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The map label for this gene is hemA [H]

Identifier: 182680113

GI number: 182680113

Start: 3651727

End: 3653034

Strand: Reverse

Name: hemA [H]

Synonym: Bind_3210

Alternate gene names: 182680113

Gene position: 3653034-3651727 (Counterclockwise)

Preceding gene: 182680114

Following gene: 182680108

Centisome position: 87.6

GC content: 58.49

Gene sequence:

>1308_bases
ATGATAGAGTACGGCCAATTTTTTGACGACGCGATCCTGCGGCTCAAGGCAGAGCGGCGCTATCGGGTCTTTGCTGATCT
CGAACGCGACGCCGCTACCTATCCCGTCGCTCGTTGGCATCGCGCGCCCGATAGAATCGAAGATGTCGTCATCTGGTGCT
CCAACGATTATCTCTGCATGGGCCGGCACCCGGATGTCATCGCCGCCATGAGCGAGGCTGCGTCCCGGTACGGTGTCGGC
GCTGGCGGCACCCGCAATATTTCCGGCACCAATCATCCCTTGGTGCAGCTCGAAGACGAACTCGCCAGCCTGCACGACAA
GCCTGCGGCTCTCGTCTTTACCTCTGGCTGGATCTCCAATCTCGCGGCTATTTCGACCATCGCCGACCTGTTGCCCAATT
GCCTGATCCTTTCTGATCAGCTCAATCATAATTCGATGATCGAGGGGATCAGACGGTCCTCAGCCAAGCGGCAGATCTTC
CGCCACAATGATCTTGCCCATCTTGAGGAATTATTGGCGGCGGCGGATCCCGACCAGGCCAAGCTCATCGTCTTCGAAAG
CCTCTATTCGATGAATGGCGATATCGCGCCAATCGCCGCGATCGCGGATCTCGCCGATCGCTATAATGCCATGACCTATA
TGGATGAAGTGCATGCGGTCGGCCTTTATGGCCCGCATGGTGGCGGCATTGGCGAGCGCGATGGTGTCATGGACCGCATC
GACGTGATCGAGGGGACGCTTGCCAAGGGGTTTGGCACGCTCGGCGGCTATATTGCCGCGAGTAAGTCCATCATCGATGC
CGTGCGCTCCTATGCGCCGTCTTTCATCTTTACTACGGCTCTGCCGCCCGCCGTTGCCGCGGCCGCTCATGCCGCCGTGC
GCCTCCTGAAGGATGGCAAGGAATGGCGCGCCCAGCACCAGCGCCAATCCATGCTGACCAAGCATGCTCTGAGCGCGGCG
GGTTTGCCGGTCATGAACAATCCCTCGCATATCGTGCCCGTTCTCGTGGGCGATGCGGAATTGTGCAAGACCGCCACCGA
TATGCTGCTCGAACGGCACAATATTTACATTCAGCCGATCAATTATCCGACTGTCGCAAAAGGCACGGAAAGACTGCGTA
TCACGCCGAGCCCCTTGCATACGGATGCCCATGTCGTGCATCTCGTCGAGGCCATGGTCGATGTCTGGCAGACCTTGAAA
CTGCCTTTTGTCGCCGAGCCGAAGATTGTCGCTTTCCGCCGCGAGAAGGAAAAGGAAACGGAGGAAGCCCGCTGCACTTT
CCCCGAATTCAAGAAAGCCGCCGAATAG

Upstream 100 bases:

>100_bases
AAACCTTTATCAACCTCAGAGTCGTCCAGACGCGGGGACTGGGCGTACGGCTCTTCCACCTCCGGCCCGAAACCGGGGCA
GCAGGACTGGCAAATATCCC

Downstream 100 bases:

>100_bases
GCTTTGCGACGGGCCGAGCCTGAAGATTTTTCAAGAAACCCAAAAGTGCCGGTCACTTTTGGGTTTCTTGTTTTGGGGCC
AGTGTCCAAAATCTCCCATC

Product: 5-aminolevulinate synthase

Products: NA

Alternate protein names: 5-aminolevulinic acid synthase; Delta-ALA synthase; Delta-aminolevulinate synthase [H]

Number of amino acids: Translated: 435; Mature: 435

Protein sequence:

>435_residues
MIEYGQFFDDAILRLKAERRYRVFADLERDAATYPVARWHRAPDRIEDVVIWCSNDYLCMGRHPDVIAAMSEAASRYGVG
AGGTRNISGTNHPLVQLEDELASLHDKPAALVFTSGWISNLAAISTIADLLPNCLILSDQLNHNSMIEGIRRSSAKRQIF
RHNDLAHLEELLAAADPDQAKLIVFESLYSMNGDIAPIAAIADLADRYNAMTYMDEVHAVGLYGPHGGGIGERDGVMDRI
DVIEGTLAKGFGTLGGYIAASKSIIDAVRSYAPSFIFTTALPPAVAAAAHAAVRLLKDGKEWRAQHQRQSMLTKHALSAA
GLPVMNNPSHIVPVLVGDAELCKTATDMLLERHNIYIQPINYPTVAKGTERLRITPSPLHTDAHVVHLVEAMVDVWQTLK
LPFVAEPKIVAFRREKEKETEEARCTFPEFKKAAE

Sequences:

>Translated_435_residues
MIEYGQFFDDAILRLKAERRYRVFADLERDAATYPVARWHRAPDRIEDVVIWCSNDYLCMGRHPDVIAAMSEAASRYGVG
AGGTRNISGTNHPLVQLEDELASLHDKPAALVFTSGWISNLAAISTIADLLPNCLILSDQLNHNSMIEGIRRSSAKRQIF
RHNDLAHLEELLAAADPDQAKLIVFESLYSMNGDIAPIAAIADLADRYNAMTYMDEVHAVGLYGPHGGGIGERDGVMDRI
DVIEGTLAKGFGTLGGYIAASKSIIDAVRSYAPSFIFTTALPPAVAAAAHAAVRLLKDGKEWRAQHQRQSMLTKHALSAA
GLPVMNNPSHIVPVLVGDAELCKTATDMLLERHNIYIQPINYPTVAKGTERLRITPSPLHTDAHVVHLVEAMVDVWQTLK
LPFVAEPKIVAFRREKEKETEEARCTFPEFKKAAE
>Mature_435_residues
MIEYGQFFDDAILRLKAERRYRVFADLERDAATYPVARWHRAPDRIEDVVIWCSNDYLCMGRHPDVIAAMSEAASRYGVG
AGGTRNISGTNHPLVQLEDELASLHDKPAALVFTSGWISNLAAISTIADLLPNCLILSDQLNHNSMIEGIRRSSAKRQIF
RHNDLAHLEELLAAADPDQAKLIVFESLYSMNGDIAPIAAIADLADRYNAMTYMDEVHAVGLYGPHGGGIGERDGVMDRI
DVIEGTLAKGFGTLGGYIAASKSIIDAVRSYAPSFIFTTALPPAVAAAAHAAVRLLKDGKEWRAQHQRQSMLTKHALSAA
GLPVMNNPSHIVPVLVGDAELCKTATDMLLERHNIYIQPINYPTVAKGTERLRITPSPLHTDAHVVHLVEAMVDVWQTLK
LPFVAEPKIVAFRREKEKETEEARCTFPEFKKAAE

Specific function: Unknown

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI83977442, Length=406, Percent_Identity=49.0147783251232, Blast_Score=409, Evalue=1e-114,
Organism=Homo sapiens, GI83977444, Length=406, Percent_Identity=49.0147783251232, Blast_Score=409, Evalue=1e-114,
Organism=Homo sapiens, GI83977440, Length=406, Percent_Identity=49.0147783251232, Blast_Score=409, Evalue=1e-114,
Organism=Homo sapiens, GI4502025, Length=403, Percent_Identity=48.8833746898263, Blast_Score=382, Evalue=1e-106,
Organism=Homo sapiens, GI40316939, Length=403, Percent_Identity=48.8833746898263, Blast_Score=382, Evalue=1e-106,
Organism=Homo sapiens, GI7657118, Length=348, Percent_Identity=35.0574712643678, Blast_Score=219, Evalue=4e-57,
Organism=Homo sapiens, GI284448556, Length=348, Percent_Identity=35.0574712643678, Blast_Score=218, Evalue=7e-57,
Organism=Homo sapiens, GI119220554, Length=381, Percent_Identity=29.1338582677165, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI4758668, Length=380, Percent_Identity=30, Blast_Score=152, Evalue=7e-37,
Organism=Homo sapiens, GI5454084, Length=260, Percent_Identity=27.3076923076923, Blast_Score=115, Evalue=9e-26,
Organism=Escherichia coli, GI1790046, Length=354, Percent_Identity=34.180790960452, Blast_Score=207, Evalue=8e-55,
Organism=Escherichia coli, GI1786993, Length=365, Percent_Identity=31.5068493150685, Blast_Score=158, Evalue=8e-40,
Organism=Caenorhabditis elegans, GI71994529, Length=356, Percent_Identity=34.8314606741573, Blast_Score=223, Evalue=2e-58,
Organism=Caenorhabditis elegans, GI32566772, Length=367, Percent_Identity=31.6076294277929, Blast_Score=162, Evalue=3e-40,
Organism=Caenorhabditis elegans, GI17560912, Length=371, Percent_Identity=28.3018867924528, Blast_Score=146, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI17560914, Length=371, Percent_Identity=28.8409703504043, Blast_Score=146, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI71982617, Length=268, Percent_Identity=26.865671641791, Blast_Score=107, Evalue=9e-24,
Organism=Caenorhabditis elegans, GI71982625, Length=268, Percent_Identity=26.865671641791, Blast_Score=107, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6320438, Length=425, Percent_Identity=47.5294117647059, Blast_Score=416, Evalue=1e-117,
Organism=Saccharomyces cerevisiae, GI6320267, Length=347, Percent_Identity=28.5302593659942, Blast_Score=139, Evalue=8e-34,
Organism=Saccharomyces cerevisiae, GI6323954, Length=282, Percent_Identity=23.0496453900709, Blast_Score=85, Evalue=2e-17,
Organism=Drosophila melanogaster, GI17137420, Length=401, Percent_Identity=45.8852867830424, Blast_Score=375, Evalue=1e-104,
Organism=Drosophila melanogaster, GI24662918, Length=382, Percent_Identity=33.2460732984293, Blast_Score=234, Evalue=6e-62,
Organism=Drosophila melanogaster, GI17136286, Length=355, Percent_Identity=28.169014084507, Blast_Score=134, Evalue=1e-31,
Organism=Drosophila melanogaster, GI24653280, Length=262, Percent_Identity=27.0992366412214, Blast_Score=101, Evalue=8e-22,
Organism=Drosophila melanogaster, GI24653276, Length=262, Percent_Identity=27.0992366412214, Blast_Score=101, Evalue=8e-22,
Organism=Drosophila melanogaster, GI24653278, Length=262, Percent_Identity=27.0992366412214, Blast_Score=101, Evalue=8e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010961
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.37 [H]

Molecular weight: Translated: 47922; Mature: 47922

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIEYGQFFDDAILRLKAERRYRVFADLERDAATYPVARWHRAPDRIEDVVIWCSNDYLCM
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCCCEEEEEECCCEEEE
GRHPDVIAAMSEAASRYGVGAGGTRNISGTNHPLVQLEDELASLHDKPAALVFTSGWISN
CCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEHHHHHHHCCCCCEEEEECHHHHH
LAAISTIADLLPNCLILSDQLNHNSMIEGIRRSSAKRQIFRHNDLAHLEELLAAADPDQA
HHHHHHHHHHHCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCC
KLIVFESLYSMNGDIAPIAAIADLADRYNAMTYMDEVHAVGLYGPHGGGIGERDGVMDRI
EEEEEHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCHHHHH
DVIEGTLAKGFGTLGGYIAASKSIIDAVRSYAPSFIFTTALPPAVAAAAHAAVRLLKDGK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHCCH
EWRAQHQRQSMLTKHALSAAGLPVMNNPSHIVPVLVGDAELCKTATDMLLERHNIYIQPI
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHCCEEEEEC
NYPTVAKGTERLRITPSPLHTDAHVVHLVEAMVDVWQTLKLPFVAEPKIVAFRREKEKET
CCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEHHHHHHHHH
EEARCTFPEFKKAAE
HHHCCCCHHHHHCCC
>Mature Secondary Structure
MIEYGQFFDDAILRLKAERRYRVFADLERDAATYPVARWHRAPDRIEDVVIWCSNDYLCM
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCCCEEEEEECCCEEEE
GRHPDVIAAMSEAASRYGVGAGGTRNISGTNHPLVQLEDELASLHDKPAALVFTSGWISN
CCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEHHHHHHHCCCCCEEEEECHHHHH
LAAISTIADLLPNCLILSDQLNHNSMIEGIRRSSAKRQIFRHNDLAHLEELLAAADPDQA
HHHHHHHHHHHCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCC
KLIVFESLYSMNGDIAPIAAIADLADRYNAMTYMDEVHAVGLYGPHGGGIGERDGVMDRI
EEEEEHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCHHHHH
DVIEGTLAKGFGTLGGYIAASKSIIDAVRSYAPSFIFTTALPPAVAAAAHAAVRLLKDGK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHCCH
EWRAQHQRQSMLTKHALSAAGLPVMNNPSHIVPVLVGDAELCKTATDMLLERHNIYIQPI
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHCCEEEEEC
NYPTVAKGTERLRITPSPLHTDAHVVHLVEAMVDVWQTLKLPFVAEPKIVAFRREKEKET
CCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEHHHHHHHHH
EEARCTFPEFKKAAE
HHHCCCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3609750; 12597275 [H]