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The map label for this gene is pleC [H]

Identifier: 182678998

GI number: 182678998

Start: 2324637

End: 2327030

Strand: Reverse

Name: pleC [H]

Synonym: Bind_2033

Alternate gene names: 182678998

Gene position: 2327030-2324637 (Counterclockwise)

Preceding gene: 182679009

Following gene: 182678994

Centisome position: 55.8

GC content: 58.77

Gene sequence:

>2394_bases
ATGGCGCGTGCAGACGCAGCCAATGTGTCCGTGCGAGCGGGGACATTGCTAGGACTTGCCTGTACGACGACGCATCGCGC
GTTTTCACGGCTCATTGCGCATGAGGTCTGGATTCGCCGTGCGGTTCCAGTCATGGTCGCTTTTTTTGTTGCGGCTTTGG
TGGCACTTGCCGTCGTTATTGGCCGTGAATCCTACGATCATGGCGTGGCCGAAGCCATGGAGAATCTCGATCTGGTCGGG
ACTCTCGTCGCCCACGATCTGTCGGCCCATCTGACCAAAAAAGGCGTGGTGCCGACGGATGACGGCTTGCGCCAGATGAT
CTCTCCTTCGCTGCTGGCGCGTGGGCAGGAAGTGCTCGTCGCTGATCCGAGCGGGCGCATCATTGGTGCCTATCCGGCGA
TTCCCGGGCTCAAAGGAACCCTTGCGGATTATTTAGGCCCTGCCCAGCCTCTGACGACATTTGCTGAAAAAGCGGGTGTG
TTGCGCATCACCTTGGCCGATGCGACGGAAGCTCTGGCCACGGTTCGGACGCTCGGCCTTGCCTCAGCCGGTCAAGTGGC
TTTGATCCACCCCATGACAGAGGTTTTGTCGGAGTGGCGTGCTAACAGTTGGCGCGCCGGTCTGCTTCTGTTCTCGACAT
CCTTTGTCCTTGTCGCATTGGCTTGCGCCTATTTCTGGCAGGCCACGCGTGCCAAGGAGGCTGGCGAAACCTGCGAGCGC
ATGCGCGAACGGATCGACACAGCGTTGAACCGGGGCCGCTGCGGCCTTTGGGATTGGGATCTTGCGCGCGGGCGCGTGTT
CTGGTCGCAGTCCATGTATGAAATTCTCGGCATGTCGCCGAGCGAGCAGTTCATTTCCTTCGGCGATATTAATGCGCTGA
TGCATCCTCAGGATGGTGATCTCGCGGCCATCGCCGAAATGCTCGCTGCCTCGAAAACGGATGCCATCGATCACGCCTTC
CGCATGCGCAATGTCGCGGGAGATTGGGTTTGGCTGCGCGCGCGCGCGGAGCTTGTCCGTGACCATCTCTCGAACACGCC
GCATCTCGTTGGCATTTGTGTTGACATTACCGAGCATAAGGTTCTGGCGGAACGCACCGCCACGGCCGATATGCGGTTGC
GTGATGCGATCGAGACTGTTTCTGAGGCCTTCGTGCTCTGGGACGCCGATAACCGGCTCGTCATGTGCAACGAGAAGTTC
CAGCGTTTCCATAATCTCGCGAATGATATCCTGGTACCGGGCACGCCCTATATGCAGGTGATGGCGAAAGGCACGCCACC
TCTGATCCAGTCGCAGATTGCTTTGGGTGAAAGACCGCAGGCGGGCGCGCGCACCTATGAAGCGCGGCTGGGCGATGGCC
GCTGGCTACAGATTAACGAAAGGCGCACCAAGGACGGCGGTTATGTCTCCGTTGGCACGGATATTACCACGCTCAAACGT
CATGAAGAGCAATTGATGGAATCCGAGCGCCGGCTGATGGCAACCATCGCCGACCTGCGCAAATCCCGCCAGACCTTGGA
ACTGCAGGCGCAACAGCTTGCCGATCTCGCCGAAAAATATCTTGAGCAGAAGGCGGAGGCCGAAACGGCGAACCGCGCGA
AATCTGAATTCCTCACCAATATGAGCCATGAATTGCGGACCCCGCTCAACGCGATTATCGGCTTTTCCGAATTGATGGGC
CAGGAGCCCTATGGCCCCCTCGGCTCACCGCGTTATCTCGATTATTGCAATGATATCCGCCAAAGCGGGCAATATTTGCT
TGGCGTGATTTCCGACGTTCTCGACATGTCACGTCTTGAGGCGGGTCGCGTCCGGCTCGAAAAGACCGATTTCGAGATCG
ACACGGTGGTTTCCAAGGCGATTGCGGGCGTCAAGGCCACGGCGGAGGAAAAGGAAATCACCCTTCTGGCCGAGACGACG
CCGCAAACAAGCGTCCACGCCGATCGAGGAGCGATCGAGAAAATCCTGCTTATCCTGCTTCGCAACGCAATCAAATTCAC
GCCCGCGCAAGGCCGGGTAACTGTGCGTACGCGCATGATCCAGGGGGCCTTGAATATTTATGTCGAGGATACCGGCATGG
GTATTCCGCCGGCTCCCTTGGCGCGTCTTGGGCGCCCCTTCGAGCAATTGCACGGGTCGATGGCCAATGGCATGAAGGGA
TCGGGCCTGGGTCTCGCAATCGCCCGCTCACTTGTTGATCTGCATGGAGGTTCCATGCGTATCCGTTCGACGGTGGGCTC
CGGCACGATCGTCCTCGTGCGTATTCCCGAGCCCAATGATATCTCCCGTCAGAAGATCCTGCTTGCGTCCGCCGTTGCTT
CATCCGCCAACGCCAACCGGTTGGCAGCCCAAAAACAAGATGTTTCGGTGATACGGGCTTCGACGCGGCGATAA

Upstream 100 bases:

>100_bases
TCTTTAAGGCCTGGACAAATAGGTGAAGACGCCTTCTGATAGAGACGATTCGAAGAGATGCGGCACATAGCTTCGAATCG
GTTTCGAGGGGGCCTGTGAC

Downstream 100 bases:

>100_bases
GCTTTATTGGCTACAAAGTGGACGGCCACACGCTTGTTTCGAACAGCGAGTGGACATCGATAGCGTGCTCGAAGACATTT
TCGCGCGTGAAGACGTCGGC

Product: multi-sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 797; Mature: 796

Protein sequence:

>797_residues
MARADAANVSVRAGTLLGLACTTTHRAFSRLIAHEVWIRRAVPVMVAFFVAALVALAVVIGRESYDHGVAEAMENLDLVG
TLVAHDLSAHLTKKGVVPTDDGLRQMISPSLLARGQEVLVADPSGRIIGAYPAIPGLKGTLADYLGPAQPLTTFAEKAGV
LRITLADATEALATVRTLGLASAGQVALIHPMTEVLSEWRANSWRAGLLLFSTSFVLVALACAYFWQATRAKEAGETCER
MRERIDTALNRGRCGLWDWDLARGRVFWSQSMYEILGMSPSEQFISFGDINALMHPQDGDLAAIAEMLAASKTDAIDHAF
RMRNVAGDWVWLRARAELVRDHLSNTPHLVGICVDITEHKVLAERTATADMRLRDAIETVSEAFVLWDADNRLVMCNEKF
QRFHNLANDILVPGTPYMQVMAKGTPPLIQSQIALGERPQAGARTYEARLGDGRWLQINERRTKDGGYVSVGTDITTLKR
HEEQLMESERRLMATIADLRKSRQTLELQAQQLADLAEKYLEQKAEAETANRAKSEFLTNMSHELRTPLNAIIGFSELMG
QEPYGPLGSPRYLDYCNDIRQSGQYLLGVISDVLDMSRLEAGRVRLEKTDFEIDTVVSKAIAGVKATAEEKEITLLAETT
PQTSVHADRGAIEKILLILLRNAIKFTPAQGRVTVRTRMIQGALNIYVEDTGMGIPPAPLARLGRPFEQLHGSMANGMKG
SGLGLAIARSLVDLHGGSMRIRSTVGSGTIVLVRIPEPNDISRQKILLASAVASSANANRLAAQKQDVSVIRASTRR

Sequences:

>Translated_797_residues
MARADAANVSVRAGTLLGLACTTTHRAFSRLIAHEVWIRRAVPVMVAFFVAALVALAVVIGRESYDHGVAEAMENLDLVG
TLVAHDLSAHLTKKGVVPTDDGLRQMISPSLLARGQEVLVADPSGRIIGAYPAIPGLKGTLADYLGPAQPLTTFAEKAGV
LRITLADATEALATVRTLGLASAGQVALIHPMTEVLSEWRANSWRAGLLLFSTSFVLVALACAYFWQATRAKEAGETCER
MRERIDTALNRGRCGLWDWDLARGRVFWSQSMYEILGMSPSEQFISFGDINALMHPQDGDLAAIAEMLAASKTDAIDHAF
RMRNVAGDWVWLRARAELVRDHLSNTPHLVGICVDITEHKVLAERTATADMRLRDAIETVSEAFVLWDADNRLVMCNEKF
QRFHNLANDILVPGTPYMQVMAKGTPPLIQSQIALGERPQAGARTYEARLGDGRWLQINERRTKDGGYVSVGTDITTLKR
HEEQLMESERRLMATIADLRKSRQTLELQAQQLADLAEKYLEQKAEAETANRAKSEFLTNMSHELRTPLNAIIGFSELMG
QEPYGPLGSPRYLDYCNDIRQSGQYLLGVISDVLDMSRLEAGRVRLEKTDFEIDTVVSKAIAGVKATAEEKEITLLAETT
PQTSVHADRGAIEKILLILLRNAIKFTPAQGRVTVRTRMIQGALNIYVEDTGMGIPPAPLARLGRPFEQLHGSMANGMKG
SGLGLAIARSLVDLHGGSMRIRSTVGSGTIVLVRIPEPNDISRQKILLASAVASSANANRLAAQKQDVSVIRASTRR
>Mature_796_residues
ARADAANVSVRAGTLLGLACTTTHRAFSRLIAHEVWIRRAVPVMVAFFVAALVALAVVIGRESYDHGVAEAMENLDLVGT
LVAHDLSAHLTKKGVVPTDDGLRQMISPSLLARGQEVLVADPSGRIIGAYPAIPGLKGTLADYLGPAQPLTTFAEKAGVL
RITLADATEALATVRTLGLASAGQVALIHPMTEVLSEWRANSWRAGLLLFSTSFVLVALACAYFWQATRAKEAGETCERM
RERIDTALNRGRCGLWDWDLARGRVFWSQSMYEILGMSPSEQFISFGDINALMHPQDGDLAAIAEMLAASKTDAIDHAFR
MRNVAGDWVWLRARAELVRDHLSNTPHLVGICVDITEHKVLAERTATADMRLRDAIETVSEAFVLWDADNRLVMCNEKFQ
RFHNLANDILVPGTPYMQVMAKGTPPLIQSQIALGERPQAGARTYEARLGDGRWLQINERRTKDGGYVSVGTDITTLKRH
EEQLMESERRLMATIADLRKSRQTLELQAQQLADLAEKYLEQKAEAETANRAKSEFLTNMSHELRTPLNAIIGFSELMGQ
EPYGPLGSPRYLDYCNDIRQSGQYLLGVISDVLDMSRLEAGRVRLEKTDFEIDTVVSKAIAGVKATAEEKEITLLAETTP
QTSVHADRGAIEKILLILLRNAIKFTPAQGRVTVRTRMIQGALNIYVEDTGMGIPPAPLARLGRPFEQLHGSMANGMKGS
GLGLAIARSLVDLHGGSMRIRSTVGSGTIVLVRIPEPNDISRQKILLASAVASSANANRLAAQKQDVSVIRASTRR

Specific function: Member of the two-component regulatory system involved in the regulation of polar organelle development. PleC functions as a membrane-associated protein kinase that transfers phosphate to the response regulator pleD, leading to its activation [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1789149, Length=269, Percent_Identity=34.5724907063197, Blast_Score=139, Evalue=5e-34,
Organism=Escherichia coli, GI145693157, Length=242, Percent_Identity=35.5371900826446, Blast_Score=129, Evalue=7e-31,
Organism=Escherichia coli, GI87081816, Length=289, Percent_Identity=33.5640138408304, Blast_Score=122, Evalue=7e-29,
Organism=Escherichia coli, GI1788713, Length=249, Percent_Identity=32.1285140562249, Blast_Score=107, Evalue=3e-24,
Organism=Escherichia coli, GI48994928, Length=250, Percent_Identity=31.6, Blast_Score=105, Evalue=1e-23,
Organism=Escherichia coli, GI1786600, Length=225, Percent_Identity=30.2222222222222, Blast_Score=104, Evalue=3e-23,
Organism=Escherichia coli, GI1786912, Length=236, Percent_Identity=29.2372881355932, Blast_Score=101, Evalue=2e-22,
Organism=Escherichia coli, GI1790861, Length=252, Percent_Identity=30.952380952381, Blast_Score=90, Evalue=7e-19,
Organism=Escherichia coli, GI87082128, Length=230, Percent_Identity=27.3913043478261, Blast_Score=80, Evalue=4e-16,
Organism=Escherichia coli, GI1786783, Length=263, Percent_Identity=25.8555133079848, Blast_Score=78, Evalue=2e-15,
Organism=Escherichia coli, GI1788549, Length=253, Percent_Identity=24.5059288537549, Blast_Score=78, Evalue=2e-15,
Organism=Escherichia coli, GI1788393, Length=255, Percent_Identity=21.5686274509804, Blast_Score=70, Evalue=4e-13,
Organism=Escherichia coli, GI1788279, Length=217, Percent_Identity=25.3456221198157, Blast_Score=70, Evalue=5e-13,
Organism=Escherichia coli, GI1790436, Length=219, Percent_Identity=25.1141552511416, Blast_Score=70, Evalue=6e-13,
Organism=Escherichia coli, GI1790300, Length=244, Percent_Identity=27.8688524590164, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1790346, Length=225, Percent_Identity=24, Blast_Score=63, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 87203; Mature: 87072

Theoretical pI: Translated: 7.68; Mature: 7.68

Prosite motif: PS50113 PAC ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARADAANVSVRAGTLLGLACTTTHRAFSRLIAHEVWIRRAVPVMVAFFVAALVALAVVI
CCCCCCCCCEEECCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GRESYDHGVAEAMENLDLVGTLVAHDLSAHLTKKGVVPTDDGLRQMISPSLLARGQEVLV
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCHHHHHCCCEEEE
ADPSGRIIGAYPAIPGLKGTLADYLGPAQPLTTFAEKAGVLRITLADATEALATVRTLGL
ECCCCCEEECCCCCCCCCHHHHHHCCCCCHHHHHHHHCCEEEEEECHHHHHHHHHHHHCC
ASAGQVALIHPMTEVLSEWRANSWRAGLLLFSTSFVLVALACAYFWQATRAKEAGETCER
CCCCCEEEEHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MRERIDTALNRGRCGLWDWDLARGRVFWSQSMYEILGMSPSEQFISFGDINALMHPQDGD
HHHHHHHHHCCCCCCCCCCHHHCCEEHHHHHHHHHHCCCCHHHHHHHCCCCEEECCCCCC
LAAIAEMLAASKTDAIDHAFRMRNVAGDWVWLRARAELVRDHLSNTPHLVGICVDITEHK
HHHHHHHHHCCCCHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHCCCCCEEEEEEEHHHHH
VLAERTATADMRLRDAIETVSEAFVLWDADNRLVMCNEKFQRFHNLANDILVPGTPYMQV
HHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCEEEECHHHHHHHHHHHCCCCCCCHHHHH
MAKGTPPLIQSQIALGERPQAGARTYEARLGDGRWLQINERRTKDGGYVSVGTDITTLKR
EECCCCHHHHHHHHCCCCCCCCCHHHHHCCCCCCEEEEECCCCCCCCEEEECCCHHHHHH
HEEQLMESERRLMATIADLRKSRQTLELQAQQLADLAEKYLEQKAEAETANRAKSEFLTN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MSHELRTPLNAIIGFSELMGQEPYGPLGSPRYLDYCNDIRQSGQYLLGVISDVLDMSRLE
HHHHHHCHHHHHHCHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AGRVRLEKTDFEIDTVVSKAIAGVKATAEEKEITLLAETTPQTSVHADRGAIEKILLILL
HCCEEEECCCCHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHH
RNAIKFTPAQGRVTVRTRMIQGALNIYVEDTGMGIPPAPLARLGRPFEQLHGSMANGMKG
HHHHHCCCCCCEEEHHHHHHHHHEEEEEEECCCCCCCHHHHHHCCCHHHHCCHHHCCCCC
SGLGLAIARSLVDLHGGSMRIRSTVGSGTIVLVRIPEPNDISRQKILLASAVASSANANR
CCHHHHHHHHHHHHCCCCEEEEEECCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCCHH
LAAQKQDVSVIRASTRR
HHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
ARADAANVSVRAGTLLGLACTTTHRAFSRLIAHEVWIRRAVPVMVAFFVAALVALAVVI
CCCCCCCCEEECCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GRESYDHGVAEAMENLDLVGTLVAHDLSAHLTKKGVVPTDDGLRQMISPSLLARGQEVLV
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCHHHHHCCCEEEE
ADPSGRIIGAYPAIPGLKGTLADYLGPAQPLTTFAEKAGVLRITLADATEALATVRTLGL
ECCCCCEEECCCCCCCCCHHHHHHCCCCCHHHHHHHHCCEEEEEECHHHHHHHHHHHHCC
ASAGQVALIHPMTEVLSEWRANSWRAGLLLFSTSFVLVALACAYFWQATRAKEAGETCER
CCCCCEEEEHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MRERIDTALNRGRCGLWDWDLARGRVFWSQSMYEILGMSPSEQFISFGDINALMHPQDGD
HHHHHHHHHCCCCCCCCCCHHHCCEEHHHHHHHHHHCCCCHHHHHHHCCCCEEECCCCCC
LAAIAEMLAASKTDAIDHAFRMRNVAGDWVWLRARAELVRDHLSNTPHLVGICVDITEHK
HHHHHHHHHCCCCHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHCCCCCEEEEEEEHHHHH
VLAERTATADMRLRDAIETVSEAFVLWDADNRLVMCNEKFQRFHNLANDILVPGTPYMQV
HHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCEEEECHHHHHHHHHHHCCCCCCCHHHHH
MAKGTPPLIQSQIALGERPQAGARTYEARLGDGRWLQINERRTKDGGYVSVGTDITTLKR
EECCCCHHHHHHHHCCCCCCCCCHHHHHCCCCCCEEEEECCCCCCCCEEEECCCHHHHHH
HEEQLMESERRLMATIADLRKSRQTLELQAQQLADLAEKYLEQKAEAETANRAKSEFLTN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MSHELRTPLNAIIGFSELMGQEPYGPLGSPRYLDYCNDIRQSGQYLLGVISDVLDMSRLE
HHHHHHCHHHHHHCHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AGRVRLEKTDFEIDTVVSKAIAGVKATAEEKEITLLAETTPQTSVHADRGAIEKILLILL
HCCEEEECCCCHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHH
RNAIKFTPAQGRVTVRTRMIQGALNIYVEDTGMGIPPAPLARLGRPFEQLHGSMANGMKG
HHHHHCCCCCCEEEHHHHHHHHHEEEEEEECCCCCCCHHHHHHCCCHHHHCCHHHCCCCC
SGLGLAIARSLVDLHGGSMRIRSTVGSGTIVLVRIPEPNDISRQKILLASAVASSANANR
CCHHHHHHHHHHHHCCCCEEEEEECCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCCHH
LAAQKQDVSVIRASTRR
HHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8421698; 11259647 [H]