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The map label for this gene is pyrE [H]

Identifier: 182679010

GI number: 182679010

Start: 2337296

End: 2337994

Strand: Direct

Name: pyrE [H]

Synonym: Bind_2045

Alternate gene names: 182679010

Gene position: 2337296-2337994 (Clockwise)

Preceding gene: 182679008

Following gene: 182679011

Centisome position: 56.05

GC content: 56.51

Gene sequence:

>699_bases
ATGACCGAACCATCGTTCGAGAGCCAGAGCATCGCGCGCGAAACAGCCAAAATGCTGCTTGAGGTCAAGGCCATTTTGTT
CAATGCCGAGACGCCCTTCATTTTCGCCTCCGGCTGGGCCAGCCCTGTCTATACCGATATGCGCAAGCTGATCTCCTACC
CCCGCCTGCGTCGCAAGATCATCGATTTCGCGGCGACCACAATCGAACAGGAAATCGGTTACGAAAGCCTTGACGTGATC
GCTGGCGGTGAGACAGCGGGCATTCCCTATGCCGCCTGGCTCGCTGACCGCTTGATGCTGCCCATGCAATATATCCGCAA
GAAGCCGAAAGGATACGGCCGCAACGCGCAGATCGAGGGCAATCTTCACGATGGCGGCCGCGCGCTCCTCGTCGAAGATC
TCGCGACGGACGGACGCAGCAAAGTCAATTTCTGTAATGCCTTGCGCGAAGCCGGACAGCGCTGTGATCATGCGTTTGTT
TTTTTCTATTATGATATTTTTCCCCATACTCAGACCGTCATGGCCGATCTCGGTCTTACCCTGCATTATCTCGTGACCTG
GTGGGACGTGCTGAAGGTCGCCCGCGAGACTGCGCTGATCGATCCAGCGACCCTCGACAAGGTCGAGGAATTTCTGAAAT
CCCCGGCGCAATGGTCGGCAGCGCATGGTGGTATTGCCGAATTCAAGCCTGCCAGTTGA

Upstream 100 bases:

>100_bases
ACGTTTGTAAAAAATCGTCTATAAGCAGGCACAATAGAATTGAAAGGCACCGTTGAAACAAGCGCCTTTGTGTCACAGCC
TGAAAGGACACCCGAATTTC

Downstream 100 bases:

>100_bases
ACCCCGTCGTTTGCGTCCCAGCCATCTATGCATCCCTCCACTCTCGCCGATTTTCTCGACAGCGAAGCTGGCGCCGCACT
GCGGGCCAGTTTCCACGAGC

Product: orotate phosphoribosyltransferase

Products: NA

Alternate protein names: OPRT; OPRTase [H]

Number of amino acids: Translated: 232; Mature: 231

Protein sequence:

>232_residues
MTEPSFESQSIARETAKMLLEVKAILFNAETPFIFASGWASPVYTDMRKLISYPRLRRKIIDFAATTIEQEIGYESLDVI
AGGETAGIPYAAWLADRLMLPMQYIRKKPKGYGRNAQIEGNLHDGGRALLVEDLATDGRSKVNFCNALREAGQRCDHAFV
FFYYDIFPHTQTVMADLGLTLHYLVTWWDVLKVARETALIDPATLDKVEEFLKSPAQWSAAHGGIAEFKPAS

Sequences:

>Translated_232_residues
MTEPSFESQSIARETAKMLLEVKAILFNAETPFIFASGWASPVYTDMRKLISYPRLRRKIIDFAATTIEQEIGYESLDVI
AGGETAGIPYAAWLADRLMLPMQYIRKKPKGYGRNAQIEGNLHDGGRALLVEDLATDGRSKVNFCNALREAGQRCDHAFV
FFYYDIFPHTQTVMADLGLTLHYLVTWWDVLKVARETALIDPATLDKVEEFLKSPAQWSAAHGGIAEFKPAS
>Mature_231_residues
TEPSFESQSIARETAKMLLEVKAILFNAETPFIFASGWASPVYTDMRKLISYPRLRRKIIDFAATTIEQEIGYESLDVIA
GGETAGIPYAAWLADRLMLPMQYIRKKPKGYGRNAQIEGNLHDGGRALLVEDLATDGRSKVNFCNALREAGQRCDHAFVF
FYYDIFPHTQTVMADLGLTLHYLVTWWDVLKVARETALIDPATLDKVEEFLKSPAQWSAAHGGIAEFKPAS

Specific function: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) [H]

COG id: COG0461

COG function: function code F; Orotate phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily [H]

Homologues:

Organism=Homo sapiens, GI4507835, Length=206, Percent_Identity=28.1553398058252, Blast_Score=92, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17508631, Length=119, Percent_Identity=36.9747899159664, Blast_Score=75, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17554964, Length=170, Percent_Identity=30, Blast_Score=65, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004467
- InterPro:   IPR023031
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.10 [H]

Molecular weight: Translated: 26026; Mature: 25895

Theoretical pI: Translated: 6.03; Mature: 6.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEPSFESQSIARETAKMLLEVKAILFNAETPFIFASGWASPVYTDMRKLISYPRLRRKI
CCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHH
IDFAATTIEQEIGYESLDVIAGGETAGIPYAAWLADRLMLPMQYIRKKPKGYGRNAQIEG
HHHHHHHHHHHCCCCHHHEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEC
NLHDGGRALLVEDLATDGRSKVNFCNALREAGQRCDHAFVFFYYDIFPHTQTVMADLGLT
CCCCCCCEEEEHHHHCCCCHHHHHHHHHHHHHHHCCCEEEEEEEHHCCCHHHHHHHHHHH
LHYLVTWWDVLKVARETALIDPATLDKVEEFLKSPAQWSAAHGGIAEFKPAS
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
TEPSFESQSIARETAKMLLEVKAILFNAETPFIFASGWASPVYTDMRKLISYPRLRRKI
CCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHH
IDFAATTIEQEIGYESLDVIAGGETAGIPYAAWLADRLMLPMQYIRKKPKGYGRNAQIEG
HHHHHHHHHHHCCCCHHHEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEC
NLHDGGRALLVEDLATDGRSKVNFCNALREAGQRCDHAFVFFYYDIFPHTQTVMADLGLT
CCCCCCCEEEEHHHHCCCCHHHHHHHHHHHHHHHCCCEEEEEEEHHCCCHHHHHHHHHHH
LHYLVTWWDVLKVARETALIDPATLDKVEEFLKSPAQWSAAHGGIAEFKPAS
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA