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The map label for this gene is fabF [H]

Identifier: 182679253

GI number: 182679253

Start: 2629037

End: 2630299

Strand: Reverse

Name: fabF [H]

Synonym: Bind_2297

Alternate gene names: 182679253

Gene position: 2630299-2629037 (Counterclockwise)

Preceding gene: 182679254

Following gene: 182679252

Centisome position: 63.07

GC content: 59.38

Gene sequence:

>1263_bases
ATGCGAAGGGTGGTGATCACTGGGCTCGGCATGGTTTCTCCTCTCGCCTGTGGCGTCGAGCCTTCGTGGAAGGCTTTGCT
CGGTGGCGTGAGCGGTGCCGGTCTCATTAAGGGTTTCGAGACGGATGATCTGGCGTGCAAGATCGCCATGCAGGTTCCGC
GTGGCAATGGCGGCGACGGCAGTTTCAATCCTGACGAGTGGATGGAGCCGAAAGAGCAGCGCAAGGTCGATGACTTCATC
ATCTATGCTGTCGCCGCCGCGACGCAGGCGCTGCGTGATGCCAATTGGAATCCGCAAACTTATGATCAGCAGATCAAGAC
TGGGGTGCTGATCGGTTCAGGCATCGGTGGTCTCGGCGGTATTTACGAAACATCGATCGTTCTGAAGGAAAAGGGGCCGC
GGCGCATCTCGCCCTTCTTCATTCCTGGCCGCCTCATCAATCTGGCTGGCGGCTATGTCTCGATCATGCACGGATTGCGC
GGACCGAACCATGCGGTCGTAACCGCCTGCTCAACCGGATCCCATGCCATTGGCGATGCGGCGCGGCTGGTGGCCCTTGA
GGATGCCGAAGTCATGGTGGCGGGCGGCGCCGAATCAGCGATCAATCGTATCGGTATCGCGGGTTTTGCGGCCTGCCGCG
CCCTGTCCACCGCTTTCAACGACCGGCCGAAACAAGCCTCGCGGCCTTGGGATAAGGATCGCGACGGTTTCGTGATGGGC
GAGGGGGCGGGATGCGTCGTCCTCGAATCCTATGACCATGCCAAGGCTCGTGGCGCTCGCATCTATGCCGAGGTCATTGG
TTATGGTCTTTCAGGCGATGCCTACCATATTACCGCGCCGCAGGAATCCGGCGACGGCGCCTATCGGGCCATGGAAGCCG
CGATCAAACGGGCGGGTATCGGGCCAGCCGACATCGATTATATCAATGCCCACGGGACTTCGACCCCGCTTGGCGACGAA
ATCGAATTGCATGCGGTGCATCGCATGATCGGTGATACTGACCCGACGCTTTCCATGTCTTCGACGAAATCGGCAATCGG
CCATTTGCTTGGTGCCGCTGGTGCCGTCGAGGCGATCTTCTCGGTTCTGGCTATTCGCGATCAAATCGTTCCGCCGACGC
TCAATCTCGACAATCCTTCCGTCGAAACCAAGATCGATCTCGTGCCCTTGCACGCGCGCAAGCGGAAGGTTGAAACCGTC
CTGTCGAATTCCTTCGGCTTTGGTGGTACCAATGCATCGCTGGTTTTCCGGCACGCCGAATAG

Upstream 100 bases:

>100_bases
GAGTCAAAGAGATAGAGAGCCTTTCCGGTTGCATTGGCCGGACGCTTTCTTGGGCCCATCGGGATGGCCGGCTTGGCCCC
CCTTTTCTTCAAGGTTGTTT

Downstream 100 bases:

>100_bases
ATTGAGAGCGCGAATGTCCCAAATTTGCGCTTTTTTAAGGGTACGAGCGAAAAGATGAGAATGTTCCAAAGCTCATTCTT
ATGGGTCTTGGAACAAGATG

Product: 3-oxoacyl-(acyl-carrier-protein) synthase 2

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 420; Mature: 420

Protein sequence:

>420_residues
MRRVVITGLGMVSPLACGVEPSWKALLGGVSGAGLIKGFETDDLACKIAMQVPRGNGGDGSFNPDEWMEPKEQRKVDDFI
IYAVAAATQALRDANWNPQTYDQQIKTGVLIGSGIGGLGGIYETSIVLKEKGPRRISPFFIPGRLINLAGGYVSIMHGLR
GPNHAVVTACSTGSHAIGDAARLVALEDAEVMVAGGAESAINRIGIAGFAACRALSTAFNDRPKQASRPWDKDRDGFVMG
EGAGCVVLESYDHAKARGARIYAEVIGYGLSGDAYHITAPQESGDGAYRAMEAAIKRAGIGPADIDYINAHGTSTPLGDE
IELHAVHRMIGDTDPTLSMSSTKSAIGHLLGAAGAVEAIFSVLAIRDQIVPPTLNLDNPSVETKIDLVPLHARKRKVETV
LSNSFGFGGTNASLVFRHAE

Sequences:

>Translated_420_residues
MRRVVITGLGMVSPLACGVEPSWKALLGGVSGAGLIKGFETDDLACKIAMQVPRGNGGDGSFNPDEWMEPKEQRKVDDFI
IYAVAAATQALRDANWNPQTYDQQIKTGVLIGSGIGGLGGIYETSIVLKEKGPRRISPFFIPGRLINLAGGYVSIMHGLR
GPNHAVVTACSTGSHAIGDAARLVALEDAEVMVAGGAESAINRIGIAGFAACRALSTAFNDRPKQASRPWDKDRDGFVMG
EGAGCVVLESYDHAKARGARIYAEVIGYGLSGDAYHITAPQESGDGAYRAMEAAIKRAGIGPADIDYINAHGTSTPLGDE
IELHAVHRMIGDTDPTLSMSSTKSAIGHLLGAAGAVEAIFSVLAIRDQIVPPTLNLDNPSVETKIDLVPLHARKRKVETV
LSNSFGFGGTNASLVFRHAE
>Mature_420_residues
MRRVVITGLGMVSPLACGVEPSWKALLGGVSGAGLIKGFETDDLACKIAMQVPRGNGGDGSFNPDEWMEPKEQRKVDDFI
IYAVAAATQALRDANWNPQTYDQQIKTGVLIGSGIGGLGGIYETSIVLKEKGPRRISPFFIPGRLINLAGGYVSIMHGLR
GPNHAVVTACSTGSHAIGDAARLVALEDAEVMVAGGAESAINRIGIAGFAACRALSTAFNDRPKQASRPWDKDRDGFVMG
EGAGCVVLESYDHAKARGARIYAEVIGYGLSGDAYHITAPQESGDGAYRAMEAAIKRAGIGPADIDYINAHGTSTPLGDE
IELHAVHRMIGDTDPTLSMSSTKSAIGHLLGAAGAVEAIFSVLAIRDQIVPPTLNLDNPSVETKIDLVPLHARKRKVETV
LSNSFGFGGTNASLVFRHAE

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates and may function to supply the octanoic substrates for lipoic acid biosynthes

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=417, Percent_Identity=51.7985611510791, Blast_Score=410, Evalue=1e-114,
Organism=Homo sapiens, GI223972627, Length=229, Percent_Identity=39.7379912663755, Blast_Score=165, Evalue=6e-41,
Organism=Homo sapiens, GI41872631, Length=438, Percent_Identity=26.7123287671233, Blast_Score=107, Evalue=2e-23,
Organism=Escherichia coli, GI1787337, Length=417, Percent_Identity=54.1966426858513, Blast_Score=404, Evalue=1e-114,
Organism=Escherichia coli, GI1788663, Length=418, Percent_Identity=35.1674641148325, Blast_Score=241, Evalue=9e-65,
Organism=Caenorhabditis elegans, GI71983541, Length=423, Percent_Identity=39.0070921985816, Blast_Score=270, Evalue=1e-72,
Organism=Caenorhabditis elegans, GI71983535, Length=265, Percent_Identity=44.1509433962264, Blast_Score=208, Evalue=3e-54,
Organism=Caenorhabditis elegans, GI212642053, Length=366, Percent_Identity=27.0491803278689, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17550940, Length=280, Percent_Identity=26.4285714285714, Blast_Score=91, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6320904, Length=448, Percent_Identity=40.1785714285714, Blast_Score=299, Evalue=4e-82,
Organism=Drosophila melanogaster, GI24644341, Length=418, Percent_Identity=46.4114832535885, Blast_Score=360, Evalue=1e-100,
Organism=Drosophila melanogaster, GI19920632, Length=282, Percent_Identity=27.6595744680851, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI221330659, Length=282, Percent_Identity=27.6595744680851, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24581345, Length=365, Percent_Identity=25.4794520547945, Blast_Score=74, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 44203; Mature: 44203

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: PS00606 B_KETOACYL_SYNTHASE ; PS00107 PROTEIN_KINASE_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRVVITGLGMVSPLACGVEPSWKALLGGVSGAGLIKGFETDDLACKIAMQVPRGNGGDG
CCEEEEECCCHHHHHHCCCCCCHHHHHCCCCCCHHEECCCCCCCEEEEEEECCCCCCCCC
SFNPDEWMEPKEQRKVDDFIIYAVAAATQALRDANWNPQTYDQQIKTGVLIGSGIGGLGG
CCCCHHHCCCHHHHCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCEEEEECCCCCCCC
IYETSIVLKEKGPRRISPFFIPGRLINLAGGYVSIMHGLRGPNHAVVTACSTGSHAIGDA
HHEEEEEEECCCCCCCCCEECCCHHEECCCHHHHHHHHCCCCCCEEEEEECCCCCCCCCC
ARLVALEDAEVMVAGGAESAINRIGIAGFAACRALSTAFNDRPKQASRPWDKDRDGFVMG
EEEEEEECCCEEEECCHHHHHHHHCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEE
EGAGCVVLESYDHAKARGARIYAEVIGYGLSGDAYHITAPQESGDGAYRAMEAAIKRAGI
CCCCEEEEECCCCCHHCCCEEEEHHHCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCC
GPADIDYINAHGTSTPLGDEIELHAVHRMIGDTDPTLSMSSTKSAIGHLLGAAGAVEAIF
CCCCCEEEECCCCCCCCCCCHHHHHHHHHHCCCCCCEECHHHHHHHHHHHHHHHHHHHHH
SVLAIRDQIVPPTLNLDNPSVETKIDLVPLHARKRKVETVLSNSFGFGGTNASLVFRHAE
HHHHHHHHCCCCCCCCCCCCCCEEEEEEECHHHHHHHHHHHHCCCCCCCCCCEEEEEECC
>Mature Secondary Structure
MRRVVITGLGMVSPLACGVEPSWKALLGGVSGAGLIKGFETDDLACKIAMQVPRGNGGDG
CCEEEEECCCHHHHHHCCCCCCHHHHHCCCCCCHHEECCCCCCCEEEEEEECCCCCCCCC
SFNPDEWMEPKEQRKVDDFIIYAVAAATQALRDANWNPQTYDQQIKTGVLIGSGIGGLGG
CCCCHHHCCCHHHHCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCEEEEECCCCCCCC
IYETSIVLKEKGPRRISPFFIPGRLINLAGGYVSIMHGLRGPNHAVVTACSTGSHAIGDA
HHEEEEEEECCCCCCCCCEECCCHHEECCCHHHHHHHHCCCCCCEEEEEECCCCCCCCCC
ARLVALEDAEVMVAGGAESAINRIGIAGFAACRALSTAFNDRPKQASRPWDKDRDGFVMG
EEEEEEECCCEEEECCHHHHHHHHCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEE
EGAGCVVLESYDHAKARGARIYAEVIGYGLSGDAYHITAPQESGDGAYRAMEAAIKRAGI
CCCCEEEEECCCCCHHCCCEEEEHHHCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCC
GPADIDYINAHGTSTPLGDEIELHAVHRMIGDTDPTLSMSSTKSAIGHLLGAAGAVEAIF
CCCCCEEEECCCCCCCCCCCHHHHHHHHHHCCCCCCEECHHHHHHHHHHHHHHHHHHHHH
SVLAIRDQIVPPTLNLDNPSVETKIDLVPLHARKRKVETVLSNSFGFGGTNASLVFRHAE
HHHHHHHHCCCCCCCCCCCCCCEEEEEEECHHHHHHHHHHHHCCCCCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10784042; 11481430 [H]