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The map label for this gene is cbh [H]

Identifier: 182678887

GI number: 182678887

Start: 2189080

End: 2190150

Strand: Direct

Name: cbh [H]

Synonym: Bind_1920

Alternate gene names: 182678887

Gene position: 2189080-2190150 (Clockwise)

Preceding gene: 182678883

Following gene: 182678891

Centisome position: 52.49

GC content: 56.58

Gene sequence:

>1071_bases
ATGAGCAACACCAAACACTCATTCGCCCGCTCCCTGCTCGCGCTCAGCCTCATGTCATTGGTGATGACAACCCCCCTGGC
AGAAGCCTGTACACGGGCGGTGTTTCTCGGGCAAGATGGCCAAGTCGTCACGGCGCGTTCCATGGATTGGAAGACGGATA
TCGGCACCAATCTGTGGATCTTTCCGCGCGGCATGGAGCGCAATGGCGAGACGGGGCCGAAGACTGTTCGCTGGACGTCG
AAATATGGCAGCGTCATCGCCTCCGCCTATGATGTCTCGACCTCGGATGGTCTCAATGAGGCAGGTCTTTCGGCCAATCT
GCTTTGGCTGGTCGAGTCCCAATACCCCGCCTTCGACCCGTCCAAGCCGGGGCTCACTATCGCCGCCTGGGCGCAATATG
TGCTCGACAATTTCGCCACTGTGGCCGAGGCCGTGGATGCACTTTCACGCGAGCCTTTCGTGCCGGTGACGGCGGATATT
CCAGGAGAGACGCGCCTTGCGACCGTTCACCTTTCCATTTCCGATGCGACGGGTGACAGCGCCATCATCGAATATGTCAA
CGGCAAGCAGGTCATTCATCACGATCGCAAATATCAGGTGATGACCAATTCGCCTTTGTTCGATCAGCAATTGGCATTGG
ACTCTTATTGGCAGCAGATTGGCGGCACAATCATGCTGCCGGGCACGAACAGGGCGTCCGACCGTTTCGCACGCGCGTCC
TTTTACATCAATGCCATTCCGAAGGATGAGACGCCCAATCGCACTATTGCCAGCGTCTTCAGTGTCATTCGCAACGCATC
CGTGCCCTATGGACTGAACACGGCCGAGGAGCCCAATATTTCCTCGACACGATGGCGCACCGTCGCGGACCACAAGCGCA
AGCTTTATTTCTTTGAATCGGCGCTGACGCCCAATGTCTTCTGGGTCGATCTCAAAACCATCGACTTCTCGCCGGAAACC
GGAAAAGTGCGCAAGCTCGACCTCGGCCCGGAGCAGACCAACATCTTTTCCGGCAATGCAACGGAGAATTTCAAGGAAGC
CAAGCCATTCAGATTTTTAGGCTTGCCTTGA

Upstream 100 bases:

>100_bases
TAAAAAGTAATACTTTATCCTCATTATTACAAGAGAAAAGCAGCAAACTGGTCTTCGCCATATAGGTAAGCCAAATCTCA
CCGTCAAACTGAAACCACCC

Downstream 100 bases:

>100_bases
GCGCCGTGAACAGGCCGTTTTATACCAACGGTCATGATCAAGACCGTTGGACCGCTCTTGAATTTTCGCTCTCGCTTTGT
AAAAGCGAAAATTCAAGAAA

Product: choloylglycine hydrolase

Products: NA

Alternate protein names: Bile salt hydrolase; Conjugated bile acid hydrolase; CBAH [H]

Number of amino acids: Translated: 356; Mature: 355

Protein sequence:

>356_residues
MSNTKHSFARSLLALSLMSLVMTTPLAEACTRAVFLGQDGQVVTARSMDWKTDIGTNLWIFPRGMERNGETGPKTVRWTS
KYGSVIASAYDVSTSDGLNEAGLSANLLWLVESQYPAFDPSKPGLTIAAWAQYVLDNFATVAEAVDALSREPFVPVTADI
PGETRLATVHLSISDATGDSAIIEYVNGKQVIHHDRKYQVMTNSPLFDQQLALDSYWQQIGGTIMLPGTNRASDRFARAS
FYINAIPKDETPNRTIASVFSVIRNASVPYGLNTAEEPNISSTRWRTVADHKRKLYFFESALTPNVFWVDLKTIDFSPET
GKVRKLDLGPEQTNIFSGNATENFKEAKPFRFLGLP

Sequences:

>Translated_356_residues
MSNTKHSFARSLLALSLMSLVMTTPLAEACTRAVFLGQDGQVVTARSMDWKTDIGTNLWIFPRGMERNGETGPKTVRWTS
KYGSVIASAYDVSTSDGLNEAGLSANLLWLVESQYPAFDPSKPGLTIAAWAQYVLDNFATVAEAVDALSREPFVPVTADI
PGETRLATVHLSISDATGDSAIIEYVNGKQVIHHDRKYQVMTNSPLFDQQLALDSYWQQIGGTIMLPGTNRASDRFARAS
FYINAIPKDETPNRTIASVFSVIRNASVPYGLNTAEEPNISSTRWRTVADHKRKLYFFESALTPNVFWVDLKTIDFSPET
GKVRKLDLGPEQTNIFSGNATENFKEAKPFRFLGLP
>Mature_355_residues
SNTKHSFARSLLALSLMSLVMTTPLAEACTRAVFLGQDGQVVTARSMDWKTDIGTNLWIFPRGMERNGETGPKTVRWTSK
YGSVIASAYDVSTSDGLNEAGLSANLLWLVESQYPAFDPSKPGLTIAAWAQYVLDNFATVAEAVDALSREPFVPVTADIP
GETRLATVHLSISDATGDSAIIEYVNGKQVIHHDRKYQVMTNSPLFDQQLALDSYWQQIGGTIMLPGTNRASDRFARASF
YINAIPKDETPNRTIASVFSVIRNASVPYGLNTAEEPNISSTRWRTVADHKRKLYFFESALTPNVFWVDLKTIDFSPETG
KVRKLDLGPEQTNIFSGNATENFKEAKPFRFLGLP

Specific function: The enzyme catalyzes the degradation of conjugated bile acids in the mammalian gut [H]

COG id: COG3049

COG function: function code M; Penicillin V acylase and related amidases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase C59 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003199 [H]

Pfam domain/function: PF02275 CBAH [H]

EC number: =3.5.1.24 [H]

Molecular weight: Translated: 39360; Mature: 39229

Theoretical pI: Translated: 6.38; Mature: 6.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNTKHSFARSLLALSLMSLVMTTPLAEACTRAVFLGQDGQVVTARSMDWKTDIGTNLWI
CCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHEEEECCCCCEEEEECCCCCCCCCCEEEE
FPRGMERNGETGPKTVRWTSKYGSVIASAYDVSTSDGLNEAGLSANLLWLVESQYPAFDP
EECCCCCCCCCCCCEEEEEHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEEECCCCCCCC
SKPGLTIAAWAQYVLDNFATVAEAVDALSREPFVPVTADIPGETRLATVHLSISDATGDS
CCCCEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCEEEEEEEEEECCCCCC
AIIEYVNGKQVIHHDRKYQVMTNSPLFDQQLALDSYWQQIGGTIMLPGTNRASDRFARAS
EEEEECCCCEEEECCCEEEEEECCCCCHHHHHHHHHHHHHCCEEEECCCCCHHHHHEEEE
FYINAIPKDETPNRTIASVFSVIRNASVPYGLNTAEEPNISSTRWRTVADHKRKLYFFES
EEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHCCEEEEEEEC
ALTPNVFWVDLKTIDFSPETGKVRKLDLGPEQTNIFSGNATENFKEAKPFRFLGLP
CCCCCEEEEEEEEEECCCCCCCEEEEECCCCCCEEECCCCCCCHHHCCCEEEECCC
>Mature Secondary Structure 
SNTKHSFARSLLALSLMSLVMTTPLAEACTRAVFLGQDGQVVTARSMDWKTDIGTNLWI
CCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHEEEECCCCCEEEEECCCCCCCCCCEEEE
FPRGMERNGETGPKTVRWTSKYGSVIASAYDVSTSDGLNEAGLSANLLWLVESQYPAFDP
EECCCCCCCCCCCCEEEEEHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEEECCCCCCCC
SKPGLTIAAWAQYVLDNFATVAEAVDALSREPFVPVTADIPGETRLATVHLSISDATGDS
CCCCEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCEEEEEEEEEECCCCCC
AIIEYVNGKQVIHHDRKYQVMTNSPLFDQQLALDSYWQQIGGTIMLPGTNRASDRFARAS
EEEEECCCCEEEECCCEEEEEECCCCCHHHHHHHHHHHHHCCEEEECCCCCHHHHHEEEE
FYINAIPKDETPNRTIASVFSVIRNASVPYGLNTAEEPNISSTRWRTVADHKRKLYFFES
EEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHCCEEEEEEEC
ALTPNVFWVDLKTIDFSPETGKVRKLDLGPEQTNIFSGNATENFKEAKPFRFLGLP
CCCCCEEEEEEEEEECCCCCCCEEEEECCCCCCEEECCCCCCCHHHCCCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7618863; 11792842 [H]