Click here to switch to the map view.

The map label for this gene is nqo3 [H]

Identifier: 182679346

GI number: 182679346

Start: 2732648

End: 2734708

Strand: Reverse

Name: nqo3 [H]

Synonym: Bind_2392

Alternate gene names: 182679346

Gene position: 2734708-2732648 (Counterclockwise)

Preceding gene: 182679347

Following gene: 182679345

Centisome position: 65.58

GC content: 60.36

Gene sequence:

>2061_bases
ATGAGCATACTCATCGTCGATGGCGTAGAAATCGACGTACCGCCGGAATATACGCTGCTGCAGGCCTGTGAGGCGGCGGG
CGCGGAAATTCCACGTTTCTGTTTCCACGAGCGCCTCTCGATCGCCGGCAATTGCCGGATGTGCCTCATTGAGGTCAAGG
GCGGGCCGCCCAAGCCTACGGCCTCCTGCGCCATGGCTGTGCGCGATCTGCGTCCCGGCCCCAATGGCGAGCCGCCTGTC
GTCCTCACCAAATCCCCCATGGTGAAAAAGGCGCGCGAAGGCGTGATGGAATTCCTGCTCGTCAATCACCCTCTCGATTG
CCCGATCTGCGATCAGGGTGGTGAATGCGATCTGCAGGACCAGGCCATGGCCTTTGGCGTCGATTCCTCGCGCTATATCG
AGAACAAGCGCGCGGTCGAGGATAAATATATCGGTGCCCTCGTGCGCACCTCGATGAACCGCTGCATTCATTGCACGCGT
TGCGTCCGGTTTACGGCGGAAGTCGCCGGGACCAGCGACATGGGCGCGATCGGTCGCGGCGAGGATATGGAGATTACGAC
CTATCTCGAAACGGCGATGACATCGGAGTTGCAAGGCAATGTCGCCGACCTTTGCCCGGTTGGCGCGTTGCTCCCCAAGC
CATCGGCCTTCAGGGCGCGGGCCTGGGAAATGGTCAAAACCGAATCCATCGATGTTATGGATGCTTTGGGTTCCGCGATC
CGCATCGACACACGCGGGCGGGAAGTGATGCGTATCCTGCCGCGCGTCAATGATGTCGTGAACGAGGAATGGATTTCCGA
CAAAGCGCGGCAGATCGTCGATGGTTTGAAGACACGCCGTCTCGATAAGCCCTATGTCCGTAAGGGCGGCAAACTTGTGC
CGGCCTCCTGGCAGGAAGCTTTCGCGACCATTGCCGAAAAGGTGAAGGCGACGAATCCTGCCCGTATCGGCGCGATTGCC
GGCGATCTCGCCAGCGTCGAGGATCTCTTCGCCTTGCAAAGCCTCCTCGGCAAATTAGGCTCGGTCAATCTCGATGCTCG
GCAAGATGGCGTCAAGCTTGATCCGAAACTCGGCCGCGCATCCTATCTTTTCAACCCGACCATCGCTGGAATCGATGACG
CGGATTCCTTGCTGATCGTCGGCGCCAATCCGCGCAAGGAAGCGCCGGTTTTCAATGCCCGTATCCGCAAGCGTTGGCTC
AAGGGTCGCTTCCCCATTCATCTCATCGGCGAACAGGCCGATCTGACTTATCCTTACGATTATCTCGGCGCGGGTCCCGA
AACGCTGATGGCGCTTCTCAAAAACCCGCCTGCGAAGACGGAAAAGCCTGTCCTGCTGATTGGCCAGGGTGCTTTGGCGC
GATCCGATGGCGCGGCAATCCTGGCTTTGGCGATCAAGGCCGCCGTGGCGCTTGGCGTCATCAAGGATGGTTGGAACGGT
TTCGGCGTGTTGCATACGGCGGCCGCCCGGGTTGGAGCCCTCGATCTCGGCTTTGTACCCGGGGTGAACGGCCTGGATGC
GCAGGCGCAAGCGAAGGCTGGTGCGCTCGATGTGCTCTTCAATCTGGGAGCGGATGAAATCGCCATTGAGCCTGGTGCTT
TCGTGATCTATCAAGGGACTCACGGTGACCGGGGTGCGGCGCGTGCCGATGTCATTCTGCCGGGCGCGACCTATACGGAA
AAATCGGGCACATACGTCAATACGGAAGGACGTGTGCAATGGTCCGATCGGGCGAGTTTCCCACCCGGAGAAGCCCGCGA
GGATTGGGCGATCCTGCGTGCTTTATCTGAGATCCTGGGTGTGCGGCTGCCCTTTGATTCTCTGGCCCGGTTACGGGCCG
AGCTCTATGCGGCGCACCCGCATTTTGCTGAAATCGATGATATTGCCGCGCCCGAGGCGATCGATCCGGCGCGCTTTGTG
GCAACAGGAGAGTTCGACAAAGCTCCCTTTGTGTCACCGGTCGTCGATTTCTATGCCACCAATCCGATCGCCCGCGCTTC
CGGCGTGATGGCTGAATGCGCGGCCCTGGCGCAGGGCCTCGCGCGCCAGGCGGCCGAATAA

Upstream 100 bases:

>100_bases
AACACCTCAGGGCGTCTGTGATGATCTTGTCAAAACAGATCGAGACCTGGGCAAGGCTTGAAGACCCGCAAAACGGCGTC
TGCAATTTGGAGCCTGAAAG

Downstream 100 bases:

>100_bases
AGTAAACTCAAGGTGTGTTGGCGATGAGCGATACTAGCTGGGTGCTTCCTTTCCTCCTGATGATCGTCAAGAGCCTCGTG
CTCTTGGTGGTCCTCCTCGT

Product: NADH dehydrogenase subunit G

Products: NA

Alternate protein names: NADH dehydrogenase I, chain 3; NDH-1, chain 3 [H]

Number of amino acids: Translated: 686; Mature: 685

Protein sequence:

>686_residues
MSILIVDGVEIDVPPEYTLLQACEAAGAEIPRFCFHERLSIAGNCRMCLIEVKGGPPKPTASCAMAVRDLRPGPNGEPPV
VLTKSPMVKKAREGVMEFLLVNHPLDCPICDQGGECDLQDQAMAFGVDSSRYIENKRAVEDKYIGALVRTSMNRCIHCTR
CVRFTAEVAGTSDMGAIGRGEDMEITTYLETAMTSELQGNVADLCPVGALLPKPSAFRARAWEMVKTESIDVMDALGSAI
RIDTRGREVMRILPRVNDVVNEEWISDKARQIVDGLKTRRLDKPYVRKGGKLVPASWQEAFATIAEKVKATNPARIGAIA
GDLASVEDLFALQSLLGKLGSVNLDARQDGVKLDPKLGRASYLFNPTIAGIDDADSLLIVGANPRKEAPVFNARIRKRWL
KGRFPIHLIGEQADLTYPYDYLGAGPETLMALLKNPPAKTEKPVLLIGQGALARSDGAAILALAIKAAVALGVIKDGWNG
FGVLHTAAARVGALDLGFVPGVNGLDAQAQAKAGALDVLFNLGADEIAIEPGAFVIYQGTHGDRGAARADVILPGATYTE
KSGTYVNTEGRVQWSDRASFPPGEAREDWAILRALSEILGVRLPFDSLARLRAELYAAHPHFAEIDDIAAPEAIDPARFV
ATGEFDKAPFVSPVVDFYATNPIARASGVMAECAALAQGLARQAAE

Sequences:

>Translated_686_residues
MSILIVDGVEIDVPPEYTLLQACEAAGAEIPRFCFHERLSIAGNCRMCLIEVKGGPPKPTASCAMAVRDLRPGPNGEPPV
VLTKSPMVKKAREGVMEFLLVNHPLDCPICDQGGECDLQDQAMAFGVDSSRYIENKRAVEDKYIGALVRTSMNRCIHCTR
CVRFTAEVAGTSDMGAIGRGEDMEITTYLETAMTSELQGNVADLCPVGALLPKPSAFRARAWEMVKTESIDVMDALGSAI
RIDTRGREVMRILPRVNDVVNEEWISDKARQIVDGLKTRRLDKPYVRKGGKLVPASWQEAFATIAEKVKATNPARIGAIA
GDLASVEDLFALQSLLGKLGSVNLDARQDGVKLDPKLGRASYLFNPTIAGIDDADSLLIVGANPRKEAPVFNARIRKRWL
KGRFPIHLIGEQADLTYPYDYLGAGPETLMALLKNPPAKTEKPVLLIGQGALARSDGAAILALAIKAAVALGVIKDGWNG
FGVLHTAAARVGALDLGFVPGVNGLDAQAQAKAGALDVLFNLGADEIAIEPGAFVIYQGTHGDRGAARADVILPGATYTE
KSGTYVNTEGRVQWSDRASFPPGEAREDWAILRALSEILGVRLPFDSLARLRAELYAAHPHFAEIDDIAAPEAIDPARFV
ATGEFDKAPFVSPVVDFYATNPIARASGVMAECAALAQGLARQAAE
>Mature_685_residues
SILIVDGVEIDVPPEYTLLQACEAAGAEIPRFCFHERLSIAGNCRMCLIEVKGGPPKPTASCAMAVRDLRPGPNGEPPVV
LTKSPMVKKAREGVMEFLLVNHPLDCPICDQGGECDLQDQAMAFGVDSSRYIENKRAVEDKYIGALVRTSMNRCIHCTRC
VRFTAEVAGTSDMGAIGRGEDMEITTYLETAMTSELQGNVADLCPVGALLPKPSAFRARAWEMVKTESIDVMDALGSAIR
IDTRGREVMRILPRVNDVVNEEWISDKARQIVDGLKTRRLDKPYVRKGGKLVPASWQEAFATIAEKVKATNPARIGAIAG
DLASVEDLFALQSLLGKLGSVNLDARQDGVKLDPKLGRASYLFNPTIAGIDDADSLLIVGANPRKEAPVFNARIRKRWLK
GRFPIHLIGEQADLTYPYDYLGAGPETLMALLKNPPAKTEKPVLLIGQGALARSDGAAILALAIKAAVALGVIKDGWNGF
GVLHTAAARVGALDLGFVPGVNGLDAQAQAKAGALDVLFNLGADEIAIEPGAFVIYQGTHGDRGAARADVILPGATYTEK
SGTYVNTEGRVQWSDRASFPPGEAREDWAILRALSEILGVRLPFDSLARLRAELYAAHPHFAEIDDIAAPEAIDPARFVA
TGEFDKAPFVSPVVDFYATNPIARASGVMAECAALAQGLARQAAE

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1034

COG function: function code C; NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G)

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 2Fe-2S ferredoxin-type domain [H]

Homologues:

Organism=Homo sapiens, GI33519475, Length=704, Percent_Identity=50.7102272727273, Blast_Score=653, Evalue=0.0,
Organism=Escherichia coli, GI145693161, Length=387, Percent_Identity=29.4573643410853, Blast_Score=189, Evalue=5e-49,
Organism=Caenorhabditis elegans, GI17565758, Length=694, Percent_Identity=47.4063400576369, Blast_Score=596, Evalue=1e-170,
Organism=Caenorhabditis elegans, GI32566231, Length=591, Percent_Identity=49.5769881556684, Blast_Score=535, Evalue=1e-152,
Organism=Caenorhabditis elegans, GI193209088, Length=260, Percent_Identity=58.8461538461538, Blast_Score=308, Evalue=7e-84,
Organism=Drosophila melanogaster, GI24640559, Length=701, Percent_Identity=47.9315263908702, Blast_Score=586, Evalue=1e-167,
Organism=Drosophila melanogaster, GI24640557, Length=701, Percent_Identity=47.9315263908702, Blast_Score=586, Evalue=1e-167,

Paralogues:

None

Copy number: 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012675
- InterPro:   IPR001041
- InterPro:   IPR006656
- InterPro:   IPR000283
- InterPro:   IPR010228
- InterPro:   IPR019574
- InterPro:   IPR015405 [H]

Pfam domain/function: PF09326 DUF1982; PF00111 Fer2; PF00384 Molybdopterin; PF10588 NADH-G_4Fe-4S_3 [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 73574; Mature: 73443

Theoretical pI: Translated: 5.38; Mature: 5.38

Prosite motif: PS00642 COMPLEX1_75K_2 ; PS00643 COMPLEX1_75K_3 ; PS51085 2FE2S_FER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSILIVDGVEIDVPPEYTLLQACEAAGAEIPRFCFHERLSIAGNCRMCLIEVKGGPPKPT
CEEEEEECEEECCCCCHHHHHHHHHCCCCCHHHHHHHHHHCCCCCEEEEEEECCCCCCCH
ASCAMAVRDLRPGPNGEPPVVLTKSPMVKKAREGVMEFLLVNHPLDCPICDQGGECDLQD
HHHHHHHHHCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
QAMAFGVDSSRYIENKRAVEDKYIGALVRTSMNRCIHCTRCVRFTAEVAGTSDMGAIGRG
CHHEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
EDMEITTYLETAMTSELQGNVADLCPVGALLPKPSAFRARAWEMVKTESIDVMDALGSAI
CCCEEHHHHHHHHHHHHCCCHHHHCCCCHHCCCCCHHHHHHHHHHHHCCCHHHHHCCCEE
RIDTRGREVMRILPRVNDVVNEEWISDKARQIVDGLKTRRLDKPYVRKGGKLVPASWQEA
EEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCEECCCCHHHH
FATIAEKVKATNPARIGAIAGDLASVEDLFALQSLLGKLGSVNLDARQDGVKLDPKLGRA
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEECCCCCCC
SYLFNPTIAGIDDADSLLIVGANPRKEAPVFNARIRKRWLKGRFPIHLIGEQADLTYPYD
EEEECCCCCCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHCCCCCEEEECCCCCCCCCHH
YLGAGPETLMALLKNPPAKTEKPVLLIGQGALARSDGAAILALAIKAAVALGVIKDGWNG
HHCCCHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCC
FGVLHTAAARVGALDLGFVPGVNGLDAQAQAKAGALDVLFNLGADEIAIEPGAFVIYQGT
CHHHHHHHHHHCCEEECCCCCCCCCCCHHHHCCCHHHHHHHCCCCCEEECCCEEEEEECC
HGDRGAARADVILPGATYTEKSGTYVNTEGRVQWSDRASFPPGEAREDWAILRALSEILG
CCCCCCCCCEEEECCCCEECCCCCEECCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHC
VRLPFDSLARLRAELYAAHPHFAEIDDIAAPEAIDPARFVATGEFDKAPFVSPVVDFYAT
CCCCHHHHHHHHHHHHHCCCCCCCHHHCCCCCCCCCHHEEEECCCCCCCCHHHHHHHHHC
NPIARASGVMAECAALAQGLARQAAE
CCHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SILIVDGVEIDVPPEYTLLQACEAAGAEIPRFCFHERLSIAGNCRMCLIEVKGGPPKPT
EEEEEECEEECCCCCHHHHHHHHHCCCCCHHHHHHHHHHCCCCCEEEEEEECCCCCCCH
ASCAMAVRDLRPGPNGEPPVVLTKSPMVKKAREGVMEFLLVNHPLDCPICDQGGECDLQD
HHHHHHHHHCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
QAMAFGVDSSRYIENKRAVEDKYIGALVRTSMNRCIHCTRCVRFTAEVAGTSDMGAIGRG
CHHEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
EDMEITTYLETAMTSELQGNVADLCPVGALLPKPSAFRARAWEMVKTESIDVMDALGSAI
CCCEEHHHHHHHHHHHHCCCHHHHCCCCHHCCCCCHHHHHHHHHHHHCCCHHHHHCCCEE
RIDTRGREVMRILPRVNDVVNEEWISDKARQIVDGLKTRRLDKPYVRKGGKLVPASWQEA
EEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCEECCCCHHHH
FATIAEKVKATNPARIGAIAGDLASVEDLFALQSLLGKLGSVNLDARQDGVKLDPKLGRA
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEECCCCCCC
SYLFNPTIAGIDDADSLLIVGANPRKEAPVFNARIRKRWLKGRFPIHLIGEQADLTYPYD
EEEECCCCCCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHCCCCCEEEECCCCCCCCCHH
YLGAGPETLMALLKNPPAKTEKPVLLIGQGALARSDGAAILALAIKAAVALGVIKDGWNG
HHCCCHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCC
FGVLHTAAARVGALDLGFVPGVNGLDAQAQAKAGALDVLFNLGADEIAIEPGAFVIYQGT
CHHHHHHHHHHCCEEECCCCCCCCCCCHHHHCCCHHHHHHHCCCCCEEECCCEEEEEECC
HGDRGAARADVILPGATYTEKSGTYVNTEGRVQWSDRASFPPGEAREDWAILRALSEILG
CCCCCCCCCEEEECCCCEECCCCCEECCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHC
VRLPFDSLARLRAELYAAHPHFAEIDDIAAPEAIDPARFVATGEFDKAPFVSPVVDFYAT
CCCCHHHHHHHHHHHHHCCCCCCCHHHCCCCCCCCCHHEEEECCCCCCCCHHHHHHHHHC
NPIARASGVMAECAALAQGLARQAAE
CCHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1605643; 8422400 [H]