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The map label for this gene is apr [H]

Identifier: 182679768

GI number: 182679768

Start: 3256219

End: 3257643

Strand: Reverse

Name: apr [H]

Synonym: Bind_2856

Alternate gene names: 182679768

Gene position: 3257643-3256219 (Counterclockwise)

Preceding gene: 182679769

Following gene: 182679767

Centisome position: 78.12

GC content: 61.82

Gene sequence:

>1425_bases
ATGGCGGCAGGGGGGATGCTGGTCAAGGTTCGTGGCGATGGCAGAGCCTTTGCCATGGCGACACAGCAGGCTTTCGGCGC
GGGTGGTGTCGAGGTCAAACCGATCTTGACCATTCCCGCCGGCGTGACGGGTATGGGTCTCGCCCCTTCGAGTGGAGCGA
CCTGGCTGCATGTCTCGGCACTGAGCCAGGGCGAGGAGAATCCGTGGGATGCTGCGCATCAGCTGATGGTGCCTGGAAGT
AGTTTCGCGGCGGCTACAGGTGCCGCCGGAGCGGATGTCGAACTGATTGAACCTGACATCGAGCAAAGATGGCCTTGGCA
GCAGGAGGCTGGCGCTGTGCCTGGCCCAGGCCTTACTGAGGCAGCGGATCGCTGCACATTCATCGATCAGGATGGCAAAG
GAACCAAAGCGGAGGGGCCGGGATTCGCCTGGAGCCTCAATGACGCGTTCTCCGAGCTTGCCAAGGCGCGAGCCGGGCTT
GGAGTGGACCTTGAAAAGAAGCTCAATCAGGTCATTATCGCCCATCTCGATACGGGTTATGATCCGCATCATGTGACTCG
GCCGATCAACCTCGACACAAAGCTCCAGCGCAGCTTTGTCGATGGCGACCCAGACCCGCACGATGCTTCCGACCATACGC
CGGATGGCCTGGGAGCTGTCCGCAATCGCGGCCACGGCACGGCGACGCTAGCGCTTCTCGCCGGCAACCGCCTTGACGGC
ACCTTGCCGGATTGGTCCGGTTTCAAGGATTTCATCGGAGGAGCGCCCTTTGCCCGTGTGATCCCCATTCGGATCGCCAA
TTGGGTCGTGCGCTTTACGACCAGCACCATGGTCCAGGGGATCGAGCATGCCCGCCAGAATGGCGCGCAGATTCTCTCCA
TGAGCATGGGCGGCCTGACCTCCGCCGCTCTCGTTGATGCGATCAATCTCGCCTATGACGCGGGGATGTTTCTCGTCACG
GCGGCGGGCAATAATCTGGCCGGCAGGCTGACACCGAAATCGATTGTCTTCCCGGCTCGCTACCGGCGTGTGCTCGCTGC
TTGCGGCGTGATGGCGGATGGTCGTGCCTATGCCGGCCTCGCGCCGCCAACGATGCAGGGTAATTATGGTCCGTCCAGCA
AGATGGCGACGGCGCTCGGTGCCTATACGCCGAATGTCGCCTGGGCGATAATTGATTGCGGCAAGATGGTTGACATGAAC
GGAGCGGGCACCTCCTCGGCGACGCCACAAATCGCGGCGGCGGCTGCTTTATGGCTCGCCGAGCATGGGCCTTTGGTGGC
CCAATATCCAGAACCCTGGATGCTTTGGGGGGAAGCGCTCCGTCCGGCAGAATGCCTGTTCCATTGGTTGCGAGGCGGAT
CAGATCGCACGTGCGATGGTCGACAATCTTCAGGAAGGCGCGGAACACCGCCGAGATGTATCTGA

Upstream 100 bases:

>100_bases
TTCGTTGACGTTTATACTGATCGGTTGGGGGAATGTGAGCATCGGGCTGATCGAGCTTTGAACGTCTGATGCTCGCGAAA
AATCATCGGGAGGCACGATC

Downstream 100 bases:

>100_bases
CCGCCGTCACTAGGGGCTGGCCGGTCGAGCGTGCGCTTGCGCGAGTGCCTTCGCCTTCAATTCCGCGAGCAGCGAGGGTT
TTGACTATGCCGCGCCGTTC

Product: peptidase S8/S53 subtilisin kexin sedolisin

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 474; Mature: 473

Protein sequence:

>474_residues
MAAGGMLVKVRGDGRAFAMATQQAFGAGGVEVKPILTIPAGVTGMGLAPSSGATWLHVSALSQGEENPWDAAHQLMVPGS
SFAAATGAAGADVELIEPDIEQRWPWQQEAGAVPGPGLTEAADRCTFIDQDGKGTKAEGPGFAWSLNDAFSELAKARAGL
GVDLEKKLNQVIIAHLDTGYDPHHVTRPINLDTKLQRSFVDGDPDPHDASDHTPDGLGAVRNRGHGTATLALLAGNRLDG
TLPDWSGFKDFIGGAPFARVIPIRIANWVVRFTTSTMVQGIEHARQNGAQILSMSMGGLTSAALVDAINLAYDAGMFLVT
AAGNNLAGRLTPKSIVFPARYRRVLAACGVMADGRAYAGLAPPTMQGNYGPSSKMATALGAYTPNVAWAIIDCGKMVDMN
GAGTSSATPQIAAAAALWLAEHGPLVAQYPEPWMLWGEALRPAECLFHWLRGGSDRTCDGRQSSGRRGTPPRCI

Sequences:

>Translated_474_residues
MAAGGMLVKVRGDGRAFAMATQQAFGAGGVEVKPILTIPAGVTGMGLAPSSGATWLHVSALSQGEENPWDAAHQLMVPGS
SFAAATGAAGADVELIEPDIEQRWPWQQEAGAVPGPGLTEAADRCTFIDQDGKGTKAEGPGFAWSLNDAFSELAKARAGL
GVDLEKKLNQVIIAHLDTGYDPHHVTRPINLDTKLQRSFVDGDPDPHDASDHTPDGLGAVRNRGHGTATLALLAGNRLDG
TLPDWSGFKDFIGGAPFARVIPIRIANWVVRFTTSTMVQGIEHARQNGAQILSMSMGGLTSAALVDAINLAYDAGMFLVT
AAGNNLAGRLTPKSIVFPARYRRVLAACGVMADGRAYAGLAPPTMQGNYGPSSKMATALGAYTPNVAWAIIDCGKMVDMN
GAGTSSATPQIAAAAALWLAEHGPLVAQYPEPWMLWGEALRPAECLFHWLRGGSDRTCDGRQSSGRRGTPPRCI
>Mature_473_residues
AAGGMLVKVRGDGRAFAMATQQAFGAGGVEVKPILTIPAGVTGMGLAPSSGATWLHVSALSQGEENPWDAAHQLMVPGSS
FAAATGAAGADVELIEPDIEQRWPWQQEAGAVPGPGLTEAADRCTFIDQDGKGTKAEGPGFAWSLNDAFSELAKARAGLG
VDLEKKLNQVIIAHLDTGYDPHHVTRPINLDTKLQRSFVDGDPDPHDASDHTPDGLGAVRNRGHGTATLALLAGNRLDGT
LPDWSGFKDFIGGAPFARVIPIRIANWVVRFTTSTMVQGIEHARQNGAQILSMSMGGLTSAALVDAINLAYDAGMFLVTA
AGNNLAGRLTPKSIVFPARYRRVLAACGVMADGRAYAGLAPPTMQGNYGPSSKMATALGAYTPNVAWAIIDCGKMVDMNG
AGTSSATPQIAAAAALWLAEHGPLVAQYPEPWMLWGEALRPAECLFHWLRGGSDRTCDGRQSSGRRGTPPRCI

Specific function: Subtilisin is an extracellular alkaline serine protease, it catalyzes the hydrolysis of proteins and peptide amides [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S8 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000209
- InterPro:   IPR022398
- InterPro:   IPR015500 [H]

Pfam domain/function: PF00082 Peptidase_S8 [H]

EC number: =3.4.21.62 [H]

Molecular weight: Translated: 49668; Mature: 49537

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: PS00138 SUBTILASE_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAGGMLVKVRGDGRAFAMATQQAFGAGGVEVKPILTIPAGVTGMGLAPSSGATWLHVSA
CCCCCEEEEEECCCCEEEEEHHHHHCCCCEEEEEEEECCCCCCCCCCCCCCCCCEEEEEE
LSQGEENPWDAAHQLMVPGSSFAAATGAAGADVELIEPDIEQRWPWQQEAGAVPGPGLTE
HHCCCCCCHHHHHEEECCCCCCCCCCCCCCCCEEEECCCHHHCCCCHHHCCCCCCCCCHH
AADRCTFIDQDGKGTKAEGPGFAWSLNDAFSELAKARAGLGVDLEKKLNQVIIAHLDTGY
HHHHCEEECCCCCCCCCCCCCEEEEHHHHHHHHHHHHCCCCCCHHHHHCCEEEEEECCCC
DPHHVTRPINLDTKLQRSFVDGDPDPHDASDHTPDGLGAVRNRGHGTATLALLAGNRLDG
CCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCHHHHHCCCCCEEEEEEEECCCCCC
TLPDWSGFKDFIGGAPFARVIPIRIANWVVRFTTSTMVQGIEHARQNGAQILSMSMGGLT
CCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCH
SAALVDAINLAYDAGMFLVTAAGNNLAGRLTPKSIVFPARYRRVLAACGVMADGRAYAGL
HHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCEECHHHHHHHHHHHCCCCCCCEECCC
APPTMQGNYGPSSKMATALGAYTPNVAWAIIDCGKMVDMNGAGTSSATPQIAAAAALWLA
CCCCCCCCCCCCHHHHHHHHCCCCCCEEEEEECCCEEECCCCCCCCCCCHHHHHHHHHHH
EHGPLVAQYPEPWMLWGEALRPAECLFHWLRGGSDRTCDGRQSSGRRGTPPRCI
HCCCEEEECCCCHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
AAGGMLVKVRGDGRAFAMATQQAFGAGGVEVKPILTIPAGVTGMGLAPSSGATWLHVSA
CCCCEEEEEECCCCEEEEEHHHHHCCCCEEEEEEEECCCCCCCCCCCCCCCCCEEEEEE
LSQGEENPWDAAHQLMVPGSSFAAATGAAGADVELIEPDIEQRWPWQQEAGAVPGPGLTE
HHCCCCCCHHHHHEEECCCCCCCCCCCCCCCCEEEECCCHHHCCCCHHHCCCCCCCCCHH
AADRCTFIDQDGKGTKAEGPGFAWSLNDAFSELAKARAGLGVDLEKKLNQVIIAHLDTGY
HHHHCEEECCCCCCCCCCCCCEEEEHHHHHHHHHHHHCCCCCCHHHHHCCEEEEEECCCC
DPHHVTRPINLDTKLQRSFVDGDPDPHDASDHTPDGLGAVRNRGHGTATLALLAGNRLDG
CCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCHHHHHCCCCCEEEEEEEECCCCCC
TLPDWSGFKDFIGGAPFARVIPIRIANWVVRFTTSTMVQGIEHARQNGAQILSMSMGGLT
CCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCH
SAALVDAINLAYDAGMFLVTAAGNNLAGRLTPKSIVFPARYRRVLAACGVMADGRAYAGL
HHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCEECHHHHHHHHHHHCCCCCCCEECCC
APPTMQGNYGPSSKMATALGAYTPNVAWAIIDCGKMVDMNGAGTSSATPQIAAAAALWLA
CCCCCCCCCCCCHHHHHHHHCCCCCCEEEEEECCCEEECCCCCCCCCCCHHHHHHHHHHH
EHGPLVAQYPEPWMLWGEALRPAECLFHWLRGGSDRTCDGRQSSGRRGTPPRCI
HCCCEEEECCCCHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 6420308; 9826175 [H]