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The map label for this gene is pdxA

Identifier: 182680220

GI number: 182680220

Start: 3774670

End: 3775683

Strand: Reverse

Name: pdxA

Synonym: Bind_3318

Alternate gene names: 182680220

Gene position: 3775683-3774670 (Counterclockwise)

Preceding gene: 182680221

Following gene: 182680219

Centisome position: 90.54

GC content: 61.14

Gene sequence:

>1014_bases
ATGGTAATGCTTGATCATCCTCTCGCCGTCACCATGGGCGACCCCTCCGGCATCGGTCCGGAAATCATCGCAAAAATGTA
TCTGCGCCGTCCTGATAAACGGAACTGGATCGTCGTCGGCGATCCGCTGGTGATGGAGCATGCTATCGCGAACCTTGGAG
TTGCCGTTCAAATACGCAGGATCGCGACGGTCGAGGAGGCGGGATGCGAGGATGGCGTCCTGAACGTACTGGCCTCCTCA
TCGCTCGCGACCTTGCCAGCGGTCGGGCGTGTTTCCGCGGTCAGTGGTCAGGCGGCCTATGACGCCATTGTCACCGCTAT
CGGGCTGGCTCGGCAAGGAACGATCCGGGGCATCGTCACGGCGCCAATCCATAAGGAAGCTCTGGCTGCCGCCGGCATCC
ACTATCCTGGTCATACGGAAATCTTGGCCGAACAGGGCGGCGCGCAGCACGTTGCCATGATGCTGGCCAATGACGAGATC
CGTACGGTGCTCGTGACGATCCATTGTTCGCTTGCGGATGCGATCCGCAAAGCGGATTTCCCGGCGCAGATGCAAGCCAT
CCGTCTGGCGCATGAGGGGGCGCGTGCTCTCGGCATCGTGCAGCCGCGTATCGCGGTGGCGGGTCTGAACCCGCATGCCG
GAGAGGGTGGCTTGTTCGGTGACGAGGAAATCCGCATCATCACGCCGGCGATCGCGGCGGCGCGCGCCGAGGGCATCGAT
GCAACGGGACCGTGGCCTGGCGATACTGTCTTCATGCAGGCGCGCCTCGGCAAGTTCGATGTGGTCGTCGCGCAATATCA
CGACCAGGGCCTGATCCCGGTGAAGTTCATGGGGTTGGAAAAAGGCGTTAACATCACGCTCGGCTTGCCATTTGTCCGCA
CCAGCCCGGACCATGGGACCGCTTTCGATATTGCGGGGCGTGGCATTGCTGATTCTTCCAGCCTCGAGACAGCGTTCGAT
TATGCTACACGGCTGAAGGTTCCGACTCCCTTCTTCTCTGGAGCCATGTCATGA

Upstream 100 bases:

>100_bases
GGGTATTCTGTGCCGTCCTCGGAAAACCAGAACGGATCGGATCATTCACCCCGAACGGCGGCATGGACGTCTCCGGCGTT
TTTTCAAAGGTCTCCGATCG

Downstream 100 bases:

>100_bases
AACAGTGCGATTTCATTTTCATGCTCACACGCAATGATCGAACCGTGCCGGATGCCGCCCGACATGTCGAAACCGCCTGT
AAAGCGGGAATTCGCCATAT

Product: 4-hydroxythreonine-4-phosphate dehydrogenase

Products: NA

Alternate protein names: 4-(phosphohydroxy)-L-threonine dehydrogenase

Number of amino acids: Translated: 337; Mature: 337

Protein sequence:

>337_residues
MVMLDHPLAVTMGDPSGIGPEIIAKMYLRRPDKRNWIVVGDPLVMEHAIANLGVAVQIRRIATVEEAGCEDGVLNVLASS
SLATLPAVGRVSAVSGQAAYDAIVTAIGLARQGTIRGIVTAPIHKEALAAAGIHYPGHTEILAEQGGAQHVAMMLANDEI
RTVLVTIHCSLADAIRKADFPAQMQAIRLAHEGARALGIVQPRIAVAGLNPHAGEGGLFGDEEIRIITPAIAAARAEGID
ATGPWPGDTVFMQARLGKFDVVVAQYHDQGLIPVKFMGLEKGVNITLGLPFVRTSPDHGTAFDIAGRGIADSSSLETAFD
YATRLKVPTPFFSGAMS

Sequences:

>Translated_337_residues
MVMLDHPLAVTMGDPSGIGPEIIAKMYLRRPDKRNWIVVGDPLVMEHAIANLGVAVQIRRIATVEEAGCEDGVLNVLASS
SLATLPAVGRVSAVSGQAAYDAIVTAIGLARQGTIRGIVTAPIHKEALAAAGIHYPGHTEILAEQGGAQHVAMMLANDEI
RTVLVTIHCSLADAIRKADFPAQMQAIRLAHEGARALGIVQPRIAVAGLNPHAGEGGLFGDEEIRIITPAIAAARAEGID
ATGPWPGDTVFMQARLGKFDVVVAQYHDQGLIPVKFMGLEKGVNITLGLPFVRTSPDHGTAFDIAGRGIADSSSLETAFD
YATRLKVPTPFFSGAMS
>Mature_337_residues
MVMLDHPLAVTMGDPSGIGPEIIAKMYLRRPDKRNWIVVGDPLVMEHAIANLGVAVQIRRIATVEEAGCEDGVLNVLASS
SLATLPAVGRVSAVSGQAAYDAIVTAIGLARQGTIRGIVTAPIHKEALAAAGIHYPGHTEILAEQGGAQHVAMMLANDEI
RTVLVTIHCSLADAIRKADFPAQMQAIRLAHEGARALGIVQPRIAVAGLNPHAGEGGLFGDEEIRIITPAIAAARAEGID
ATGPWPGDTVFMQARLGKFDVVVAQYHDQGLIPVKFMGLEKGVNITLGLPFVRTSPDHGTAFDIAGRGIADSSSLETAFD
YATRLKVPTPFFSGAMS

Specific function: Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)

COG id: COG1995

COG function: function code H; Pyridoxal phosphate biosynthesis protein

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pdxA family

Homologues:

Organism=Escherichia coli, GI1786237, Length=333, Percent_Identity=39.3393393393393, Blast_Score=218, Evalue=4e-58,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PDXA_BEII9 (B2IDU5)

Other databases:

- EMBL:   CP001016
- RefSeq:   YP_001834366.1
- ProteinModelPortal:   B2IDU5
- GeneID:   6199731
- GenomeReviews:   CP001016_GR
- KEGG:   bid:Bind_3318
- HOGENOM:   HBG451136
- OMA:   DSAFAPN
- ProtClustDB:   CLSK984533
- GO:   GO:0005737
- HAMAP:   MF_00536
- InterPro:   IPR005255
- TIGRFAMs:   TIGR00557

Pfam domain/function: PF04166 PdxA

EC number: =1.1.1.262

Molecular weight: Translated: 35408; Mature: 35408

Theoretical pI: Translated: 6.28; Mature: 6.28

Prosite motif: NA

Important sites: BINDING 138-138 BINDING 139-139 BINDING 275-275 BINDING 284-284 BINDING 293-293

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVMLDHPLAVTMGDPSGIGPEIIAKMYLRRPDKRNWIVVGDPLVMEHAIANLGVAVQIRR
CEEECCCEEEEECCCCCCCHHHHHHHHHCCCCCCCEEEECCHHHHHHHHHHCCEEEEEEE
IATVEEAGCEDGVLNVLASSSLATLPAVGRVSAVSGQAAYDAIVTAIGLARQGTIRGIVT
HHHHHHCCCCCHHHHHHHCCCHHHCCCCCCEEECCCCHHHHHHHHHHHHCCCCCEEEEEE
APIHKEALAAAGIHYPGHTEILAEQGGAQHVAMMLANDEIRTVLVTIHCSLADAIRKADF
CCCHHHHHHHCCCCCCCCCHHEECCCCCCEEEEEEECCCEEEEEEEEEEHHHHHHHHCCC
PAQMQAIRLAHEGARALGIVQPRIAVAGLNPHAGEGGLFGDEEIRIITPAIAAARAEGID
CHHHHHHHHHHCCCCEEEEECCCEEEEECCCCCCCCCCCCCCCEEEEECHHHHHHHCCCC
ATGPWPGDTVFMQARLGKFDVVVAQYHDQGLIPVKFMGLEKGVNITLGLPFVRTSPDHGT
CCCCCCCCEEEEEEECCCEEEEEEEECCCCCCEEEEEEECCCCEEEEECCEEEECCCCCC
AFDIAGRGIADSSSLETAFDYATRLKVPTPFFSGAMS
EEEECCCCCCCCCCHHHHHHHHHEECCCCCHHCCCCC
>Mature Secondary Structure
MVMLDHPLAVTMGDPSGIGPEIIAKMYLRRPDKRNWIVVGDPLVMEHAIANLGVAVQIRR
CEEECCCEEEEECCCCCCCHHHHHHHHHCCCCCCCEEEECCHHHHHHHHHHCCEEEEEEE
IATVEEAGCEDGVLNVLASSSLATLPAVGRVSAVSGQAAYDAIVTAIGLARQGTIRGIVT
HHHHHHCCCCCHHHHHHHCCCHHHCCCCCCEEECCCCHHHHHHHHHHHHCCCCCEEEEEE
APIHKEALAAAGIHYPGHTEILAEQGGAQHVAMMLANDEIRTVLVTIHCSLADAIRKADF
CCCHHHHHHHCCCCCCCCCHHEECCCCCCEEEEEEECCCEEEEEEEEEEHHHHHHHHCCC
PAQMQAIRLAHEGARALGIVQPRIAVAGLNPHAGEGGLFGDEEIRIITPAIAAARAEGID
CHHHHHHHHHHCCCCEEEEECCCEEEEECCCCCCCCCCCCCCCEEEEECHHHHHHHCCCC
ATGPWPGDTVFMQARLGKFDVVVAQYHDQGLIPVKFMGLEKGVNITLGLPFVRTSPDHGT
CCCCCCCCEEEEEEECCCEEEEEEEECCCCCCEEEEEEECCCCEEEEECCEEEECCCCCC
AFDIAGRGIADSSSLETAFDYATRLKVPTPFFSGAMS
EEEECCCCCCCCCCHHHHHHHHHEECCCCCHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA