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The map label for this gene is panB [H]

Identifier: 182680199

GI number: 182680199

Start: 3749399

End: 3750220

Strand: Reverse

Name: panB [H]

Synonym: Bind_3297

Alternate gene names: 182680199

Gene position: 3750220-3749399 (Counterclockwise)

Preceding gene: 182680203

Following gene: 182680197

Centisome position: 89.93

GC content: 61.31

Gene sequence:

>822_bases
ATGAGCATGGCGGATAAGGCGGCGCGTTTTGCTGAGATGAAGAGGCGGGGCGAGCCGATCGCCATGCTGACCGCTTATGA
TGCGCCTATGGCGCGAGCGGAAGCTGCGGCCCGCGTCGATATTCTGCTCGTGGGTGATAGTGTCGGCACAAACATGCTCG
GCTATGCCAGCGAGCAGGAGGTGACGCTTGCGGATATGGCGCATCATACACGGGCGGTCCGGCGCGGTGCGCCAGACGCT
TTCGTGATTTCCGATCTCCCTGTCGCGACTTATGAAACCCCCACCGAGGCCGTGGCCAATGCCAGGGTTCTGGCCGAAGC
TGGCGCGGATATGGTGAAATTCGAAGGCTGCCGCCCCGCCATTGTGGAAGCGCTCGTCGGCGCGGGTTTTGCGGTTTGCG
GCCATCTGGGTCTTGAGCCGCAGCACCATGCCGAAAAACGCCTCAAGGGCAAACAAGCCGGTGAGGCGCATCAATTGGTC
GAGGCCGCCTTGACCATGGAGAAAGCTGGCATTGCGATGCTGGTTCTGGAACTGATCCCCGAGGAAGTGGCGGAGATCGT
CACGCAAAGGCTGAAAGTGCCGACCATTGGTATTGGCGCCGGCCGGGCGACCGATGGCCAGGTTCTGGTGATCTGCGACG
TGCTGGGCTATACTAAAGCCGCGTTTCGCCACAATAAGCGCTATGCGGAGGTCGGCGAAACGATGGAAGCCGCCGCGCGC
GCCTATGTCGGGGATGTGCATAGCAAGGCGTTTCCGGCCGCTGCCAATGCCTTTCCCATGAACAAGGAGCAATTGCCGGA
ATTCCTTGCCTCGCTGGCCTGA

Upstream 100 bases:

>100_bases
TTTTGCCCCGGTTCCGATCTATATTATGGAGTGGATTCCGGCGGTCGGCGGGTCGCGGCTCGCACCGGCCGGAAAAGGAT
GACGAGCAGGTGTGAAGAGC

Downstream 100 bases:

>100_bases
CGCTGACCGCTCAGGCCGAGAGCTTGGCCTTGACCGCGCCGGATGCCTTGCCGAAATCCATGCGGCCGGCATATTTGGCT
TTGAGGACGGCGACCACCTT

Product: 3-methyl-2-oxobutanoate hydroxymethyltransferase

Products: NA

Alternate protein names: Ketopantoate hydroxymethyltransferase; KPHMT [H]

Number of amino acids: Translated: 273; Mature: 272

Protein sequence:

>273_residues
MSMADKAARFAEMKRRGEPIAMLTAYDAPMARAEAAARVDILLVGDSVGTNMLGYASEQEVTLADMAHHTRAVRRGAPDA
FVISDLPVATYETPTEAVANARVLAEAGADMVKFEGCRPAIVEALVGAGFAVCGHLGLEPQHHAEKRLKGKQAGEAHQLV
EAALTMEKAGIAMLVLELIPEEVAEIVTQRLKVPTIGIGAGRATDGQVLVICDVLGYTKAAFRHNKRYAEVGETMEAAAR
AYVGDVHSKAFPAAANAFPMNKEQLPEFLASLA

Sequences:

>Translated_273_residues
MSMADKAARFAEMKRRGEPIAMLTAYDAPMARAEAAARVDILLVGDSVGTNMLGYASEQEVTLADMAHHTRAVRRGAPDA
FVISDLPVATYETPTEAVANARVLAEAGADMVKFEGCRPAIVEALVGAGFAVCGHLGLEPQHHAEKRLKGKQAGEAHQLV
EAALTMEKAGIAMLVLELIPEEVAEIVTQRLKVPTIGIGAGRATDGQVLVICDVLGYTKAAFRHNKRYAEVGETMEAAAR
AYVGDVHSKAFPAAANAFPMNKEQLPEFLASLA
>Mature_272_residues
SMADKAARFAEMKRRGEPIAMLTAYDAPMARAEAAARVDILLVGDSVGTNMLGYASEQEVTLADMAHHTRAVRRGAPDAF
VISDLPVATYETPTEAVANARVLAEAGADMVKFEGCRPAIVEALVGAGFAVCGHLGLEPQHHAEKRLKGKQAGEAHQLVE
AALTMEKAGIAMLVLELIPEEVAEIVTQRLKVPTIGIGAGRATDGQVLVICDVLGYTKAAFRHNKRYAEVGETMEAAARA
YVGDVHSKAFPAAANAFPMNKEQLPEFLASLA

Specific function: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate [H]

COG id: COG0413

COG function: function code H; Ketopantoate hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the panB family [H]

Homologues:

Organism=Escherichia coli, GI1786326, Length=257, Percent_Identity=40.4669260700389, Blast_Score=177, Evalue=5e-46,
Organism=Saccharomyces cerevisiae, GI6319653, Length=272, Percent_Identity=31.6176470588235, Blast_Score=135, Evalue=8e-33,

Paralogues:

None

Copy number: 1080 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003700
- InterPro:   IPR015813 [H]

Pfam domain/function: PF02548 Pantoate_transf [H]

EC number: =2.1.2.11 [H]

Molecular weight: Translated: 28993; Mature: 28862

Theoretical pI: Translated: 5.87; Mature: 5.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSMADKAARFAEMKRRGEPIAMLTAYDAPMARAEAAARVDILLVGDSVGTNMLGYASEQE
CCHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHEEEEEEECCCCCCCHHCCCCCCC
VTLADMAHHTRAVRRGAPDAFVISDLPVATYETPTEAVANARVLAEAGADMVKFEGCRPA
HHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCEEECCCCHH
IVEALVGAGFAVCGHLGLEPQHHAEKRLKGKQAGEAHQLVEAALTMEKAGIAMLVLELIP
HHHHHHHCHHHHHHHCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
EEVAEIVTQRLKVPTIGIGAGRATDGQVLVICDVLGYTKAAFRHNKRYAEVGETMEAAAR
HHHHHHHHHHHCCCEEECCCCCCCCCCEEEEEEHHHHHHHHHHHCCHHHHHHHHHHHHHH
AYVGDVHSKAFPAAANAFPMNKEQLPEFLASLA
HHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
SMADKAARFAEMKRRGEPIAMLTAYDAPMARAEAAARVDILLVGDSVGTNMLGYASEQE
CHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHEEEEEEECCCCCCCHHCCCCCCC
VTLADMAHHTRAVRRGAPDAFVISDLPVATYETPTEAVANARVLAEAGADMVKFEGCRPA
HHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCEEECCCCHH
IVEALVGAGFAVCGHLGLEPQHHAEKRLKGKQAGEAHQLVEAALTMEKAGIAMLVLELIP
HHHHHHHCHHHHHHHCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
EEVAEIVTQRLKVPTIGIGAGRATDGQVLVICDVLGYTKAAFRHNKRYAEVGETMEAAAR
HHHHHHHHHHHCCCEEECCCCCCCCCCEEEEEEHHHHHHHHHHHCCHHHHHHHHHHHHHH
AYVGDVHSKAFPAAANAFPMNKEQLPEFLASLA
HHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA