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The map label for this gene is trpF

Identifier: 182679837

GI number: 182679837

Start: 3338777

End: 3339445

Strand: Reverse

Name: trpF

Synonym: Bind_2926

Alternate gene names: 182679837

Gene position: 3339445-3338777 (Counterclockwise)

Preceding gene: 182679838

Following gene: 182679831

Centisome position: 80.08

GC content: 58.74

Gene sequence:

>669_bases
ATGCCTATCATGATAAAAATCTGTGGTCTTCGGACCGAGGAAACTCTCGACGCGGCGCTCGATCTCGGCGCCGACATGGT
CGGTTTCGTTTCCTTCAGCAAAAGCCCCCGTCATGTCTCCCTCGATCTTGCGAGCCATCTCGGCAAAAGGGTCGGCGATC
GGGCTCTCAAAGTCCTCCTGACCGTGAATGCAGATGACGCCTCATTGGCCGCCGGTATTGCTGCGCTCGATCCACAAATG
CTGCAAGTGCATGGCCGCGAGACGCCGGAACGCATTGCTTCGATCCGTGCGCGCTTCGGACTGCCCGTCATGAAGGCGAT
CAGCATCGGCGATTATAGTGATCTCGTTCAGATCCCTTTGTTCGATGCCGTGGCCGATCTGCTACTGTTCGATGCCAAGC
CCAAGGCGCCGGGAGGTCTGCCGGGCGGCAATGGCACAGCCTTCGACTGGAGCCTTTTGCGGCATGTCGAGACACGTAAG
CCCTGGTTGCTGGCAGGTGGTCTCACGTCGCAGAATGTGGCTGGCGCTATTGCCGCGACAAATGCCCAAGGCGTCGATGT
GTCTTCCGGCGTTGAAAGTGCGGCTGGCGTCAAGGATCTCGCGAAAATGGCCGCTTTCATTGAGGCCGCGCGCAAGCCAC
AATTATCGTCACAGCGGCACTTGTCCTGA

Upstream 100 bases:

>100_bases
AGCAGGACCGTTCACTGGTTTAGAACCACGCCCGCGCGAAAGCGTTTCCAAAAAGCATTTCTAAGACGATGCTTTCGCTA
ATGCGCTCGAGACCTGGATC

Downstream 100 bases:

>100_bases
TTGATGCCTCATGACCGCCGCGTCCTTTTGGGAAGCGGCGCGCGATATAAGCGGATCAAGGCGAGGACCAAACCTCCTGC
AAGGACGTACCAGGCGGGCC

Product: phosphoribosylanthranilate isomerase

Products: NA

Alternate protein names: PRAI

Number of amino acids: Translated: 222; Mature: 221

Protein sequence:

>222_residues
MPIMIKICGLRTEETLDAALDLGADMVGFVSFSKSPRHVSLDLASHLGKRVGDRALKVLLTVNADDASLAAGIAALDPQM
LQVHGRETPERIASIRARFGLPVMKAISIGDYSDLVQIPLFDAVADLLLFDAKPKAPGGLPGGNGTAFDWSLLRHVETRK
PWLLAGGLTSQNVAGAIAATNAQGVDVSSGVESAAGVKDLAKMAAFIEAARKPQLSSQRHLS

Sequences:

>Translated_222_residues
MPIMIKICGLRTEETLDAALDLGADMVGFVSFSKSPRHVSLDLASHLGKRVGDRALKVLLTVNADDASLAAGIAALDPQM
LQVHGRETPERIASIRARFGLPVMKAISIGDYSDLVQIPLFDAVADLLLFDAKPKAPGGLPGGNGTAFDWSLLRHVETRK
PWLLAGGLTSQNVAGAIAATNAQGVDVSSGVESAAGVKDLAKMAAFIEAARKPQLSSQRHLS
>Mature_221_residues
PIMIKICGLRTEETLDAALDLGADMVGFVSFSKSPRHVSLDLASHLGKRVGDRALKVLLTVNADDASLAAGIAALDPQML
QVHGRETPERIASIRARFGLPVMKAISIGDYSDLVQIPLFDAVADLLLFDAKPKAPGGLPGGNGTAFDWSLLRHVETRKP
WLLAGGLTSQNVAGAIAATNAQGVDVSSGVESAAGVKDLAKMAAFIEAARKPQLSSQRHLS

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0135

COG function: function code E; Phosphoribosylanthranilate isomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpF family

Homologues:

Organism=Escherichia coli, GI87081863, Length=212, Percent_Identity=31.1320754716981, Blast_Score=68, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6320210, Length=228, Percent_Identity=28.5087719298246, Blast_Score=77, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TRPF_BEII9 (B2IKV4)

Other databases:

- EMBL:   CP001016
- RefSeq:   YP_001833983.1
- GeneID:   6198370
- GenomeReviews:   CP001016_GR
- KEGG:   bid:Bind_2926
- HOGENOM:   HBG554803
- OMA:   IQLHGRE
- ProtClustDB:   CLSK2405792
- HAMAP:   MF_00135_B
- InterPro:   IPR013785
- InterPro:   IPR001240
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70

Pfam domain/function: PF00697 PRAI; SSF51366 RibP_bind_barrel

EC number: =5.3.1.24

Molecular weight: Translated: 23315; Mature: 23184

Theoretical pI: Translated: 7.73; Mature: 7.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPIMIKICGLRTEETLDAALDLGADMVGFVSFSKSPRHVSLDLASHLGKRVGDRALKVLL
CCEEEEECCCCCHHHHHHHHHCCCHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHHEEEEE
TVNADDASLAAGIAALDPQMLQVHGRETPERIASIRARFGLPVMKAISIGDYSDLVQIPL
EECCCCHHHHHHHHHCCHHHHHHCCCCCHHHHHHHHHHHCCCHHHHCCCCCHHHHHHHHH
FDAVADLLLFDAKPKAPGGLPGGNGTAFDWSLLRHVETRKPWLLAGGLTSQNVAGAIAAT
HHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEECCCCCCCCCCEEEEC
NAQGVDVSSGVESAAGVKDLAKMAAFIEAARKPQLSSQRHLS
CCCCCCCCCCCHHHCCHHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
PIMIKICGLRTEETLDAALDLGADMVGFVSFSKSPRHVSLDLASHLGKRVGDRALKVLL
CEEEEECCCCCHHHHHHHHHCCCHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHHEEEEE
TVNADDASLAAGIAALDPQMLQVHGRETPERIASIRARFGLPVMKAISIGDYSDLVQIPL
EECCCCHHHHHHHHHCCHHHHHHCCCCCHHHHHHHHHHHCCCHHHHCCCCCHHHHHHHHH
FDAVADLLLFDAKPKAPGGLPGGNGTAFDWSLLRHVETRKPWLLAGGLTSQNVAGAIAAT
HHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEECCCCCCCCCCEEEEC
NAQGVDVSSGVESAAGVKDLAKMAAFIEAARKPQLSSQRHLS
CCCCCCCCCCCHHHCCHHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA