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The map label for this gene is lolC [H]

Identifier: 182678767

GI number: 182678767

Start: 2034418

End: 2035737

Strand: Reverse

Name: lolC [H]

Synonym: Bind_1796

Alternate gene names: 182678767

Gene position: 2035737-2034418 (Counterclockwise)

Preceding gene: 182678768

Following gene: 182678766

Centisome position: 48.82

GC content: 58.71

Gene sequence:

>1320_bases
GTGACCCAGACAAGACAAGAGTCGCCCCGGCAAGAACAGGAGAATGTATATCGCGAGGGCACCGCAGGGGCCACGCGTCC
TTTCGCGCCCTTCGAGTGGATGATCGCCTTGCGTTACCTGCGCGCACGCCGCTCGCAGGGATTCGTTTCGGTCATTGCCG
GCTTTTCCTTTCTCGGCATTACACTTGGCGTGGCGACGCTCATCGTCGTCATGTCAGTGATGAATGGATTCCACAAGGAA
TTGCTCGACAAGATCGTCGGTATCAACGGCCATATCTTTCTCCAGGCGACGGAATCGCCCCTGACCGATTATGAATCCGT
TGTCCACCAGATCGATGGCCTGCCGGGCATCGAACTCGCGCTTCCCCTCGTCGAGGCGCCGGCGGCGGCCTCGACCACCA
ATATGGCCTTTGCCCTTGTGCGCGGCATCCGTGAGGTTGATCTGAAACGCCTGCCAGGCATTGCTGGCCATGTGACGCTC
GGGACATTGGACGGGTTCGATAAAGCGGGGGGTGTCGTCATCGGCCAGAGGCTCGCGGAGAATCTTGGGCTCGGCCTTGG
CGACAAGATCAAGCTTCTGACCGCCAATGGCACGCAGACGCCCTTTGGTGTGACGCCCCGCAGCAAGGTCTATACGGTTA
CGGGCATTTTCCAGATCGGCATGGCTGAATTCGACAATCTCTTCGTCTATCTTCCCTTGCCGGAGGCACAGGCCTTCTTC
AACAAGGAGGGCGAGGCGAGTGTTATCGAAATTTTCCTGACGGATCCTGATCGGATTGATGCCGCGCGCCACGTGCTGCA
AGACCATATCACCCGGCCGATGATCATGACCGATTGGCGTGAGCGTAACCGCACCTTCTTTGACGCGCTGAATGTCGAAC
GCAATGTCATGTTCATCATTCTGACGCTCATCGTGCTCGTCGCGGCCTTGAACATCATTTCCGGCCTGATCATGCTGGTG
AAGGACAAGGGACGCGATATTGCGATCCTGCGGACCATGGGCGTGACTCGCGGTGGCGTCATGCGGATCTTTCTCATCAC
CGGCGCCTCGATTGGCATCGTTGGAACCTTTGCAGGCTTCCTGTTGGGCCTGCTCGTCGCCAGCAATGTCGAGGCGATCC
GCCAGATGTTGAACCGTCTGCTCGACGCCAATCTGTTTCCCGCCGAGATCTATTTTCTGTCACGCTTGCCGTCCGTGGTC
GATCCCGGTGATGTCTTTTCGGTGGTCGCGCTGACGCTCGTTCTCTCCGTGCTTGCCACGCTCTATCCGTCCTGGCGGGC
GGCGCGTCTCGACCCGGTCGAAGCCTTGCGTTACGAATGA

Upstream 100 bases:

>100_bases
GACCCAAGGGTCTTGCCGAGGGCAAGATCGAGATGAAGACGCGCGCGACGGGCGCACGGGAAAATCTATCGATTGCCGCA
GTCATCGAACGGTTTACGAC

Downstream 100 bases:

>100_bases
TCATGAGCACTCCGGCCCTGTATCTTCATAAGGTTGAAAGGCGTTTCCAGGAGGCCGGTGAGCCTCTGGAAATCCTGCGC
GGTGCGGAATTCAGCCTTTG

Product: LolC/E family lipoprotein releasing system, transmembrane protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 439; Mature: 438

Protein sequence:

>439_residues
MTQTRQESPRQEQENVYREGTAGATRPFAPFEWMIALRYLRARRSQGFVSVIAGFSFLGITLGVATLIVVMSVMNGFHKE
LLDKIVGINGHIFLQATESPLTDYESVVHQIDGLPGIELALPLVEAPAAASTTNMAFALVRGIREVDLKRLPGIAGHVTL
GTLDGFDKAGGVVIGQRLAENLGLGLGDKIKLLTANGTQTPFGVTPRSKVYTVTGIFQIGMAEFDNLFVYLPLPEAQAFF
NKEGEASVIEIFLTDPDRIDAARHVLQDHITRPMIMTDWRERNRTFFDALNVERNVMFIILTLIVLVAALNIISGLIMLV
KDKGRDIAILRTMGVTRGGVMRIFLITGASIGIVGTFAGFLLGLLVASNVEAIRQMLNRLLDANLFPAEIYFLSRLPSVV
DPGDVFSVVALTLVLSVLATLYPSWRAARLDPVEALRYE

Sequences:

>Translated_439_residues
MTQTRQESPRQEQENVYREGTAGATRPFAPFEWMIALRYLRARRSQGFVSVIAGFSFLGITLGVATLIVVMSVMNGFHKE
LLDKIVGINGHIFLQATESPLTDYESVVHQIDGLPGIELALPLVEAPAAASTTNMAFALVRGIREVDLKRLPGIAGHVTL
GTLDGFDKAGGVVIGQRLAENLGLGLGDKIKLLTANGTQTPFGVTPRSKVYTVTGIFQIGMAEFDNLFVYLPLPEAQAFF
NKEGEASVIEIFLTDPDRIDAARHVLQDHITRPMIMTDWRERNRTFFDALNVERNVMFIILTLIVLVAALNIISGLIMLV
KDKGRDIAILRTMGVTRGGVMRIFLITGASIGIVGTFAGFLLGLLVASNVEAIRQMLNRLLDANLFPAEIYFLSRLPSVV
DPGDVFSVVALTLVLSVLATLYPSWRAARLDPVEALRYE
>Mature_438_residues
TQTRQESPRQEQENVYREGTAGATRPFAPFEWMIALRYLRARRSQGFVSVIAGFSFLGITLGVATLIVVMSVMNGFHKEL
LDKIVGINGHIFLQATESPLTDYESVVHQIDGLPGIELALPLVEAPAAASTTNMAFALVRGIREVDLKRLPGIAGHVTLG
TLDGFDKAGGVVIGQRLAENLGLGLGDKIKLLTANGTQTPFGVTPRSKVYTVTGIFQIGMAEFDNLFVYLPLPEAQAFFN
KEGEASVIEIFLTDPDRIDAARHVLQDHITRPMIMTDWRERNRTFFDALNVERNVMFIILTLIVLVAALNIISGLIMLVK
DKGRDIAILRTMGVTRGGVMRIFLITGASIGIVGTFAGFLLGLLVASNVEAIRQMLNRLLDANLFPAEIYFLSRLPSVVD
PGDVFSVVALTLVLSVLATLYPSWRAARLDPVEALRYE

Specific function: Part of an ATP-dependent transport system responsible for the release of lipoproteins targeted to the outer membrane from the inner membrane. Such a release is dependent of the sorting-signal (absence of an Asp at position 2 of the mature lipoprotein) and

COG id: COG4591

COG function: function code M; ABC-type transport system, involved in lipoprotein release, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787360, Length=415, Percent_Identity=31.3253012048193, Blast_Score=179, Evalue=3e-46,
Organism=Escherichia coli, GI1787362, Length=413, Percent_Identity=31.2348668280872, Blast_Score=178, Evalue=5e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003838
- InterPro:   IPR011925 [H]

Pfam domain/function: PF02687 FtsX [H]

EC number: NA

Molecular weight: Translated: 48099; Mature: 47968

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQTRQESPRQEQENVYREGTAGATRPFAPFEWMIALRYLRARRSQGFVSVIAGFSFLGI
CCCCCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
TLGVATLIVVMSVMNGFHKELLDKIVGINGHIFLQATESPLTDYESVVHQIDGLPGIELA
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHCCCCCHHHH
LPLVEAPAAASTTNMAFALVRGIREVDLKRLPGIAGHVTLGTLDGFDKAGGVVIGQRLAE
HHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCHHHHHHHHH
NLGLGLGDKIKLLTANGTQTPFGVTPRSKVYTVTGIFQIGMAEFDNLFVYLPLPEAQAFF
HHCCCCCCCEEEEECCCCCCCCCCCCCCCEEEEHHHHHHHHHHHCCEEEEEECCHHHHHH
NKEGEASVIEIFLTDPDRIDAARHVLQDHITRPMIMTDWRERNRTFFDALNVERNVMFII
CCCCCCEEEEEEECCCHHHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHCCCCHHHHHH
LTLIVLVAALNIISGLIMLVKDKGRDIAILRTMGVTRGGVMRIFLITGASIGIVGTFAGF
HHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCEEEEEEEECCCHHHHHHHHHH
LLGLLVASNVEAIRQMLNRLLDANLFPAEIYFLSRLPSVVDPGDVFSVVALTLVLSVLAT
HHHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHH
LYPSWRAARLDPVEALRYE
HCCCCCCCCCCHHHHHCCC
>Mature Secondary Structure 
TQTRQESPRQEQENVYREGTAGATRPFAPFEWMIALRYLRARRSQGFVSVIAGFSFLGI
CCCCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
TLGVATLIVVMSVMNGFHKELLDKIVGINGHIFLQATESPLTDYESVVHQIDGLPGIELA
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHCCCCCHHHH
LPLVEAPAAASTTNMAFALVRGIREVDLKRLPGIAGHVTLGTLDGFDKAGGVVIGQRLAE
HHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCHHHHHHHHH
NLGLGLGDKIKLLTANGTQTPFGVTPRSKVYTVTGIFQIGMAEFDNLFVYLPLPEAQAFF
HHCCCCCCCEEEEECCCCCCCCCCCCCCCEEEEHHHHHHHHHHHCCEEEEEECCHHHHHH
NKEGEASVIEIFLTDPDRIDAARHVLQDHITRPMIMTDWRERNRTFFDALNVERNVMFII
CCCCCCEEEEEEECCCHHHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHCCCCHHHHHH
LTLIVLVAALNIISGLIMLVKDKGRDIAILRTMGVTRGGVMRIFLITGASIGIVGTFAGF
HHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCEEEEEEEECCCHHHHHHHHHH
LLGLLVASNVEAIRQMLNRLLDANLFPAEIYFLSRLPSVVDPGDVFSVVALTLVLSVLAT
HHHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHH
LYPSWRAARLDPVEALRYE
HCCCCCCCCCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10910347 [H]