGCGAGGCGACCTTGCAGCCGATCCGCCGCTTCGGCTTCGATGCAGCGATC
TTGTTCAGCGATATTCTGGTGATTCCCGATGCGCTCGGCCAAAAGGTGCGCTTCGAACAGGGTGAAGGTCCCCGCCTCGA
ACCGATCGCCACGCTCGACGATTTTCTCCGCTTACGGGAAACCATCGATCTCAACCTGCTCGCGCCGGTATTCGAAACCG
TGGACCGCGTCGCGAAGGCCTTGCCTCCTGCTACGGCCTTGATTGGATTTTGCGGCGCGCCTTGGACGGTCGCGAGCTAT
ATGATCGCCGGACGGGGCACACCCGATCAGGCGCCGGCGCGGCTCTTTGCCTATCACCACCGTGACCTGTTCCAGCGCCT
GATTGATCGTCTCGTTGCAGCGAGCGTGGATTATCTCAGCCGGCAGTTCGAGGCTGGTGTCGAAATTGTCCAGATTTTCG
ATTCTTGGGCGGGCGTCCTCCCACAATCGGAATATGAGGCCTGGTGCCTTGAGCCCATTCGCGCCATTGTAGAGGGAGTG
CGTCAACGCTATCCTGGCGCGAAAATCATCGGTTTCCCGCGTGGGATCGGCAGCAGGCTGGAAAGTTTCGCGAAAATAAC
CGGGGTCGATGTGCTGGGCCTCGACACCAGCGCGGAACTGACCTTTGCGGCCGGGCTCGATCCGCGGCTCGTCTTTCAGG
GCAATCTTGATCCGCTTGCTTTGCTGGCCGGCGGCGAGGCGCTGGAACGAGGCGTCGCAGCGATTTTATCCGACCTGCAG
GGGCGGCCATTCATTTTCAACTTGGGTCATGGCATTCTCCCCACGACTCCCATTGCCCATGTGGAACGGCTGGTCGCGCT
GCTGCGGGCATGA

Upstream 100 bases:

>100_bases
GAACCCGTGTGCACAGTCGCGAATGAACCCAATTCCCTCCCTAAAAGAAGATAAAAACCCAAATTCAAAGATTCTTTGAA
TTATTTTGAGGAATATCCTT

Downstream 100 bases:

>100_bases
TATCGGGCTGGTTTTCCGTTTGGACGGATCCGAACGAAGGACTTTTACCCTGGAGAAGGCATGGATAATCCCTACCTCTG
GATCAAAACCCTGCATGTCC

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D [H]

Number of amino acids: Translated: 350; Mature: 350

Protein sequence:

>350_residues
MKPADTCPSPSTGKPLLDVCQGKIFSKPPVWLMRQAGRYLPEYQAIRAQSASFLDFCYNPLAASEATLQPIRRFGFDAAI
LFSDILVIPDALGQKVRFEQGEGPRLEPIATLDDFLRLRETIDLNLLAPVFETVDRVAKALPPATALIGFCGAPWTVASY
MIAGRGTPDQAPARLFAYHHRDLFQRLIDRLVAASVDYLSRQFEAGVEIVQIFDSWAGVLPQSEYEAWCLEPIRAIVEGV
RQRYPGAKIIGFPRGIGSRLESFAKITGVDVLGLDTSAELTFAAGLDPRLVFQGNLDPLALLAGGEALERGVAAILSDLQ
GRPFIFNLGHGILPTTPIAHVERLVALLRA

Sequences:

>Translated_350_residues
MKPADTCPSPSTGKPLLDVCQGKIFSKPPVWLMRQAGRYLPEYQAIRAQSASFLDFCYNPLAASEATLQPIRRFGFDAAI
LFSDILVIPDALGQKVRFEQGEGPRLEPIATLDDFLRLRETIDLNLLAPVFETVDRVAKALPPATALIGFCGAPWTVASY
MIAGRGTPDQAPARLFAYHHRDLFQRLIDRLVAASVDYLSRQFEAGVEIVQIFDSWAGVLPQSEYEAWCLEPIRAIVEGV
RQRYPGAKIIGFPRGIGSRLESFAKITGVDVLGLDTSAELTFAAGLDPRLVFQGNLDPLALLAGGEALERGVAAILSDLQ
GRPFIFNLGHGILPTTPIAHVERLVALLRA
>Mature_350_residues
MKPADTCPSPSTGKPLLDVCQGKIFSKPPVWLMRQAGRYLPEYQAIRAQSASFLDFCYNPLAASEATLQPIRRFGFDAAI
LFSDILVIPDALGQKVRFEQGEGPRLEPIATLDDFLRLRETIDLNLLAPVFETVDRVAKALPPATALIGFCGAPWTVASY
MIAGRGTPDQAPARLFAYHHRDLFQRLIDRLVAASVDYLSRQFEAGVEIVQIFDSWAGVLPQSEYEAWCLEPIRAIVEGV
RQRYPGAKIIGFPRGIGSRLESFAKITGVDVLGLDTSAELTFAAGLDPRLVFQGNLDPLALLAGGEALERGVAAILSDLQ
GRPFIFNLGHGILPTTPIAHVERLVALLRA

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III [H]

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family [H]

Homologues:

Organism=Homo sapiens, GI71051616, Length=325, Percent_Identity=39.0769230769231, Blast_Score=191, Evalue=8e-49,
Organism=Escherichia coli, GI2367337, Length=317, Percent_Identity=40.3785488958991, Blast_Score=221, Evalue=4e-59,
Organism=Saccharomyces cerevisiae, GI6320252, Length=333, Percent_Identity=34.5345345345345, Blast_Score=182, Evalue=5e-47,
Organism=Drosophila melanogaster, GI221330099, Length=337, Percent_Identity=37.3887240356083, Blast_Score=213, Evalue=1e-55,
Organism=Drosophila melanogaster, GI19921920, Length=337, Percent_Identity=37.3887240356083, Blast_Score=213, Evalue=1e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006361
- InterPro:   IPR000257 [H]

Pfam domain/function: PF01208 URO-D [H]

EC number: =4.1.1.37 [H]

Molecular weight: Translated: 38238; Mature: 38238

Theoretical pI: Translated: 5.77; Mature: 5.77

Prosite motif: PS00906 UROD_1 ; PS00907 UROD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPADTCPSPSTGKPLLDVCQGKIFSKPPVWLMRQAGRYLPEYQAIRAQSASFLDFCYNP
CCCCCCCCCCCCCCHHHHHHCCCCCCCCCHHHHHHHCCCCCHHHHHHHCCHHHHHHHCCC
LAASEATLQPIRRFGFDAAILFSDILVIPDALGQKVRFEQGEGPRLEPIATLDDFLRLRE
HHCCHHHHHHHHHHCCHHHHHHHHHHHCCHHHCCCEECCCCCCCCCCHHHHHHHHHHHHH
TIDLNLLAPVFETVDRVAKALPPATALIGFCGAPWTVASYMIAGRGTPDQAPARLFAYHH
HHCHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCHHHHHHHHHHCCCCCCHHHHHHHHHHH
RDLFQRLIDRLVAASVDYLSRQFEAGVEIVQIFDSWAGVLPQSEYEAWCLEPIRAIVEGV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
RQRYPGAKIIGFPRGIGSRLESFAKITGVDVLGLDTSAELTFAAGLDPRLVFQGNLDPLA
HHHCCCCEEEECCCHHHHHHHHHHHHHCCEEEECCCCCCEEEECCCCCEEEEECCCCCEE
LLAGGEALERGVAAILSDLQGRPFIFNLGHGILPTTPIAHVERLVALLRA
EEECCHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MKPADTCPSPSTGKPLLDVCQGKIFSKPPVWLMRQAGRYLPEYQAIRAQSASFLDFCYNP
CCCCCCCCCCCCCCHHHHHHCCCCCCCCCHHHHHHHCCCCCHHHHHHHCCHHHHHHHCCC
LAASEATLQPIRRFGFDAAILFSDILVIPDALGQKVRFEQGEGPRLEPIATLDDFLRLRE
HHCCHHHHHHHHHHCCHHHHHHHHHHHCCHHHCCCEECCCCCCCCCCHHHHHHHHHHHHH
TIDLNLLAPVFETVDRVAKALPPATALIGFCGAPWTVASYMIAGRGTPDQAPARLFAYHH
HHCHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCHHHHHHHHHHCCCCCCHHHHHHHHHHH
RDLFQRLIDRLVAASVDYLSRQFEAGVEIVQIFDSWAGVLPQSEYEAWCLEPIRAIVEGV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
RQRYPGAKIIGFPRGIGSRLESFAKITGVDVLGLDTSAELTFAAGLDPRLVFQGNLDPLA
HHHCCCCEEEECCCHHHHHHHHHHHHHCCEEEECCCCCCEEEECCCCCEEEEECCCCCEE
LLAGGEALERGVAAILSDLQGRPFIFNLGHGILPTTPIAHVERLVALLRA
EEECCHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA