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The map label for this gene is trxA [C]

Identifier: 182679139

GI number: 182679139

Start: 2487768

End: 2488088

Strand: Direct

Name: trxA [C]

Synonym: Bind_2176

Alternate gene names: 182679139

Gene position: 2487768-2488088 (Clockwise)

Preceding gene: 182679138

Following gene: 182679140

Centisome position: 59.66

GC content: 57.63

Gene sequence:

>321_bases
ATGGCCACGGTTAAAGTTACAGATGCCACGTTCAAGAACGACGTGGTCGATGCCAAGGCTCCTGTCGTGGTGGACTTCTG
GGCCGAATGGTGCGGCCCGTGCAAAATGATTGGGCCGGCGCTCGAAGAAATCGCTGACGAACTGGCCGACAAGGTCAAGA
TCGTCAAGCTCAACGTCGACGAGAACCCCGGCGTTTCCGGCGCCTATGGCATTCGCACGATCCCGACCCTGCTCCTCTTC
AAGGATGGCAAGATCGCCAATACCAAGATCGGCGCCGCACCCAAGGGTGAGCTGAAGAAATGGATTTCAGACGCGCTCTG
A

Upstream 100 bases:

>100_bases
CAAGGCTGAACGAGGGGCCTGCTTGACGCCGTCCTGATGTCTTCTTACTTTGCAATTCATAGTGGGGCTCGATGCCCCGG
GAAATAGACGCGAGGCGATA

Downstream 100 bases:

>100_bases
TCCCTTTATTCATCACCGCGCTTGTGCAAAGGACCTCGCAAGAGGTCCTTTTTGCTTTATAAACCGCTCCCATGAGCCAT
TACGCCGTAAAAGAAATTTT

Product: thioredoxin

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 106; Mature: 105

Protein sequence:

>106_residues
MATVKVTDATFKNDVVDAKAPVVVDFWAEWCGPCKMIGPALEEIADELADKVKIVKLNVDENPGVSGAYGIRTIPTLLLF
KDGKIANTKIGAAPKGELKKWISDAL

Sequences:

>Translated_106_residues
MATVKVTDATFKNDVVDAKAPVVVDFWAEWCGPCKMIGPALEEIADELADKVKIVKLNVDENPGVSGAYGIRTIPTLLLF
KDGKIANTKIGAAPKGELKKWISDAL
>Mature_105_residues
ATVKVTDATFKNDVVDAKAPVVVDFWAEWCGPCKMIGPALEEIADELADKVKIVKLNVDENPGVSGAYGIRTIPTLLLFK
DGKIANTKIGAAPKGELKKWISDAL

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=103, Percent_Identity=33.0097087378641, Blast_Score=79, Evalue=1e-15,
Organism=Escherichia coli, GI87082331, Length=99, Percent_Identity=57.5757575757576, Blast_Score=130, Evalue=2e-32,
Organism=Escherichia coli, GI1788936, Length=105, Percent_Identity=40, Blast_Score=97, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI212646193, Length=96, Percent_Identity=38.5416666666667, Blast_Score=79, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17509965, Length=100, Percent_Identity=40, Blast_Score=75, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI115532380, Length=81, Percent_Identity=39.5061728395062, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI115532378, Length=81, Percent_Identity=39.5061728395062, Blast_Score=67, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17544108, Length=81, Percent_Identity=39.5061728395062, Blast_Score=66, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17556044, Length=80, Percent_Identity=33.75, Blast_Score=62, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6319925, Length=103, Percent_Identity=36.8932038834951, Blast_Score=74, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6321648, Length=73, Percent_Identity=45.2054794520548, Blast_Score=72, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6323072, Length=73, Percent_Identity=46.5753424657534, Blast_Score=70, Evalue=5e-14,
Organism=Drosophila melanogaster, GI28573567, Length=100, Percent_Identity=33, Blast_Score=84, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24639826, Length=70, Percent_Identity=42.8571428571429, Blast_Score=80, Evalue=2e-16,
Organism=Drosophila melanogaster, GI17648013, Length=74, Percent_Identity=43.2432432432432, Blast_Score=72, Evalue=7e-14,
Organism=Drosophila melanogaster, GI24583090, Length=74, Percent_Identity=43.2432432432432, Blast_Score=72, Evalue=7e-14,
Organism=Drosophila melanogaster, GI24664269, Length=61, Percent_Identity=42.6229508196721, Blast_Score=69, Evalue=7e-13,
Organism=Drosophila melanogaster, GI21358065, Length=96, Percent_Identity=31.25, Blast_Score=67, Evalue=3e-12,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 11384; Mature: 11253

Theoretical pI: Translated: 5.15; Mature: 5.15

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATVKVTDATFKNDVVDAKAPVVVDFWAEWCGPCKMIGPALEEIADELADKVKIVKLNVD
CCEEEECCCCCCCCCCCCCCCEEEEEHHHHCCCHHHHHHHHHHHHHHHHCCEEEEEEECC
ENPGVSGAYGIRTIPTLLLFKDGKIANTKIGAAPKGELKKWISDAL
CCCCCCCCCCHHHHHEHEEECCCCCCCCCCCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
ATVKVTDATFKNDVVDAKAPVVVDFWAEWCGPCKMIGPALEEIADELADKVKIVKLNVD
CEEEECCCCCCCCCCCCCCCEEEEEHHHHCCCHHHHHHHHHHHHHHHHCCEEEEEEECC
ENPGVSGAYGIRTIPTLLLFKDGKIANTKIGAAPKGELKKWISDAL
CCCCCCCCCCHHHHHEHEEECCCCCCCCCCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7021558 [H]